메뉴 건너뛰기




Volumn 27, Issue 1, 1998, Pages 1-39

The role of neuronal growth factors in neurodegenerative disorders of the human brain

Author keywords

BDNF; GDNF; IGF I; Neurodegeneration; Neurotrophin; NGF; NT 3; TGF ; Trk Receptor

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN 3; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA; TYROSINE KINASE RECEPTOR;

EID: 0032102110     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(98)00004-6     Document Type: Review
Times cited : (505)

References (500)
  • 3
    • 0024347261 scopus 로고
    • Insulin-like growth factor 1 (IGF-1) receptors in the human brain: Quantitative autoradiographic localization
    • [3] A. Adem, S.S. Jossan, R. d'Argy, P.G. Gillberg, A. Nordberg, B. Winblad, V. Sara, Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization, Brain Res. 503 (1989) 299-303.
    • (1989) Brain Res. , vol.503 , pp. 299-303
    • Adem, A.1    Jossan, S.S.2    D'Argy, R.3    Gillberg, P.G.4    Nordberg, A.5    Winblad, B.6    Sara, V.7
  • 4
    • 0027058672 scopus 로고
    • Immunohistochemical localization of insulin-like growth factor I in the hypothalamo-hypophyseal system of the adult rat
    • [4] F. Aguado, T. Fernandez, R. Martinez-Murillo, J. Rodrigo, L. Cacicedo, F. Sanchez-Franco, Immunohistochemical localization of insulin-like growth factor I in the hypothalamo-hypophyseal system of the adult rat, Neuroendocrinology 56 (1992) 856-863.
    • (1992) Neuroendocrinology , vol.56 , pp. 856-863
    • Aguado, F.1    Fernandez, T.2    Martinez-Murillo, R.3    Rodrigo, J.4    Cacicedo, L.5    Sanchez-Franco, F.6
  • 5
    • 0026567293 scopus 로고
    • Subcellular localisation of insulin-like growth factor I (IGF-I) in Purkinje cells of the adult rat: An immunocytochemical study
    • [5] F. Aguado, F. Sanchez-Franco, L. Cacidedo, T. Fernandez, J. Rodrigo, R. Martinez-Murillo, Subcellular localisation of insulin-like growth factor I (IGF-I) in Purkinje cells of the adult rat: an immunocytochemical study, Neurosci. Lett. 135 (1992) 171-174.
    • (1992) Neurosci. Lett. , vol.135 , pp. 171-174
    • Aguado, F.1    Sanchez-Franco, F.2    Cacidedo, L.3    Fernandez, T.4    Rodrigo, J.5    Martinez-Murillo, R.6
  • 6
    • 0028214583 scopus 로고
    • Insulin-like growth factor 1-immunoreactive peptide in adult human cerebellar Purkinje cells: Co-localisation with low-affinity nerve growth factor receptor
    • [6] F. Aguado, F. Sanchez-Franco, J. Rodrigo, L. Cacicedo, R. Martinez-Murillo, Insulin-like growth factor 1-immunoreactive peptide in adult human cerebellar Purkinje cells: co-localisation with low-affinity nerve growth factor receptor, Neuroscience 59 (1994) 641-650.
    • (1994) Neuroscience , vol.59 , pp. 641-650
    • Aguado, F.1    Sanchez-Franco, F.2    Rodrigo, J.3    Cacicedo, L.4    Martinez-Murillo, R.5
  • 7
    • 0023103339 scopus 로고
    • Brain neurons develop in a serum and glial free environment: Effects of transferrin, insulin, insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation
    • [7] Y. Aizenman, J. de Vellis, Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin, insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation, Brain Res. 406 (1987) 32-42.
    • (1987) Brain Res. , vol.406 , pp. 32-42
    • Aizenman, Y.1    De Vellis, J.2
  • 8
    • 0029586158 scopus 로고
    • Selective acid vulnerability of dopaminergic neurons and its recovery by brain-derived neurotrophic factor
    • [8] Y. Akaneya, M. Takahashi, H. Hatanaka, Selective acid vulnerability of dopaminergic neurons and its recovery by brain-derived neurotrophic factor, Brain Res. 704 (1995) 175-183.
    • (1995) Brain Res. , vol.704 , pp. 175-183
    • Akaneya, Y.1    Takahashi, M.2    Hatanaka, H.3
  • 9
    • 0025168085 scopus 로고
    • Brain-derived neurotrophic factor increases survival and differentiated function of rat septal cholinergic neurons in culture
    • [9] R.F. Alderson, A.L. Alterman, Y. Barde, R.M. Lindsay, Brain-derived neurotrophic factor increases survival and differentiated function of rat septal cholinergic neurons in culture, Neuron 5 (1990) 297-306.
    • (1990) Neuron , vol.5 , pp. 297-306
    • Alderson, R.F.1    Alterman, A.L.2    Barde, Y.3    Lindsay, R.M.4
  • 10
    • 0027214522 scopus 로고
    • Trophic actions of transforming growth factor α on mesencephalic dopaminergic neurons developing in culture
    • [10] T. Alexi, F. Hefti, Trophic actions of transforming growth factor α on mesencephalic dopaminergic neurons developing in culture, Neuroscience 55 (1993) 903-918.
    • (1993) Neuroscience , vol.55 , pp. 903-918
    • Alexi, T.1    Hefti, F.2
  • 11
    • 0028153174 scopus 로고
    • Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis
    • [11] M.E. Alexianu, A.M. Mohamed, R.G. Smith, L.V. Colom, S.H. Appel, Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis, J. Neurochem. 63 (1994) 2365-2368.
    • (1994) J. Neurochem. , vol.63 , pp. 2365-2368
    • Alexianu, M.E.1    Mohamed, A.M.2    Smith, R.G.3    Colom, L.V.4    Appel, S.H.5
  • 14
    • 0026718899 scopus 로고
    • Programmed cell death: The paths to suicide
    • [14] L. Altman, Programmed cell death: the paths to suicide, Trends Neurosci. 15 (1992) 278-280.
    • (1992) Trends Neurosci. , vol.15 , pp. 278-280
    • Altman, L.1
  • 15
    • 0028210761 scopus 로고
    • Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: Association with pathology
    • [15] A.J. Anderson, B.J. Cummings, C.W. Cotman, Increased immunoreactivity for Jun-and Fos-related proteins in Alzheimer's disease: association with pathology, Exp. Neurol. 125 (1994) 286-295.
    • (1994) Exp. Neurol. , vol.125 , pp. 286-295
    • Anderson, A.J.1    Cummings, B.J.2    Cotman, C.W.3
  • 16
    • 0029133850 scopus 로고
    • Differential induction of IEGs in response to A-beta peptides in cultured neurons: Association between c-Jun immunoreactivity and A-beta-mediated apoptosis
    • [16] A.J. Anderson, C.J. Pike, C.W. Cotman, Differential induction of IEGs in response to A-beta peptides in cultured neurons: association between c-Jun immunoreactivity and A-beta-mediated apoptosis, J. Neurochem. 65 (1995) 1487-1498.
    • (1995) J. Neurochem. , vol.65 , pp. 1487-1498
    • Anderson, A.J.1    Pike, C.J.2    Cotman, C.W.3
  • 17
    • 0029976253 scopus 로고    scopus 로고
    • DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area and effect of postmortem delay
    • [17] A.J. Anderson, J.H. Sum, C.W. Cotman, DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area and effect of postmortem delay, J. Neurosci. 16 (1996) 1710-1719.
    • (1996) J. Neurosci. , vol.16 , pp. 1710-1719
    • Anderson, A.J.1    Sum, J.H.2    Cotman, C.W.3
  • 20
    • 0019781601 scopus 로고
    • A unifying hypothesis for the cause of amyotrophic lateral sclerosis, Parkinsonism, and Alzheimer's disease
    • [20] S.H. Appel, A unifying hypothesis for the cause of amyotrophic lateral sclerosis, Parkinsonism, and Alzheimer's disease, Ann. Neurol. 10 (1981) 499-505.
    • (1981) Ann. Neurol. , vol.10 , pp. 499-505
    • Appel, S.H.1
  • 21
    • 0024510181 scopus 로고
    • Insulin-like growth factor-1 (somatomedin-C) receptors in the rat brain: Distribution and interaction with the hippocampal cholinergic system
    • [21] D.M. Araujo, P.A. Lapchak, B. Collier, J.-G. Chabot, R. Quirion, Insulin-like growth factor-1 (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system, Brain Res. 484 (1989) 130-138.
    • (1989) Brain Res. , vol.484 , pp. 130-138
    • Araujo, D.M.1    Lapchak, P.A.2    Collier, B.3    Chabot, J.-G.4    Quirion, R.5
  • 22
    • 0025663169 scopus 로고
    • Potential neurotrophic factors in the mammalian central nervous system: Functional significance in the developing and aging brain
    • [22] D.M. Araujo, J.G. Chabot, R. Quirion, Potential neurotrophic factors in the mammalian central nervous system: functional significance in the developing and aging brain, Int. Rev. Neurobiol. 32 (1990) 141-173.
    • (1990) Int. Rev. Neurobiol. , vol.32 , pp. 141-173
    • Araujo, D.M.1    Chabot, J.G.2    Quirion, R.3
  • 23
    • 0028953736 scopus 로고
    • Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury: II. Reactive expression of the nerve growth factor gene in astrocytes
    • [23] T. Ardent, M.K. Bruckner, T. Krell, S. Pagliusi, L. Kruska, R. Heumann, Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury: II. Reactive expression of the nerve growth factor gene in astrocytes, Neuroscience 65 (1995) 647-659.
    • (1995) Neuroscience , vol.65 , pp. 647-659
    • Ardent, T.1    Bruckner, M.K.2    Krell, T.3    Pagliusi, S.4    Kruska, L.5    Heumann, R.6
  • 24
    • 0028915938 scopus 로고
    • Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury: I. Degeneration and plastic response of basal forebrain neurons
    • [24] T. Ardent, M.K. Bruckner, S. Pagliusi, T. Krell, Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury: I. Degeneration and plastic response of basal forebrain neurons, Neuroscience 65 (1995) 633-645.
    • (1995) Neuroscience , vol.65 , pp. 633-645
    • Ardent, T.1    Bruckner, M.K.2    Pagliusi, S.3    Krell, T.4
  • 25
    • 0028039812 scopus 로고
    • Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo
    • [25] E. Arenas, H. Persson, Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo, Nature 367 (1994) 368-371.
    • (1994) Nature , vol.367 , pp. 368-371
    • Arenas, E.1    Persson, H.2
  • 26
    • 0029584686 scopus 로고
    • GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo
    • [26] E. Arenas, M. Trupp, P. Akerud, C.F. Ibanez, GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo, Neuron 15 (1995) 1465-1473.
    • (1995) Neuron , vol.15 , pp. 1465-1473
    • Arenas, E.1    Trupp, M.2    Akerud, P.3    Ibanez, C.F.4
  • 27
    • 0028980467 scopus 로고
    • Beta-amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarised hippocampal slices
    • [27] C. Arias, I. Arrieta, R. Tapia, Beta-amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarised hippocampal slices, J. Neurosci. Res. 41 (1995) 561-566.
    • (1995) J. Neurosci. Res. , vol.41 , pp. 561-566
    • Arias, C.1    Arrieta, I.2    Tapia, R.3
  • 28
    • 0028324174 scopus 로고
    • Multiple cholinergic markers are unexpectedly not altered in the rat dentate gyrus following entorhinal cortex lesions
    • [28] I. Aubert, J. Poirier, S. Gauthier, R. Quirion, Multiple cholinergic markers are unexpectedly not altered in the rat dentate gyrus following entorhinal cortex lesions, J. Neurosci. 14 (1994) 2476-2484.
    • (1994) J. Neurosci. , vol.14 , pp. 2476-2484
    • Aubert, I.1    Poirier, J.2    Gauthier, S.3    Quirion, R.4
  • 29
    • 0023926865 scopus 로고
    • Expression of β-nerve growth factor gene in hippocampal neurons
    • [29] I. Ayer-LeLievre, L. Olson, T. Ebendal, A. Seiger, H. Persson, Expression of β-nerve growth factor gene in hippocampal neurons, Science 240 (1988) 1339-1340.
    • (1988) Science , vol.240 , pp. 1339-1340
    • Ayer-LeLievre, I.1    Olson, L.2    Ebendal, T.3    Seiger, A.4    Persson, H.5
  • 30
    • 0026090405 scopus 로고
    • Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain
    • [30] M.A. Bach, Z. Shen-Orr, W.L. Lowe, C.T. Roberts, D. LeRoith, Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain, Mol. Brain Res. 10 (1991) 43-48.
    • (1991) Mol. Brain Res. , vol.10 , pp. 43-48
    • Bach, M.A.1    Shen-Orr, Z.2    Lowe, W.L.3    Roberts, C.T.4    LeRoith, D.5
  • 31
    • 0029843679 scopus 로고    scopus 로고
    • Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy
    • [31] C. Backman, G.M. Rose, B.J. Hoffer, M.A. Henry, R.T. Bartus, P. Friden, A.-C. Granholm, Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy, J. Neurosci. 16 (1996) 5437-5442.
    • (1996) J. Neurosci. , vol.16 , pp. 5437-5442
    • Backman, C.1    Rose, G.M.2    Hoffer, B.J.3    Henry, M.A.4    Bartus, R.T.5    Friden, P.6    Granholm, A.-C.7
  • 32
    • 0345557871 scopus 로고    scopus 로고
    • Carrier mediated delivery of NGF: Alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors
    • [32] C. Backman, G.M. Rose, R.T. Bartus, B.J. Hoffer, E.J. Mufson, A.C. Granholm, Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors, J. Comp. Neurol. 387 (1997) 1-11.
    • (1997) J. Comp. Neurol. , vol.387 , pp. 1-11
    • Backman, C.1    Rose, G.M.2    Bartus, R.T.3    Hoffer, B.J.4    Mufson, E.J.5    Granholm, A.C.6
  • 33
    • 0025951696 scopus 로고
    • Hippocampal damage and kainic acid injection induce a rapid increase in BDNF and NGF mRNA in the rat brain
    • [33] M. Ballarin, P. Ernfors, N. Lindefors, H. Persson, Hippocampal damage and kainic acid injection induce a rapid increase in BDNF and NGF mRNA in the rat brain, Exp. Neurol. 114 (1991) 35-43.
    • (1991) Exp. Neurol. , vol.114 , pp. 35-43
    • Ballarin, M.1    Ernfors, P.2    Lindefors, N.3    Persson, H.4
  • 35
    • 0026510312 scopus 로고
    • The nerve growth factor receptor: A multicomponent system that mediates the actions of the neurotrophin family of proteins
    • [35] P.A. Barker, R.A. Murphy, The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins, Mol. Cell. Biochem. 110 (1992) 1-15.
    • (1992) Mol. Cell. Biochem. , vol.110 , pp. 1-15
    • Barker, P.A.1    Murphy, R.A.2
  • 36
    • 0029974984 scopus 로고    scopus 로고
    • Dissociation of p75 receptors and nerve growth factor neurotrophic effects - Lack of p75 immunoreactivity in striatum following physical trauma, excitotoxicity and NGF administration
    • [36] R.T. Bartus, R.L. Dean, S. Abelleira, V. Charles, J.H. Kordower, Dissociation of p75 receptors and nerve growth factor neurotrophic effects - lack of p75 immunoreactivity in striatum following physical trauma, excitotoxicity and NGF administration, Restor. Neurol. Neurosci. 10 (1996) 49-59.
    • (1996) Restor. Neurol. Neurosci. , vol.10 , pp. 49-59
    • Bartus, R.T.1    Dean, R.L.2    Abelleira, S.3    Charles, V.4    Kordower, J.H.5
  • 38
    • 0024332481 scopus 로고
    • Nerve growth factor receptor and choline acetyltransferase colocalisation in neurons within the rat forebrain: Response to fimbria-fornix transection
    • [38] P.E. Batchelor, D.M. Armstrong, S.N. Blaker, F.H. Gage, Nerve growth factor receptor and choline acetyltransferase colocalisation in neurons within the rat forebrain: response to fimbria-fornix transection, J. Comp. Neurol. 284 (1989) 187-204.
    • (1989) J. Comp. Neurol. , vol.284 , pp. 187-204
    • Batchelor, P.E.1    Armstrong, D.M.2    Blaker, S.N.3    Gage, F.H.4
  • 39
    • 0026046948 scopus 로고
    • Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: Correlation with suppression of endonuclease activity
    • [39] A. Batistatou, L.A. Greene, Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity, J. Cell Biol. 115 (1991) 461-471.
    • (1991) J. Cell Biol. , vol.115 , pp. 461-471
    • Batistatou, A.1    Greene, L.A.2
  • 40
    • 0023735546 scopus 로고
    • Characterization of the acid-labile subunit of the growth hormone-dependent insulin-like growth factor binding protein complex
    • [40] B.C. Baxter, Characterization of the acid-labile subunit of the growth hormone-dependent insulin-like growth factor binding protein complex, J. Clin. Endocrinol. Metab. 67 (1988) 265-270.
    • (1988) J. Clin. Endocrinol. Metab. , vol.67 , pp. 265-270
    • Baxter, B.C.1
  • 42
    • 0028795044 scopus 로고
    • Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
    • [42] K.D. Beck, J. Valverde, T. Alexi, K. Poulsen, B. Moffat, R.A. Vandlen, A. Rosenthal, F. Hefti, Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain, Nature 373 (1995) 339-341.
    • (1995) Nature , vol.373 , pp. 339-341
    • Beck, K.D.1    Valverde, J.2    Alexi, T.3    Poulsen, K.4    Moffat, B.5    Vandlen, R.A.6    Rosenthal, A.7    Hefti, F.8
  • 43
    • 0028207907 scopus 로고
    • Amyloid β peptide induces necrosis rather than apoptosis
    • [43] C. Behl, J.B. Davis, F.G. Klier, D. Schubert, Amyloid β peptide induces necrosis rather than apoptosis, Brain Res. 645 (1994) 253-264.
    • (1994) Brain Res. , vol.645 , pp. 253-264
    • Behl, C.1    Davis, J.B.2    Klier, F.G.3    Schubert, D.4
  • 44
    • 0027159841 scopus 로고
    • Differential expression of insulin-like growth factor binding proteins (IGFBP) 4 and 5 mRNA in the rat brain after transient hypoxic-ischemic injury
    • [44] E.J. Beilharz, N.D. Klempt, M. Klempt, E. Sirimanne, M. Dragunow, P.D. Gluckman, Differential expression of insulin-like growth factor binding proteins (IGFBP) 4 and 5 mRNA in the rat brain after transient hypoxic-ischemic injury, Mol. Brain Res. 18 (1993) 209-215.
    • (1993) Mol. Brain Res. , vol.18 , pp. 209-215
    • Beilharz, E.J.1    Klempt, N.D.2    Klempt, M.3    Sirimanne, E.4    Dragunow, M.5    Gluckman, P.D.6
  • 45
    • 0010470866 scopus 로고
    • Cloning rat and human GDNF: A distant member of the TGF-β superfamily active on midbrain dopaminergic neurons
    • [45] S. Bektesh, D.H. Doherty, B. Weaver, B.R. Rosenzweig, D. Pratt, F. Collins, Cloning rat and human GDNF: a distant member of the TGF-β superfamily active on midbrain dopaminergic neurons, Soc. Neurosci. Abstr. 19 (1993) 651.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 651
    • Bektesh, S.1    Doherty, D.H.2    Weaver, B.3    Rosenzweig, B.R.4    Pratt, D.5    Collins, F.6
  • 46
    • 0027312843 scopus 로고
    • Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus
    • [46] M.D.P. Berzaghi, J. Cooper, E. Castren, F. Zafra, M. Sofroniew, H. Thoenen, D. Lindholm, Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus, J. Neurosci. 13 (1993) 3818-3826.
    • (1993) J. Neurosci. , vol.13 , pp. 3818-3826
    • Berzaghi, M.D.P.1    Cooper, J.2    Castren, E.3    Zafra, F.4    Sofroniew, M.5    Thoenen, H.6    Lindholm, D.7
  • 47
    • 0030795798 scopus 로고    scopus 로고
    • Intrastriatal injection of an adenoviral vector expressing glial cell line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioural impairment in a rat model of Parkinson's disease
    • [47] A. Bilang-Bleuel, F. Revah, P. Colin, I. Locquet, J.J. Robert, J. Mallet, P. Horellou, Intrastriatal injection of an adenoviral vector expressing glial cell line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioural impairment in a rat model of Parkinson's disease, Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 8818-8823.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 8818-8823
    • Bilang-Bleuel, A.1    Revah, F.2    Colin, P.3    Locquet, I.4    Robert, J.J.5    Mallet, J.6    Horellou, P.7
  • 48
    • 0023736761 scopus 로고
    • Immunoreactive epidermal growth factor receptors in neuritic plaques from patients with Alzheimer's disease
    • [48] E. Birecree, W.O. Whetsell, C. Stoscheck, L.E. King, L.B. Nanney, Immunoreactive epidermal growth factor receptors in neuritic plaques from patients with Alzheimer's disease, J. Neuropathol. Exp. Neurobiol. 47 (1988) 549-560.
    • (1988) J. Neuropathol. Exp. Neurobiol. , vol.47 , pp. 549-560
    • Birecree, E.1    Whetsell, W.O.2    Stoscheck, C.3    King, L.E.4    Nanney, L.B.5
  • 49
    • 0030725572 scopus 로고    scopus 로고
    • Studies of neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
    • [49] A. Bjorklund, C. Rosenblad, C. Winkler, D. Kirik, Studies of neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease, Neurobiol. Dis. 4 (1997) 186-200.
    • (1997) Neurobiol. Dis. , vol.4 , pp. 186-200
    • Bjorklund, A.1    Rosenblad, C.2    Winkler, C.3    Kirik, D.4
  • 52
    • 0030956532 scopus 로고    scopus 로고
    • p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells
    • [52] D. Blum, Y. Wu, M.F. Nissou, S. Arnaud, A. Louis-Benabid, J.M. Verna, p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells, Brain Res. 751 (1997) 139-142.
    • (1997) Brain Res. , vol.751 , pp. 139-142
    • Blum, D.1    Wu, Y.2    Nissou, M.F.3    Arnaud, S.4    Louis-Benabid, A.5    Verna, J.M.6
  • 53
    • 0023849428 scopus 로고
    • Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography
    • [53] N.J. Bohannon, E.S. Corp, B.J. Wilcox, D.P. Figlewicz, D.M. Dorsa, D.G. Baskin, Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography, Brain Res. 444 (1988) 205-213.
    • (1988) Brain Res. , vol.444 , pp. 205-213
    • Bohannon, N.J.1    Corp, E.S.2    Wilcox, B.J.3    Figlewicz, D.P.4    Dorsa, D.M.5    Baskin, D.G.6
  • 56
    • 0025718514 scopus 로고
    • Transient IGF-I gene expression during maturation of functionally related central projection neurons
    • [56] C. Bondy, Transient IGF-I gene expression during maturation of functionally related central projection neurons, J. Neurosci. 11 (1991) 3442-3455.
    • (1991) J. Neurosci. , vol.11 , pp. 3442-3455
    • Bondy, C.1
  • 57
    • 0026556829 scopus 로고
    • Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II
    • [57] C. Bondy, H. Werner, C.T. Roberts, D. LeRoith, Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II, Neuroscience 46 (1992) 909-923.
    • (1992) Neuroscience , vol.46 , pp. 909-923
    • Bondy, C.1    Werner, H.2    Roberts, C.T.3    LeRoith, D.4
  • 59
    • 0031105553 scopus 로고    scopus 로고
    • Gene therapeutic strategies for neuroprotection: Implications for Parkinson's disease
    • [59] W.J. Bowers, D.F. Howard, H.J. Federoff, Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease, Exp. Neurol. 144 (1997) 58-68.
    • (1997) Exp. Neurol. , vol.144 , pp. 58-68
    • Bowers, W.J.1    Howard, D.F.2    Federoff, H.J.3
  • 63
    • 0024317164 scopus 로고
    • Production and characterisation of biologically active recombinant human nerve growth factor
    • [63] G. Bruce, G. Heinrich, Production and characterisation of biologically active recombinant human nerve growth factor, Neurobiol. Aging 10 (1989) 89-94.
    • (1989) Neurobiol. Aging , vol.10 , pp. 89-94
    • Bruce, G.1    Heinrich, G.2
  • 64
    • 0029969678 scopus 로고    scopus 로고
    • Mechanisms of selective motor neuron death in ALS: Insights from transgenic mouse models of motor neuron disease
    • [64] L.I. Bruijn, D.W. Cleveland, Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease, Neuropathol. Appl. Neurobiol. 22 (1996) 373-387.
    • (1996) Neuropathol. Appl. Neurobiol. , vol.22 , pp. 373-387
    • Bruijn, L.I.1    Cleveland, D.W.2
  • 65
    • 0001875277 scopus 로고
    • Huntington's chorea: Current neuropathological status
    • [65] E.W. Bruyn, T.A. Bots, R. Dom, Huntington's chorea: current neuropathological status, Adv. Neurol. 23 (1979) 83-93.
    • (1979) Adv. Neurol. , vol.23 , pp. 83-93
    • Bruyn, E.W.1    Bots, T.A.2    Dom, R.3
  • 66
    • 0024541824 scopus 로고
    • Epidermal growth factor and transforming growth factor α
    • [66] A.W. Burgess, Epidermal growth factor and transforming growth factor α, Br. Med. Bull. 45 (1989) 401-424.
    • (1989) Br. Med. Bull. , vol.45 , pp. 401-424
    • Burgess, A.W.1
  • 67
    • 0023644495 scopus 로고
    • Characterization of a neuronal subtype of a insulin-like growth factor I receptor
    • [67] S.K. Burgess, S. Jacobs, P. Cuatrecasa, N. Sahyoun, Characterization of a neuronal subtype of a insulin-like growth factor I receptor, J. Biol. Chem. 262 (1987) 1618-1622.
    • (1987) J. Biol. Chem. , vol.262 , pp. 1618-1622
    • Burgess, S.K.1    Jacobs, S.2    Cuatrecasa, P.3    Sahyoun, N.4
  • 68
    • 0029078561 scopus 로고
    • NGF-mediated synaptic sprouting in the cerebral cortex of lesioned primate brain
    • [68] I. Burgos, A.C. Cuello, P. Liberini, E. Pioro, E. Masliah, NGF-mediated synaptic sprouting in the cerebral cortex of lesioned primate brain, Brain Res. 692 (1995) 154-160.
    • (1995) Brain Res. , vol.692 , pp. 154-160
    • Burgos, I.1    Cuello, A.C.2    Liberini, P.3    Pioro, E.4    Masliah, E.5
  • 69
    • 0028643630 scopus 로고
    • Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: Rescue by neurotrophins
    • [69] M.A. Burke, W.C. Mobley, J. Cho, S.J. Wiegand, R.M. Lindsay, E.J. Mufson, J.H. Kordower, Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins, Exp. Neurol. 130 (1994) 178-195.
    • (1994) Exp. Neurol. , vol.130 , pp. 178-195
    • Burke, M.A.1    Mobley, W.C.2    Cho, J.3    Wiegand, S.J.4    Lindsay, R.M.5    Mufson, E.J.6    Kordower, J.H.7
  • 70
    • 0024386288 scopus 로고
    • Neurotrophic agents may exacerbate the pathological cascade of Alzheimer's disease
    • [70] L.L. Butcher, N.J. Woolf, Neurotrophic agents may exacerbate the pathological cascade of Alzheimer's disease, Neurobiol. Aging 10 (1989) 557-570.
    • (1989) Neurobiol. Aging , vol.10 , pp. 557-570
    • Butcher, L.L.1    Woolf, N.J.2
  • 71
    • 0027269766 scopus 로고
    • Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice
    • [71] M.J. Carson, R.R. Behringer, R.L. Brinster, F.A. McMorris, Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice, Neuron 10 (1993) 729-740.
    • (1993) Neuron , vol.10 , pp. 729-740
    • Carson, M.J.1    Behringer, R.R.2    Brinster, R.L.3    McMorris, F.A.4
  • 73
    • 0029021457 scopus 로고
    • p75 and Trk: A two-receptor system
    • [73] M.V. Chao, B.L. Hempstead, p75 and Trk: a two-receptor system, Trends Neurosci. 18 (1995) 321-326.
    • (1995) Trends Neurosci. , vol.18 , pp. 321-326
    • Chao, M.V.1    Hempstead, B.L.2
  • 74
    • 0030605874 scopus 로고    scopus 로고
    • Atrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugate
    • [74] V. Charles, E.J. Mufson, P.M. Friden, R.T. Bartus, J.H. Kordower, Atrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugate, Brain Res. 728 (1996) 193-203.
    • (1996) Brain Res. , vol.728 , pp. 193-203
    • Charles, V.1    Mufson, E.J.2    Friden, P.M.3    Bartus, R.T.4    Kordower, J.H.5
  • 75
    • 0024317621 scopus 로고
    • Role of neurotrophic factors in Alzheimer's disease
    • [75] K.S. Chen, M.H. Tuszynski, F.H. Gage, Role of neurotrophic factors in Alzheimer's disease, Neurobiol. Aging 10 (1989) 545-546.
    • (1989) Neurobiol. Aging , vol.10 , pp. 545-546
    • Chen, K.S.1    Tuszynski, M.H.2    Gage, F.H.3
  • 76
    • 0029923901 scopus 로고    scopus 로고
    • Neuropathology of synthetic beta-amyloid peptide analogs in vivo
    • [76] S.-Y. Chen, J.W. Harding, C.D. Barnes, Neuropathology of synthetic beta-amyloid peptide analogs in vivo, Brain Res. 715 (1996) 44-50.
    • (1996) Brain Res. , vol.715 , pp. 44-50
    • Chen, S.-Y.1    Harding, J.W.2    Barnes, C.D.3
  • 77
    • 0026521942 scopus 로고
    • IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage
    • [77] B. Cheng, M.P. Mattson, IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage, J. Neurosci. 12 (1992) 1558-1566.
    • (1992) J. Neurosci. , vol.12 , pp. 1558-1566
    • Cheng, B.1    Mattson, M.P.2
  • 79
    • 0029552813 scopus 로고
    • GDNF reduces apoptosis in dopaminergic neurons in vitro
    • [79] E.D. Clarkson, W.M. Zawada, C.R. Freed, GDNF reduces apoptosis in dopaminergic neurons in vitro, NeuroReport 7 (1995) 145-149.
    • (1995) NeuroReport , vol.7 , pp. 145-149
    • Clarkson, E.D.1    Zawada, W.M.2    Freed, C.R.3
  • 80
    • 0030740377 scopus 로고    scopus 로고
    • GDNF improves survival and reduces apoptosis in human embryonic dopaminergic neurons in vitro
    • [80] E.D. Clarkson, W.M. Zawada, C.R. Freed, GDNF improves survival and reduces apoptosis in human embryonic dopaminergic neurons in vitro, Cell Tissue Res. 289 (1997) 207-210.
    • (1997) Cell Tissue Res. , vol.289 , pp. 207-210
    • Clarkson, E.D.1    Zawada, W.M.2    Freed, C.R.3
  • 81
    • 0022875838 scopus 로고
    • Cholinergic function and intellectual decline in Alzheimer's disease
    • [81] D. Collerton, Cholinergic function and intellectual decline in Alzheimer's disease, Neuroscience 19 (1986) 1-28.
    • (1986) Neuroscience , vol.19 , pp. 1-28
    • Collerton, D.1
  • 82
    • 0029866703 scopus 로고    scopus 로고
    • Maintenance of sympathetic innervation into the hippocampal formation requires a continuous local availability of nerve growth factor
    • [82] J.M. Conner, S. Varon, Maintenance of sympathetic innervation into the hippocampal formation requires a continuous local availability of nerve growth factor, Neuroscience 72 (1996) 933-945.
    • (1996) Neuroscience , vol.72 , pp. 933-945
    • Conner, J.M.1    Varon, S.2
  • 83
    • 0028199150 scopus 로고
    • Changes in nerve growth factor immunoreactivity following entorhinal cortex lesions: Possible molecular mechanism regulating cholinergic sprouting
    • [83] J.M. Conner, B. Fass-Holmes, S. Varon, Changes in nerve growth factor immunoreactivity following entorhinal cortex lesions: possible molecular mechanism regulating cholinergic sprouting, J. Comp. Neurol. 345 (1994) 409-418.
    • (1994) J. Comp. Neurol. , vol.345 , pp. 409-418
    • Conner, J.M.1    Fass-Holmes, B.2    Varon, S.3
  • 85
    • 0030656250 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF-1) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus
    • [85] B. Connor, E.J. Beilharz, C. Williams, P.D. Gluckman, R.L.M. Faull, M. Dragunow, Insulin-like growth factor (IGF-1) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus, Mol. Brain Res. 49 (1997) 283-290.
    • (1997) Mol. Brain Res. , vol.49 , pp. 283-290
    • Connor, B.1    Beilharz, E.J.2    Williams, C.3    Gluckman, P.D.4    Faull, R.L.M.5    Dragunow, M.6
  • 87
    • 0028171962 scopus 로고
    • Reduced transport of [I] nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats
    • [87] J.D. Cooper, D. Lindholm, M.V. Sofroniew, Reduced transport of [I] nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats, Neuroscience 62 (1994) 625-629.
    • (1994) Neuroscience , vol.62 , pp. 625-629
    • Cooper, J.D.1    Lindholm, D.2    Sofroniew, M.V.3
  • 88
    • 0029994286 scopus 로고    scopus 로고
    • Delayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early postnatal development in the rat
    • [88] J.D. Cooper, J.N. Skepper, M. Da Penha Berzaghi, D. Lindholm, M.V. Sofroniew, Delayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early postnatal development in the rat, Exp. Neurol. 139 (1996) 143-155.
    • (1996) Exp. Neurol. , vol.139 , pp. 143-155
    • Cooper, J.D.1    Skepper, J.N.2    Da Penha Berzaghi, M.3    Lindholm, D.4    Sofroniew, M.V.5
  • 89
    • 0029886779 scopus 로고    scopus 로고
    • Nerve growth factor (NGF)-mediated protection of neural crest cells from antimitotic agent-induced apoptosis: The role of the low-affinity NGF receptor
    • [89] M.H. Cortazzo, E.S. Kassis, K.A. Sproul, N.F. Schor, Nerve growth factor (NGF)-mediated protection of neural crest cells from antimitotic agent-induced apoptosis: the role of the low-affinity NGF receptor, J. Neurosci. 16 (1996) 3895-3899.
    • (1996) J. Neurosci. , vol.16 , pp. 3895-3899
    • Cortazzo, M.H.1    Kassis, E.S.2    Sproul, K.A.3    Schor, N.F.4
  • 90
    • 0029245289 scopus 로고
    • A potential role for apoptosis in neurodegeneration and Alzheimer's disease
    • [90] C.W. Cotman, A.J. Anderson, A potential role for apoptosis in neurodegeneration and Alzheimer's disease, Mol. Neurobiol. 10 (1995) 19-45.
    • (1995) Mol. Neurobiol. , vol.10 , pp. 19-45
    • Cotman, C.W.1    Anderson, A.J.2
  • 91
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • [91] J.T. Coyle, D.L. Price, M.R. DeLong, Alzheimer's disease: a disorder of cortical cholinergic innervation, Science 219 (1983) 1184-1190.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    DeLong, M.R.3
  • 92
    • 0026572765 scopus 로고
    • Insulin-like growth factor I receptor binding in brains of Alzheimer's and alcoholic patients
    • [92] F.T. Crews, R. McElhaney, G. Freund, W.E. Ballinger, M.K. Raizada, Insulin-like growth factor I receptor binding in brains of Alzheimer's and alcoholic patients, J. Neurochem. 58 (1992) 1205-1210.
    • (1992) J. Neurochem. , vol.58 , pp. 1205-1210
    • Crews, F.T.1    McElhaney, R.2    Freund, G.3    Ballinger, W.E.4    Raizada, M.K.5
  • 95
    • 0027197191 scopus 로고
    • Detection of NGF-like activity in human brain tissue: Increased levels in Alzheimer's disease
    • [95] K.A. Crutcher, S.A. Scott, S. Liang, W.V. Everson, J. Weingartner, Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease, J. Neurosci. 13 (1993) 2540-2550.
    • (1993) J. Neurosci. , vol.13 , pp. 2540-2550
    • Crutcher, K.A.1    Scott, S.A.2    Liang, S.3    Everson, W.V.4    Weingartner, J.5
  • 96
    • 0027443553 scopus 로고
    • Trophic responses of forebrain cholinergic neurons: A discussion
    • [96] C.A. Cuello, Trophic responses of forebrain cholinergic neurons: a discussion, Prog. Brain Res. 98 (1993) 265-277.
    • (1993) Prog. Brain Res. , vol.98 , pp. 265-277
    • Cuello, C.A.1
  • 98
    • 0029940366 scopus 로고    scopus 로고
    • Cografting with polymer-encapsulated human nerve growth factor-secreting cells and chromaffin cell survival and behavioural recovery in hemiparkinsonian rats
    • [98] I. Date, T. Ohmoto, T. Imaoka, T. Ono, J.P. Hammang, J. Francis, C. Greco, D.F. Emerich, Cografting with polymer-encapsulated human nerve growth factor-secreting cells and chromaffin cell survival and behavioural recovery in hemiparkinsonian rats, J. Neurosurg. 84 (1996) 1006-1012.
    • (1996) J. Neurosurg. , vol.84 , pp. 1006-1012
    • Date, I.1    Ohmoto, T.2    Imaoka, T.3    Ono, T.4    Hammang, J.P.5    Francis, J.6    Greco, C.7    Emerich, D.F.8
  • 99
    • 0030513849 scopus 로고    scopus 로고
    • Oxidative mechanisms in beta-amyloid cytotoxicity
    • [99] J.B. Davis, Oxidative mechanisms in beta-amyloid cytotoxicity, Neurodegeneration 5 (1996) 441-444.
    • (1996) Neurodegeneration , vol.5 , pp. 441-444
    • Davis, J.B.1
  • 101
    • 0028278398 scopus 로고
    • Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer's disease, and in Huntington's disease
    • [101] J. De Keyser, N. Wilczak, A. Goossen, Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer's disease, and in Huntington's disease, Neurosci. Lett. 172 (1994) 93-96.
    • (1994) Neurosci. Lett. , vol.172 , pp. 93-96
    • De Keyser, J.1    Wilczak, N.2    Goossen, A.3
  • 102
    • 0027511389 scopus 로고
    • The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system
    • [102] M. DeLacoste, C.L. White, The role of cortical connectivity in Alzheimer's disease pathogenesis: a review and model system, Neurobiol. Aging 14 (1993) 1-16.
    • (1993) Neurobiol. Aging , vol.14 , pp. 1-16
    • DeLacoste, M.1    White, C.L.2
  • 103
    • 0023807364 scopus 로고
    • Transforming growth factor α
    • [103] R. Derynck, Transforming growth factor α, Cell 54 (1988) 593-595.
    • (1988) Cell , vol.54 , pp. 593-595
    • Derynck, R.1
  • 104
    • 0021752924 scopus 로고
    • Human transforming growth factor-α: Precursor structure and expression in E. coli
    • [104] R. Derynck, A.B. Roberts, M.E. Winkler, E.Y. Chen, D.V. Goeddel, Human transforming growth factor-α: precursor structure and expression in E. coli, Cell 38 (1984) 287-297.
    • (1984) Cell , vol.38 , pp. 287-297
    • Derynck, R.1    Roberts, A.B.2    Winkler, M.E.3    Chen, E.Y.4    Goeddel, D.V.5
  • 105
    • 0027730637 scopus 로고
    • Immunohistochemical localisation of transforming growth factor-α in the choriod plexus of rat and chicken
    • [105] C. Diaz-Ruiz, R. Perez-Tomas, J. Domingo, I. Ferrer, Immunohistochemical localisation of transforming growth factor-α in the choriod plexus of rat and chicken, Neurosci. Lett. 164 (1993) 44-45.
    • (1993) Neurosci. Lett. , vol.164 , pp. 44-45
    • Diaz-Ruiz, C.1    Perez-Tomas, R.2    Domingo, J.3    Ferrer, I.4
  • 106
    • 0027483920 scopus 로고
    • Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
    • [106] S.R. D'Mello, C. Galli, T. Ciotti, P. Calissano, Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP, Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 10989-10993.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 10989-10993
    • D'Mello, S.R.1    Galli, C.2    Ciotti, T.3    Calissano, P.4
  • 107
    • 0004532403 scopus 로고    scopus 로고
    • Distribution and levels of insulin-like growth factor (IGF-I and IGF-II) and insulin receptor binding sites in the spinal cord of amyotrophic lateral sclerosis (ALS) patients
    • [107] S. Dore, C. Krieger, S. Kar, R. Quirion, Distribution and levels of insulin-like growth factor (IGF-I and IGF-II) and insulin receptor binding sites in the spinal cord of amyotrophic lateral sclerosis (ALS) patients, Mol. Brain Res. 41 (1996) 128-133.
    • (1996) Mol. Brain Res. , vol.41 , pp. 128-133
    • Dore, S.1    Krieger, C.2    Kar, S.3    Quirion, R.4
  • 108
    • 0030902595 scopus 로고    scopus 로고
    • Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid-and human amylin-induced toxicity
    • [108] S. Dore, S. Kar, R. Quirion, Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid-and human amylin-induced toxicity, Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 4772-4777.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 4772-4777
    • Dore, S.1    Kar, S.2    Quirion, R.3
  • 109
    • 0343765729 scopus 로고    scopus 로고
    • Rediscovering an old friend, IGF-I: Potential use in the treatment of neurodegenerative diseases
    • [109] S. Dore, S. Kar, R. Quirion, Rediscovering an old friend, IGF-I: potential use in the treatment of neurodegenerative diseases, Trends Neurosci. 20 (1997) 326-331.
    • (1997) Trends Neurosci. , vol.20 , pp. 326-331
    • Dore, S.1    Kar, S.2    Quirion, R.3
  • 110
    • 0030610902 scopus 로고    scopus 로고
    • 125I]insulin receptor binding sites in the hippocampus of aged memory-unimpaired and -impaired rats
    • 125I]insulin receptor binding sites in the hippocampus of aged memory-unimpaired and -impaired rats, Neuroscience 80 (1997) 1033-1040.
    • (1997) Neuroscience , vol.80 , pp. 1033-1040
    • Dore, S.1    Kar, S.2    Rowe, W.3    Quirion, R.4
  • 111
    • 0031035608 scopus 로고    scopus 로고
    • Bcl-xl-specific antibody labels activated microglia associated with Alzheimer's disease and other pathological states
    • [111] B. Drache, G.E. Diehl, K. Beyreuther, L.S. Perlmutter, G. Konig, Bcl-xl-specific antibody labels activated microglia associated with Alzheimer's disease and other pathological states, J. Neurosci. Res. 47 (1997) 98-108.
    • (1997) J. Neurosci. Res. , vol.47 , pp. 98-108
    • Drache, B.1    Diehl, G.E.2    Beyreuther, K.3    Perlmutter, L.S.4    Konig, G.5
  • 112
    • 0026012807 scopus 로고
    • Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I
    • [112] J. Drago, M. Murphy, S.M. Carroll, R.P. Harveym, P.F. Bartlett, Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I, Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 2199-2203.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 2199-2203
    • Drago, J.1    Murphy, M.2    Carroll, S.M.3    Harveym, R.P.4    Bartlett, P.F.5
  • 114
    • 0028866102 scopus 로고
    • The role of inducible transcription factors in apoptotic nerve cell death
    • [114] M. Dragunow, K. Preston, The role of inducible transcription factors in apoptotic nerve cell death, Brain Res. Rev. 21 (1995) 1-28.
    • (1995) Brain Res. Rev. , vol.21 , pp. 1-28
    • Dragunow, M.1    Preston, K.2
  • 117
    • 0028356223 scopus 로고
    • Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to young rat brain
    • [117] M. Dragunow, E. Beilharz, E. Sirimanne, P. Lawlor, C. Williams, R. Bravo, P. Gluckman, Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to young rat brain, Mol. Brain Res. 25 (1994) 19-33.
    • (1994) Mol. Brain Res. , vol.25 , pp. 19-33
    • Dragunow, M.1    Beilharz, E.2    Sirimanne, E.3    Lawlor, P.4    Williams, C.5    Bravo, R.6    Gluckman, P.7
  • 118
    • 0029040355 scopus 로고
    • In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes
    • [118] M. Dragunow, R.L.M. Faull, P. Lawlor, E.J. Beilharz, K. Singleton, E.B. Walker, E. Mee, In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes, NeuroReport 6 (1995) 1053-1057.
    • (1995) NeuroReport , vol.6 , pp. 1053-1057
    • Dragunow, M.1    Faull, R.L.M.2    Lawlor, P.3    Beilharz, E.J.4    Singleton, K.5    Walker, E.B.6    Mee, E.7
  • 121
    • 0029123107 scopus 로고
    • DNA fragmentation and immediate early gene expression in rat striatum following quinolinic acid administration
    • [121] L.S. Dure, S. Wiess, D.G. Standaert, G. Rudolf, C.M. Testa, A.B. Young, DNA fragmentation and immediate early gene expression in rat striatum following quinolinic acid administration, Exp. Neurol. 133 (1995) 207-214.
    • (1995) Exp. Neurol. , vol.133 , pp. 207-214
    • Dure, L.S.1    Wiess, S.2    Standaert, D.G.3    Rudolf, G.4    Testa, C.M.5    Young, A.B.6
  • 122
    • 0030777650 scopus 로고    scopus 로고
    • Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS
    • [122] H.D. Durham, J. Roy, L. Dong, D.A. Figlewicz, Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS, J. Neuropathol. Exp. Neurol. 56 (1997) 523-530.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 523-530
    • Durham, H.D.1    Roy, J.2    Dong, L.3    Figlewicz, D.A.4
  • 123
    • 0025910376 scopus 로고
    • Loss of calbindin-28K immunoreactivity in hippocampal slices from aged rats: A role for calcium?
    • [123] P. Dutar, B. Potier, Y. Lamour, P.C. Emson, M.C. Semut, Loss of calbindin-28K immunoreactivity in hippocampal slices from aged rats: a role for calcium?, Eur. J. Neurosci. 3 (1991) 839-849.
    • (1991) Eur. J. Neurosci. , vol.3 , pp. 839-849
    • Dutar, P.1    Potier, B.2    Lamour, Y.3    Emson, P.C.4    Semut, M.C.5
  • 125
    • 0029940115 scopus 로고    scopus 로고
    • Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signalling
    • [125] F.F. Eide, E.R. Vining, B.L. Eide, K. Zang, X.-Y. Wang, L.F. Reichardt, Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signalling, J. Neurosci. 16 (1996) 3121-3129.
    • (1996) J. Neurosci. , vol.16 , pp. 3121-3129
    • Eide, F.F.1    Vining, E.R.2    Eide, B.L.3    Zang, K.4    Wang, X.-Y.5    Reichardt, L.F.6
  • 126
    • 0027763350 scopus 로고
    • Pathogenic mechanisms in sporadic amyotrophic lateral sclerosis
    • [126] A. Eisen, C. Krieger, Pathogenic mechanisms in sporadic amyotrophic lateral sclerosis, Can. J. Neurol. Sci. 20 (1993) 286-296.
    • (1993) Can. J. Neurol. Sci. , vol.20 , pp. 286-296
    • Eisen, A.1    Krieger, C.2
  • 127
    • 0342476502 scopus 로고
    • An insulin-like growth factor (IGF) binding protein enhances the biological response to IGF-I
    • [127] R.G. Elgin, W.H. Busby, D.R. Clemmons, An insulin-like growth factor (IGF) binding protein enhances the biological response to IGF-I, Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 3254-3258.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 3254-3258
    • Elgin, R.G.1    Busby, W.H.2    Clemmons, D.R.3
  • 128
    • 0028130227 scopus 로고
    • Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: Rescue and sprouting of degenerating cholinergic basal forebrain neurons
    • [128] D.F. Emerich, S.R. Winn, J. Harper, J.P. Hammang, E.E. Baetge, J.H. Kordower, Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons, J. Comp. Neurol. 349 (1994) 148-164.
    • (1994) J. Comp. Neurol. , vol.349 , pp. 148-164
    • Emerich, D.F.1    Winn, S.R.2    Harper, J.3    Hammang, J.P.4    Baetge, E.E.5    Kordower, J.H.6
  • 129
    • 0029761786 scopus 로고    scopus 로고
    • Implants of encapsulated human CNTF-producing fibroblasts prevent behavioural deficits and striatal degeneration in a rodent model of Huntington's disease
    • [129] D.F. Emerich, M.D. Lindner, S.R. Winn, E.-Y. Chen, B.R. Frydel, J.H. Kordower, Implants of encapsulated human CNTF-producing fibroblasts prevent behavioural deficits and striatal degeneration in a rodent model of Huntington's disease, J. Neurosci. 16 (1996) 5168-5181.
    • (1996) J. Neurosci. , vol.16 , pp. 5168-5181
    • Emerich, D.F.1    Lindner, M.D.2    Winn, S.R.3    Chen, E.-Y.4    Frydel, B.R.5    Kordower, J.H.6
  • 130
    • 0030583639 scopus 로고    scopus 로고
    • Alleviation of behavioral deficits in aged rodents following implantation of encapsulated GDNF-producing fibroblasts
    • [130] D.F. Emerich, M. Plone, J. Francis, B.R. Frydel, S.R. Winn, M.D. Lindner, Alleviation of behavioral deficits in aged rodents following implantation of encapsulated GDNF-producing fibroblasts, Brain Res. 736 (1996) 99-110.
    • (1996) Brain Res. , vol.736 , pp. 99-110
    • Emerich, D.F.1    Plone, M.2    Francis, J.3    Frydel, B.R.4    Winn, S.R.5    Lindner, M.D.6
  • 131
    • 0030911441 scopus 로고    scopus 로고
    • Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease
    • [131] D.F. Emerich, C.K. Cain, C. Greco, J.A. Saydoff, Z.Y. Hu, H. Liu, M.D. Lindner, Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease, Cell Transplant. 6 (1997) 249-266.
    • (1997) Cell Transplant. , vol.6 , pp. 249-266
    • Emerich, D.F.1    Cain, C.K.2    Greco, C.3    Saydoff, J.A.4    Hu, Z.Y.5    Liu, H.6    Lindner, M.D.7
  • 133
    • 0028913801 scopus 로고
    • Dose-response comparison of recombinant human nerve growth factor and recombinant human basic fibroblast growth factor in the fimbria fornix model of acute cholinergic degeneration
    • [133] C.J. Emmett, S.P. Aswani, G.R. Stewart, D. Fairchild, R.M. Johnson, Dose-response comparison of recombinant human nerve growth factor and recombinant human basic fibroblast growth factor in the fimbria fornix model of acute cholinergic degeneration, Brain Res. 673 (1995) 199-207.
    • (1995) Brain Res. , vol.673 , pp. 199-207
    • Emmett, C.J.1    Aswani, S.P.2    Stewart, G.R.3    Fairchild, D.4    Johnson, R.M.5
  • 134
    • 0010429496 scopus 로고
    • Identification of a glial-derived neurotrophic factor for mesencephalic dopaminergic neurons
    • [134] J. Engele, H. Rieck, M.C. Bohn, Identification of a glial-derived neurotrophic factor for mesencephalic dopaminergic neurons, Soc. Neurosci. Abstr. 19 (1993) 652.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 652
    • Engele, J.1    Rieck, H.2    Bohn, M.C.3
  • 135
    • 0024999375 scopus 로고
    • Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: Developmental and topographical expression in the brain
    • [135] P. Ernfors, C.F. Ibanez, T. Ebendal, L. Olson, H. Persson, Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain, Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 5454-5458.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 5454-5458
    • Ernfors, P.1    Ibanez, C.F.2    Ebendal, T.3    Olson, L.4    Persson, H.5
  • 136
    • 0027946686 scopus 로고
    • Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
    • [136] S. Estus, W.J. Zaks, R.S. Freeman, M. Gruda, R. Bravo, E.M. Johnson, Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis, J. Cell Biol. 127 (1994) 1717-1727.
    • (1994) J. Cell Biol. , vol.127 , pp. 1717-1727
    • Estus, S.1    Zaks, W.J.2    Freeman, R.S.3    Gruda, M.4    Bravo, R.5    Johnson, E.M.6
  • 137
    • 0025979940 scopus 로고
    • Expression of IGF-I and insulin receptor genes in the rat central nervous system: A development, regional and cellular analysis
    • [137] A.B.-V. Evercooren, C. Olichon-Berthe, A. Kowalski, G. Visciano, E. Van Obberghen, Expression of IGF-I and insulin receptor genes in the rat central nervous system: a development, regional and cellular analysis, J. Neurosci. Res. 28 (1991) 244-253.
    • (1991) J. Neurosci. Res. , vol.28 , pp. 244-253
    • Evercooren, A.B.-V.1    Olichon-Berthe, C.2    Kowalski, A.3    Visciano, G.4    Van Obberghen, E.5
  • 138
    • 0025104109 scopus 로고
    • Cholinergic sprouting in the hippocampus: A proposal for IL-1
    • [138] A.M. Fagan, F.H. Gage, Cholinergic sprouting in the hippocampus: a proposal for IL-1, Exp. Neurol. 110 (1990) 105-120.
    • (1990) Exp. Neurol. , vol.110 , pp. 105-120
    • Fagan, A.M.1    Gage, F.H.2
  • 139
    • 0026464676 scopus 로고
    • Cortical transynaptic activation of tyrosine kinase receptor TrkB messenger RNA expression in rat hippocampus
    • [139] T. Falkenberg, P. Ernfors, H. Persson, N. Lindfors, Cortical transynaptic activation of tyrosine kinase receptor TrkB messenger RNA expression in rat hippocampus, Neuroscience 51 (1992) 883-889.
    • (1992) Neuroscience , vol.51 , pp. 883-889
    • Falkenberg, T.1    Ernfors, P.2    Persson, H.3    Lindfors, N.4
  • 140
    • 0027358703 scopus 로고
    • Entorhinal cortex regulation of multiple brain-derived neurotrophic factor promoters in the rat hippocampus
    • [140] T. Falkenberg, M. Metsis, T. Timmusk, N. Lindefors, Entorhinal cortex regulation of multiple brain-derived neurotrophic factor promoters in the rat hippocampus, Neuroscience 57 (1993) 891-896.
    • (1993) Neuroscience , vol.57 , pp. 891-896
    • Falkenberg, T.1    Metsis, M.2    Timmusk, T.3    Lindefors, N.4
  • 141
    • 0025117662 scopus 로고
    • Localisation of cells containing transforming growth factor-α precursor immunoreactivity in the basal ganglia of the adult rat brain
    • [141] J.H. Fallon, C.M. Annis, L.E. Gentry, D.R. Twardzik, S.E. Loughlin, Localisation of cells containing transforming growth factor-α precursor immunoreactivity in the basal ganglia of the adult rat brain, Growth Factors 2 (1990) 241-250.
    • (1990) Growth Factors , vol.2 , pp. 241-250
    • Fallon, J.H.1    Annis, C.M.2    Gentry, L.E.3    Twardzik, D.R.4    Loughlin, S.E.5
  • 142
    • 0028322183 scopus 로고
    • Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
    • [142] I. Farinas, K.R. Jones, C. Backus, X.Y. Wang, L.F. Reichardt, Severe sensory and sympathetic deficits in mice lacking neurotrophin-3, Nature 369 (1994) 658-661.
    • (1994) Nature , vol.369 , pp. 658-661
    • Farinas, I.1    Jones, K.R.2    Backus, C.3    Wang, X.Y.4    Reichardt, L.F.5
  • 143
    • 0028956978 scopus 로고
    • Trophic-factor modulation of cortical acetylcholinesterase reappearance following transection of the medial cholinergic pathway in the adult rat
    • [143] T.W. Farris, L.L. Butcher, J.D. Oh, N.J. Wolf, Trophic-factor modulation of cortical acetylcholinesterase reappearance following transection of the medial cholinergic pathway in the adult rat, Exp. Neurol. 131 (1995) 180-192.
    • (1995) Exp. Neurol. , vol.131 , pp. 180-192
    • Farris, T.W.1    Butcher, L.L.2    Oh, J.D.3    Wolf, N.J.4
  • 145
    • 0023643241 scopus 로고
    • Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
    • [145] W. Fischer, K. Wictorin, A. Bjorklund, L.R. Wiliams, S. Varon, F.H. Gage, Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor, Nature 329 (1987) 65-68.
    • (1987) Nature , vol.329 , pp. 65-68
    • Fischer, W.1    Wictorin, K.2    Bjorklund, A.3    Wiliams, L.R.4    Varon, S.5    Gage, F.H.6
  • 146
    • 0028064960 scopus 로고
    • Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophin 3 and 4/5 but not brain-derived neurotrophic factor
    • [146] W. Fischer, A. Sirevaag, S.J. Wiegand, R.M. Lindsay, A. Bjorklund, Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophin 3 and 4/5 but not brain-derived neurotrophic factor, Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 8607-8611.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 8607-8611
    • Fischer, W.1    Sirevaag, A.2    Wiegand, S.J.3    Lindsay, R.M.4    Bjorklund, A.5
  • 147
  • 148
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • [148] L.S. Forno, Neuropathology of Parkinson's disease, J. Neuropathol. Exp. Neurol. 55 (1996) 259-272.
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 149
    • 0027269660 scopus 로고
    • Cortical pyramidal neuron loss may cause glutaminergic hypoactivity and cognitive impairment in Alzheimer's disease: Investigative and therapeutic perspectives
    • [149] P.T. Francis, N.R. Sims, A.W. Procter, D.M. Bowen, Cortical pyramidal neuron loss may cause glutaminergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives, J. Neurochem. 5 (1993) 1589-1601.
    • (1993) J. Neurochem. , vol.5 , pp. 1589-1601
    • Francis, P.T.1    Sims, N.R.2    Procter, A.W.3    Bowen, D.M.4
  • 150
    • 0021012836 scopus 로고
    • The human gene for the beta-subunit of nerve growth factor is located on the proximal short arm of chromosome 1
    • [150] U. Francke, B. DeMartinville, L. Coussens, A. Ullrich, The human gene for the beta-subunit of nerve growth factor is located on the proximal short arm of chromosome 1, Science 222 (1983) 1248-1250.
    • (1983) Science , vol.222 , pp. 1248-1250
    • Francke, U.1    DeMartinville, B.2    Coussens, L.3    Ullrich, A.4
  • 155
    • 0028961302 scopus 로고
    • Synergistic trophic actions on rat basal forebrain neurons revealed by a synthetic NGF/BDNF chimaeric molecule
    • [155] W.J. Friedman, I.B. Black, H. Persson, C.F. Ibanez, Synergistic trophic actions on rat basal forebrain neurons revealed by a synthetic NGF/BDNF chimaeric molecule, Eur. J. Neurosci. 7 (1995) 656-662.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 656-662
    • Friedman, W.J.1    Black, I.B.2    Persson, H.3    Ibanez, C.F.4
  • 156
    • 0027404049 scopus 로고
    • Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum
    • [156] D.M. Frim, M.P. Short, W.S. Rosenberg, J. Simpson, X.O. Breakefield, O. Isacson, Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum, J. Neurosurg. 78 (1993) 267-273.
    • (1993) J. Neurosurg. , vol.78 , pp. 267-273
    • Frim, D.M.1    Short, M.P.2    Rosenberg, W.S.3    Simpson, J.4    Breakefield, X.O.5    Isacson, O.6
  • 159
    • 0023835556 scopus 로고
    • Morphological response of axotomised septal neurons to nerve growth factor
    • [159] F.H. Gage, D.M. Armstrong, L.R. Williams, S. Varon, Morphological response of axotomised septal neurons to nerve growth factor, J. Comp. Neurol. 269 (1988) 147-155.
    • (1988) J. Comp. Neurol. , vol.269 , pp. 147-155
    • Gage, F.H.1    Armstrong, D.M.2    Williams, L.R.3    Varon, S.4
  • 160
    • 0026670651 scopus 로고
    • Regulation of brain neurotrophin expression by physiological activity
    • [160] C.M. Gall, Regulation of brain neurotrophin expression by physiological activity, Trends Pharmacol. 13 (1992) 401-403.
    • (1992) Trends Pharmacol. , vol.13 , pp. 401-403
    • Gall, C.M.1
  • 161
    • 0026578776 scopus 로고
    • Brain-derived neurotrophic factor and neurotrophin-3 mRNAs are expressed in ventral midbrain regions containing dopaminergic neurons
    • [161] C.M. Gall, S.J. Gold, P.J. Isackson, K.B. Seroogy, Brain-derived neurotrophic factor and neurotrophin-3 mRNAs are expressed in ventral midbrain regions containing dopaminergic neurons, Mol. Cell. Neurosci. 3 (1992) 56-63.
    • (1992) Mol. Cell. Neurosci. , vol.3 , pp. 56-63
    • Gall, C.M.1    Gold, S.J.2    Isackson, P.J.3    Seroogy, K.B.4
  • 162
    • 0028924891 scopus 로고
    • Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin and IGF-1 through distinct mechanisms of action: The involvement of intracellular calcium and RNA synthesis
    • [162] C. Galli, O. Meucci, A. Scorziello, T.M. Werge, P. Calissano, G. Schettini, Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis, J. Neurosci. 15 (1995) 1172-1179.
    • (1995) J. Neurosci. , vol.15 , pp. 1172-1179
    • Galli, C.1    Meucci, O.2    Scorziello, A.3    Werge, T.M.4    Calissano, P.5    Schettini, G.6
  • 163
    • 0029978443 scopus 로고    scopus 로고
    • Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration
    • [163] W.R. Galpern, D.M. Frim, S.B. Tatter, C.A. Altar, M.F. Beal, O. Isacson, Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration, Cell Transplant. 5 (1996) 225-232.
    • (1996) Cell Transplant. , vol.5 , pp. 225-232
    • Galpern, W.R.1    Frim, D.M.2    Tatter, S.B.3    Altar, C.A.4    Beal, M.F.5    Isacson, O.6
  • 165
    • 0026700490 scopus 로고
    • Expression of insulin-like growth factor 1 by astrocytes in response to injury
    • [165] J. Garcia-Estrada, L.M. Garcia-Segura, I. Torres-Aleman, Expression of insulin-like growth factor 1 by astrocytes in response to injury, Brain Res. 592 (1992) 343-347.
    • (1992) Brain Res. , vol.592 , pp. 343-347
    • Garcia-Estrada, J.1    Garcia-Segura, L.M.2    Torres-Aleman, I.3
  • 166
    • 0026010614 scopus 로고
    • Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain
    • [166] L.M. Garcia-Segura, J. Perez, S. Pons, M.T. Rejas, I. Torres-Aleman, Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain, Brain Res. 560 (1991) 167-174.
    • (1991) Brain Res. , vol.560 , pp. 167-174
    • Garcia-Segura, L.M.1    Perez, J.2    Pons, S.3    Rejas, M.T.4    Torres-Aleman, I.5
  • 169
    • 0022480016 scopus 로고
    • Time course of the elevation of nerve growth factor (NGF) content in the hippocampus and septum following lesions of the septohippocampal pathway in rats
    • [169] U.E. Gasser, G. Weskamp, U. Otten, A.R. Dravid, Time course of the elevation of nerve growth factor (NGF) content in the hippocampus and septum following lesions of the septohippocampal pathway in rats, Brain 376 (1986) 351-356.
    • (1986) Brain , vol.376 , pp. 351-356
    • Gasser, U.E.1    Weskamp, G.2    Otten, U.3    Dravid, A.R.4
  • 170
    • 0023127653 scopus 로고
    • Expression and characterisation of transforming growth factor α precursor protein in transfected mammalian cells
    • [170] L.E. Gentry, D.R. Twardzik, G.J. Lim, J.E. Ranchalis, D.C. Lee, Expression and characterisation of transforming growth factor α precursor protein in transfected mammalian cells, Mol. Cell. Biol. 7 (1987) 1585-1591.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 1585-1591
    • Gentry, L.E.1    Twardzik, D.R.2    Lim, G.J.3    Ranchalis, J.E.4    Lee, D.C.5
  • 171
    • 0028217132 scopus 로고
    • Requirement of BDNF in activity-dependent survival of cortical neurons
    • [171] A. Ghosh, J. Carnahan, M.E. Greenberg, Requirement of BDNF in activity-dependent survival of cortical neurons, Science 263 (1994) 1618-1623.
    • (1994) Science , vol.263 , pp. 1618-1623
    • Ghosh, A.1    Carnahan, J.2    Greenberg, M.E.3
  • 172
    • 0025936378 scopus 로고
    • Effects of fimbria-fornix and angular bundle transection on expression of the p75 mRNA by cells in the medial septum and diagonal band of Broca: Correlations with cell survival, synaptic reorganisation and sprouting
    • [172] R.B. Gibbs, M.V. Chao, D.W. Pfaff, Effects of fimbria-fornix and angular bundle transection on expression of the p75 mRNA by cells in the medial septum and diagonal band of Broca: correlations with cell survival, synaptic reorganisation and sprouting, Mol. Brain Res. 11 (1991) 207-219.
    • (1991) Mol. Brain Res. , vol.11 , pp. 207-219
    • Gibbs, R.B.1    Chao, M.V.2    Pfaff, D.W.3
  • 173
    • 0030580456 scopus 로고    scopus 로고
    • Expression pattern of candidate cell death effector proteins Bax, Bcl-2, Bcl-X and c-Jun in sensory and motor neurons following sciatic nerve transection in the rat
    • [173] F. Gillardon, L. Klimaschewski, H. Wickert, S. Krajewski, J.C. Reed, M. Zimmermann, Expression pattern of candidate cell death effector proteins Bax, Bcl-2, Bcl-X and c-Jun in sensory and motor neurons following sciatic nerve transection in the rat, Brain Res. 739 (1996) 244-250.
    • (1996) Brain Res. , vol.739 , pp. 244-250
    • Gillardon, F.1    Klimaschewski, L.2    Wickert, H.3    Krajewski, S.4    Reed, J.C.5    Zimmermann, M.6
  • 176
    • 0027420369 scopus 로고
    • Tau protein and the neurofibrillary pathology of Alzheimer's disease
    • [176] M. Goedert, Tau protein and the neurofibrillary pathology of Alzheimer's disease, Trends Neurosci. 16 (1993) 460-465.
    • (1993) Trends Neurosci. , vol.16 , pp. 460-465
    • Goedert, M.1
  • 177
    • 46149128942 scopus 로고
    • Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease
    • [177] M. Goedert, A. Fine, S.P. Hunt, A. Ullrich, Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease, Mol. Brain Res. 1 (1986) 85-92.
    • (1986) Mol. Brain Res. , vol.1 , pp. 85-92
    • Goedert, M.1    Fine, A.2    Hunt, S.P.3    Ullrich, A.4
  • 178
    • 0029614836 scopus 로고
    • Growth factors and apoptosis in development - The role of insulin-like growth factor I and TGF-beta-1 in regulating cell growth and cell death in a human teratocarcinoma-derived cell line
    • [178] M. Granerus, P. Schofield, P. Bierke, W. Engstrom, Growth factors and apoptosis in development - the role of insulin-like growth factor I and TGF-beta-1 in regulating cell growth and cell death in a human teratocarcinoma-derived cell line, Int. J. Dev. Biol. 39 (1995) 759-764.
    • (1995) Int. J. Dev. Biol. , vol.39 , pp. 759-764
    • Granerus, M.1    Schofield, P.2    Bierke, P.3    Engstrom, W.4
  • 181
    • 0030953519 scopus 로고    scopus 로고
    • Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors
    • [181] G. Haase, P. Kennel, B. Pettmann, E. Vigne, S. Akli, F. Revah, H. Schmalbruch, A. Kahn, Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors, Nat. Med. 3 (1997) 429-436.
    • (1997) Nat. Med. , vol.3 , pp. 429-436
    • Haase, G.1    Kennel, P.2    Pettmann, B.3    Vigne, E.4    Akli, S.5    Revah, F.6    Schmalbruch, H.7    Kahn, A.8
  • 182
    • 0029012476 scopus 로고
    • A c-jun dominant negative mutant protects neurons against programmed cell death
    • [182] J. Ham, C. Babji, J. Whitfield, C.M. Pfarr, D. Lallemand, M. Yaniv, L.L. Rubin, A c-jun dominant negative mutant protects neurons against programmed cell death, Neuron 14 (1995) 927-939.
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babji, C.2    Whitfield, J.3    Pfarr, C.M.4    Lallemand, D.5    Yaniv, M.6    Rubin, L.L.7
  • 183
    • 0024595972 scopus 로고
    • Synaptic loss in Alzheimer's disease and other dementias
    • [183] J.E. Hamos, L.J. DeGannaro, D.A. Drachman, Synaptic loss in Alzheimer's disease and other dementias, Neurology 39 (1989) 355-361.
    • (1989) Neurology , vol.39 , pp. 355-361
    • Hamos, J.E.1    DeGannaro, L.J.2    Drachman, D.A.3
  • 184
    • 0023715049 scopus 로고
    • Rat astroglial somatomedin/insulin-like growth factor binding proteins: Characterization and evidence of biological function
    • [184] V.K.M. Han, J.M. Lauder, A.J. D'Ercole, Rat astroglial somatomedin/insulin-like growth factor binding proteins: characterization and evidence of biological function, J. Neurosci. 8 (1988) 3135-3143.
    • (1988) J. Neurosci. , vol.8 , pp. 3135-3143
    • Han, V.K.M.1    Lauder, J.M.2    D'Ercole, A.J.3
  • 185
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • [185] J.A. Hardy, G.A. Higgins, Alzheimer's disease: the amyloid cascade hypothesis, Science 256 (1992) 184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 187
    • 0028050217 scopus 로고
    • Nerve growth factor-induced differentiation in neuroblastoma cells expressing TrkA but lacking p75 NGFR
    • [187] D.S. Hartman, C. Hertel, Nerve growth factor-induced differentiation in neuroblastoma cells expressing TrkA but lacking p75 NGFR, J. Neurochem. 63 (1994) 1261-1270.
    • (1994) J. Neurochem. , vol.63 , pp. 1261-1270
    • Hartman, D.S.1    Hertel, C.2
  • 188
    • 0029670980 scopus 로고    scopus 로고
    • Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of mice
    • [188] I. Hassouna, H. Wickert, M. Zimmermann, F. Gillardon, Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of mice, Neurosci. Lett. 204 (1996) 85-88.
    • (1996) Neurosci. Lett. , vol.204 , pp. 85-88
    • Hassouna, I.1    Wickert, H.2    Zimmermann, M.3    Gillardon, F.4
  • 189
    • 0020666935 scopus 로고
    • Is Alzheimer's disease caused by lack of nerve growth factor?
    • [189] F. Hefti, Is Alzheimer's disease caused by lack of nerve growth factor?, Ann. Neurol. 13 (1983) 109-110.
    • (1983) Ann. Neurol. , vol.13 , pp. 109-110
    • Hefti, F.1
  • 190
    • 0010429889 scopus 로고
    • Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after injury
    • [190] F. Hefti, Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after injury, Proc. Soc. Neurosci. 11 (1985) 660.
    • (1985) Proc. Soc. Neurosci. , vol.11 , pp. 660
    • Hefti, F.1
  • 191
    • 0022486717 scopus 로고
    • Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
    • [191] F. Hefti, Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections, J. Neurosci. 6 (1986) 2155-2162.
    • (1986) J. Neurosci. , vol.6 , pp. 2155-2162
    • Hefti, F.1
  • 192
    • 0024351750 scopus 로고
    • Localisation of nerve growth factor receptors in the normal human brain and in Alzheimer's disease
    • [192] F. Hefti, D.C. Mash, Localisation of nerve growth factor receptors in the normal human brain and in Alzheimer's disease, Neurobiol. Aging 10 (1989) 75-87.
    • (1989) Neurobiol. Aging , vol.10 , pp. 75-87
    • Hefti, F.1    Mash, D.C.2
  • 193
    • 0022549757 scopus 로고
    • Nerve growth factor and Alzheimer's disease
    • [193] F. Hefti, W.J. Weiner, Nerve growth factor and Alzheimer's disease, Ann. Neurol. 20 (1986) 275-281.
    • (1986) Ann. Neurol. , vol.20 , pp. 275-281
    • Hefti, F.1    Weiner, W.J.2
  • 194
    • 0021359024 scopus 로고
    • Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions
    • [194] F. Hefti, A. Dravid, J. Hartikka, Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions, Brain Res. 293 (1984) 305-311.
    • (1984) Brain Res. , vol.293 , pp. 305-311
    • Hefti, F.1    Dravid, A.2    Hartikka, J.3
  • 195
    • 0022547630 scopus 로고
    • Localisation of nerve growth factor receptors in cholinergic neurons of the human basal forebrain
    • [195] F. Hefti, J. Hartikka, A. Salvatierra, W.J. Weiner, D.C. Mash, Localisation of nerve growth factor receptors in cholinergic neurons of the human basal forebrain, Neurosci. Lett. 69 (1986) 37-41.
    • (1986) Neurosci. Lett. , vol.69 , pp. 37-41
    • Hefti, F.1    Hartikka, J.2    Salvatierra, A.3    Weiner, W.J.4    Mash, D.C.5
  • 196
    • 0027424459 scopus 로고
    • Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections
    • [196] F. Hefti, B. Knusel, P.A. Lapchak, Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections, Prog. Brain Res. 98 (1993) 257-263.
    • (1993) Prog. Brain Res. , vol.98 , pp. 257-263
    • Hefti, F.1    Knusel, B.2    Lapchak, P.A.3
  • 197
    • 0028330489 scopus 로고
    • NMDA potentiates NGF-induced sprouting of septal cholinergic fibres
    • [197] C.-P. Heisenberg, J.D. Cooper, J. Berke, M.V. Sofroniew, NMDA potentiates NGF-induced sprouting of septal cholinergic fibres, NeuroReport 5 (1994) 413-416.
    • (1994) NeuroReport , vol.5 , pp. 413-416
    • Heisenberg, C.-P.1    Cooper, J.D.2    Berke, J.3    Sofroniew, M.V.4
  • 198
    • 0030600002 scopus 로고    scopus 로고
    • Glial-derived neurotrophic factor (GDNF) induced morphological differentiation of an immortalized monoclonal hybrid dopaminergic cell line of mesencephalic neuronal origin
    • [198] A. Heller, S. Price, L. Won, Glial-derived neurotrophic factor (GDNF) induced morphological differentiation of an immortalized monoclonal hybrid dopaminergic cell line of mesencephalic neuronal origin, Brain Res. 725 (1996) 132-136.
    • (1996) Brain Res. , vol.725 , pp. 132-136
    • Heller, A.1    Price, S.2    Won, L.3
  • 199
    • 0025641211 scopus 로고
    • Nerve growth factor levels and choline acetlytransferase activity in the brain of aged rats with spatial memory impairments
    • [199] R. Hellweg, W. Fischer, C. Hock, F.H. Gage, A. Bjorklund, H. Thoenen, Nerve growth factor levels and choline acetlytransferase activity in the brain of aged rats with spatial memory impairments, Brain Res. 537 (1990) 123-130.
    • (1990) Brain Res. , vol.537 , pp. 123-130
    • Hellweg, R.1    Fischer, W.2    Hock, C.3    Gage, F.H.4    Bjorklund, A.5    Thoenen, H.6
  • 200
    • 0024579301 scopus 로고
    • Expression of functional nerve growth factor receptors after gene transfer
    • [200] B.L. Hempstead, L.S. Schleifer, M.V. Chao, Expression of functional nerve growth factor receptors after gene transfer, Science 243 (1989) 373-375.
    • (1989) Science , vol.243 , pp. 373-375
    • Hempstead, B.L.1    Schleifer, L.S.2    Chao, M.V.3
  • 201
    • 0029964643 scopus 로고    scopus 로고
    • Role of neurotrophic factors in neuronal development
    • [201] C.E. Henderson, Role of neurotrophic factors in neuronal development, Curr. Opin. Neurobiol. 6 (1996) 64-70.
    • (1996) Curr. Opin. Neurobiol. , vol.6 , pp. 64-70
    • Henderson, C.E.1
  • 202
    • 0022624745 scopus 로고
    • Polypeptide growth factors and the CNS
    • [202] H.R. Herschman, Polypeptide growth factors and the CNS, Trends Neurosci. 9 (1986) 53-58.
    • (1986) Trends Neurosci. , vol.9 , pp. 53-58
    • Herschman, H.R.1
  • 203
    • 0024807135 scopus 로고
    • NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease
    • [203] G.A. Higgins, E.J. Mufson, NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease, Exp. Neurol. 106 (1989) 222-236.
    • (1989) Exp. Neurol. , vol.106 , pp. 222-236
    • Higgins, G.A.1    Mufson, E.J.2
  • 204
    • 0029117841 scopus 로고
    • Glutamate regulation of GDNF gene expression in the striatum and primary striatal astrocytes
    • [204] A. Ho, A.C. Gore, C.S. Weickert, M. Blum, Glutamate regulation of GDNF gene expression in the striatum and primary striatal astrocytes, NeuroReport 6 (1995) 1454-1458.
    • (1995) NeuroReport , vol.6 , pp. 1454-1458
    • Ho, A.1    Gore, A.C.2    Weickert, C.S.3    Blum, M.4
  • 205
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • [205] D.M. Hockenbery, G. Nunez, C. Milliman, R.D. Schreiber, S.J. Korsmeyer, Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death, Nature 348 (1990) 334-336.
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenbery, D.M.1    Nunez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 206
    • 0023855585 scopus 로고
    • Brain-derived neurotrophic factor prevents neuronal death in vivo
    • [206] H.M. Hofer, Y.A. Barde, Brain-derived neurotrophic factor prevents neuronal death in vivo, Nature 331 (1988) 261-262.
    • (1988) Nature , vol.331 , pp. 261-262
    • Hofer, H.M.1    Barde, Y.A.2
  • 208
    • 0027249839 scopus 로고
    • Transplantation of a polymer-encapsulated cell line genetically engineered to release NGF
    • [208] D. Hoffman, X.O. Breakefield, M.P. Short, P. Aebischer, Transplantation of a polymer-encapsulated cell line genetically engineered to release NGF, Exp. Neurol. 122 (1993) 100-106.
    • (1993) Exp. Neurol. , vol.122 , pp. 100-106
    • Hoffman, D.1    Breakefield, X.O.2    Short, M.P.3    Aebischer, P.4
  • 209
    • 0025317838 scopus 로고
    • Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic family
    • [209] A. Hohn, J. Leibrock, K. Bailey, Y.-A. Barde, Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic family, Nature 344 (1990) 339-340.
    • (1990) Nature , vol.344 , pp. 339-340
    • Hohn, A.1    Leibrock, J.2    Bailey, K.3    Barde, Y.-A.4
  • 210
    • 0028657601 scopus 로고
    • Neurotrophic factors and neurologic disease
    • [210] D.M. Holtzman, W.C. Mobley, Neurotrophic factors and neurologic disease, West. J. Med. 161 (1994) 246-254.
    • (1994) West. J. Med. , vol.161 , pp. 246-254
    • Holtzman, D.M.1    Mobley, W.C.2
  • 211
    • 0027742330 scopus 로고
    • Nerve growth factor reverses neuronal atrophy in a down syndrome model of age-related neurodegeneration
    • [211] D.M. Holtzman, Y. Li, K. Chen, F.H. Gage, C.J. Epstein, W.C. Mobley, Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration, Neurology 43 (1993) 2668-2673.
    • (1993) Neurology , vol.43 , pp. 2668-2673
    • Holtzman, D.M.1    Li, Y.2    Chen, K.3    Gage, F.H.4    Epstein, C.J.5    Mobley, W.C.6
  • 212
    • 0030723933 scopus 로고    scopus 로고
    • In vivo adenovirus-mediated gene transfer for Parkinson's disease
    • [212] P. Horellou, A. Bilang-Bleuel, J. Mallet, In vivo adenovirus-mediated gene transfer for Parkinson's disease, Neurobiol. Dis. 4 (1997) 280-287.
    • (1997) Neurobiol. Dis. , vol.4 , pp. 280-287
    • Horellou, P.1    Bilang-Bleuel, A.2    Mallet, J.3
  • 213
    • 0031106006 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer to the central nervous system for Parkinson's disease
    • [213] P. Horellou, O. Sabate, M.H. Buc-Caron, J. Mallet, Adenovirus-mediated gene transfer to the central nervous system for Parkinson's disease, Exp. Neurol. 144 (1997) 131-138.
    • (1997) Exp. Neurol. , vol.144 , pp. 131-138
    • Horellou, P.1    Sabate, O.2    Buc-Caron, M.H.3    Mallet, J.4
  • 214
    • 0030767741 scopus 로고    scopus 로고
    • Pathophysiological aspects of human neurodegenerative diseases
    • [214] H. Hortnagl, R. Hellweg, Pathophysiological aspects of human neurodegenerative diseases, Wien Klin Wochenschr 109 (1997) 623-635.
    • (1997) Wien Klin Wochenschr , vol.109 , pp. 623-635
    • Hortnagl, H.1    Hellweg, R.2
  • 215
    • 0030031116 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methyl-4-phenylpyridinium
    • [215] J.-G.G. Hou, L.-F.H. Lin, C. Mytilineou, Glial cell line-derived neurotrophic factor exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methyl-4-phenylpyridinium, J. Neurochem. 66 (1996) 74-82.
    • (1996) J. Neurochem. , vol.66 , pp. 74-82
    • Hou, J.-G.G.1    Lin, L.-F.H.2    Mytilineou, C.3
  • 217
    • 0027362029 scopus 로고
    • Brain-derived neurotrophic factor is induced as an immediate early gene following N-methyl-D-aspartate receptor activation
    • [217] P. Hughes, E. Beilharz, P. Gluckman, M. Dragunow, Brain-derived neurotrophic factor is induced as an immediate early gene following N-methyl-D-aspartate receptor activation, Neuroscience 57 (1993) 319-328.
    • (1993) Neuroscience , vol.57 , pp. 319-328
    • Hughes, P.1    Beilharz, E.2    Gluckman, P.3    Dragunow, M.4
  • 218
    • 0028302831 scopus 로고
    • Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in response to kainate-induced excitation
    • [218] C. Humpel, I. Stromberg, S. Bektesh, F. Collins, L. Olson, Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in response to kainate-induced excitation, Neuroscience 59 (1994) 791-795.
    • (1994) Neuroscience , vol.59 , pp. 791-795
    • Humpel, C.1    Stromberg, I.2    Bektesh, S.3    Collins, F.4    Olson, L.5
  • 219
    • 0026498160 scopus 로고
    • Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex
    • [219] G.W. Huntley, D.L. Benson, E.G. Jones, P.J. Isackson, Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex, Dev. Brain Res. 70 (1992) 53-63.
    • (1992) Dev. Brain Res. , vol.70 , pp. 53-63
    • Huntley, G.W.1    Benson, D.L.2    Jones, E.G.3    Isackson, P.J.4
  • 220
    • 0021145680 scopus 로고
    • Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
    • [220] B.T. Hyman, G.W. Van Hoesen, A.R. Damasio, C.L. Barnes, Alzheimer's disease: cell-specific pathology isolates the hippocampal formation, Science 225 (1984) 1168-1169.
    • (1984) Science , vol.225 , pp. 1168-1169
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 221
    • 0022535539 scopus 로고
    • Perforant pathway changes and the memory impairment of Alzheimer's disease
    • [221] B.T. Hyman, G.W. Van Hoesen, L.J. Kromer, A.R. Damasio, Perforant pathway changes and the memory impairment of Alzheimer's disease, Ann. Neurol. 20 (1986) 472-481.
    • (1986) Ann. Neurol. , vol.20 , pp. 472-481
    • Hyman, B.T.1    Van Hoesen, G.W.2    Kromer, L.J.3    Damasio, A.R.4
  • 222
    • 0023095310 scopus 로고
    • Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease
    • [222] B.T. Hyman, B.A. Kromer, G.W. Van Hoesen, Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease, Ann. Neurol. 21 (1987) 259-267.
    • (1987) Ann. Neurol. , vol.21 , pp. 259-267
    • Hyman, B.T.1    Kromer, B.A.2    Van Hoesen, G.W.3
  • 224
    • 0025358695 scopus 로고
    • Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegeneration diseases
    • [224] A.M. Iacopino, S. Christakos, Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegeneration diseases, Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 4078-4082.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 4078-4082
    • Iacopino, A.M.1    Christakos, S.2
  • 225
    • 0026504821 scopus 로고
    • Calbindin D28K-containing neurons in animal models of neurodegeneration: Possible detection from excitotoxicity
    • [225] A.M. Iacopino, S. Christakos, D. German, P.K. Sonsalla, C.A. Altar, Calbindin D28K-containing neurons in animal models of neurodegeneration: possible detection from excitotoxicity, Mol. Brain Res. 13 (1992) 251-261.
    • (1992) Mol. Brain Res. , vol.13 , pp. 251-261
    • Iacopino, A.M.1    Christakos, S.2    German, D.3    Sonsalla, P.K.4    Altar, C.A.5
  • 226
    • 0028916844 scopus 로고
    • Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
    • [226] K. Ikeda, B. Klinkosz, T. Greene, J.M. Cedarbaum, V. Wong, R.M. Lindsay, H. Mitsumoto, Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease, Ann. Neurol. 37 (1995) 505-511.
    • (1995) Ann. Neurol. , vol.37 , pp. 505-511
    • Ikeda, K.1    Klinkosz, B.2    Greene, T.3    Cedarbaum, J.M.4    Wong, V.5    Lindsay, R.M.6    Mitsumoto, H.7
  • 227
    • 0027183083 scopus 로고
    • Cultured hippocampal neurons show responses to BDNF, NT-3 and NT-4, but not NGF
    • [227] N.Y. Ip, Y. Li, G.D. Yancopoulos, R.M. Lindsay, Cultured hippocampal neurons show responses to BDNF, NT-3 and NT-4, but not NGF, J. Neurosci. 13 (1993) 3394-3405.
    • (1993) J. Neurosci. , vol.13 , pp. 3394-3405
    • Ip, N.Y.1    Li, Y.2    Yancopoulos, G.D.3    Lindsay, R.M.4
  • 228
    • 0029982615 scopus 로고    scopus 로고
    • Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos
    • [228] N.D. James, D.R. Davis, J. Sindon, D.P. Hanger, J.-P. Brion, C.C.J. Miller, M.P. Rosenberg, B.H. Anderton, F. Propst, Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos, Neurobiol. Aging 17 (1996) 235-241.
    • (1996) Neurobiol. Aging , vol.17 , pp. 235-241
    • James, N.D.1    Davis, D.R.2    Sindon, J.3    Hanger, D.P.4    Brion, J.-P.5    Miller, C.C.J.6    Rosenberg, M.P.7    Anderton, B.H.8    Propst, F.9
  • 229
    • 0028965738 scopus 로고
    • A single intraseptal injection of nerve growth factor facilitates radial maze performance following damage to the medial septum in rats
    • [229] L.S. Janis, M.M. Glasier, G. Martin, R.W. Stackman, T.J. Walsh, D.G. Stein, A single intraseptal injection of nerve growth factor facilitates radial maze performance following damage to the medial septum in rats, Brain Res. 679 (1995) 99-109.
    • (1995) Brain Res. , vol.679 , pp. 99-109
    • Janis, L.S.1    Glasier, M.M.2    Martin, G.3    Stackman, R.W.4    Walsh, T.J.5    Stein, D.G.6
  • 230
    • 0026740057 scopus 로고
    • New insights into the cause of Parkinson's disease
    • [230] P. Jenner, A.H.V. Schapira, C.D. Marsden, New insights into the cause of Parkinson's disease, Neurology 42 (1992) 2241-2250.
    • (1992) Neurology , vol.42 , pp. 2241-2250
    • Jenner, P.1    Schapira, A.H.V.2    Marsden, C.D.3
  • 232
    • 0028129444 scopus 로고
    • NGF mRNA is not decreased in frontal cortex from Alzheimer's disease patients
    • [232] N. Jette, M.S. Cole, M. Fahnestock, NGF mRNA is not decreased in frontal cortex from Alzheimer's disease patients, Mol. Brain Res. 25 (1994) 242-250.
    • (1994) Mol. Brain Res. , vol.25 , pp. 242-250
    • Jette, N.1    Cole, M.S.2    Fahnestock, M.3
  • 233
    • 0027050178 scopus 로고
    • Nerve growth factor mediates signal transduction through trk homodimer receptor
    • [233] S. Jing, P. Tapley, M. Barbacid, Nerve growth factor mediates signal transduction through trk homodimer receptor, Neuron 9 (1992) 1067-1079.
    • (1992) Neuron , vol.9 , pp. 1067-1079
    • Jing, S.1    Tapley, P.2    Barbacid, M.3
  • 235
    • 0023547047 scopus 로고
    • Nerve growth factor (NGF) receptors in the central nervous system
    • [235] E.M. Johnson, M. Taniuchi, Nerve growth factor (NGF) receptors in the central nervous system, Biochem. Pharmacol. 36 (1987) 4189-4195.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 4189-4195
    • Johnson, E.M.1    Taniuchi, M.2
  • 237
    • 0030071176 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs
    • [237] B.M. Johnston, E.C. Mallard, C.E. Williams, P.D. Gluckman, Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs, J. Clin. Invest. 97 (1996) 300-308.
    • (1996) J. Clin. Invest. , vol.97 , pp. 300-308
    • Johnston, B.M.1    Mallard, E.C.2    Williams, C.E.3    Gluckman, P.D.4
  • 238
    • 0025153360 scopus 로고
    • Long-term administration of mouse nerve growth factor to adult rats with parial lesions of the cholinergic septohippocampal pathway
    • [238] E.O. Junard, C.N. Montero, F. Hefti, Long-term administration of mouse nerve growth factor to adult rats with parial lesions of the cholinergic septohippocampal pathway, Exp. Neurol. 110 (1990) 25-38.
    • (1990) Exp. Neurol. , vol.110 , pp. 25-38
    • Junard, E.O.1    Montero, C.N.2    Hefti, F.3
  • 239
    • 0029670038 scopus 로고    scopus 로고
    • Suppression of interleukin-1-beta-converting enzyme-mediated cell death by insulin-like growth factor
    • [239] Y.K. Jung, M. Miura, J.Y. Yuan, Suppression of interleukin-1-beta-converting enzyme-mediated cell death by insulin-like growth factor, J. Biol. Chem. 271 (1996) 5112-5117.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5112-5117
    • Jung, Y.K.1    Miura, M.2    Yuan, J.Y.3
  • 240
    • 0028341895 scopus 로고
    • Transforming growth factor α (TGFα) expression in degenerating motoneurons of the murine mutant wobbler: A neuronal signal for astrogliosis?
    • [240] M.-P. Junier, M. Coulpier, N. Le Forestier, J. Cadusseau, F. Suzuki, M. Peschanski, P.A. Dreyfus, Transforming growth factor α (TGFα) expression in degenerating motoneurons of the murine mutant wobbler: a neuronal signal for astrogliosis?, J. Neurosci. 14 (1994) 4206-4216.
    • (1994) J. Neurosci. , vol.14 , pp. 4206-4216
    • Junier, M.-P.1    Coulpier, M.2    Le Forestier, N.3    Cadusseau, J.4    Suzuki, F.5    Peschanski, M.6    Dreyfus, P.A.7
  • 241
    • 0030990750 scopus 로고    scopus 로고
    • Prevention of apoptotic motoneuron death in vitro by neurotrophins and muscle extract
    • [241] E.C. Kaal, E.A. Joosten, P.R. Bar, Prevention of apoptotic motoneuron death in vitro by neurotrophins and muscle extract, Neurochem. Int. 31 (1997) 193-201.
    • (1997) Neurochem. Int. , vol.31 , pp. 193-201
    • Kaal, E.C.1    Joosten, E.A.2    Bar, P.R.3
  • 242
  • 243
    • 0028988240 scopus 로고
    • Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus
    • [243] H. Kang, E.M. Schuman, Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus, Science 267 (1995) 1658-1662.
    • (1995) Science , vol.267 , pp. 1658-1662
    • Kang, H.1    Schuman, E.M.2
  • 244
    • 0025735392 scopus 로고
    • The trk proto-oncogene product: A signal transducing receptor for nerve growth factor
    • [244] D.R. Kaplan, B.L. Hempstead, D. Martin-Zanca, M.V. Chao, L.F. Parada, The trk proto-oncogene product: a signal transducing receptor for nerve growth factor, Science 252 (1991) 554-557.
    • (1991) Science , vol.252 , pp. 554-557
    • Kaplan, D.R.1    Hempstead, B.L.2    Martin-Zanca, D.3    Chao, M.V.4    Parada, L.F.5
  • 247
    • 0027098011 scopus 로고
    • Comparison between epidermal growth factor, transforming growth factor-α and EGF receptor levels in regions of adult rat brain
    • [247] M.R. Kaser, J. Lakshmana, D.A. Fisher, Comparison between epidermal growth factor, transforming growth factor-α and EGF receptor levels in regions of adult rat brain, Mol. Brain Res. 16 (1992) 316-322.
    • (1992) Mol. Brain Res. , vol.16 , pp. 316-322
    • Kaser, M.R.1    Lakshmana, J.2    Fisher, D.A.3
  • 248
    • 0026017334 scopus 로고
    • Distribution of nerve growth factor receptor immunoreactivity in the human hippocampus
    • [248] J. Kerwin, C. Morris, A. Oakley, R. Perry, E. Perry, Distribution of nerve growth factor receptor immunoreactivity in the human hippocampus, Neurosci. Lett. 121 (1990) 178-182.
    • (1990) Neurosci. Lett. , vol.121 , pp. 178-182
    • Kerwin, J.1    Morris, C.2    Oakley, A.3    Perry, R.4    Perry, E.5
  • 249
    • 0026726972 scopus 로고
    • Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease
    • [249] J.M. Kerwin, C.M. Morris, R.H. Perry, E.K. Perry, Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease, Neurosci. Lett. 143 (1992) 101-104.
    • (1992) Neurosci. Lett. , vol.143 , pp. 101-104
    • Kerwin, J.M.1    Morris, C.M.2    Perry, R.H.3    Perry, E.K.4
  • 251
    • 0025281397 scopus 로고
    • The trkB tyrosine protein kinase receptor gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
    • [251] R. Klein, D. Conway, L.F. Parada, M. Barbacid, The trkB tyrosine protein kinase receptor gene codes for a second neurogenic receptor that lacks the catalytic kinase domain, Cell 61 (1990) 647-656.
    • (1990) Cell , vol.61 , pp. 647-656
    • Klein, R.1    Conway, D.2    Parada, L.F.3    Barbacid, M.4
  • 252
    • 0025857391 scopus 로고
    • The trk proto-oncogene encodes a receptor for nerve growth factor
    • [252] R. Klein, S. Jing, V. Nanduri, E. O'Rourke, M. Barbacid, The trk proto-oncogene encodes a receptor for nerve growth factor, Cell 65 (1991) 189-197.
    • (1991) Cell , vol.65 , pp. 189-197
    • Klein, R.1    Jing, S.2    Nanduri, V.3    O'Rourke, E.4    Barbacid, M.5
  • 254
    • 0027491104 scopus 로고
    • Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
    • [254] R. Klein, R.J. Smeyne, W. Wurst, L.K. Long, B.A. Auerbach, A.L. Joyner, M. Barbacid, Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death, Cell 75 (1993) 113-122.
    • (1993) Cell , vol.75 , pp. 113-122
    • Klein, R.1    Smeyne, R.J.2    Wurst, W.3    Long, L.K.4    Auerbach, B.A.5    Joyner, A.L.6    Barbacid, M.7
  • 255
    • 0026672497 scopus 로고
    • Expression of insulin-like growth factor-binding protein 2 (IGF-BP2) following transient hypoxia-ischemia in the infant rat brain
    • [255] N.D. Klempt, M. Klempt, A.J. Gunn, K. Singh, P.D. Gluckman, Expression of insulin-like growth factor-binding protein 2 (IGF-BP2) following transient hypoxia-ischemia in the infant rat brain, Mol. Brain Res. 15 (1992) 55-61.
    • (1992) Mol. Brain Res. , vol.15 , pp. 55-61
    • Klempt, N.D.1    Klempt, M.2    Gunn, A.J.3    Singh, K.4    Gluckman, P.D.5
  • 256
    • 0028266334 scopus 로고
    • Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus
    • [256] M. Knipper, M.D.P. Berzagh, A. Blochl, H. Breer, H. Thoenen, D. Lindholm, Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus, Eur. J. Neurosci. 6 (1994) 668-671.
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 668-671
    • Knipper, M.1    Berzagh, M.D.P.2    Blochl, A.3    Breer, H.4    Thoenen, H.5    Lindholm, D.6
  • 257
    • 0028266334 scopus 로고
    • Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus
    • [257] M. Knipper, M. da Penha Berzaghi, A. Blochl, H. Breer, H. Thoenen, D. Lindholm, Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus, Eur. J. Neurosci. 6 (1994) 668-671.
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 668-671
    • Knipper, M.1    Da Penha Berzaghi, M.2    Blochl, A.3    Breer, H.4    Thoenen, H.5    Lindholm, D.6
  • 258
    • 0025265681 scopus 로고
    • Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II
    • [258] B. Knusel, P.P. Michel, J.S. Schwaber, F. Hefti, Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II, J. Neurosci. 10 (1990) 558-570.
    • (1990) J. Neurosci. , vol.10 , pp. 558-570
    • Knusel, B.1    Michel, P.P.2    Schwaber, J.S.3    Hefti, F.4
  • 259
    • 0026574673 scopus 로고
    • Brain-derived neurotrophic factor administration protects basal brain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain
    • [259] B. Knusel, K.D. Beck, J.W. Winslow, A. Rosenthal, L.E. Burton, H.R. Widmer, K. Nikolics, F. Hefti, Brain-derived neurotrophic factor administration protects basal brain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain, J. Neurosci. 12 (1992) 4391-4402.
    • (1992) J. Neurosci. , vol.12 , pp. 4391-4402
    • Knusel, B.1    Beck, K.D.2    Winslow, J.W.3    Rosenthal, A.4    Burton, L.E.5    Widmer, H.R.6    Nikolics, K.7    Hefti, F.8
  • 260
    • 0024850531 scopus 로고
    • Localisation of nerve growth factor receptor messenger RNA and protein in the adult rat brain
    • [260] S. Koh, G.A. Oyler, G.A. Higgins, Localisation of nerve growth factor receptor messenger RNA and protein in the adult rat brain, Exp. Neurol. 106 (1989) 209-221.
    • (1989) Exp. Neurol. , vol.106 , pp. 209-221
    • Koh, S.1    Oyler, G.A.2    Higgins, G.A.3
  • 263
    • 0025780387 scopus 로고
    • Recombinant human nerve growth factor prevents retrograde degeneration of axotomised basal forebrain cholinergic neurons in the rat
    • [263] V.E. Koliatsos, M.D. Applegate, B. Knusel, E.O. Junard, L.E. Burton, W.C. Mobley, F. Hefti, D. Price, Recombinant human nerve growth factor prevents retrograde degeneration of axotomised basal forebrain cholinergic neurons in the rat, Exp. Neurol. 112 (1991) 161-173.
    • (1991) Exp. Neurol. , vol.112 , pp. 161-173
    • Koliatsos, V.E.1    Applegate, M.D.2    Knusel, B.3    Junard, E.O.4    Burton, L.E.5    Mobley, W.C.6    Hefti, F.7    Price, D.8
  • 265
    • 0028334932 scopus 로고
    • Highly selective effects of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons
    • [265] V.E. Koliatsos, D.L. Price, G.K. Gouras, M.H. Cayouette, L.E. Burton, J.W. Winslow, Highly selective effects of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons, J. Comp. Neurol. 343 (1994) 247-262.
    • (1994) J. Comp. Neurol. , vol.343 , pp. 247-262
    • Koliatsos, V.E.1    Price, D.L.2    Gouras, G.K.3    Cayouette, M.H.4    Burton, L.E.5    Winslow, J.W.6
  • 266
    • 0024333157 scopus 로고
    • Nerve growth factor receptor and choline acetyltransferase remain colocalised in the nucleus basalis (Ch4) of Alzheimer's patients
    • [266] J.H. Kordower, D.M. Gash, M. Bothwell, L. Hersh, E.J. Mufson, Nerve growth factor receptor and choline acetyltransferase remain colocalised in the nucleus basalis (Ch4) of Alzheimer's patients, Neurobiol. Aging 10 (1989) 67-74.
    • (1989) Neurobiol. Aging , vol.10 , pp. 67-74
    • Kordower, J.H.1    Gash, D.M.2    Bothwell, M.3    Hersh, L.4    Mufson, E.J.5
  • 267
    • 0028558577 scopus 로고
    • Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in the model of Huntington disease
    • [267] J.H. Kordower, V. Charles, R. Bayer, R.T. Bartus, S. Putney, L.R. Walus, P.M. Friden, Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in the model of Huntington disease, Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 9077-9080.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 9077-9080
    • Kordower, J.H.1    Charles, V.2    Bayer, R.3    Bartus, R.T.4    Putney, S.5    Walus, L.R.6    Friden, P.M.7
  • 268
    • 0027944164 scopus 로고
    • TRK-immunoreactivity in the monkey central nervous system: Forebrain
    • [268] J.H. Kordower, E. Chen, J.R. Sladek, E.J. Mufson, TRK-immunoreactivity in the monkey central nervous system: forebrain, J. Comp. Neurol. 349 (1994) 20-35.
    • (1994) J. Comp. Neurol. , vol.349 , pp. 20-35
    • Kordower, J.H.1    Chen, E.2    Sladek, J.R.3    Mufson, E.J.4
  • 269
    • 0028020905 scopus 로고
    • The aged monkey basal forebrain: Rescue and sprouting of axotomised basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor
    • [269] J.H. Kordower, S.R. Winn, Y. Liu, E.J. Mufson, J.R. Sladek, J.P. Hammang, E.E. Baetge, D.F. Emerich, The aged monkey basal forebrain: rescue and sprouting of axotomised basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor, Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 10898-10902.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 10898-10902
    • Kordower, J.H.1    Winn, S.R.2    Liu, Y.3    Mufson, E.J.4    Sladek, J.R.5    Hammang, J.P.6    Baetge, E.E.7    Emerich, D.F.8
  • 270
    • 0029986086 scopus 로고    scopus 로고
    • Intrastriatal implants of polymer encapsulated cells genetically modified to secrete human nerve growth factor: Trophic effects upon cholinergic and noncholinergic striatal neurons
    • [270] J.H. Kordower, E.Y. Chen, E.J. Mufson, S.R. Winn, D.F. Emerich, Intrastriatal implants of polymer encapsulated cells genetically modified to secrete human nerve growth factor: trophic effects upon cholinergic and noncholinergic striatal neurons, Neuroscience 72 (1996) 63-77.
    • (1996) Neuroscience , vol.72 , pp. 63-77
    • Kordower, J.H.1    Chen, E.Y.2    Mufson, E.J.3    Winn, S.R.4    Emerich, D.F.5
  • 271
    • 0030848990 scopus 로고    scopus 로고
    • Cellular delivery of NGF does not alter the expression of beta-amyloid immunoreactivity in young or aged nonhuman primates
    • [271] J.H. Kordower, E.J. Mufson, N. Fox, L. Martel, D.F. Emerich, Cellular delivery of NGF does not alter the expression of beta-amyloid immunoreactivity in young or aged nonhuman primates, Exp. Neurol. 145 (1997) 586-591.
    • (1997) Exp. Neurol. , vol.145 , pp. 586-591
    • Kordower, J.H.1    Mufson, E.J.2    Fox, N.3    Martel, L.4    Emerich, D.F.5
  • 272
    • 0344106663 scopus 로고
    • Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation
    • [272] S. Korsching, G. Auburger, R. Heumann, J. Scott, H. Thoenen, Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation, EMBO J. 4 (1985) 1389-1393.
    • (1985) EMBO J. , vol.4 , pp. 1389-1393
    • Korsching, S.1    Auburger, G.2    Heumann, R.3    Scott, J.4    Thoenen, H.5
  • 275
    • 0025730696 scopus 로고
    • Alzheimer plaques and tangles: Advances on both fronts
    • [275] K.S. Kosik, Alzheimer plaques and tangles: advances on both fronts, Trends Neurosci. 14 (1991) 218-219.
    • (1991) Trends Neurosci. , vol.14 , pp. 218-219
    • Kosik, K.S.1
  • 276
    • 0028986656 scopus 로고
    • TGF-β superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity
    • [276] K. Krieglstein, C. Suter-Crazzolara, K. Unsicker, TGF-β superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity, EMBO J. 14 (1995) 736-742.
    • (1995) EMBO J. , vol.14 , pp. 736-742
    • Krieglstein, K.1    Suter-Crazzolara, C.2    Unsicker, K.3
  • 278
    • 0029414744 scopus 로고
    • Neuronal transplantation and neurotrophic factors in the treatment of Parkinson's disease - Update February 1995
    • [278] A. Kupsch, W.H. Oertel, C.D. Earl, J. Sautter, Neuronal transplantation and neurotrophic factors in the treatment of Parkinson's disease - update February 1995, J. Neural Transm. Suppl. 46 (1995) 193-207.
    • (1995) J. Neural Transm. Suppl. , vol.46 , pp. 193-207
    • Kupsch, A.1    Oertel, W.H.2    Earl, C.D.3    Sautter, J.4
  • 279
    • 0027771726 scopus 로고
    • Nerve growth factor pharmacology: Application to the treatment of cholinergic neurodegeneration in Alzheimer's disease
    • [279] P.A. Lapchack, Nerve growth factor pharmacology: application to the treatment of cholinergic neurodegeneration in Alzheimer's disease, Exp. Neurol. 124 (1993) 16-20.
    • (1993) Exp. Neurol. , vol.124 , pp. 16-20
    • Lapchack, P.A.1
  • 280
    • 0025732221 scopus 로고
    • 3H]acetylcholine release and choline acetyltransferase activity
    • 3H]acetylcholine release and choline acetyltransferase activity, Neuroscience 42 (1991) 639-649.
    • (1991) Neuroscience , vol.42 , pp. 639-649
    • Lapchak, P.A.1    Hefti, F.2
  • 281
    • 0027532456 scopus 로고
    • BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions
    • [281] P.A. Lapchak, D.M. Araujo, F. Hefti, BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions, NeuroReport 4 (1993) 191-194.
    • (1993) NeuroReport , vol.4 , pp. 191-194
    • Lapchak, P.A.1    Araujo, D.M.2    Hefti, F.3
  • 283
    • 0026569026 scopus 로고
    • Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-α mRNA in mouse brain by quantitative nuclease protection assay
    • [283] L.M. Lazar, M. Blum, Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-α mRNA in mouse brain by quantitative nuclease protection assay, J. Neurosci. 12 (1992) 1688-1697.
    • (1992) J. Neurosci. , vol.12 , pp. 1688-1697
    • Lazar, L.M.1    Blum, M.2
  • 284
    • 0026459309 scopus 로고
    • Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development
    • [284] W.-H. Lee, S. Javedan, C.A. Bondy, Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development, J. Neurosci. 12 (1992) 4737-4744.
    • (1992) J. Neurosci. , vol.12 , pp. 4737-4744
    • Lee, W.-H.1    Javedan, S.2    Bondy, C.A.3
  • 286
    • 0023710363 scopus 로고
    • Receptors for insulin-like growth factor I and II: Autoradiographic localization in rat brain and comparison to receptors for insulin
    • [286] M.A. Lesniak, J.M. Hill, W. Kiess, M. Rojeski, C.B. Pert, J. Roth, Receptors for insulin-like growth factor I and II: autoradiographic localization in rat brain and comparison to receptors for insulin, Endocrinology 123 (1988) 2089-2099.
    • (1988) Endocrinology , vol.123 , pp. 2089-2099
    • Lesniak, M.A.1    Hill, J.M.2    Kiess, W.3    Rojeski, M.4    Pert, C.B.5    Roth, J.6
  • 287
    • 0013067786 scopus 로고
    • The nerve growth factor: Thirty-five years later
    • [287] R. Levi-Montalcini, The nerve growth factor: thirty-five years later, EMBO J. 6 (1987) 1145-1154.
    • (1987) EMBO J. , vol.6 , pp. 1145-1154
    • Levi-Montalcini, R.1
  • 288
    • 0029610630 scopus 로고
    • Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease
    • [288] M. Levivier, S. Przedborski, C. Bencsics, U.J. Kang, Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease, J. Neurosci. 15 (1995) 7810-7820.
    • (1995) J. Neurosci. , vol.15 , pp. 7810-7820
    • Levivier, M.1    Przedborski, S.2    Bencsics, C.3    Kang, U.J.4
  • 289
    • 0026010958 scopus 로고
    • Expression of IGF-I and -II mRNA in the brain and craniofacial region of the rat fetus
    • [289] C.A.-L. Lievre, P.-A. Stahlbom, V.R. Sara, Expression of IGF-I and -II mRNA in the brain and craniofacial region of the rat fetus, Development 111 (1991) 105-115.
    • (1991) Development , vol.111 , pp. 105-115
    • Lievre, C.A.-L.1    Stahlbom, P.-A.2    Sara, V.R.3
  • 290
    • 0010429496 scopus 로고
    • Recombinant human GDNF specifically promotes the survival and morphological differentiation of midbrain dopaminergic neurons
    • [290] J.D. Lile, T.J. Zhang, D. Smith, T. Malmstrom, H. Musa, P. Huettl, F. Collins, Recombinant human GDNF specifically promotes the survival and morphological differentiation of midbrain dopaminergic neurons, Soc. Neurosci. Abstr. 19 (1993) 652.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 652
    • Lile, J.D.1    Zhang, T.J.2    Smith, D.3    Malmstrom, T.4    Musa, H.5    Huettl, P.6    Collins, F.7
  • 291
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • [291] L.-F.H. Lin, D.H. Doherty, J.D. Lile, S. Bektesh, F. Collins, GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons, Science 260 (1993) 1130-1132.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.-F.H.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 292
    • 0010507687 scopus 로고
    • Purification of GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • [292] L.-F.H. Lin, T.J. Zhang, D. Smith, J. Ross, L.G. Armes, F. Collins, Purification of GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons, Soc. Neurosci. Abstr. 19 (1993) 651.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 651
    • Lin, L.-F.H.1    Zhang, T.J.2    Smith, D.3    Ross, J.4    Armes, L.G.5    Collins, F.6
  • 293
    • 0028059301 scopus 로고
    • Purification and initial characterisation of rat B49 glial cell line-derived neurotrophic factor
    • [293] L.-F.H. Lin, T.J. Zhang, F. Collins, L.G. Armes, Purification and initial characterisation of rat B49 glial cell line-derived neurotrophic factor, J. Neurochem. 63 (1994) 758-768.
    • (1994) J. Neurochem. , vol.63 , pp. 758-768
    • Lin, L.-F.H.1    Zhang, T.J.2    Collins, F.3    Armes, L.G.4
  • 294
    • 0026573196 scopus 로고
    • Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor and β-nerve growth factor mRNA in rat hippocampus
    • [294] N. Lindefors, P. Ernfors, T. Falkenberg, H. Persson, Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor and β-nerve growth factor mRNA in rat hippocampus, Exp. Brain Res. 88 (1992) 78-90.
    • (1992) Exp. Brain Res. , vol.88 , pp. 78-90
    • Lindefors, N.1    Ernfors, P.2    Falkenberg, T.3    Persson, H.4
  • 295
    • 0028960484 scopus 로고
    • Spatiotemporal selective effects on brain-derived neurotrophic factor and trkB messenger RNA in rat hippocampus electroconvulsive shock
    • [295] N. Lindefors, E. Brodin, M. Metsis, Spatiotemporal selective effects on brain-derived neurotrophic factor and trkB messenger RNA in rat hippocampus electroconvulsive shock, Neuroscience 65 (1995) 661-670.
    • (1995) Neuroscience , vol.65 , pp. 661-670
    • Lindefors, N.1    Brodin, E.2    Metsis, M.3
  • 297
    • 0029915408 scopus 로고    scopus 로고
    • Effects of intraventricular encapsulated hNGF-secreting fibroblasts in aged rats
    • [297] M.D. Lindner, C.E. Kearns, S.R. Winn, B. Frydel, D.F. Emerich, Effects of intraventricular encapsulated hNGF-secreting fibroblasts in aged rats, Cell Transplant. 5 (1996) 205-223.
    • (1996) Cell Transplant. , vol.5 , pp. 205-223
    • Lindner, M.D.1    Kearns, C.E.2    Winn, S.R.3    Frydel, B.4    Emerich, D.F.5
  • 298
    • 0028592625 scopus 로고
    • Neurotrophins and receptors
    • [298] R.M. Lindsay, Neurotrophins and receptors, Prog. Brain Res. 103 (1994) 3-14.
    • (1994) Prog. Brain Res. , vol.103 , pp. 3-14
    • Lindsay, R.M.1
  • 301
    • 0028609839 scopus 로고
    • Retrograde axonal transport and lesion-induced upregulation of the trkA high-affinity NGF receptor
    • [301] R. Loy, M.B. Lachyankar, P.J. Condon, D.K. Poluha, A.H. Ross, Retrograde axonal transport and lesion-induced upregulation of the trkA high-affinity NGF receptor, Exp. Neurol. 130 (1994) 377-386.
    • (1994) Exp. Neurol. , vol.130 , pp. 377-386
    • Loy, R.1    Lachyankar, M.B.2    Condon, P.J.3    Poluha, D.K.4    Ross, A.H.5
  • 302
    • 0027983492 scopus 로고
    • Region-specific regulation of transforming growth factor α (TGFα) gene expression in astrocytes of the neuroendocrine brain
    • [302] Y.J. Ma, K. Berg-von der Emde, M. Moholt-Siebert, D.F. Hill, S.R. Ojeda, Region-specific regulation of transforming growth factor α (TGFα) gene expression in astrocytes of the neuroendocrine brain, J. Neurosci. 14 (1994) 5644-5651.
    • (1994) J. Neurosci. , vol.14 , pp. 5644-5651
    • Ma, Y.J.1    Berg-Von Der Emde, K.2    Moholt-Siebert, M.3    Hill, D.F.4    Ojeda, S.R.5
  • 306
    • 0020806079 scopus 로고
    • Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: Amino-acid sequence homology with epidermal growth factor
    • [306] H. Marquardt, M.W. Hunkapiller, L.E. Hood, D.R. Twardzik, J.E. De Larco, J.R. Stephenson, G.J. Todaro, Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino-acid sequence homology with epidermal growth factor, Proc. Natl. Acad. Sci. U.S.A. 80 (1983) 4684-4688.
    • (1983) Proc. Natl. Acad. Sci. U.S.A. , vol.80 , pp. 4684-4688
    • Marquardt, H.1    Hunkapiller, M.W.2    Hood, L.E.3    Twardzik, D.R.4    De Larco, J.E.5    Stephenson, J.R.6    Todaro, G.J.7
  • 307
    • 0031558778 scopus 로고    scopus 로고
    • Upregulation of the anti-apoptotic protein Bcl-2 may be an early event in neurodegeneration: Studies on Parkinson's and incidental Lewy Body disease
    • [307] K.A. Marshall, S.E. Daniel, N. Cairns, P. Jenner, B. Halliwell, Upregulation of the anti-apoptotic protein Bcl-2 may be an early event in neurodegeneration: studies on Parkinson's and incidental Lewy Body disease, Biochem. Biophys. Res. Commun. 240 (1997) 84-87.
    • (1997) Biochem. Biophys. Res. Commun. , vol.240 , pp. 84-87
    • Marshall, K.A.1    Daniel, S.E.2    Cairns, N.3    Jenner, P.4    Halliwell, B.5
  • 308
    • 0029068923 scopus 로고
    • Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat
    • [308] D. Martin, G. Miller, M. Rosendahl, D.A. Russell, Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat, Brain Res. 683 (1995) 172-178.
    • (1995) Brain Res. , vol.683 , pp. 172-178
    • Martin, D.1    Miller, G.2    Rosendahl, M.3    Russell, D.A.4
  • 309
    • 0029934782 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor: The lateral cerebral ventricle as a site of administration for stimulation of the substantia nigra dopamine system in rats
    • [309] D. Martin, G. Miller, N. Fischer, D. Dix, T. Cullen, D. Russell, Glial cell line-derived neurotrophic factor: the lateral cerebral ventricle as a site of administration for stimulation of the substantia nigra dopamine system in rats, Eur. J. Neurosci. 8 (1996) 1249-1255.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1249-1255
    • Martin, D.1    Miller, G.2    Fischer, N.3    Dix, D.4    Cullen, T.5    Russell, D.6
  • 310
    • 0029905329 scopus 로고    scopus 로고
    • Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells
    • [310] A. Martinez-Serrano, A. Bjorklund, Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells, J. Neurosci. 16 (1996) 4606-4616.
    • (1996) J. Neurosci. , vol.16 , pp. 4606-4616
    • Martinez-Serrano, A.1    Bjorklund, A.2
  • 311
    • 0029123286 scopus 로고
    • CNS-derived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain: Complete rescue of axotomised cholinergic neurons after transplantation into the septum
    • [311] A. Martinez-Serrano, P. Horellou, W. Fischer, C. Bentiage, K. Campbell, R.D.G. McKay, J. Mallet, A. Bjorklund, CNS-derived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain: complete rescue of axotomised cholinergic neurons after transplantation into the septum, J. Neurosci. 15 (1995) 5668-5680.
    • (1995) J. Neurosci. , vol.15 , pp. 5668-5680
    • Martinez-Serrano, A.1    Horellou, P.2    Fischer, W.3    Bentiage, C.4    Campbell, K.5    McKay, R.D.G.6    Mallet, J.7    Bjorklund, A.8
  • 312
    • 0029902122 scopus 로고    scopus 로고
    • Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain
    • [312] A. Martinez-Serrano, W. Fischer, S. Soderstrom, T. Ebendal, A. Bjorklund, Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain, Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 6355-6360.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 6355-6360
    • Martinez-Serrano, A.1    Fischer, W.2    Soderstrom, S.3    Ebendal, T.4    Bjorklund, A.5
  • 313
    • 0029867844 scopus 로고    scopus 로고
    • Ex vivo gene transfer of brain-derived neurotrophic factor to intact rat forebrain: Neurotrophic effects on cholinergic neurons
    • [313] A. Martinez-Serrano, P.A. Hantzopoulos, A. Bjorklund, Ex vivo gene transfer of brain-derived neurotrophic factor to intact rat forebrain: neurotrophic effects on cholinergic neurons, Eur. J. Neurosci. 8 (1996) 727-735.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 727-735
    • Martinez-Serrano, A.1    Hantzopoulos, P.A.2    Bjorklund, A.3
  • 314
    • 0025156782 scopus 로고
    • NGF and Alzheimer's: Hopes and fears
    • [314] J. Marx, NGF and Alzheimer's: hopes and fears, Science 247 (1990) 408-410.
    • (1990) Science , vol.247 , pp. 408-410
    • Marx, J.1
  • 315
    • 0027367765 scopus 로고
    • β-amyloid precursor protein metabolites and loss of neuronal calcium homeostasis in Alzheimer's disease
    • [315] M.P. Mattson, S.W. Barger, B. Cheng, I. Lieberburg, V.L. Smith-Swintosky, R.E. Rydel, β-amyloid precursor protein metabolites and loss of neuronal calcium homeostasis in Alzheimer's disease, Trends Neurosci. 16 (1993) 409-414.
    • (1993) Trends Neurosci. , vol.16 , pp. 409-414
    • Mattson, M.P.1    Barger, S.W.2    Cheng, B.3    Lieberburg, I.4    Smith-Swintosky, V.L.5    Rydel, R.E.6
  • 316
    • 0027527155 scopus 로고
    • Regulation of oligodendrocyte development and central nervous system myelination by insulin-like growth factors
    • [316] F.A. McMorris, R.L. Mozell, M.J. Carson, Y. Shinar, R.D. Meyer, N. Marchetti, Regulation of oligodendrocyte development and central nervous system myelination by insulin-like growth factors, Ann. NY Acad. Sci. 692 (1993) 321-334.
    • (1993) Ann. NY Acad. Sci. , vol.692 , pp. 321-334
    • McMorris, F.A.1    Mozell, R.L.2    Carson, M.J.3    Shinar, Y.4    Meyer, R.D.5    Marchetti, N.6
  • 317
    • 0026766860 scopus 로고
    • The nerve growth factor family of receptors
    • [317] S.O. Meakin, E.M. Shooter, The nerve growth factor family of receptors, Trends Neurosci. 15 (1992) 323-330.
    • (1992) Trends Neurosci. , vol.15 , pp. 323-330
    • Meakin, S.O.1    Shooter, E.M.2
  • 318
    • 0026561025 scopus 로고
    • The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor
    • [318] S.O. Meakin, U. Suter, C.C. Drinkwater, A.A. Welcher, E.M. Shooter, The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor, Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 2374-2378.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 2374-2378
    • Meakin, S.O.1    Suter, U.2    Drinkwater, C.C.3    Welcher, A.A.4    Shooter, E.M.5
  • 319
    • 0027071804 scopus 로고
    • Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons
    • [319] P.W. Mesner, T.R. Winters, S.H. Green, Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons, J. Cell Biol. 119 (1992) 1669-1680.
    • (1992) J. Cell Biol. , vol.119 , pp. 1669-1680
    • Mesner, P.W.1    Winters, T.R.2    Green, S.H.3
  • 320
    • 0028839253 scopus 로고
    • A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells
    • [320] P.W. Mesner, C.L. Epting, J.L. Hegarty, S.H. Green, A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells, J. Neurosci. 15 (1995) 7357-7366.
    • (1995) J. Neurosci. , vol.15 , pp. 7357-7366
    • Mesner, P.W.1    Epting, C.L.2    Hegarty, J.L.3    Green, S.H.4
  • 321
    • 0029952139 scopus 로고    scopus 로고
    • Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis
    • [321] R.G. Miller, W.W. Bryan, M.A. Dietz, T.L. Musat, J.H. Petajan, S.A. Smith, J.C. Goodpasture, Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis, Neurology 47 (1996) 1329-1331.
    • (1996) Neurology , vol.47 , pp. 1329-1331
    • Miller, R.G.1    Bryan, W.W.2    Dietz, M.A.3    Musat, T.L.4    Petajan, J.H.5    Smith, S.A.6    Goodpasture, J.C.7
  • 323
    • 0026663993 scopus 로고
    • The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth
    • [323] E.A. Milward, R. Papadopoulos, S.J. Fuller, R.D. Moir, D. Small, K. Beyreuther, C.L. Masters, The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth, Neuron 9 (1992) 129-137.
    • (1992) Neuron , vol.9 , pp. 129-137
    • Milward, E.A.1    Papadopoulos, R.2    Fuller, S.J.3    Moir, R.D.4    Small, D.5    Beyreuther, K.6    Masters, C.L.7
  • 324
    • 0027301972 scopus 로고
    • Neuronal colocalisation of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions
    • [324] R.C. Miranda, F. Sohrabji, C.D. Toran-Allerand, Neuronal colocalisation of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions, Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 6439-6443.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 6439-6443
    • Miranda, R.C.1    Sohrabji, F.2    Toran-Allerand, C.D.3
  • 325
    • 0028095440 scopus 로고
    • The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neurons disease
    • [325] H. Mitsumoto, K. Ikeda, T. Holmlund, T. Greene, J.M. Cedarbaum, V. Wong, R.M. Lindsay, The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neurons disease, Ann. Neurol. 36 (1994) 142-148.
    • (1994) Ann. Neurol. , vol.36 , pp. 142-148
    • Mitsumoto, H.1    Ikeda, K.2    Holmlund, T.3    Greene, T.4    Cedarbaum, J.M.5    Wong, V.6    Lindsay, R.M.7
  • 326
    • 0001585073 scopus 로고
    • Nerve growth factor increases mRNA levels for the prion protein and the β-amyloid protein precursor in developing hamster brain
    • [326] W.C. Mobley, R.L. Neve, S.B. Prusiner, M.P. McKinley, Nerve growth factor increases mRNA levels for the prion protein and the β-amyloid protein precursor in developing hamster brain, Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 9811-9815.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 9811-9815
    • Mobley, W.C.1    Neve, R.L.2    Prusiner, S.B.3    McKinley, M.P.4
  • 327
    • 0029942337 scopus 로고    scopus 로고
    • Histochemical detection of apoptosis in Parkinson's disease
    • [327] H. Mochizuki, K. Goto, H. Mori, Y. Mizuno, Histochemical detection of apoptosis in Parkinson's disease, J. Neurol. Sci. 137 (1996) 120-123.
    • (1996) J. Neurol. Sci. , vol.137 , pp. 120-123
    • Mochizuki, H.1    Goto, K.2    Mori, H.3    Mizuno, Y.4
  • 328
    • 0030614648 scopus 로고    scopus 로고
    • Apoptosis in neurodegenerative disorders
    • [328] H. Mochizuki, H. Mori, Y. Mizuno, Apoptosis in neurodegenerative disorders, J. Neural Transm. 50 (1997) 125-140.
    • (1997) J. Neural Transm. , vol.50 , pp. 125-140
    • Mochizuki, H.1    Mori, H.2    Mizuno, Y.3
  • 331
    • 0023814370 scopus 로고
    • Rescue of lesioned septal cholinergic neurons by nerve growth factor: Specificity and requirement for chronic treatment
    • [331] C.N. Montera, F. Hefti, Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment, J. Neurosci. 8 (1987) 2986-2999.
    • (1987) J. Neurosci. , vol.8 , pp. 2986-2999
    • Montera, C.N.1    Hefti, F.2
  • 332
    • 0029787513 scopus 로고    scopus 로고
    • Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons
    • [332] X. Mu, J. He, D.W. Anderson, J.Q. Trojanowski, J.E. Springer, Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons, Ann. Neurol. 40 (1996) 379-386.
    • (1996) Ann. Neurol. , vol.40 , pp. 379-386
    • Mu, X.1    He, J.2    Anderson, D.W.3    Trojanowski, J.Q.4    Springer, J.E.5
  • 333
    • 0026571233 scopus 로고
    • Cortical neurons express nerve growth factor receptors in advancing age and Alzheimer's disease
    • [333] E.J. Mufson, J.H. Kordower, Cortical neurons express nerve growth factor receptors in advancing age and Alzheimer's disease, Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 569-573.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 569-573
    • Mufson, E.J.1    Kordower, J.H.2
  • 334
    • 0024374634 scopus 로고
    • Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: Colocalisation with cholinergic neurons
    • [334] E.J. Mufson, M. Bothwell, L.B. Hersh, J.H. Kordower, Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: colocalisation with cholinergic neurons, J. Comp. Neurol. 285 (1988) 196-217.
    • (1988) J. Comp. Neurol. , vol.285 , pp. 196-217
    • Mufson, E.J.1    Bothwell, M.2    Hersh, L.B.3    Kordower, J.H.4
  • 335
    • 0024449354 scopus 로고
    • Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain
    • [335] E.J. Mufson, M. Bothwell, J.H. Kordower, Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain, Exp. Neurol. 105 (1989) 221-232.
    • (1989) Exp. Neurol. , vol.105 , pp. 221-232
    • Mufson, E.J.1    Bothwell, M.2    Kordower, J.H.3
  • 336
    • 0028214892 scopus 로고
    • Nerve growth factor-like immunoreactive profiles in the primate basal forebrain and hippocampal formation
    • [336] E.J. Mufson, J.M. Conner, S. Varon, J.H. Kordower, Nerve growth factor-like immunoreactive profiles in the primate basal forebrain and hippocampal formation, J. Comp. Neurol. 341 (1994) 507-519.
    • (1994) J. Comp. Neurol. , vol.341 , pp. 507-519
    • Mufson, E.J.1    Conner, J.M.2    Varon, S.3    Kordower, J.H.4
  • 337
    • 0028113077 scopus 로고
    • Intrastriatal infusions of brain-derived neurotrophic factor: Retrograde transport and colocalisation with dopamine containing substantia nigra neurons in rat
    • [337] E.J. Mufson, J.S. Krion, T. Sobreviela, M.A. Burke, J.H. Kordower, R.D. Penn, J.A. Miller, Intrastriatal infusions of brain-derived neurotrophic factor: retrograde transport and colocalisation with dopamine containing substantia nigra neurons in rat, Exp. Neurol. 129 (1994) 15-26.
    • (1994) Exp. Neurol. , vol.129 , pp. 15-26
    • Mufson, E.J.1    Krion, J.S.2    Sobreviela, T.3    Burke, M.A.4    Kordower, J.H.5    Penn, R.D.6    Miller, J.A.7
  • 338
    • 0029039162 scopus 로고
    • Nerve growth factor in Alzheimer's disease: Defective retrograde transport to nucleus basalis
    • [338] E.J. Mufson, J.M. Conner, J.H. Kordower, Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis, NeuroReport 6 (1995) 1063-1066.
    • (1995) NeuroReport , vol.6 , pp. 1063-1066
    • Mufson, E.J.1    Conner, J.M.2    Kordower, J.H.3
  • 339
    • 0030052736 scopus 로고    scopus 로고
    • Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: Distribution, retrograde transport and co-localisation with substantia nigra dopamine-containing neurons
    • [339] E.J. Mufson, J.S. Kroin, Y.-T. Liu, T. Sobreviela, R.D. Penn, J.A. Miller, J.H. Kordower, Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: distribution, retrograde transport and co-localisation with substantia nigra dopamine-containing neurons, Neuroscience 71 (1996) 179-191.
    • (1996) Neuroscience , vol.71 , pp. 179-191
    • Mufson, E.J.1    Kroin, J.S.2    Liu, Y.-T.3    Sobreviela, T.4    Penn, R.D.5    Miller, J.A.6    Kordower, J.H.7
  • 340
    • 0030939457 scopus 로고    scopus 로고
    • Decreased trkA gene expression within the basal forebrain neurons in Alzheimer's disease
    • [340] E.J. Mufson, J.M. Li, T. Sobreviela, J.H. Kordower, Decreased trkA gene expression within the basal forebrain neurons in Alzheimer's disease, NeuroReport 8 (1996) 25-29.
    • (1996) NeuroReport , vol.8 , pp. 25-29
    • Mufson, E.J.1    Li, J.M.2    Sobreviela, T.3    Kordower, J.H.4
  • 341
    • 0027276502 scopus 로고
    • NGF level is not decreased in the serum, brain-spinal fluid, hippocampus or parietal cortex of individuals with Alzheimer's disease
    • [341] K. Murase, T. Nabeshima, Y. Robitaille, R. Quirion, M. Ogawa, K. Hayashi, NGF level is not decreased in the serum, brain-spinal fluid, hippocampus or parietal cortex of individuals with Alzheimer's disease, Biochem. Biophys. Res. Commun. 193 (1993) 198-203.
    • (1993) Biochem. Biophys. Res. Commun. , vol.193 , pp. 198-203
    • Murase, K.1    Nabeshima, T.2    Robitaille, Y.3    Quirion, R.4    Ogawa, M.5    Hayashi, K.6
  • 342
    • 0028338797 scopus 로고
    • Neurotrophin-3 (NT-3) levels in the developing rat nervous system and in human samples
    • [342] K. Murase, K. Igarashi, K. Hayashi, Neurotrophin-3 (NT-3) levels in the developing rat nervous system and in human samples, Clin. Chim. Acta 227 (1994) 23-36.
    • (1994) Clin. Chim. Acta , vol.227 , pp. 23-36
    • Murase, K.1    Igarashi, K.2    Hayashi, K.3
  • 343
    • 0023127046 scopus 로고
    • Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat
    • [343] L.J. Murphy, G.I. Bell, H.G. Friesen, Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat, Endocrinology 120 (1987) 1279-1282.
    • (1987) Endocrinology , vol.120 , pp. 1279-1282
    • Murphy, L.J.1    Bell, G.I.2    Friesen, H.G.3
  • 344
    • 0028297574 scopus 로고
    • Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease
    • [344] K.D. Murray, C.M. Gall, E.G. Jones, P.J. Isackson, Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease, Neuroscience 60 (1994) 37-48.
    • (1994) Neuroscience , vol.60 , pp. 37-48
    • Murray, K.D.1    Gall, C.M.2    Jones, E.G.3    Isackson, P.J.4
  • 345
    • 0031194454 scopus 로고    scopus 로고
    • Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease
    • [345] E.J. Musfon, N. Lavine, S. Jaffar, J.H. Kordower, R. Quirion, H.U. Saragovi, Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease, Exp. Neurol. 146 (1997) 91-103.
    • (1997) Exp. Neurol. , vol.146 , pp. 91-103
    • Musfon, E.J.1    Lavine, N.2    Jaffar, S.3    Kordower, J.H.4    Quirion, R.5    Saragovi, H.U.6
  • 347
    • 0030451939 scopus 로고    scopus 로고
    • Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease
    • [347] M. Narisawa-Saito, K. Wakabayashi, S. Tsuji, H. Takahashi, H. Nawa, Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease, NeuroReport 7 (1996) 2925-2928.
    • (1996) NeuroReport , vol.7 , pp. 2925-2928
    • Narisawa-Saito, M.1    Wakabayashi, K.2    Tsuji, S.3    Takahashi, H.4    Nawa, H.5
  • 348
    • 0029031207 scopus 로고
    • BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: Partial disagreement with mRNA levels
    • [348] H. Nawa, J. Carnahan, C. Gail, BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: partial disagreement with mRNA levels, Eur. J. Neurosci. 7 (1995) 1527-1535.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1527-1535
    • Nawa, H.1    Carnahan, J.2    Gail, C.3
  • 349
    • 0023730586 scopus 로고
    • Epidermal growth factor receptor immunoreactivity in rat brain astrocytes: Response to injury
    • [349] M. Nieto-Sampedro, F. Gomez-Pinilla, D.J. Knauer, J.T. Broderick, Epidermal growth factor receptor immunoreactivity in rat brain astrocytes: response to injury, Neurosci. Lett. 91 (1988) 276-282.
    • (1988) Neurosci. Lett. , vol.91 , pp. 276-282
    • Nieto-Sampedro, M.1    Gomez-Pinilla, F.2    Knauer, D.J.3    Broderick, J.T.4
  • 350
    • 0027332575 scopus 로고
    • Effects of oral administration of a stimulator for nerve growth factor synthesis in basal forebrain-lesioned rats
    • [350] A. Nitta, K. Murase, Y. Furukawa, K. Hayashi, T. Hasegawa, T. Nabeshima, Effects of oral administration of a stimulator for nerve growth factor synthesis in basal forebrain-lesioned rats, Eur. J. Pharmacol. 250 (1993) 23-30.
    • (1993) Eur. J. Pharmacol. , vol.250 , pp. 23-30
    • Nitta, A.1    Murase, K.2    Furukawa, Y.3    Hayashi, K.4    Hasegawa, T.5    Nabeshima, T.6
  • 351
    • 0029038125 scopus 로고
    • Cultured basal forebrain cholinergic neurons from postnatal rats show both overlapping and non-overlapping responses to the neurotrophins
    • [351] T. Nonomura, C. Nishio, R.M. Lindsay, H. Hatanaka, Cultured basal forebrain cholinergic neurons from postnatal rats show both overlapping and non-overlapping responses to the neurotrophins, Brain Res. 683 (1995) 129-139.
    • (1995) Brain Res. , vol.683 , pp. 129-139
    • Nonomura, T.1    Nishio, C.2    Lindsay, R.M.3    Hatanaka, H.4
  • 352
    • 0025024590 scopus 로고
    • Characterization of insulin-like growth factor binding proteins produced in the rat central nervous system
    • [352] I. Ocrant, C.T. Fay, J.T. Parmelee, Characterization of insulin-like growth factor binding proteins produced in the rat central nervous system, Endocrinology 127 (1990) 1260-1267.
    • (1990) Endocrinology , vol.127 , pp. 1260-1267
    • Ocrant, I.1    Fay, C.T.2    Parmelee, J.T.3
  • 353
    • 0030971573 scopus 로고    scopus 로고
    • Dopamine-melanin induces apoptosis in PC12 cells; possible implications for the etiology of Parkinson's disease
    • [353] D. Offen, I. Ziv, A. Barzilai, S. Gorodin, E. Glater, A. Hochman, E. Melemed, Dopamine-melanin induces apoptosis in PC12 cells; possible implications for the etiology of Parkinson's disease, Neurochem. Int. 31 (1997) 207-216.
    • (1997) Neurochem. Int. , vol.31 , pp. 207-216
    • Offen, D.1    Ziv, I.2    Barzilai, A.3    Gorodin, S.4    Glater, E.5    Hochman, A.6    Melemed, E.7
  • 356
    • 0027745626 scopus 로고
    • NGF and the treatment of Alzheimer's disease
    • [356] L. Olson, NGF and the treatment of Alzheimer's disease, Exp. Neurol. 124 (1993) 5-15.
    • (1993) Exp. Neurol. , vol.124 , pp. 5-15
    • Olson, L.1
  • 357
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • [357] Z. Oltivai, C. Milliman, S.J. Korsmeyer, Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death, Cell 74 (1993) 609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltivai, Z.1    Milliman, C.2    Korsmeyer, S.J.3
  • 358
    • 0029552094 scopus 로고
    • GDNF protects against 6-OHDA nigrostriatal lesion: In vivo study with microdialysis and PET
    • [358] J. Opacka-Juffry, S. Ashworth, S.P. Hume, D. Martin, D.J. Brooks, S.B. Blunt, GDNF protects against 6-OHDA nigrostriatal lesion: in vivo study with microdialysis and PET, NeuroReport 7 (1995) 348-352.
    • (1995) NeuroReport , vol.7 , pp. 348-352
    • Opacka-Juffry, J.1    Ashworth, S.2    Hume, S.P.3    Martin, D.4    Brooks, D.J.5    Blunt, S.B.6
  • 359
    • 0026058318 scopus 로고
    • Cell death during development of the nervous system
    • [359] R.W. Oppenheim, Cell death during development of the nervous system, Annu. Rev. Neurosci. 14 (1991) 453-501.
    • (1991) Annu. Rev. Neurosci. , vol.14 , pp. 453-501
    • Oppenheim, R.W.1
  • 360
    • 0027094145 scopus 로고
    • Brain-derived neurotrophic factor rescues developing avian motor neurons from cell death
    • [360] D.W. Oppenheim, Y. Qin-Wei, D. Prevette, Q. Yan, Brain-derived neurotrophic factor rescues developing avian motor neurons from cell death, Nature 360 (1992) 755-757.
    • (1992) Nature , vol.360 , pp. 755-757
    • Oppenheim, D.W.1    Qin-Wei, Y.2    Prevette, D.3    Yan, Q.4
  • 362
    • 0029860523 scopus 로고    scopus 로고
    • Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons
    • [362] E. Paradis, H. Douillard, M. Koutroumanis, C. Goodyer, A. LeBlanc, Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons, J. Neurosci. 16 (1996) 7533-7539.
    • (1996) J. Neurosci. , vol.16 , pp. 7533-7539
    • Paradis, E.1    Douillard, H.2    Koutroumanis, M.3    Goodyer, C.4    LeBlanc, A.5
  • 363
    • 0030601657 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage
    • [363] E. Perez-Navarro, E. Arenas, J. Reiriz, N. Calvo, J. Alberch, Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage, Neuroscience 75 (1996) 345-352.
    • (1996) Neuroscience , vol.75 , pp. 345-352
    • Perez-Navarro, E.1    Arenas, E.2    Reiriz, J.3    Calvo, N.4    Alberch, J.5
  • 364
    • 0028134961 scopus 로고
    • Perforant path damage results in progressive neuronal damage and somal atrophy in layer II of entorhinal cortex and functional impairment with increasing postdamage age
    • [364] D.A. Peterson, C.A. Luccidi-Phillips, K.L. Eagle, F.H. Gage, Perforant path damage results in progressive neuronal damage and somal atrophy in layer II of entorhinal cortex and functional impairment with increasing postdamage age, J. Neurosci. 14 (1994) 6872-6885.
    • (1994) J. Neurosci. , vol.14 , pp. 6872-6885
    • Peterson, D.A.1    Luccidi-Phillips, C.A.2    Eagle, K.L.3    Gage, F.H.4
  • 366
    • 0024990331 scopus 로고
    • Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons
    • [366] H.S. Phillips, J.M. Hains, G.R. Laramee, A. Rosenthal, J.W. Winslow, Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons, Science 250 (1990) 290-293.
    • (1990) Science , vol.250 , pp. 290-293
    • Phillips, H.S.1    Hains, J.M.2    Laramee, G.R.3    Rosenthal, A.4    Winslow, J.W.5
  • 368
    • 0028981219 scopus 로고
    • Structure-activity analyses of β-amyloid peptides: Contributions of the β25-35 region to aggregation and neurotoxicity
    • [368] C.J. Pike, A.J. Walencewicz-Wasserman, J. Kosmoski, D.H. Cribbs, G.G. Glabe, C.W. Cotman, Structure-activity analyses of β-amyloid peptides: contributions of the β25-35 region to aggregation and neurotoxicity, J. Neurochem. 64 (1995) 253-265.
    • (1995) J. Neurochem. , vol.64 , pp. 253-265
    • Pike, C.J.1    Walencewicz-Wasserman, A.J.2    Kosmoski, J.3    Cribbs, D.H.4    Glabe, G.G.5    Cotman, C.W.6
  • 369
    • 0027320760 scopus 로고
    • A system for characterising cellular and molecular events in programmed neuronal cell death
    • [369] R.N. Pittman, S. Wang, A.J. DiBenedetto, J.C. Mills, A system for characterising cellular and molecular events in programmed neuronal cell death, J. Neurosci. 13 (1993) 3669-3680.
    • (1993) J. Neurosci. , vol.13 , pp. 3669-3680
    • Pittman, R.N.1    Wang, S.2    DiBenedetto, A.J.3    Mills, J.C.4
  • 370
    • 0029072690 scopus 로고
    • Evidence for apoptotic cell death in huntington disease and excitotoxic animal models
    • [370] C. Portera-Cailliau, J.C. Hedreen, D.L. Price, V.E. Koliatsos, Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models, J. Neurosci. 15 (1995) 3775-3787.
    • (1995) J. Neurosci. , vol.15 , pp. 3775-3787
    • Portera-Cailliau, C.1    Hedreen, J.C.2    Price, D.L.3    Koliatsos, V.E.4
  • 371
    • 0031029859 scopus 로고    scopus 로고
    • Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum
    • [371] C. Portera-Cailliau, D.L. Price, L.J. Martin, Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum, J. Comp. Neurol. 378 (1997) 70-87.
    • (1997) J. Comp. Neurol. , vol.378 , pp. 70-87
    • Portera-Cailliau, C.1    Price, D.L.2    Martin, L.J.3
  • 372
    • 0026739087 scopus 로고
    • Toxicity of synthetic A β peptides and modeling of Alzheimer's disease
    • [372] D.L. Price, D.R. Borchelt, L.C. Walker, S.S. Sisodia, Toxicity of synthetic A β peptides and modeling of Alzheimer's disease, Neurobiol. Aging 13 (1992) 623-625.
    • (1992) Neurobiol. Aging , vol.13 , pp. 623-625
    • Price, D.L.1    Borchelt, D.R.2    Walker, L.C.3    Sisodia, S.S.4
  • 376
    • 0027996904 scopus 로고
    • Expression of the low-affinity nerve growth factor receptor enhances β-amyloid peptide toxicity
    • [376] S. Rabizadeh, C.M. Bitler, L.L. Butcher, D.E. Bredesen, Expression of the low-affinity nerve growth factor receptor enhances β-amyloid peptide toxicity, Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 10703-10706.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 10703-10706
    • Rabizadeh, S.1    Bitler, C.M.2    Butcher, L.L.3    Bredesen, D.E.4
  • 377
    • 0031105522 scopus 로고    scopus 로고
    • Application of ex vivo gene therapy in the treatment of Parkinson's disease
    • [377] H.K. Raymon, S. Thode, F.H. Gage, Application of ex vivo gene therapy in the treatment of Parkinson's disease, Exp. Neurol. 144 (1997) 82-91.
    • (1997) Exp. Neurol. , vol.144 , pp. 82-91
    • Raymon, H.K.1    Thode, S.2    Gage, F.H.3
  • 378
    • 0027530859 scopus 로고
    • Neuroanatomical connections and specific regional vulnerability in Alzheimer's disease
    • [378] G.W. Rebeck, B.T. Hyman, Neuroanatomical connections and specific regional vulnerability in Alzheimer's disease, Neurobiol. Aging 14 (1993) 45-47.
    • (1993) Neurobiol. Aging , vol.14 , pp. 45-47
    • Rebeck, G.W.1    Hyman, B.T.2
  • 379
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • [379] J.C. Reed, Bcl-2 and the regulation of programmed cell death, Cell Biol. 124 (1994) 1-6.
    • (1994) Cell Biol. , vol.124 , pp. 1-6
    • Reed, J.C.1
  • 380
    • 0019359370 scopus 로고
    • Human transforming growth factors induce tyrosine phosphorylation of EGF receptors
    • [380] F.H. Reynolds, G.J. Todaro, C. Fryling, J.R. Stephenson, Human transforming growth factors induce tyrosine phosphorylation of EGF receptors, Nature 292 (1981) 259-262.
    • (1981) Nature , vol.292 , pp. 259-262
    • Reynolds, F.H.1    Todaro, G.J.2    Fryling, C.3    Stephenson, J.R.4
  • 381
    • 0027267360 scopus 로고
    • Neuronal death and neurotrophin gene expression: Long-lasting stimulation of neurotrophin-3 messenger RNA in the degenerating CA1 and CA4 pyramidal cell layers
    • [381] N. Rocamora, L. Massieu, H.W. Boddeke, G. Mengod, J.M. Palacios, Neuronal death and neurotrophin gene expression: long-lasting stimulation of neurotrophin-3 messenger RNA in the degenerating CA1 and CA4 pyramidal cell layers, Neuroscience 53 (1993) 905-908.
    • (1993) Neuroscience , vol.53 , pp. 905-908
    • Rocamora, N.1    Massieu, L.2    Boddeke, H.W.3    Mengod, G.4    Palacios, J.M.5
  • 384
  • 385
    • 0019935058 scopus 로고
    • A post-mortem study of the cholinergic and GABA systems in senile dementia
    • [385] M. Rossor, N.J. Garrett, A.L. Johnson, C.Q. Mountjoy, M. Roth, L.L. Iversen, A post-mortem study of the cholinergic and GABA systems in senile dementia, Brain 105 (1982) 313-330.
    • (1982) Brain , vol.105 , pp. 313-330
    • Rossor, M.1    Garrett, N.J.2    Johnson, A.L.3    Mountjoy, C.Q.4    Roth, M.5    Iversen, L.L.6
  • 386
    • 0011016769 scopus 로고
    • Differential expression of insulin-like growth factor genes in rat central nervous system
    • [386] P. Rotwein, S.K. Burgess, J.D. Milbrandt, J.E. Krause, Differential expression of insulin-like growth factor genes in rat central nervous system, Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 265-269.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 265-269
    • Rotwein, P.1    Burgess, S.K.2    Milbrandt, J.D.3    Krause, J.E.4
  • 387
    • 0026734281 scopus 로고
    • Should intracerebroventricular nerve growth factor be used to treat Alzheimer's disease?
    • [387] B.N. Saffran, Should intracerebroventricular nerve growth factor be used to treat Alzheimer's disease?, Perspect. Biol. Med. 35 (1992) 471-486.
    • (1992) Perspect. Biol. Med. , vol.35 , pp. 471-486
    • Saffran, B.N.1
  • 388
    • 0026095599 scopus 로고
    • Epidermal growth factor and transforming growth factor a induce c-fos gene expression in retinal muller cells in vivo
    • [388] S.M. Sagar, R.H. Edwards, F.R. Sharp, Epidermal growth factor and transforming growth factor a induce c-fos gene expression in retinal muller cells in vivo, J. Neurosci. Res. 29 (1991) 549-559.
    • (1991) J. Neurosci. Res. , vol.29 , pp. 549-559
    • Sagar, S.M.1    Edwards, R.H.2    Sharp, F.R.3
  • 389
    • 0028447615 scopus 로고
    • Cellular mechanisms of signal transduction for neurotrophins
    • [389] A.R. Saitiel, S.J. Decker, Cellular mechanisms of signal transduction for neurotrophins, BioEssays 16 (1994) 405-411.
    • (1994) BioEssays , vol.16 , pp. 405-411
    • Saitiel, A.R.1    Decker, S.J.2
  • 390
    • 0027379653 scopus 로고
    • Hyperactivation of signal transduction systems in Alzheimer's disease
    • [390] T. Saitoh, K. Horsburgh, E. Masliah, Hyperactivation of signal transduction systems in Alzheimer's disease, Ann. NY Acad. Sci. 640 (1991) 34-41.
    • (1991) Ann. NY Acad. Sci. , vol.640 , pp. 34-41
    • Saitoh, T.1    Horsburgh, K.2    Masliah, E.3
  • 391
    • 0023768544 scopus 로고
    • The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma
    • [391] A.-C. Sandberg, C. Engberg, M. Lake, H. von Holst, V.R. Sara, The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma, Neurosci. Lett. 93 (1988) 114-119.
    • (1988) Neurosci. Lett. , vol.93 , pp. 114-119
    • Sandberg, A.-C.1    Engberg, C.2    Lake, M.3    Von Holst, H.4    Sara, V.R.5
  • 392
    • 0028921365 scopus 로고
    • High level of synthesis and local effects of nerve growth factor in the septal region of the adult rat brain
    • [392] M.S. Saporito, S. Carswell, High level of synthesis and local effects of nerve growth factor in the septal region of the adult rat brain, J. Neurosci. 15 (1995) 2280-2286.
    • (1995) J. Neurosci. , vol.15 , pp. 2280-2286
    • Saporito, M.S.1    Carswell, S.2
  • 394
    • 0029047329 scopus 로고
    • Glial cell line-derived neurotrophic factor but not transforming growth factor beta-3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion
    • [394] H. Sauer, C. Rosenbald, A. Bjorklund, Glial cell line-derived neurotrophic factor but not transforming growth factor beta-3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion, Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 8935-8939.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 8935-8939
    • Sauer, H.1    Rosenbald, C.2    Bjorklund, A.3
  • 395
    • 0027730253 scopus 로고
    • Regional and cell-specific expression of GDNF in rat brain
    • [395] D.G. Schaar, B.-A. Sieber, C.F. Dreyfus, I.B. Black, Regional and cell-specific expression of GDNF in rat brain, Exp. Neurol. 124 (1993) 368-371.
    • (1993) Exp. Neurol. , vol.124 , pp. 368-371
    • Schaar, D.G.1    Sieber, B.-A.2    Dreyfus, C.F.3    Black, I.B.4
  • 397
    • 0023839066 scopus 로고
    • Expression of NGF receptor in the developing and adult primate central nervous system
    • [397] G.C. Schatteman, L. Gibbs, A.A. Lanahan, P. Calude, M. Bothwell, Expression of NGF receptor in the developing and adult primate central nervous system, J. Neurosci. 8 (1988) 860-873.
    • (1988) J. Neurosci. , vol.8 , pp. 860-873
    • Schatteman, G.C.1    Gibbs, L.2    Lanahan, A.A.3    Calude, P.4    Bothwell, M.5
  • 398
    • 0028967425 scopus 로고
    • Enhanced but delayed axonal sprouting of the commissural/associational pathway following a combined entorhinal cortex/fimbria fornix lesion
    • [398] P.E. Schauwecker, T.H. McNeill, Enhanced but delayed axonal sprouting of the commissural/associational pathway following a combined entorhinal cortex/fimbria fornix lesion, J. Comp. Neurol. 351 (1995) 453-464.
    • (1995) J. Comp. Neurol. , vol.351 , pp. 453-464
    • Schauwecker, P.E.1    McNeill, T.H.2
  • 399
    • 0028096652 scopus 로고
    • Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats
    • [399] R. Schmidt-Kastner, A. Tomac, B. Hoffer, S. Bektesh, B. Rosenzweig, L. Olson, Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats, Mol. Brain Res. 26 (1994) 325-330.
    • (1994) Mol. Brain Res. , vol.26 , pp. 325-330
    • Schmidt-Kastner, R.1    Tomac, A.2    Hoffer, B.3    Bektesh, S.4    Rosenzweig, B.5    Olson, L.6
  • 400
    • 0029747240 scopus 로고    scopus 로고
    • Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multiple roles in hippocampus, stratum and cortex
    • [400] R. Schmidt-Kastner, C. Wetmore, L. Olson, Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multiple roles in hippocampus, stratum and cortex, Neuroscience 74 (1996) 161-183.
    • (1996) Neuroscience , vol.74 , pp. 161-183
    • Schmidt-Kastner, R.1    Wetmore, C.2    Olson, L.3
  • 401
    • 0020569341 scopus 로고
    • Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor
    • [401] J. Scott, M. Selby, M. Urdea, M. Quiroga, G.I. Bell, W.J. Rutter, Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor, Nature 302 (1983) 538-539.
    • (1983) Nature , vol.302 , pp. 538-539
    • Scott, J.1    Selby, M.2    Urdea, M.3    Quiroga, M.4    Bell, G.I.5    Rutter, W.J.6
  • 402
    • 0020569341 scopus 로고
    • Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor
    • [402] J. Scott, M. Selby, M. Urdea, M. Quiroga, G.I. Bell, W.J. Rutter, Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor, Nature 302 (1993) 538-540.
    • (1993) Nature , vol.302 , pp. 538-540
    • Scott, J.1    Selby, M.2    Urdea, M.3    Quiroga, M.4    Bell, G.I.5    Rutter, W.J.6
  • 403
    • 0029022112 scopus 로고
    • Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis
    • [403] S.A. Scott, E.J. Mufson, J.A. Weingartner, K.A. Skau, K.A. Crutcher, Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis, J. Neurosci. 15 (1995) 6213-6221.
    • (1995) J. Neurosci. , vol.15 , pp. 6213-6221
    • Scott, S.A.1    Mufson, E.J.2    Weingartner, J.A.3    Skau, K.A.4    Crutcher, K.A.5
  • 405
    • 0021257975 scopus 로고
    • Specific retrograde transport of nerve growth factor (ngf) from neocortex to nucleus basalis in the rat
    • [405] M. Seiler, M.E. Schwab, Specific retrograde transport of nerve growth factor (ngf) from neocortex to nucleus basalis in the rat, Brain Res. 300 (1984) 33-39.
    • (1984) Brain Res. , vol.300 , pp. 33-39
    • Seiler, M.1    Schwab, M.E.2
  • 406
    • 0025991945 scopus 로고
    • Amyloid protein and Alzheimer's disease
    • November
    • [406] D.J. Selkoe, Amyloid protein and Alzheimer's disease, Scientific American, November 1991, 40-47.
    • (1991) Scientific American , pp. 40-47
    • Selkoe, D.J.1
  • 407
    • 0028852556 scopus 로고
    • Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis
    • [407] C. Sell, R. Baserga, R. Rubin, Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis, Cancer Res. 55 (1995) 303-306.
    • (1995) Cancer Res. , vol.55 , pp. 303-306
    • Sell, C.1    Baserga, R.2    Rubin, R.3
  • 408
    • 0027070473 scopus 로고
    • Brain-derived neurotrophic factor prevents death of motorneurons in newborn rats after nerve section
    • [408] M. Sendtner, B. Holtmann, R. Kolbeck, H. Thoenen, Y.A. Barde, Brain-derived neurotrophic factor prevents death of motorneurons in newborn rats after nerve section, Nature 360 (1992) 757-759.
    • (1992) Nature , vol.360 , pp. 757-759
    • Sendtner, M.1    Holtmann, B.2    Kolbeck, R.3    Thoenen, H.4    Barde, Y.A.5
  • 409
    • 0026749255 scopus 로고
    • Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy
    • [409] M. Sendtner, H. Schmalbruch, K.A. Stockli, P. Carroll, G.W. Kreutzberg, H. Thoenen, Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy, Nature 358 (1992) 502-504.
    • (1992) Nature , vol.358 , pp. 502-504
    • Sendtner, M.1    Schmalbruch, H.2    Stockli, K.A.3    Carroll, P.4    Kreutzberg, G.W.5    Thoenen, H.6
  • 411
    • 0025828428 scopus 로고
    • Regional expression of transforming growth factor-α mRNA in the rat central nervous system
    • [411] K.B. Seroogy, V.K.H. Han, D.C. Lee, Regional expression of transforming growth factor-α mRNA in the rat central nervous system, Neurosci. Lett. 125 (1991) 241-245.
    • (1991) Neurosci. Lett. , vol.125 , pp. 241-245
    • Seroogy, K.B.1    Han, V.K.H.2    Lee, D.C.3
  • 412
    • 0027174238 scopus 로고
    • Cellular localisation of transforming growth factor-α mRNA in rat forebrain
    • [412] K.B. Seroogy, K.H. Lundgren, D.C. Lee, K.M. Guthrie, C.M. Gall, Cellular localisation of transforming growth factor-α mRNA in rat forebrain, J. Neurochem. 60 (1993) 1777-1782.
    • (1993) J. Neurochem. , vol.60 , pp. 1777-1782
    • Seroogy, K.B.1    Lundgren, K.H.2    Lee, D.C.3    Guthrie, K.M.4    Gall, C.M.5
  • 413
    • 0000901144 scopus 로고
    • Studies on the expression of the β nerve growth factor (β NGF) gene in the central nervous system: Level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons
    • [413] D.L. Shelton, L.F. Reichardt, Studies on the expression of the β nerve growth factor (β NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons, Proc. Natl. Acad. Sci. U.S.A. 83 (1986) 2714-2718.
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 2714-2718
    • Shelton, D.L.1    Reichardt, L.F.2
  • 414
    • 0025830381 scopus 로고
    • Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human
    • [414] S. Shimasaki, M. Shimonaka, H.-P. Zhang, N. Ling, Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human, J. Biol. Chem. 266 (1991) 10646-10653.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10646-10653
    • Shimasaki, S.1    Shimonaka, M.2    Zhang, H.-P.3    Ling, N.4
  • 415
    • 0027715281 scopus 로고
    • Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons
    • [415] S. Shimohama, Y. Tamura, A. Akaike, T. Tsukahara, O. Ohara, S. Watanabe, J. Kimura, Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons, Neurosci. Lett. 164 (1993) 55-58.
    • (1993) Neurosci. Lett. , vol.164 , pp. 55-58
    • Shimohama, S.1    Tamura, Y.2    Akaike, A.3    Tsukahara, T.4    Ohara, O.5    Watanabe, S.6    Kimura, J.7
  • 416
    • 0029035602 scopus 로고
    • BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine
    • [416] C.W. Shults, T. Kimber, C.A. Altar, BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine, NeuroReport 6 (1995) 1109-1112.
    • (1995) NeuroReport , vol.6 , pp. 1109-1112
    • Shults, C.W.1    Kimber, T.2    Altar, C.A.3
  • 417
    • 0029963121 scopus 로고    scopus 로고
    • Intrastriatal injection of GDNF attenuates the effects of 6-hydroxydopamine
    • [417] C.W. Shults, T. Kimber, D. Martin, Intrastriatal injection of GDNF attenuates the effects of 6-hydroxydopamine, NeuroReport 7 (1996) 627-631.
    • (1996) NeuroReport , vol.7 , pp. 627-631
    • Shults, C.W.1    Kimber, T.2    Martin, D.3
  • 418
    • 0029738916 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis
    • [418] J.R. Singleton, A.E. Randolph, E.L. Feldman, Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis, Cancer Res. 56 (1996) 4522-4529.
    • (1996) Cancer Res. , vol.56 , pp. 4522-4529
    • Singleton, J.R.1    Randolph, A.E.2    Feldman, E.L.3
  • 419
    • 0024511528 scopus 로고
    • Insulin-like growth factor (IGF-I) as a stimulator of regeneration in the freeze-injured rat sciatic nerve
    • [419] J. Sjoberg, M. Kanje, Insulin-like growth factor (IGF-I) as a stimulator of regeneration in the freeze-injured rat sciatic nerve, Brain Res. 485 (1989) 102-108.
    • (1989) Brain Res. , vol.485 , pp. 102-108
    • Sjoberg, J.1    Kanje, M.2
  • 420
    • 0028351986 scopus 로고
    • Intraventricular application of BDNF and NT-3 failed to protect nucleus basalis magnocellularis cholinergic neurons
    • [420] M.H. Skup, B.C. Figueiredo, A.C. Cuello, Intraventricular application of BDNF and NT-3 failed to protect nucleus basalis magnocellularis cholinergic neurons, NeuroReport 5 (1994) 1105-1109.
    • (1994) NeuroReport , vol.5 , pp. 1105-1109
    • Skup, M.H.1    Figueiredo, B.C.2    Cuello, A.C.3
  • 421
    • 0024545587 scopus 로고
    • Calcium-binding protein (calbindin D28k) and parvalbumin immunohistochemistry: Localisation in the rat hippocampus with specific reference to selective vulnerability of hippocampal neurons to seizure activity
    • [421] R.S. Sloviter, Calcium-binding protein (calbindin D28k) and parvalbumin immunohistochemistry: localisation in the rat hippocampus with specific reference to selective vulnerability of hippocampal neurons to seizure activity, J. Comp. Neurol. 280 (1989) 183-190.
    • (1989) J. Comp. Neurol. , vol.280 , pp. 183-190
    • Sloviter, R.S.1
  • 423
    • 0027938821 scopus 로고
    • TrkA-immunoreactive profiles in the central nervous system: Colocalisation with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin
    • [423] T. Sobreviela, D.O. Clary, L.F. Reichardt, M.M. Brandabur, J.H. Kordower, E.J. Mufson, TrkA-immunoreactive profiles in the central nervous system: colocalisation with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin, J. Comp. Neurol. 350 (1994) 587-611.
    • (1994) J. Comp. Neurol. , vol.350 , pp. 587-611
    • Sobreviela, T.1    Clary, D.O.2    Reichardt, L.F.3    Brandabur, M.M.4    Kordower, J.H.5    Mufson, E.J.6
  • 424
    • 0025136826 scopus 로고
    • Survival of adult basal cholinergic neurons after loss of target neurons
    • [424] M.V. Sofroniew, N.P. Galletly, O. Isacson, C.N. Svendsen, Survival of adult basal cholinergic neurons after loss of target neurons, Science 247 (1990) 338-342.
    • (1990) Science , vol.247 , pp. 338-342
    • Sofron, M.V.1    Galletly, N.P.2    Isacson, O.3    Svendsen, C.N.4
  • 425
    • 0022391616 scopus 로고
    • Fast and slow nerve growth factor binding sites in human neuroblastoma and rat pheochromocytoma cell lines: Relationship of sites to each other and to neurite formation
    • [425] K.H. Sonnenfeld, D.N. Ishii, Fast and slow nerve growth factor binding sites in human neuroblastoma and rat pheochromocytoma cell lines: relationship of sites to each other and to neurite formation, J. Neurosci. 5 (1985) 1717-1728.
    • (1985) J. Neurosci. , vol.5 , pp. 1717-1728
    • Sonnenfeld, K.H.1    Ishii, D.N.2
  • 427
    • 0027772389 scopus 로고
    • Experimental evidence for growth factor treatment and function in certain neurological disorders
    • [427] J.E. Springer, Experimental evidence for growth factor treatment and function in certain neurological disorders, Exp. Neurol. 124 (1993) 2-4.
    • (1993) Exp. Neurol. , vol.124 , pp. 2-4
    • Springer, J.E.1
  • 428
  • 429
    • 0028273079 scopus 로고
    • Neurotrophic factor mRNA expression in dentate gyrus is increased following in vivo stimulation of the angular bundle
    • [429] J.E. Springer, B.J. Gwag, F.M. Sessler, Neurotrophic factor mRNA expression in dentate gyrus is increased following in vivo stimulation of the angular bundle, Mol. Brain Res. 23 (1994) 135-143.
    • (1994) Mol. Brain Res. , vol.23 , pp. 135-143
    • Springer, J.E.1    Gwag, B.J.2    Sessler, F.M.3
  • 430
    • 0027256011 scopus 로고
    • High-affinity nerve growth factor receptor (trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brain
    • [430] T.L. Steininger, B.H. Wainer, R. Klein, M. Barbacid, H.C. Palfrey, High-affinity nerve growth factor receptor (trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brain, Brain Res. 612 (1993) 330-335.
    • (1993) Brain Res. , vol.612 , pp. 330-335
    • Steininger, T.L.1    Wainer, B.H.2    Klein, R.3    Barbacid, M.4    Palfrey, H.C.5
  • 431
    • 0029874135 scopus 로고    scopus 로고
    • Increased expression of type I insulin-like factor receptor messenger RNA in rat hippocampal formation is associated with aging and behavioural impairment
    • [431] K.L. Stenvers, P.K. Lund, M. Gallagher, Increased expression of type I insulin-like factor receptor messenger RNA in rat hippocampal formation is associated with aging and behavioural impairment, Neuroscience 72 (1996) 505-518.
    • (1996) Neuroscience , vol.72 , pp. 505-518
    • Stenvers, K.L.1    Lund, P.K.2    Gallagher, M.3
  • 432
    • 0026438936 scopus 로고
    • Does loss of nerve growth factor receptors precede loss of cholinergic neurons in Alzheimer's disease? An autoradiographic study in the human striatum and basal forebrain
    • [432] O. Strada, E.C. Hirsch, F. Javoy-Agid, S. Lehericy, M. Ruberg, J.J. Hauw, Y. Agid, Does loss of nerve growth factor receptors precede loss of cholinergic neurons in Alzheimer's disease? An autoradiographic study in the human striatum and basal forebrain, J. Neurosci. 12 (1992) 4766-4774.
    • (1992) J. Neurosci. , vol.12 , pp. 4766-4774
    • Strada, O.1    Hirsch, E.C.2    Javoy-Agid, F.3    Lehericy, S.4    Ruberg, M.5    Hauw, J.J.6    Agid, Y.7
  • 433
    • 0027731592 scopus 로고
    • Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopaminergic neurons in vivo
    • [433] I. Stromberg, L. Bjorklund, M. Johansson, A. Tomac, F. Collins, L. Olson, B. Hoffer, C. Humpel, Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopaminergic neurons in vivo, Exp. Neurol. 124 (1993) 401-412.
    • (1993) Exp. Neurol. , vol.124 , pp. 401-412
    • Stromberg, I.1    Bjorklund, L.2    Johansson, M.3    Tomac, A.4    Collins, F.5    Olson, L.6    Hoffer, B.7    Humpel, C.8
  • 434
    • 0029867999 scopus 로고    scopus 로고
    • Effect of brain-derived neurotrophic factor on neuronal structure of dopaminergic neurons in dissociated cultures of human fetal mesencephalon
    • [434] L. Studer, C. Spenger, R.W. Seiler, A. Othberg, O. Lindvall, P. Odin, Effect of brain-derived neurotrophic factor on neuronal structure of dopaminergic neurons in dissociated cultures of human fetal mesencephalon, Exp. Brain Res. 108 (1996) 328-336.
    • (1996) Exp. Brain Res. , vol.108 , pp. 328-336
    • Studer, L.1    Spenger, C.2    Seiler, R.W.3    Othberg, A.4    Lindvall, O.5    Odin, P.6
  • 435
    • 0028577208 scopus 로고
    • Immunohistochemical evidence for apoptosis in Alzheimer's disease
    • [435] J.H. Su, A.J. Anderson, B.J. Cummings, C.W. Cotman, Immunohistochemical evidence for apoptosis in Alzheimer's disease, NeuroReport 5 (1994) 2529-2533.
    • (1994) NeuroReport , vol.5 , pp. 2529-2533
    • Su, J.H.1    Anderson, A.J.2    Cummings, B.J.3    Cotman, C.W.4
  • 436
    • 0026597610 scopus 로고
    • Reduction of vitamin D hormone receptor mRNA levels in Alzheimer's compared to Huntington's hippocampus: Correlation with calbindin-28 K mRNA levels
    • [436] M.K. Sutherland, M.J. Somerville, L.K.K. Yoong, C. Bergeron, M.R. Haussler, D.R. Craaper McLochlan, Reduction of vitamin D hormone receptor mRNA levels in Alzheimer's compared to Huntington's hippocampus: correlation with calbindin-28 K mRNA levels, Mol. Brain Res. 13 (1992) 239-250.
    • (1992) Mol. Brain Res. , vol.13 , pp. 239-250
    • Sutherland, M.K.1    Somerville, M.J.2    Yoong, L.K.K.3    Bergeron, C.4    Haussler, M.R.5    Craaper McLochlan, D.R.6
  • 438
    • 0000066209 scopus 로고
    • The limbic region: The septohippocampal system
    • Elsevier, Amsterdam
    • [438] L.W. Swamson, C. Kohler, A. Bjorklund, The limbic region: the septohippocampal system, Handbook of Chemical Neuroanatomy, Vol. 5, Elsevier, Amsterdam, 1987, pp. 125-277.
    • (1987) Handbook of Chemical Neuroanatomy , vol.5 , pp. 125-277
    • Swamson, L.W.1    Kohler, C.2    Bjorklund, A.3
  • 439
    • 0029658996 scopus 로고    scopus 로고
    • Suppression of p140trkA does not abolish nerve growth factor-mediated rescue of serum-free PC12 cells
    • [439] G. Taglialatela, C.J. Hibbert, L.A. Hutton, K. Werrbach-Perez, J.R. Perez-Polo, Suppression of p140trkA does not abolish nerve growth factor-mediated rescue of serum-free PC12 cells, J. Neurochem. 66 (1996) 1826-1835.
    • (1996) J. Neurochem. , vol.66 , pp. 1826-1835
    • Taglialatela, G.1    Hibbert, C.J.2    Hutton, L.A.3    Werrbach-Perez, K.4    Perez-Polo, J.R.5
  • 440
    • 0026558376 scopus 로고
    • Decreased expression of neurotrophin-3 mRNA in the rat hippocampus following transient forebrain ischemia
    • [440] A. Takeda, H. Onodera, Y. Yamasaki, K. Furukawa, K. Kogure, M. Obinata, S. Shibahara, Decreased expression of neurotrophin-3 mRNA in the rat hippocampus following transient forebrain ischemia, Brain Res. 569 (1992) 177-180.
    • (1992) Brain Res. , vol.569 , pp. 177-180
    • Takeda, A.1    Onodera, H.2    Yamasaki, Y.3    Furukawa, K.4    Kogure, K.5    Obinata, M.6    Shibahara, S.7
  • 441
    • 0029779609 scopus 로고    scopus 로고
    • Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF
    • [441] S.A. Tan, N. Deglon, A.D. Zurn, E.E. Baetge, B. Bamber, A.C. Kato, P. Aebischer, Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF, Cell Transplant. 5 (1996) 577-587.
    • (1996) Cell Transplant. , vol.5 , pp. 577-587
    • Tan, S.A.1    Deglon, N.2    Zurn, A.D.3    Baetge, E.E.4    Bamber, B.5    Kato, A.C.6    Aebischer, P.7
  • 443
    • 0030888286 scopus 로고    scopus 로고
    • In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining
    • [443] N.A. Tatton, S.J. Kish, In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining, Neuroscience 77 (1997) 1037-1048.
    • (1997) Neuroscience , vol.77 , pp. 1037-1048
    • Tatton, N.A.1    Kish, S.J.2
  • 444
    • 0027170501 scopus 로고
    • Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer's type
    • [444] A. Tham, A. Nordberg, F.E. Grission, C. Carlsson-Skwirut, M. Viitanen, V.R. Sara, Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer's type, J. Neural Transm. 5 (1993) 165-176.
    • (1993) J. Neural Transm. , vol.5 , pp. 165-176
    • Tham, A.1    Nordberg, A.2    Grission, F.E.3    Carlsson-Skwirut, C.4    Viitanen, M.5    Sara, V.R.6
  • 445
    • 0025877704 scopus 로고
    • The changing scene of neurotrophic factors
    • [445] H. Thoenen, The changing scene of neurotrophic factors, Trends Neurosci. 14 (1991) 165-170.
    • (1991) Trends Neurosci. , vol.14 , pp. 165-170
    • Thoenen, H.1
  • 446
    • 0023497758 scopus 로고
    • The physiological function of nerve growth factor in the central nervous system: Comparison with the periphery
    • [446] H. Thoenen, C. Bandtlow, R. Heumann, The physiological function of nerve growth factor in the central nervous system: comparison with the periphery, Rev. Physiol. Biochem. Pharmacol. 109 (1987) 145-178.
    • (1987) Rev. Physiol. Biochem. Pharmacol. , vol.109 , pp. 145-178
    • Thoenen, H.1    Bandtlow, C.2    Heumann, R.3
  • 447
    • 0026378719 scopus 로고
    • The synthesis of nerve growth factor and brain-derived neurotrophic factor in hippocampal and cortical neurons is regulated by specific transmitter systems
    • [447] H. Thoenen, F. Zafra, B. Hengerer, D. Lindholm, The synthesis of nerve growth factor and brain-derived neurotrophic factor in hippocampal and cortical neurons is regulated by specific transmitter systems, Ann. NY Acad. Sci. 640 (1991) 86-89.
    • (1991) Ann. NY Acad. Sci. , vol.640 , pp. 86-89
    • Thoenen, H.1    Zafra, F.2    Hengerer, B.3    Lindholm, D.4
  • 449
  • 450
    • 0029114190 scopus 로고
    • Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult
    • [450] A. Tomac, J. Widenfalk, L.-F.H. Lin, T. Kohno, T. Ebendal, B.J. Hoffer, L. Olson, Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult, Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 8274-8278.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 8274-8278
    • Tomac, A.1    Widenfalk, J.2    Lin, L.-F.H.3    Kohno, T.4    Ebendal, T.5    Hoffer, B.J.6    Olson, L.7
  • 451
    • 0031013141 scopus 로고    scopus 로고
    • Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons
    • [451] M.M. Tompkins, E.J. Basgall, E. Zamrini, W.D. Hill, Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons, Am. J. Pathol. 150 (1997) 119-131.
    • (1997) Am. J. Pathol. , vol.150 , pp. 119-131
    • Tompkins, M.M.1    Basgall, E.J.2    Zamrini, E.3    Hill, W.D.4
  • 452
    • 0025334309 scopus 로고
    • Trophic effects of insulin-like growth factor-I on fetal rat hypothalamic cells in culture
    • [452] I. Torres-Aleman, F. Naftolin, R.J. Robbins, Trophic effects of insulin-like growth factor-I on fetal rat hypothalamic cells in culture, Neuroscience 35 (1990) 601-608.
    • (1990) Neuroscience , vol.35 , pp. 601-608
    • Torres-Aleman, I.1    Naftolin, F.2    Robbins, R.J.3
  • 453
    • 0026699261 scopus 로고
    • Survival of Purkinje cells in cerebellar cultures is increased by insulin-like growth factor I
    • [453] I. Torres-Aleman, S. Pons, F.F. Santos-Benito, Survival of Purkinje cells in cerebellar cultures is increased by insulin-like growth factor I, Eur. J. Neurosci. 4 (1992) 864-869.
    • (1992) Eur. J. Neurosci. , vol.4 , pp. 864-869
    • Torres-Aleman, I.1    Pons, S.2    Santos-Benito, F.F.3
  • 454
    • 0025968661 scopus 로고
    • Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain
    • [454] J.J.S. Treanor, D. Dawbarn, S.J. Allen, S.H. MacGowan, G.K. Wilcock, Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain, Neurosci. Lett. 121 (1991) 73-76.
    • (1991) Neurosci. Lett. , vol.121 , pp. 73-76
    • Treanor, J.J.S.1    Dawbarn, D.2    Allen, S.J.3    MacGowan, S.H.4    Wilcock, G.K.5
  • 456
    • 0028106342 scopus 로고
    • A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene
    • [456] J. Trejo, T. Massamiri, T. Deng, N.N. Dewji, R.M. Bayney, J. Heller Brown, A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene, J. Biol. Chem. 269 (1994) 21682-21690.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21682-21690
    • Trejo, J.1    Massamiri, T.2    Deng, T.3    Dewji, N.N.4    Bayney, R.M.5    Brown, J.H.6
  • 457
    • 0029066687 scopus 로고
    • Apoptosis in ALS is not restricted to motoneurons: Bcl-2 is increased in post-central gyrus, adjacent to the affected motor cortex
    • [457] D. Troost, J. Aten, F. Morsink, J.M. de Jong, Apoptosis in ALS is not restricted to motoneurons: Bcl-2 is increased in post-central gyrus, adjacent to the affected motor cortex, J. Neurol. Sci. 129 (1995) 79-80.
    • (1995) J. Neurol. Sci. , vol.129 , pp. 79-80
    • Troost, D.1    Aten, J.2    Morsink, F.3    De Jong, J.M.4
  • 458
    • 0029563461 scopus 로고
    • Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons. Bcl-2 expression is increased in unaffected post-central gyrus
    • [458] D. Troost, J. Aten, F. Morsink, J. de Jong, Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons. Bcl-2 expression is increased in unaffected post-central gyrus, Neuropathol. Appl. Neurobiol. 21 (1995) 498-504.
    • (1995) Neuropathol. Appl. Neurobiol. , vol.21 , pp. 498-504
    • Troost, D.1    Aten, J.2    Morsink, F.3    De Jong, J.4
  • 460
    • 0029103262 scopus 로고
    • Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in monkeys
    • [460] T. Tsukahara, M. Takeda, S. Shimohama, O. Ohara, N. Hashimoto, Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in monkeys, Neurosurgery 37 (1995) 733-741.
    • (1995) Neurosurgery , vol.37 , pp. 733-741
    • Tsukahara, T.1    Takeda, M.2    Shimohama, S.3    Ohara, O.4    Hashimoto, N.5
  • 461
    • 0020545095 scopus 로고
    • Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study
    • [461] W.A. Turski, E.A. Cavalheiro, M. Schwarz, S.J. Czuzwar, Z. Kleinrok, L. Turski, Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study, Behav. Brain Res. 9 (1983) 315-335.
    • (1983) Behav. Brain Res. , vol.9 , pp. 315-335
    • Turski, W.A.1    Cavalheiro, E.A.2    Schwarz, M.3    Czuzwar, S.J.4    Kleinrok, Z.5    Turski, L.6
  • 462
    • 0025513602 scopus 로고
    • Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration
    • [462] M.H. Tuszynski, H. Sang, D.G. Amaral, F.H. Gage, Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration, J. Neurosci. 10 (1990) 3604-3614.
    • (1990) J. Neurosci. , vol.10 , pp. 3604-3614
    • Tuszynski, M.H.1    Sang, H.2    Amaral, D.G.3    Gage, F.H.4
  • 463
    • 0026008812 scopus 로고
    • Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain
    • [463] M.H. Tuszynski, H. Sang, K. Yoshida, F.H. Gage, Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain, Ann. Neurol. 30 (1991) 625-636.
    • (1991) Ann. Neurol. , vol.30 , pp. 625-636
    • Tuszynski, M.H.1    Sang, H.2    Yoshida, K.3    Gage, F.H.4
  • 464
    • 0030002982 scopus 로고    scopus 로고
    • Gene therapy in the adult primate brain-intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration
    • [464] M.H. Tuszynski, J. Roberts, M.C. Senut, F.H. Gage, Gene therapy in the adult primate brain-intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration, Gene Ther. 3 (1996) 305-314.
    • (1996) Gene Ther. , vol.3 , pp. 305-314
    • Tuszynski, M.H.1    Roberts, J.2    Senut, M.C.3    Gage, F.H.4
  • 465
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • [465] A. Ullrich, J. Schlessinger, Signal transduction by receptors with tyrosine kinase activity, Cell 61 (1990) 203-212.
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 466
    • 0020617520 scopus 로고
    • Human β-nerve growth factor gene sequence highly homologous to that of mouse
    • [466] A. Ullrich, A. Gray, C. Berman, T.J. Dull, Human β-nerve growth factor gene sequence highly homologous to that of mouse, Nature 303 (1983) 821-822.
    • (1983) Nature , vol.303 , pp. 821-822
    • Ullrich, A.1    Gray, A.2    Berman, C.3    Dull, T.J.4
  • 468
    • 0026469380 scopus 로고
    • Antibody to NGF inhibits collateral sprouting of septohippocampal fibers following entorhinal cortex lesion in adult rats
    • [468] C.E.E.M. Van Der Zee, J. Fawcett, J. Diamond, Antibody to NGF inhibits collateral sprouting of septohippocampal fibers following entorhinal cortex lesion in adult rats, J. Comp. Neurol. 326 (1992) 91-100.
    • (1992) J. Comp. Neurol. , vol.326 , pp. 91-100
    • Van Der Zee, C.E.E.M.1    Fawcett, J.2    Diamond, J.3
  • 469
    • 0028286955 scopus 로고
    • Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: Effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration
    • [469] J.L. Venero, B. Knusel, K.D. Beck, F. Hefti, Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration, Neuroscience 59 (1994) 797-815.
    • (1994) Neuroscience , vol.59 , pp. 797-815
    • Venero, J.L.1    Knusel, B.2    Beck, K.D.3    Hefti, F.4
  • 470
    • 0028885279 scopus 로고
    • Retrograde transport of nerve growth factor from hippocampus and amygdala to trkA messenger RNA expressing neurons in paraventricular and reuniens nuclei of the thalamus
    • [470] J.L. Venero, F. Hefti, K.D. Beck, Retrograde transport of nerve growth factor from hippocampus and amygdala to trkA messenger RNA expressing neurons in paraventricular and reuniens nuclei of the thalamus, Neuroscience 64 (1995) 855-860.
    • (1995) Neuroscience , vol.64 , pp. 855-860
    • Venero, J.L.1    Hefti, F.2    Beck, K.D.3
  • 471
    • 0030020475 scopus 로고    scopus 로고
    • Trophic effect of exogenous nerve growth factor on rat striatal cholinergic neurons: Comparison between intraparenchymal and intraventricular administration
    • [471] J.L. Venero, F. Hefti, B. Knusel, Trophic effect of exogenous nerve growth factor on rat striatal cholinergic neurons: comparison between intraparenchymal and intraventricular administration, Mol. Pharmacol. 49 (1996) 303-310.
    • (1996) Mol. Pharmacol. , vol.49 , pp. 303-310
    • Venero, J.L.1    Hefti, F.2    Knusel, B.3
  • 472
    • 0024413110 scopus 로고
    • Neurotrophic factors and Alzheimer's disease
    • [472] B.H. Wainer, Neurotrophic factors and Alzheimer's disease, Neurobiol. Aging 10 (1989) 540-542.
    • (1989) Neurobiol. Aging , vol.10 , pp. 540-542
    • Wainer, B.H.1
  • 474
    • 0025071211 scopus 로고
    • Localisation of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridisation
    • [474] C. Wetmore, P. Ernfors, H. Persson, L. Olson, Localisation of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridisation, Exp. Neurol. 109 (1990) 141-152.
    • (1990) Exp. Neurol. , vol.109 , pp. 141-152
    • Wetmore, C.1    Ernfors, P.2    Persson, H.3    Olson, L.4
  • 475
    • 0026046426 scopus 로고
    • Brain-derived neurotrophic factor: Subcellular compartmentalization and interneuronal transfer as visualised with anti-peptide antibodies
    • [475] C. Wetmore, Y. Cao, R.F. Pettersson, L. Olson, Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualised with anti-peptide antibodies, Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 9843-9847.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 9843-9847
    • Wetmore, C.1    Cao, Y.2    Pettersson, R.F.3    Olson, L.4
  • 476
  • 477
    • 0023626621 scopus 로고
    • The expression, localisation and functional significance of β-nerve growth factor in the central nervous system
    • [477] S.R. Whittemore, A. Seiger, The expression, localisation and functional significance of β-nerve growth factor in the central nervous system, Brain Res. Rev. 12 (1987) 439-464.
    • (1987) Brain Res. Rev. , vol.12 , pp. 439-464
    • Whittemore, S.R.1    Seiger, A.2
  • 478
    • 0027537226 scopus 로고
    • TGFα stimulation of phosphatidylinositol hydrolysis in mesencephalic cultures requires neuron-glia interactions
    • [478] H.R. Widmer, T. Alexi, J. Valverde, B. Knusel, F. Hefti, TGFα stimulation of phosphatidylinositol hydrolysis in mesencephalic cultures requires neuron-glia interactions, NeuroReport 4 (1993) 407-410.
    • (1993) NeuroReport , vol.4 , pp. 407-410
    • Widmer, H.R.1    Alexi, T.2    Valverde, J.3    Knusel, B.4    Hefti, F.5
  • 479
    • 0023930614 scopus 로고
    • Localisation of cells synthesizing transforming growth factor-α mRNA in the mouse brain
    • [479] J.N. Wilcox, R. Derynck, Localisation of cells synthesizing transforming growth factor-α mRNA in the mouse brain, J. Neurosci. 8 (1988) 1901-1904.
    • (1988) J. Neurosci. , vol.8 , pp. 1901-1904
    • Wilcox, J.N.1    Derynck, R.2
  • 480
    • 0029126251 scopus 로고
    • Nerve growth factor prevents apoptotic cell death in injured central cholinergic neurons
    • [480] B.J. Wilcox, M.D. Applegate, C. Portera-Cailliau, V.E. Koliatsos, Nerve growth factor prevents apoptotic cell death in injured central cholinergic neurons, J. Comp. Neurol. 359 (1995) 573-585.
    • (1995) J. Comp. Neurol. , vol.359 , pp. 573-585
    • Wilcox, B.J.1    Applegate, M.D.2    Portera-Cailliau, C.3    Koliatsos, V.E.4
  • 482
    • 0030437247 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor sustains axotomized basal forebrain cholinergic neurons in vivo: Dose-response comparison to nerve growth factor and brain-derived neurotrophic factor
    • [482] L.R. Williams, G. Inouye, V. Cummins, M.A. Pelleymounter, Glial cell line-derived neurotrophic factor sustains axotomized basal forebrain cholinergic neurons in vivo: dose-response comparison to nerve growth factor and brain-derived neurotrophic factor, J. Pharmacol. Exp. Ther. 277 (1996) 1140-1151.
    • (1996) J. Pharmacol. Exp. Ther. , vol.277 , pp. 1140-1151
    • Williams, L.R.1    Inouye, G.2    Cummins, V.3    Pelleymounter, M.A.4
  • 483
    • 0001251256 scopus 로고
    • Clinical potential of growth factors in neurological disorders
    • [483] J. Winkler, L.J. Thal, Clinical potential of growth factors in neurological disorders, CNS Drugs 2 (1994) 465-478.
    • (1994) CNS Drugs , vol.2 , pp. 465-478
    • Winkler, J.1    Thal, L.J.2
  • 484
    • 0025910351 scopus 로고
    • Increase in extracellular insulin-like growth factor 1 (IGF-1) concentration following electrolytical lesion in rat hippocampus
    • [484] F. Yamaguchi, T. Itano, O. Miyamoto, N.A. Janjua, T. Ohmoto, K. Hosokawa, O. Hatase, Increase in extracellular insulin-like growth factor 1 (IGF-1) concentration following electrolytical lesion in rat hippocampus, Neurosci. Lett. 128 (1991) 273-276.
    • (1991) Neurosci. Lett. , vol.128 , pp. 273-276
    • Yamaguchi, F.1    Itano, T.2    Miyamoto, O.3    Janjua, N.A.4    Ohmoto, T.5    Hosokawa, K.6    Hatase, O.7
  • 485
    • 0027067035 scopus 로고
    • Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death
    • [485] Q. Yan, J. Elliott, W.D. Snider, Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death, Nature 360 (1992) 753-755.
    • (1992) Nature , vol.360 , pp. 753-755
    • Yan, Q.1    Elliott, J.2    Snider, W.D.3
  • 487
    • 0026653429 scopus 로고
    • Messenger ribonucleic acid for transforming growth factor-α, but not for epidermal growth factor, is expressed in fetal and neonatal mouse brain
    • [487] J. Yeh, K.M. Rosen, L. Villa-Komaroff, Messenger ribonucleic acid for transforming growth factor-α, but not for epidermal growth factor, is expressed in fetal and neonatal mouse brain, Am. J. Obstet. Gynecol. 167 (1992) 242-245.
    • (1992) Am. J. Obstet. Gynecol. , vol.167 , pp. 242-245
    • Yeh, J.1    Rosen, K.M.2    Villa-Komaroff, L.3
  • 488
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
    • [488] X.M. Yin, Z.N. Oltvai, S.J. Korsmeyer, BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax, Nature 369 (1994) 321-323.
    • (1994) Nature , vol.369 , pp. 321-323
    • Yin, X.M.1    Oltvai, Z.N.2    Korsmeyer, S.J.3
  • 489
    • 0029134980 scopus 로고
    • Astrocytes retrovirally transduced with BDNF elicit behavioural improvement in a rat model of Parkinson's disease
    • [489] Y. Yoshimoto, Q. Lin, T.J. Collier, D.M. Frim, X.O. Breakefield, M.C. Bohn, Astrocytes retrovirally transduced with BDNF elicit behavioural improvement in a rat model of Parkinson's disease, Brain Res. 691 (1995) 25-36.
    • (1995) Brain Res. , vol.691 , pp. 25-36
    • Yoshimoto, Y.1    Lin, Q.2    Collier, T.J.3    Frim, D.M.4    Breakefield, X.O.5    Bohn, M.C.6
  • 490
    • 0028101227 scopus 로고
    • Apoptosis related antigen, Le(Y) and nick-end labeling are positive to motor neurons in amyotrophic lateral sclerosis
    • [490] Y. Yoshiyama, T. Yamada, K. Asanuma, T. Asahi, Apoptosis related antigen, Le(Y) and nick-end labeling are positive to motor neurons in amyotrophic lateral sclerosis, Acta Neuropathol. 88 (1994) 207-211.
    • (1994) Acta Neuropathol. , vol.88 , pp. 207-211
    • Yoshiyama, Y.1    Yamada, T.2    Asanuma, K.3    Asahi, T.4
  • 491
    • 0028945660 scopus 로고
    • Evidence that A β42 is the real culprit in Alzheimer's disease
    • [491] S.G. Younkin, Evidence that A β42 is the real culprit in Alzheimer's disease, Ann. Neurol. 37 (1995) 287-288.
    • (1995) Ann. Neurol. , vol.37 , pp. 287-288
    • Younkin, S.G.1
  • 492
    • 0030053470 scopus 로고    scopus 로고
    • BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons
    • [492] D.M. Yurek, W. Lu, S. Hipkens, S.J. Wiegand, BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons, Exp. Neurol. 137 (1996) 105-118.
    • (1996) Exp. Neurol. , vol.137 , pp. 105-118
    • Yurek, D.M.1    Lu, W.2    Hipkens, S.3    Wiegand, S.J.4
  • 493
    • 0025889012 scopus 로고
    • Interplay between glutamate and γ-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons
    • [493] F. Zafra, E. Castren, H. Thoene, D. Lindholm, Interplay between glutamate and γ-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons, Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 10037-10041.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 10037-10041
    • Zafra, F.1    Castren, E.2    Thoene, H.3    Lindholm, D.4
  • 494
    • 84993912315 scopus 로고
    • Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue
    • [494] S. Zeitlin, J.P. Liu, D.L. Chapman, V.E. Papaioannou, A. Efstratiadis, Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue, Nat. Genet. 11 (1995) 155-163.
    • (1995) Nat. Genet. , vol.11 , pp. 155-163
    • Zeitlin, S.1    Liu, J.P.2    Chapman, D.L.3    Papaioannou, V.E.4    Efstratiadis, A.5
  • 496
    • 0028295930 scopus 로고
    • Localisation of neurotrophin-3-like immunoreactivity in the rat central nervous system
    • [496] X.F. Zhou, R.A. Rush, Localisation of neurotrophin-3-like immunoreactivity in the rat central nervous system, Brain Res. 643 (1994) 162-172.
    • (1994) Brain Res. , vol.643 , pp. 162-172
    • Zhou, X.F.1    Rush, R.A.2
  • 497
    • 0027161055 scopus 로고
    • Distribution of trkB tyrosine kinase immunoreactivity in the rat central nervous system
    • [497] X.-F. Zhou, L.F. Parada, D. Soppet, R.A. Rush, Distribution of trkB tyrosine kinase immunoreactivity in the rat central nervous system, Brain Res. 622 (1993) 63-70.
    • (1993) Brain Res. , vol.622 , pp. 63-70
    • Zhou, X.-F.1    Parada, L.F.2    Soppet, D.3    Rush, R.A.4
  • 498
    • 0028107446 scopus 로고
    • Intraventricular administration of insulin and IGF-1 in transient forebrain ischemia
    • [498] C.Z. Zhu, R.N. Auer, Intraventricular administration of insulin and IGF-1 in transient forebrain ischemia, J. Cereb. Blood Flow Metab. 14 (1994) 237-242.
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 237-242
    • Zhu, C.Z.1    Auer, R.N.2
  • 499
    • 0030612197 scopus 로고    scopus 로고
    • Nigrostriatal neuronal death in Parkinson's disease - A passive or an active genetically-controlled process?
    • [499] I. Ziv, A. Barzilai, D. Offen, N. Nardi, E. Melamed, Nigrostriatal neuronal death in Parkinson's disease - a passive or an active genetically-controlled process?, J. Neural Transm. 49 (1997) 69-76.
    • (1997) J. Neural Transm. , vol.49 , pp. 69-76
    • Ziv, I.1    Barzilai, A.2    Offen, D.3    Nardi, N.4    Melamed, E.5
  • 500
    • 0030937038 scopus 로고    scopus 로고
    • Cellular and molecular neurosurgery: Pathways from concept to reality: II. Vector systems and delivery methodologies for gene therapy of the central nervous system
    • [500] B.V. Zlokovic, M.L.J. Apuzzo, Cellular and molecular neurosurgery: pathways from concept to reality: II. Vector systems and delivery methodologies for gene therapy of the central nervous system, Neurosurgery 40 (1997) 805-813.
    • (1997) Neurosurgery , vol.40 , pp. 805-813
    • Zlokovic, B.V.1    Apuzzo, M.L.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.