Mitochondrial optic neuropathies - Disease mechanisms and therapeutic strategies

Progress in Retinal and Eye Research

Volumn 30, Issue 2, 2011, Pages 81-114

  Yu Wai Man, Patrick ^a,b,c   Griffiths, Philip G ^a,b   Chinnery, Patrick F ^a,c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b ROYAL VICTORIA INFIRMARY   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Dominant optic atrophy; Glaucoma; Hereditary spastic paraplegia; Leber hereditary optic neuropathy; Mitochondrial DNA; Mitofusin; Multiple sclerosis; Neuroprotection; Optic neuritis; Optic neuropathy; Retinal ganglion cell

Indexed keywords

ADENOSINE; ANTIRETROVIRUS AGENT; ASCORBIC ACID; BIOLOGICAL FACTOR; BRIMONIDINE; CHLORAMPHENICOL; CYTOSINE; DROSOPHILA PROTEIN; ERYTHROMYCIN; ETHAMBUTOL; GUANOSINE; IDEBENONE; LINEZOLID; MELANOPSIN; MEMANTINE; MEMBRANE PROTEIN; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; MUTANT PROTEIN; MYOCILIN; PARVOVIRUS VECTOR; PLACEBO; PROSTAGLANDIN J2; RIBOFLAVIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; THYMINE; UBIDECARENONE; UNINDEXED DRUG; VALPROIC ACID; ZEBRAFISH PROTEIN;

ALCOHOL CONSUMPTION; AUTOSOMAL DOMINANT OPTIC ATROPHY; AUTOSOMAL RECESSIVE DISORDER; BIOENERGY; CARDIOMYOPATHY; CELL LOSS; CLINICAL PRACTICE; CYSTIC FIBROSIS; CYTOSKELETON; DISEASE PREDISPOSITION; DISEASE TRANSMISSION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA POLYMORPHISM; ENTEROCOCCAL INFECTION; FRIEDREICH ATAXIA; GENDER BIAS; GENE; GENE MUTATION; GENE THERAPY; GENETIC CODE; GENETIC COUNSELING; GLAUCOMA; HAPLOTYPE; HEREDITARY MOTOR SENSORY NEUROPATHY; HETEROPLASMY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMAGING; IMPORT DISEASE; IN VITRO STUDY; IN VIVO STUDY; LACTIC ACIDOSIS; LEBER HEREDITARY OPTIC NEUROPATHY; LIGHT EXPOSURE; LIVER TOXICITY; LOW TENSION GLAUCOMA; META ANALYSIS (TOPIC); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL ENCEPHALOMYOPATHY; MITOCHONDRIAL GENETICS; MITOCHONDRIAL TOXICITY; MULTIPLE SCLEROSIS; MYOPATHY; NERVE DEGENERATION; NERVE FIBER TRANSPORT; NEUROPROTECTION; NONHUMAN; NUTRITIONAL DEFICIENCY; OPA1 GENE; OPA3 GENE; OPHTHALMOPLEGIA; OPTIC NERVE; OPTIC NERVE DISEASE; OPTIC NEURITIS; OXIDATIVE PHOSPHORYLATION; PATHOPHYSIOLOGY; PERIPHERAL NEUROPATHY; PHASE 3 CLINICAL TRIAL (TOPIC); PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN FUNCTION; PTOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY CHAIN; RETINA GANGLION CELL; REVIEW; SIDE EFFECT; SMOKING; TISSUE SPECIFICITY; TUBERCULOSIS; VISION;

ANIMALS; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; HUMANS; OPTIC ATROPHY, AUTOSOMAL DOMINANT; OPTIC ATROPHY, HEREDITARY, LEBER; OPTIC NERVE; PHENOTYPE; POINT MUTATION; RETINAL GANGLION CELLS;

EID: 79551638162     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2010.11.002     Document Type: Review

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