mGluR1 antagonist decreases tyrosine phosphorylation of NMDA receptor and attenuates infarct size after transient focal cerebral ischemia

Journal of Neurochemistry

Volumn 105, Issue 5, 2008, Pages 1625-1634

  Murotomi, Kazutoshi ^a   Takagi, Norio ^a   Takayanagi, Gen ^a   Ono, Megumi ^a   Takeo, Satoshi ^a   Tanonaka, Kouichi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Ischemia; Metabotropic glutamate receptor; NMDA receptor; Post synaptic density; Tyrosine phosphorylation

Indexed keywords

4 CARBOXY 2 METHYLPHENYLGLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN TYROSINE KINASE;

ARTICLE; BRAIN INFARCTION SIZE; DISEASE ASSOCIATION; DRUG EFFECT; ENZYME ACTIVATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; BENZOATES; CEREBRAL INFARCTION; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; ISCHEMIC ATTACK, TRANSIENT; MALE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; TYROSINE;

RATTUS;

EID: 43549091334     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05260.x     Document Type: Article

References (48)

1. Bederson J. B., Pitts L. H., Tsuji M., Nishimura M. C., Davis R. L. Bartkowski H. (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17, 472 476.
2. Boast C. A., Gerhardt S. C., Pastor G., Lehmann J., Etienne P. E. Liebman J. M. (1988) The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils. Brain Res. 442, 345 348.
3. Carlin R. K., Grab D. J., Cohen R. S. Siekevitz P. (1980) Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities. J. Cell Biol. 86, 831 845.
4. Chen C. Leonard J. P. (1996) Protein tyrosine kinase-mediated potentiation of currents from cloned NMDA receptors. J. Neurochem. 67, 194 200.
5. Cheung H. H. Gurd J. W. (2001) Tyrosine phosphorylation of the N-methyl-D-aspartate receptor by exogenous and postsynaptic density-associated Src-family kinases. J. Neurochem. 78, 524 534.
6. Cheung H. H., Takagi N., Teves L., Logan R., Wallace M. C. Gurd J. W. (2000) Altered association of protein tyrosine kinases with postsynaptic densities after transient cerebral ischemia in the rat brain. J. Cereb. Blood Flow Metab. 20, 505 512.
7. Cho K. O., Hunt C. A. Kennedy M. B. (1992) The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9, 929 942.
8. Codazzi F., Di Cesare A., Chiulli N., Albanese A., Meyer T., Zacchetti D. Grohovaz F. (2006) Synergistic control of protein kinase Cγ activity by ionotropic and metabotropic glutamate receptor inputs in hippocampal neurons. J. Neurosci. 26, 3404 3411.
9. Dingledine R., Borges K., Bowie D. Traynelis S. F. (1999) The glutamate receptor ion channels. Pharmacol. Rev. 51, 7 61.
10. Fitzjohn S. M., Irving A. J., Palmer M. J., Harvey J., Lodge D. Collingridge G. L. (1996) Activation of group I mGluRs potentiates NMDA responses in rat hippocampal slices. Neurosci. Lett. 203, 211 213.
11. Gill R., Foster A. C. Woodruff G. N. (1988) MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period. Neurosci. 25, 847 855.
12. Guo W., Wei F., Zou S. et al. (2004) Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia. J. Neurosci. 24, 9161 9173.
13. Heidinger V., Manzerra P., Wang X. Q., Strasser U., Yu S. P., Choi D. W. Behrens M. M. (2002) Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J. Neurosci. 22, 5452 5461.
14. Heuss C., Scanziani M., Gahwiler B. H. Gerber U. (1999) G-protein-independent signaling mediated by metabotropic glutamate receptors. Nat. Neurosci. 2, 1070 1077.
15. Hisatsune C., Umemori H., Mishina M. Yamamoto T. (1999) Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor epsilon 2 subunit with phosphatidylinositol 3-kinase. Genes Cells 4, 657 666.
16. Hollmann M. Heinemann S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31 108.
17. Hopfield J. F., Tank D. W., Greengard P. Huganir R. L. (1988) Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation. Nature 336, 677 680.
18. Hu B. R., Park M., Martone M. E., Fischer W. H., Ellisman M. H. Zivin J. A. (1998) Assembly of proteins to postsynaptic densities after transient cerebral ischemia. J. Neurosci. 18, 625 633.
19. Kindy M. S. (1993) Inhibition of tyrosine phosphorylation prevents delayed neuronal death following cerebral ischemia. J. Cereb. Blood Flow Metab. 13, 372 377.
20. Kohr G. Seeburg P. H. (1996) Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family. J. Physiol. 492, 445 452.
21. Lau L. F. Huganir R. L. (1995) Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 270, 20036 20041.
22. Liu Y., Wong T. P., Aarts M. et al. (2007) NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J. Neurosci. 27, 2846 2857.
23. Longa E. Z., Weinstein P. R., Carlson S. Cummins R. (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20, 84 91.
24. Lu W. Y., Xiong Z. G., Lei S., Orser B. A., Dudek E., Browning M. D. MacDonald J. F. (1999) G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Nat. Neurosci. 2, 331 338.
25. Lujan R., Nusser Z., Roberts J. D., Shigemoto R. Somogyi P. (1996) Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Eur. J. Neurosci. 8, 1488 1500.
26. Moon I. S., Apperson M. L. Kennedy M. B. (1994) The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B. Proc. Natl Acad. Sci. USA 91, 3954 3958.
27. Morikawa E., Mori H., Kiyama Y., Mishina M., Asano T. Kirino T. (1998) Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor. J. Neurosci. 18, 9727 9732.
28. Moroni F., Attucci S., Cozzi A. et al. (2002) The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology 42, 741 751.
29. Muir K. W. Lees K. R. (1995) Clinical experience with excitatory amino acid antagonist drugs. Stroke 26, 503 513.
30. O'Dell T. J., Kandel E. R. Grant S. G. (1991) Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353, 558 560.
31. Park C. K., Nehls D. G., Graham D. I., Teasdale G. M. McCulloch J. (1988) The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann. Neurol. 24, 543 551.
32. Paul R., Zhang Z. G., Eliceiri B. P., Jiang Q., Boccia A. D., Zhang R. L., Chopp M. Cheresh D. A. (2001) Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat. Med. 7, 222 227.
33. Pellegrini-Giampietro D. E. (2003) The distinct role of mGlu1 receptors in post-ischemic neuronal death. Trends Pharmacol. Sci. 24, 461 470.
34. Pin J.-P. Duvoisin R. (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacol. 34, 1 26.
35. Rong R., Ahn J. Y., Huang H. et al. (2003) PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat. Neurosci. 6, 1153 1161.
36. Salter M. W. Kalia L. V. (2004) Src kinases: a hub for NMDA receptor regulation. Nat. Rev. Neurosci. 5, 317 328.
37. Shamloo M. Wieloch T. (1999) Changes in protein tyrosine phosphorylation in the rat brain after cerebral ischemia in a model of ischemic tolerance. J. Cereb. Blood Flow Metab. 19, 173 183.
38. Takagi N., Shinno K., Teves L., Bissoon N., Wallace M. C. Gurd J. W. (1997) Transient ischemia differentially increases tyrosine phosphorylation of NMDA receptor subunits 2A and 2B. J. Neurochem. 69, 1060 1065.
39. Takagi N., Cheung H. H., Bissoon N., Teves L., Wallace M. C. Gurd J. W. (1999) The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains. J. Cereb. Blood Flow Metab. 19, 880 888.
40. Takagi N., Logan R., Teves L., Wallace M. C. Gurd J. W. (2000) Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia. J. Neurochem. 74, 169 178.
41. Takagi N., Sasakawa K., Besshoh S., Miyake-Takagi K. Takeo S. (2003) Transient ischemia enhances tyrosine phosphorylation and binding of the NMDA receptor to the Src homology 2 domain of phosphatidylinositol 3-kinase in the rat hippocampus. J. Neurochem. 84, 67 76.
42. Takasu M. A., Dalva M. B., Zigmond R. E. Greenberg M. E. (2002) Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science 295, 491 495.
43. Uematsu D., Araki N., Greenberg J. H., Sladky J. Reivich M. (1991) Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage. Neurol. 41, 88 94.
44. Wang Y. T. Salter M. W. (1994) Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369, 233 235.
45. Wang Y. T., Yu X. M. Salter M. W. (1996) Ca(2+)-independent reduction of N-methyl-D-aspartate channel activity by protein tyrosine phosphatase. Proc. Natl Acad. Sci. USA 93, 1721 1725.
46. Woodrow S., Bissoon N. Gurd J. W. (1992) Depolarization-dependent tyrosine phosphorylation in rat brain synaptosomes. J. Neurochem. 59, 857 862.
47. Zheng F., Gingrich M. B., Traynelis S. F. Conn P. J. (1998) Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nat. Neurosci. 1, 185 191.
48. Zhou M. Baudry M. (2006) Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. J. Neurosci. 26, 2956 2963.