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Volumn 30, Issue 1, 2010, Pages 316-324

Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIHYDROXYPHENYLGLYCINE; CALCIUM ION; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C;

EID: 74849091009     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4974-09.2010     Document Type: Article
Times cited : (84)

References (48)
  • 2
    • 23644445510 scopus 로고    scopus 로고
    • NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin
    • Alagarsamy S, Saugstad J, Warren L, Mansuy IM, Gereau RW 4th, Conn PJ (2005) NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin. Neuropharmacology 49 [Suppl 1]:135-145.
    • (2005) Neuropharmacology , vol.49 , Issue.SUPPL. 1 , pp. 135-145
    • Alagarsamy, S.1    Saugstad, J.2    Warren, L.3    Mansuy, I.M.4    Gereau 4th, R.W.5    Conn, P.J.6
  • 4
    • 23644442109 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis
    • Baskys A, Bayazitov I, Fang L, Blaabjerg M, Poulsen FR, Zimmer J (2005) Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis. Neuropharmacology 49 [Suppl 1]:146 -156.
    • (2005) Neuropharmacology , vol.49 , Issue.SUPPL. 1 , pp. 146-156
    • Baskys, A.1    Bayazitov, I.2    Fang, L.3    Blaabjerg, M.4    Poulsen, F.R.5    Zimmer, J.6
  • 5
    • 0026043565 scopus 로고
    • Chronic quinolic acid lesions in rats closely resemble Huntington's disease
    • Beal MF, Ferrante RJ, Swartz KJ, Kowall NW (1991) Chronic quinolic acid lesions in rats closely resemble Huntington's disease. J Neurosci 11:1649 -1659.
    • (1991) J Neurosci , vol.11 , pp. 1649-1659
    • Beal, M.F.1    Ferrante, R.J.2    Swartz, K.J.3    Kowall, N.W.4
  • 7
    • 0032818776 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors and cell-type-specific vulnerability in the striatum: Implication for ischemia and Huntington's disease
    • Calabresi P, Centonze D, Pisani A, Bernardi G (1999) Metabotropic glutamate receptors and cell-type-specific vulnerability in the striatum: implication for ischemia and Huntington's disease. Exp Neurol 158:97-108.
    • (1999) Exp Neurol , vol.158 , pp. 97-108
    • Calabresi, P.1    Centonze, D.2    Pisani, A.3    Bernardi, G.4
  • 10
    • 3543141113 scopus 로고    scopus 로고
    • Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release
    • LesortM
    • Choo YS, Johnson GV, MacDonald M, Detloff PJ, LesortM (2004) Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release. Hum Mol Genet 13:1407-1420.
    • (2004) Hum Mol Genet , vol.13 , pp. 1407-1420
    • Choo, Y.S.1    Johnson, G.V.2    MacDonald, M.3    Detloff, P.J.4
  • 11
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn PJ, Pin JP (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37:205-237.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.P.2
  • 12
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13:2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 13
    • 33646812582 scopus 로고    scopus 로고
    • Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis
    • Dhami GK, Ferguson SS (2006) Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis. Pharmacol Ther 111:260-271.
    • (2006) Pharmacol Ther , vol.111 , pp. 260-271
    • Dhami, G.K.1    Ferguson, S.S.2
  • 14
    • 0037067705 scopus 로고    scopus 로고
    • Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2
    • Dhami GK, Anborgh PH, Dale LB, Sterne-Marr R, Ferguson SS (2002) Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2. J Biol Chem 277:25266 -25272.
    • (2002) J Biol Chem , vol.277 , pp. 25266-25272
    • Dhami, G.K.1    Anborgh, P.H.2    Dale, L.B.3    Sterne-Marr, R.4    Ferguson, S.S.5
  • 15
    • 21644483602 scopus 로고    scopus 로고
    • Phosphorylation-independent regulation of metabotropic glutamate receptor 1 signaling requires g protein-coupled receptor kinase 2 binding to the second intracellular loop
    • Dhami GK, Babwah AV, Sterne-Marr R, Ferguson SS (2005) Phosphorylation-independent regulation of metabotropic glutamate receptor 1 signaling requires g protein-coupled receptor kinase 2 binding to the second intracellular loop. J Biol Chem 280:24420-24427.
    • (2005) J Biol Chem , vol.280 , pp. 24420-24427
    • Dhami, G.K.1    Babwah, A.V.2    Sterne-Marr, R.3    Ferguson, S.S.4
  • 16
    • 0025363346 scopus 로고
    • Excitotoxic injury of the neostriatum: A model for Huntington's disease
    • DiFiglia M (1990) Excitotoxic injury of the neostriatum: a model for Huntington's disease. Trends Neurosci 13:286 -289.
    • (1990) Trends Neurosci , vol.13 , pp. 286-289
    • DiFiglia, M.1
  • 18
    • 0346749473 scopus 로고    scopus 로고
    • Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-Daspartate receptor activation in Huntington's disease knock-in striatal cells
    • Gines S, Ivanova E, Seong IS, Saura CA, MacDonald ME (2003) Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-Daspartate receptor activation in Huntington's disease knock-in striatal cells. J Biol Chem 278:50514 -50522.
    • (2003) J Biol Chem , vol.278 , pp. 50514-50522
    • Gines, S.1    Ivanova, E.2    Seong, I.S.3    Saura, C.A.4    MacDonald, M.E.5
  • 19
    • 0032861127 scopus 로고    scopus 로고
    • Extracellular-signal-regulated kinase signalling in neurons
    • Grewal SS, York RD, Stork PJ (1999) Extracellular-signal-regulated kinase signalling in neurons. Curr Opin Neurobiol 9:544 -553.
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 544-553
    • Grewal, S.S.1    York, R.D.2    Stork, P.J.3
  • 20
    • 0021895138 scopus 로고
    • A new generation of Ca2+indicators with greatly improved fluorescence properties
    • Grynkiewicz G, Poenie M, Tsien RY (1985) A new generation of Ca2+indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
    • (1985) J Biol Chem , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 21
    • 3242724040 scopus 로고    scopus 로고
    • Activation of the phosphoinositide 3-kinase-Aktmammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
    • Hou L, Klann E (2004) Activation of the phosphoinositide 3-kinase-Aktmammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. J Neurosci 24:6352-6361.
    • (2004) J Neurosci , vol.24 , pp. 6352-6361
    • Hou, L.1    Klann, E.2
  • 23
    • 0033604585 scopus 로고    scopus 로고
    • The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
    • Kandel ES, Hay N (1999) The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 253:210 -229.
    • (1999) Exp Cell Res , vol.253 , pp. 210-229
    • Kandel, E.S.1    Hay, N.2
  • 24
    • 1242338856 scopus 로고    scopus 로고
    • Huntingtin-protein interactions and the pathogenesis of Huntington's disease
    • Li SH, Li XJ (2004) Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet 20:146 -154.
    • (2004) Trends Genet , vol.20 , pp. 146-154
    • Li, S.H.1    Li, X.J.2
  • 25
    • 0030954048 scopus 로고    scopus 로고
    • Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
    • Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, Wojtowicz JM, Roder JC (1997) Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci 17:5196 -5205.
    • (1997) J Neurosci , vol.17 , pp. 5196-5205
    • Lu, Y.M.1    Jia, Z.2    Janus, C.3    Henderson, J.T.4    Gerlai, R.5    Wojtowicz, J.M.6    Roder, J.C.7
  • 26
    • 14944372499 scopus 로고    scopus 로고
    • The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons
    • Mao L, Yang L, Tang Q, Samdani S, Zhang G, Wang JQ (2005) The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci 25:2741-2752.
    • (2005) J Neurosci , vol.25 , pp. 2741-2752
    • Mao, L.1    Yang, L.2    Tang, Q.3    Samdani, S.4    Zhang, G.5    Wang, J.Q.6
  • 27
    • 0027938848 scopus 로고
    • Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity
    • Nakanishi S (1994) Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity. Neuron 13:1031-1037.
    • (1994) Neuron , vol.13 , pp. 1031-1037
    • Nakanishi, S.1
  • 28
    • 0030029427 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?
    • Nicoletti F, Bruno V, Copani A, Casabona G, Knöpfel T (1996) Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci 19:267-271.
    • (1996) Trends Neurosci , vol.19 , pp. 267-271
    • Nicoletti, F.1    Bruno, V.2    Copani, A.3    Casabona, G.4    Knöpfel, T.5
  • 30
    • 0028912822 scopus 로고
    • The metabotropic glutamate receptors: Structure and functions
    • Pin JP, Duvoisin R (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34:1-26.
    • (1995) Neuropharmacology , vol.34 , pp. 1-26
    • Pin, J.P.1    Duvoisin, R.2
  • 32
    • 69949181911 scopus 로고    scopus 로고
    • Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in striatal neurons
    • Ribeiro FM, Ferreira LT, Paquet M, Cregan T, Ding Q, Gros R, Ferguson SS (2009) Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in striatal neurons. J Biol Chem 284:23444 -23453.
    • (2009) J Biol Chem , vol.284 , pp. 23444-23453
    • Ribeiro, F.M.1    Ferreira, L.T.2    Paquet, M.3    Cregan, T.4    Ding, Q.5    Gros, R.6    Ferguson, S.S.7
  • 34
    • 38349029199 scopus 로고    scopus 로고
    • Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation
    • HuberKM
    • Ronesi JA, HuberKM (2008) Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. J Neurosci 28:543-547.
    • (2008) J Neurosci , vol.28 , pp. 543-547
    • Ronesi, J.A.1
  • 36
    • 4043164771 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease
    • Schiefer J, Sprünken A, Puls C, Lüesse HG, Milkereit A, Milkereit E, Johann V, Kosinski CM (2004) The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease. Brain Res 1019:246-254.
    • (2004) Brain Res , vol.1019 , pp. 246-254
    • Schiefer, J.1    Sprünken, A.2    Puls, C.3    Lüesse, H.G.4    Milkereit, A.5    Milkereit, E.6    Johann, V.7    Kosinski, C.M.8
  • 37
    • 0035816627 scopus 로고    scopus 로고
    • Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95
    • Sun Y, Savanenin A, Reddy PH, Liu YF (2001) Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95. J Biol Chem 276:24713-24718.
    • (2001) J Biol Chem , vol.276 , pp. 24713-24718
    • Sun, Y.1    Savanenin, A.2    Reddy, P.H.3    Liu, Y.F.4
  • 38
    • 0041963057 scopus 로고    scopus 로고
    • Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
    • Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39:227-239.
    • (2003) Neuron , vol.39 , pp. 227-239
    • Tang, T.S.1    Tu, H.2    Chan, E.Y.3    Maximov, A.4    Wang, Z.5    Wellington, C.L.6    Hayden, M.R.7    Bezprozvanny, I.8
  • 41
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group
    • The Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72:971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 46
    • 0037316787 scopus 로고    scopus 로고
    • Huntingtin in health and disease
    • Young AB (2003) Huntingtin in health and disease. J Clin Invest 111:299-302.
    • (2003) J Clin Invest , vol.111 , pp. 299-302
    • Young, A.B.1
  • 48
    • 0037075624 scopus 로고    scopus 로고
    • Increased sensitivity to N-methyl-Daspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
    • Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P, Hayden MR, Raymond LA (2002) Increased sensitivity to N-methyl-Daspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron 33:849-860.
    • (2002) Neuron , vol.33 , pp. 849-860
    • Zeron, M.M.1    Hansson, O.2    Chen, N.3    Wellington, C.L.4    Leavitt, B.R.5    Brundin, P.6    Hayden, M.R.7    Raymond, L.A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.