PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

Nature Neuroscience

Volumn 6, Issue 11, 2003, Pages 1153-1161

  Rong, Rong ^a   Ahn, Jee Yin ^a   Huang, Honglian ^a   Nagata, Eiichiro ^b   Kalman, Daniel ^a   Kapp, Judith A ^a   Tu, Jiancheng ^b   Worley, Paul F ^b   Snyder, Solomon H ^b   Ye, Keqiang ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIHYDROXYPHENYLGLYCINE; ADAPTOR PROTEIN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GUANOSINE TRIPHOSPHATASE; HOMER PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR HOMER PIKE L COMPLEX; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ENHANCER HOMER COMPLEX; PROTEIN PIKE L; PROTEIN PIKE S; QUISQUALIC ACID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME POLYMORPHISM; HUMAN; HUMAN CELL; MOLECULAR CLONING; NERVE CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANDROSTADIENES; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN; CARRIER PROTEINS; CELL FRACTIONATION; CELLS, CULTURED; CLONING, MOLECULAR; DNA FRAGMENTATION; EMBRYO; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; LEUCINE; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; NEURONS; NEUROPEPTIDES; POLY(ADP-RIBOSE) POLYMERASES; PRECIPITIN TESTS; PROLINE; PROTEIN BINDING; PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; PYRIDINES; QUISQUALIC ACID; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAUROSPORINE; SUBCELLULAR FRACTIONS; SYNAPTOPHYSIN; TRANSFECTION;

EID: 0242353156     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1134     Document Type: Article

References (46)

1. Ye, K. et al. Pike. A nuclear GTPase that enhances PI3 kinase activity and is regulated by protein 4.1N. Cell 103, 919-930 (2000).
2. Ye, K. et al. Phospholipase C-γ 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature 415, 541-544 (2002).
3. Smith, M. R. et al. Phospholipase C-γ 1 can induce DNA synthesis by a mechanism independent of its lipase activity. Proc. Natl. Acad. Sci. USA 91, 6554-6558 (1994).
4. Huang, P.S. et al. An SH3 domain is required for the mitogenic activity of microinjected phospholipase C-γ 1. FEBS Lett. 358, 287-292 (1995).
5. Xiao, B. et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21, 707-716 (1998).
6. Tu, J.C. et al. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23, 583-592 (1999).
7. Naisbitt, S. et al. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 23, 569-582 (1999).
8. Sala, C. et al. Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron 31, 115-130 (2001).
9. Beneken, J. et al. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron 26, 143-154 (2000).
10. Tu, J.C. et al. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21, 717-726 (1998).
11. Xiao, B., Tu, J.C. & Worley, P.F. Homer: a link between neural activity and glutamate receptor function. Curr. Opin. Neurobiol. 10, 370-374 (2000).
12. Pin, J.P. & Duvoisin, R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34, 1-26 (1995).
13. Conn, P.J. & Pin, J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37, 205-237 (1997).
14. Copani, A. et al. Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture. J. Neurochem. 64, 101-108 (1995).
15. Vincent, A.M. & Maiese, K. The metabotropic glutamate system promotes neuronal survival through distinct pathways of programmed cell death. Exp. Neurol. 166, 65-82 (2000).
16. Maiese, K., Vincent, A., Lin, S.H. & Shaw, T. Group I and group III metabotropic glutamate receptor subtypes provide enhanced neuroprotection. J. Neurosci. Res. 62, 257-272 (2000).
17. Allen, J.W., Eldadah, S.A. & Faden, A.I. β-amyloid-induced apoptosis of cerebellar granule cells and cortical neurons: exacerbation by selective inhibition of group I metabotropic glutamate receptors. Neuropharmacology 38, 1243-1252 (1999).
18. Maiese, K. & Vincent, A. M. Group I metabotropic receptors down-regulate nitric oxide induced caspase-3 activity in rat hippocampal neurons. Neurosci. Lett. 264, 17-20 (1999).
19. Ferraguti, F., Baldani-Guerra, B., Corsi, M., Nakanishi, S. & Corti, C. Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors. Eur. J. Neurosci. 11, 2073-2082 (1999).
20. De Blasi, A., Conn, P.J., Pin, J. & Nicoletti, F. Molecular determinants of metabotropic glutamate receptor signaling. Trends Pharmacol. Sci. 22, 114-120 (2001).
21. Anneser, J.M., Horstmann, S., Weydt, P. & Borasio, G.D. Activation of metabotropic glutamate receptors delays apoptosis of chick embryonic motor neurons in vitro. Neuroreport 9, 2039-2043 (1998).
22. Ango, F. et al. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411, 962-965 (2001).
23. Fagni, L., Worley, P.F. & Ango, F. Homer as both a scaffold and transduction molecule. Sci STKE 137, RE8 (2002).
24. Troy, C.M. et al. Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. J. Neurosci. 21, 5007-5016 (2001).
25. Allen, J.W., Knoblach, S.M. & Faden, A.I. Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro. Cell Death Differ. 7, 470-476 (2000).
26. Jackson, T.R., Kearns, B.G. & Theibert, A.B. Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. Trends Biochem. Sci. 25, 489-495 (2000).
27. Xia, C. et al. GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. Mol. Cell. Biol. 23, 2476-2488 (2003).
28. 2+ stores and ion channels in neurons. Trends Neurosci. 23, 80-88 (2000).
29. Tang, X. & Downes, C.P. Purification and characterization of Gβγ-responsive phosphoinositide 3-kinases from pig platelet cytosol. J. Biol. Chem. 272, 14193-14199 (1997).
30. Stoyanova, S. et al. Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin. Biochem. J. 324, 489-495 (1997).
31. Lopez-Ilasaca, M., Crespo, P., Pellici, P.G., Gutkind, J.S. & Wetzker, R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ. Science 275, 394-397 (1997).
32. Leopoldt, D. et al. Gβγ stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit. J. Biol. Chem. 273, 7024-7029 (1998).
33. Bernstein, H.G., Keilhoff, G., Reiser, M., Freese, S. & Wetzker, R. Tissue distribution and subcellular localization of a G-protein activated phosphoinositide 3-kinase. An immunohistochemical study. Cell. Mol. Biol. 44, 973-983 (1998).
34. Aiba, A. et al. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell 79, 377-388 (1994).
35. Conquet, F. et al. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature 372, 237-243 (1994).
36. Finch, E.A. & Augustine, G.J. Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites. Nature 396, 753-756 (1998).
37. Kasono, K. & Hirano, T. Involvement of inositol trisphosphate in cerebellar long-term depression. Neuroreport 6, 569-572 (1995).
38. 2+ pool in cerebellar Purkinje neurons. Biophys. J. 73, 3349-3357 (1997).
39. Inoue, T., Kato, K., Kohda, K. & Mikoshiba, K. Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar Purkinje neurons. J. Neurosci. 18, 5366-5373 (1998).
40. Lu, Y. M. et al. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J. Neurosci. 17, 5196-5205 (1997).
41. Aiba, A. et al. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell 79, 365-375 (1994).
42. Datta, S. R., Brunet, A. & Greenberg, M.E. Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927 (1999).
43. Kandel, E.S. & Hay, N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 253, 210-229 (1999).
44. Ye, K., Compton, D.A., Lai, M.M., Walensky, L.D. & Snyder, S.H. Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor. J. Neurosci. 19, 10747-10756 (1999).
45. He, T.C. et al. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA 95, 2509-2514 (1998).
46. Ye, K. et al. Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells. Proc. Natl. Acad. Sci. USA 95, 1601-1606 (1998).