Ethambutol-induced toxicity is mediated by zinc and lysosomal membrane permeabilization in cultured retinal cells

Toxicology and Applied Pharmacology

Volumn 235, Issue 2, 2009, Pages 163-170

  Chung, Hyewon ^a   Yoon, Young Hee ^a   Hwang, Jung Jin ^a   Cho, Kyung Sook ^a   Koh, Jae Young ^b   Kim, June Gone ^a  

^a University of Ulsan   (South Korea)

^b Asan Medical Center   (South Korea)

Author keywords

Lysosomal membrane permeabilization; Retinopathy; Zinc

Indexed keywords

ANTIBODY; CATHEPSIN D; ETHAMBUTOL; FLUORESCENT DYE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOME ENZYME; ZINC;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL DEATH; CELL VACUOLE; CHELATION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LYSOSOME MEMBRANE; MEMBRANE PERMEABILITY; MITOCHONDRION; NEWBORN; NONHUMAN; RAT; RETINA CELL; SPRAGUE DAWLEY RAT;

ALDEHYDES; ANIMALS; ANIMALS, NEWBORN; ANTITUBERCULAR AGENTS; BLOTTING, WESTERN; CASPASE 3; CATHEPSIN D; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; ETHAMBUTOL; ETHYLENEDIAMINES; IMMUNOHISTOCHEMISTRY; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOMES; MEMBRANES; MICROSCOPY, CONFOCAL; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; RETINA; VACUOLES; ZINC;

RATTUS;

EID: 60349117188     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.11.006     Document Type: Article

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