Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms

Journal of Pain

Volumn 11, Issue 12, 2010, Pages 1420-1428

  Kinsey, Steven G ^a,c   Long, Jonathan Z ^b   Cravatt, Benjamin F ^b   Lichtman, Aron H ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c NONE   (United States)

Author keywords

2 ararchidonylglycerol (2 AG); Anandamide; Endogenous cannabinoid; Fatty acid amide hydrolase (FAAH); Monoacylglycerol lipase (MAGL); Neuropathic pain

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ACYLGLYCEROL LIPASE; ANALGESIC AGENT; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; GABAPENTIN; JZL 184; MONOACYLGLYCEROL LIPASE INHIBITOR; PF 3845; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG TARGETING; ENZYME INHIBITION; FEMALE; HYPERALGESIA; MALE; MECHANICAL STIMULATION; MOUSE; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; SCIATIC NERVE; SINGLE DRUG DOSE;

AMIDOHYDROLASES; ANIMALS; ENZYME INHIBITORS; FEMALE; MALE; MICE; MICE, KNOCKOUT; MONOACYLGLYCEROL LIPASES; NEURALGIA; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; SCIATIC NERVE;

EID: 78649685454     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2010.04.001     Document Type: Article

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