Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

Lancet Neurology

Volumn 1, Issue 6, 2002, Pages 383-386

  Ikonomidou, Chrysanthy ^a   Turski, Lechoslaw ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; 6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; APTIGANEL; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; ELIPRODIL; GAVESTINEL; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PROTEIN BCL 2; AMINO ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

APOPTOSIS; BRAIN CELL; BRAIN INJURY; CELL SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE EXACERBATION; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMAN; HYPOTHESIS; MICRODIALYSIS; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; STROKE; SYNAPTIC MEMBRANE; SYNAPTIC TRANSMISSION; TREATMENT FAILURE; CEREBROVASCULAR ACCIDENT; DRUG ANTAGONISM; METABOLISM; PATHOPHYSIOLOGY;

BRAIN INJURIES; CEREBROVASCULAR ACCIDENT; CLINICAL TRIALS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HUMANS; RECEPTORS, N-METHYL-D-ASPARTATE; TREATMENT FAILURE;

EID: 0141676771     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(02)00164-3     Document Type: Note

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