Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression

Journal of Neuroscience

Volumn 24, Issue 28, 2004, Pages 6352-6361

  Hou, Lingfei ^a   Klann, Eric ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

CA1; Hippocampus; Phosphorylation; Protein kinase; Synaptic plasticity; Translation initiation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3,5 DIHYDROXYPHENYLGLYCINE; MAMMALIAN TARGET OF RAPAMYCIN; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; PHOSPHATIDYLINOSITOL 3 KINASE; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN SLICE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE ACTIVATION; HIPPOCAMPUS; HIPPOCAMPUS PYRAMIDAL CELL LAYER; IMMUNOHISTOCHEMISTRY; LONG TERM DEPRESSION; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RECEPTOR INTRINSIC ACTIVITY; STRATUM PYRAMIDALE; SYNAPTIC TRANSMISSION; TRANSLATION INITIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; BENZOATES; CHROMONES; DENDRITES; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; GLYCINE; HIPPOCAMPUS; LONG-TERM DEPRESSION (PHYSIOLOGY); MALE; MICE; MICE, INBRED C57BL; MORPHOLINES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PYRAMIDAL CELLS; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; RESORCINOLS; SIGNAL TRANSDUCTION; SIROLIMUS; SYNAPTOSOMES; TACROLIMUS;

EID: 3242724040     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0995-04.2004     Document Type: Article

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