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Volumn 60, Issue 13-14, 2008, Pages 1561-1567

The mitochondrial cocktail: Rationale for combined nutraceutical therapy in mitochondrial cytopathies

Author keywords

Antioxidant; LHON; MELAS; Mitochondrial myopathy; Neuroprotection

Indexed keywords

CELL DEATH;

EID: 51249120293     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2008.05.001     Document Type: Review
Times cited : (132)

References (120)
  • 1
    • 0035002174 scopus 로고    scopus 로고
    • Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders
    • Tarnopolsky M.A., and Beal M.F. Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Ann. Neurol. 49 (2001) 561-574
    • (2001) Ann. Neurol. , vol.49 , pp. 561-574
    • Tarnopolsky, M.A.1    Beal, M.F.2
  • 2
  • 3
    • 33744478401 scopus 로고    scopus 로고
    • Free radical theory of aging: an update: increasing the functional life span
    • Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann. N. Y. Acad. Sci. 1067 (2006) 10-21
    • (2006) Ann. N. Y. Acad. Sci. , vol.1067 , pp. 10-21
    • Harman, D.1
  • 4
    • 33646704229 scopus 로고    scopus 로고
    • Is the mitochondrial free radical theory of aging intact?
    • Sanz A., Pamplona R., and Barja G. Is the mitochondrial free radical theory of aging intact?. Antioxid. Redox Signal. 8 (2006) 582-599
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 582-599
    • Sanz, A.1    Pamplona, R.2    Barja, G.3
  • 5
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley D.E., He J., Menshikova E.V., and Ritov V.B. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51 (2002) 2944-2950
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 6
    • 12144275294 scopus 로고    scopus 로고
    • Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
    • Ritov V., Menshikova E., He J., Ferrel R., Goodpaster B., and Kelley D. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 54 (2005) 8-14
    • (2005) Diabetes , vol.54 , pp. 8-14
    • Ritov, V.1    Menshikova, E.2    He, J.3    Ferrel, R.4    Goodpaster, B.5    Kelley, D.6
  • 8
    • 38449118776 scopus 로고    scopus 로고
    • Mitochondria and neurodegeneration
    • discussion 192-186
    • Beal M.F. Mitochondria and neurodegeneration. Novartis Found. Symp. 287 (2007) 183-192 discussion 192-186
    • (2007) Novartis Found. Symp. , vol.287 , pp. 183-192
    • Beal, M.F.1
  • 9
    • 25444474703 scopus 로고    scopus 로고
    • Mitochondria take center stage in aging and neurodegeneration
    • Beal M.F. Mitochondria take center stage in aging and neurodegeneration. Ann. Neurol. 58 (2005) 495-505
    • (2005) Ann. Neurol. , vol.58 , pp. 495-505
    • Beal, M.F.1
  • 10
    • 0033624419 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
    • Albers D.S., and Beal M.F. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J. Neural. Transm. Suppl. 59 (2000) 133-154
    • (2000) J. Neural. Transm. Suppl. , vol.59 , pp. 133-154
    • Albers, D.S.1    Beal, M.F.2
  • 11
    • 38049057905 scopus 로고    scopus 로고
    • DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
    • Passos J.F., Saretzki G., and von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?. Nucleic Acids Res 35 (2007) 7505-7513
    • (2007) Nucleic Acids Res , vol.35 , pp. 7505-7513
    • Passos, J.F.1    Saretzki, G.2    von Zglinicki, T.3
  • 12
    • 34247158550 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases
    • Trushina E., and McMurray C.T. Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. Neuroscience 145 (2007) 1233-1248
    • (2007) Neuroscience , vol.145 , pp. 1233-1248
    • Trushina, E.1    McMurray, C.T.2
  • 13
    • 0034306267 scopus 로고    scopus 로고
    • Mitochondria, oxygen free radicals, disease and ageing
    • Raha S., and Robinson B.H. Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem. Sci. 25 (2000) 502-508
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 502-508
    • Raha, S.1    Robinson, B.H.2
  • 14
    • 33745628757 scopus 로고    scopus 로고
    • Generation of superoxide by the mitochondrial complex I
    • Grivennikova V.G., and Vinogradov A.D. Generation of superoxide by the mitochondrial complex I. Biochim. Biophys. Acta 1757 (2006) 553-561
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 553-561
    • Grivennikova, V.G.1    Vinogradov, A.D.2
  • 15
    • 10344221083 scopus 로고    scopus 로고
    • Complex III releases superoxide to both sides of the inner mitochondrial membrane
    • Muller F.L., Liu Y., and Van Remmen H. Complex III releases superoxide to both sides of the inner mitochondrial membrane. J. Biol. Chem. 279 (2004) 49064-49073
    • (2004) J. Biol. Chem. , vol.279 , pp. 49064-49073
    • Muller, F.L.1    Liu, Y.2    Van Remmen, H.3
  • 16
    • 0036489190 scopus 로고    scopus 로고
    • Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase
    • Raha S., Myint A.T., Johnstone L., and Robinson B.H. Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase. Free Radic Biol Med 32 (2002) 421-430
    • (2002) Free Radic Biol Med , vol.32 , pp. 421-430
    • Raha, S.1    Myint, A.T.2    Johnstone, L.3    Robinson, B.H.4
  • 17
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • St-Pierre J., Buckingham J.A., Roebuck S.J., and Brand M.D. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J. Biol. Chem. 277 (2002) 44784-44790
    • (2002) J. Biol. Chem. , vol.277 , pp. 44784-44790
    • St-Pierre, J.1    Buckingham, J.A.2    Roebuck, S.J.3    Brand, M.D.4
  • 18
    • 0034661024 scopus 로고    scopus 로고
    • Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase
    • Raha S., McEachern G.E., Myint A.T., and Robinson B.H. Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase. Free Radic. Biol. Med. 29 (2000) 170-180
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 170-180
    • Raha, S.1    McEachern, G.E.2    Myint, A.T.3    Robinson, B.H.4
  • 22
    • 0035022784 scopus 로고    scopus 로고
    • Apoptosis and ROS detoxification enzymes correlate with cytochrome c oxidase deficiency in mitochondrial encephalomyopathies
    • Di Giovanni S., Mirabella M., Papacci M., Odoardi F., Silvestri G., and Servidei S. Apoptosis and ROS detoxification enzymes correlate with cytochrome c oxidase deficiency in mitochondrial encephalomyopathies. Mol. Cell. Neurosci. 17 (2001) 696-705
    • (2001) Mol. Cell. Neurosci. , vol.17 , pp. 696-705
    • Di Giovanni, S.1    Mirabella, M.2    Papacci, M.3    Odoardi, F.4    Silvestri, G.5    Servidei, S.6
  • 24
    • 0141480894 scopus 로고    scopus 로고
    • Overexpressions of myoglobin and antioxidant enzymes in ragged-red fibers of skeletal muscle from patients with mitochondrial encephalomyopathy
    • Kunishige M., Mitsui T., Akaike M., Kawajiri M., Shono M., Kawai H., and Matsumoto T. Overexpressions of myoglobin and antioxidant enzymes in ragged-red fibers of skeletal muscle from patients with mitochondrial encephalomyopathy. Muscle Nerve 28 (2003) 484-492
    • (2003) Muscle Nerve , vol.28 , pp. 484-492
    • Kunishige, M.1    Mitsui, T.2    Akaike, M.3    Kawajiri, M.4    Shono, M.5    Kawai, H.6    Matsumoto, T.7
  • 25
    • 1842425028 scopus 로고    scopus 로고
    • Attenuation of free radical production and paracrystalline inclusions by creatine supplementation in a patient with a novel cytochrome b mutation
    • Tarnopolsky M.A., Simon D., Roy B., Chorneyko K., Lowther S., and Johns D. Attenuation of free radical production and paracrystalline inclusions by creatine supplementation in a patient with a novel cytochrome b mutation. Muscle Nerve 29 (2004) 537-547
    • (2004) Muscle Nerve , vol.29 , pp. 537-547
    • Tarnopolsky, M.A.1    Simon, D.2    Roy, B.3    Chorneyko, K.4    Lowther, S.5    Johns, D.6
  • 26
    • 0036122920 scopus 로고    scopus 로고
    • Transcription regulation of human manganese superoxide dismutase gene
    • St Clair D.K., Porntadavity S., Xu Y., and Kiningham K. Transcription regulation of human manganese superoxide dismutase gene. Methods Enzymol. 349 (2002) 306-312
    • (2002) Methods Enzymol. , vol.349 , pp. 306-312
    • St Clair, D.K.1    Porntadavity, S.2    Xu, Y.3    Kiningham, K.4
  • 28
    • 13244255227 scopus 로고    scopus 로고
    • Scientific evidence to support a vitamin E and heart disease health claim: research needs
    • Jialal I., and Devaraj S. Scientific evidence to support a vitamin E and heart disease health claim: research needs. J. Nutr. 135 (2005) 348-353
    • (2005) J. Nutr. , vol.135 , pp. 348-353
    • Jialal, I.1    Devaraj, S.2
  • 29
    • 0034766047 scopus 로고    scopus 로고
    • Vitamin E supplementation in the prevention of coronary heart disease
    • Pruthi S., Allison T.G., and Hensrud D.D. Vitamin E supplementation in the prevention of coronary heart disease. Mayo Clin. Proc. 76 (2001) 1131-1136
    • (2001) Mayo Clin. Proc. , vol.76 , pp. 1131-1136
    • Pruthi, S.1    Allison, T.G.2    Hensrud, D.D.3
  • 30
    • 0036834582 scopus 로고    scopus 로고
    • Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy
    • Lonn E., Yusuf S., Hoogwerf B., Pogue J., Yi Q., Zinman B., Bosch J., Dagenais G., Mann J.F., and Gerstein H.C. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care 25 (2002) 1919-1927
    • (2002) Diabetes Care , vol.25 , pp. 1919-1927
    • Lonn, E.1    Yusuf, S.2    Hoogwerf, B.3    Pogue, J.4    Yi, Q.5    Zinman, B.6    Bosch, J.7    Dagenais, G.8    Mann, J.F.9    Gerstein, H.C.10
  • 33
    • 0034800655 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8, Arch Ophthalmol 119 (2001) 1417-1436.
    • A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8, Arch Ophthalmol 119 (2001) 1417-1436.
  • 34
    • 33746286897 scopus 로고    scopus 로고
    • Centrum use and progression of age-related cataract in the Age-Related Eye Disease Study: a propensity score approach
    • AREDS report No. 21
    • Milton R.C., Sperduto R.D., Clemons T.E., and Ferris 3rd F.L. Centrum use and progression of age-related cataract in the Age-Related Eye Disease Study: a propensity score approach. AREDS report No. 21. Ophthalmology 113 (2006) 1264-1270
    • (2006) Ophthalmology , vol.113 , pp. 1264-1270
    • Milton, R.C.1    Sperduto, R.D.2    Clemons, T.E.3    Ferris 3rd, F.L.4
  • 35
    • 38449115096 scopus 로고    scopus 로고
    • Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid
    • Chucair A.J., Rotstein N.P., Sangiovanni J.P., During A., Chew E.Y., and Politi L.E. Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid. Invest. Ophthalmol. Vis. Sci. 48 (2007) 5168-5177
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 5168-5177
    • Chucair, A.J.1    Rotstein, N.P.2    Sangiovanni, J.P.3    During, A.4    Chew, E.Y.5    Politi, L.E.6
  • 36
    • 38749097003 scopus 로고    scopus 로고
    • Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study
    • Tan J.S., Wang J.J., Flood V., Rochtchina E., Smith W., and Mitchell P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology 115 (2008) 334-341
    • (2008) Ophthalmology , vol.115 , pp. 334-341
    • Tan, J.S.1    Wang, J.J.2    Flood, V.3    Rochtchina, E.4    Smith, W.5    Mitchell, P.6
  • 37
    • 2342584598 scopus 로고    scopus 로고
    • Mitochondrial encephalomyopathies: therapeutic approach
    • Dimauro S., Mancuso M., and Naini A. Mitochondrial encephalomyopathies: therapeutic approach. Ann. N. Y. Acad. Sci. 1011 (2004) 232-245
    • (2004) Ann. N. Y. Acad. Sci. , vol.1011 , pp. 232-245
    • Dimauro, S.1    Mancuso, M.2    Naini, A.3
  • 38
    • 33748089976 scopus 로고    scopus 로고
    • Approaches to the treatment of mitochondrial diseases
    • DiMauro S., Hirano M., and Schon E.A. Approaches to the treatment of mitochondrial diseases. Muscle Nerve 34 (2006) 265-283
    • (2006) Muscle Nerve , vol.34 , pp. 265-283
    • DiMauro, S.1    Hirano, M.2    Schon, E.A.3
  • 40
    • 1842469055 scopus 로고    scopus 로고
    • Nutritional and exercise-based therapies in the treatment of mitochondrial disease
    • Mahoney D.J., Parise G., and Tarnopolsky M.A. Nutritional and exercise-based therapies in the treatment of mitochondrial disease. Curr. Opin. Clin. Nutr. Metab. Care 5 (2002) 619-629
    • (2002) Curr. Opin. Clin. Nutr. Metab. Care , vol.5 , pp. 619-629
    • Mahoney, D.J.1    Parise, G.2    Tarnopolsky, M.A.3
  • 41
    • 0042422222 scopus 로고    scopus 로고
    • Nutritional cofactor treatment in mitochondrial disorders
    • Marriage B., Clandinin M.T., and Glerum D.M. Nutritional cofactor treatment in mitochondrial disorders. J. Am. Diet. Assoc. 103 (2003) 1029-1038
    • (2003) J. Am. Diet. Assoc. , vol.103 , pp. 1029-1038
    • Marriage, B.1    Clandinin, M.T.2    Glerum, D.M.3
  • 42
    • 28844465125 scopus 로고    scopus 로고
    • Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options
    • Tarnopolsky M.A., and Raha S. Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options. Med. Sci. Sports Exerc. 37 (2005) 2086-2093
    • (2005) Med. Sci. Sports Exerc. , vol.37 , pp. 2086-2093
    • Tarnopolsky, M.A.1    Raha, S.2
  • 44
    • 0035968856 scopus 로고    scopus 로고
    • Lipoic acid improves survival in transgenic mouse models of Huntington's disease
    • Andreassen O.A., Ferrante R.J., Dedeoglu A., and Beal M.F. Lipoic acid improves survival in transgenic mouse models of Huntington's disease. Neuroreport 12 (2001) 3371-3373
    • (2001) Neuroreport , vol.12 , pp. 3371-3373
    • Andreassen, O.A.1    Ferrante, R.J.2    Dedeoglu, A.3    Beal, M.F.4
  • 45
    • 0033042929 scopus 로고    scopus 로고
    • (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
    • Hagen T.M., Ingersoll R.T., Lykkesfeldt J., Liu J., Wehr C.M., Vinarsky V., Bartholomew J.C., and Ames A.B. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 13 (1999) 411-418
    • (1999) FASEB J. , vol.13 , pp. 411-418
    • Hagen, T.M.1    Ingersoll, R.T.2    Lykkesfeldt, J.3    Liu, J.4    Wehr, C.M.5    Vinarsky, V.6    Bartholomew, J.C.7    Ames, A.B.8
  • 46
    • 0041736681 scopus 로고    scopus 로고
    • Effect of alpha-lipoic acid combined with creatine monohydrate on human skeletal muscle creatine and phosphagen concentration
    • Burke D.G., Chilibeck P.D., Parise G., Tarnopolsky M.A., and Candow D.G. Effect of alpha-lipoic acid combined with creatine monohydrate on human skeletal muscle creatine and phosphagen concentration. Int. J. Sport Nutr. Exerc. Metab. 13 (2003) 294-302
    • (2003) Int. J. Sport Nutr. Exerc. Metab. , vol.13 , pp. 294-302
    • Burke, D.G.1    Chilibeck, P.D.2    Parise, G.3    Tarnopolsky, M.A.4    Candow, D.G.5
  • 47
    • 0029164362 scopus 로고
    • Lipoic (thioctic) acid increases brain energy availability and skeletal muscle performance as shown by in vivo 31P-MRS in a patient with mitochondrial cytopathy
    • Barbiroli B., Medori R., Tritschler H.J., Klopstock T., Seibel P., Reichmann H., Iotti S., Lodi R., and Zaniol P. Lipoic (thioctic) acid increases brain energy availability and skeletal muscle performance as shown by in vivo 31P-MRS in a patient with mitochondrial cytopathy. J. Neurol. 242 (1995) 472-477
    • (1995) J. Neurol. , vol.242 , pp. 472-477
    • Barbiroli, B.1    Medori, R.2    Tritschler, H.J.3    Klopstock, T.4    Seibel, P.5    Reichmann, H.6    Iotti, S.7    Lodi, R.8    Zaniol, P.9
  • 48
    • 33846613681 scopus 로고    scopus 로고
    • Efficacy and safety of alpha-lipoic acid supplementation in the treatment of symptomatic diabetic neuropathy
    • Foster T.S. Efficacy and safety of alpha-lipoic acid supplementation in the treatment of symptomatic diabetic neuropathy. Diabetes Educ. 33 (2007) 111-117
    • (2007) Diabetes Educ. , vol.33 , pp. 111-117
    • Foster, T.S.1
  • 49
    • 39049190910 scopus 로고    scopus 로고
    • Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid
    • Kamenova P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens) 5 (2006) 251-258
    • (2006) Hormones (Athens) , vol.5 , pp. 251-258
    • Kamenova, P.1
  • 50
    • 2642548826 scopus 로고    scopus 로고
    • Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review
    • Ziegler D. Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review. Treat. Endocrinol. 3 (2004) 173-189
    • (2004) Treat. Endocrinol. , vol.3 , pp. 173-189
    • Ziegler, D.1
  • 51
    • 34347360989 scopus 로고    scopus 로고
    • Treatment of diabetic polyneuropathy: update 2006
    • Ziegler D. Treatment of diabetic polyneuropathy: update 2006. Ann. N. Y. Acad. Sci. 1084 (2006) 250-266
    • (2006) Ann. N. Y. Acad. Sci. , vol.1084 , pp. 250-266
    • Ziegler, D.1
  • 52
    • 0037370975 scopus 로고    scopus 로고
    • Diagnostic utility of a modified forearm ischemic exercise test and technical issues relevant to exercise testing
    • Tarnopolsky M., Stevens L., MacDonald J.R., Rodriguez C., Mahoney D., Rush J., and Maguire J. Diagnostic utility of a modified forearm ischemic exercise test and technical issues relevant to exercise testing. Muscle Nerve 27 (2003) 359-366
    • (2003) Muscle Nerve , vol.27 , pp. 359-366
    • Tarnopolsky, M.1    Stevens, L.2    MacDonald, J.R.3    Rodriguez, C.4    Mahoney, D.5    Rush, J.6    Maguire, J.7
  • 54
    • 0033935979 scopus 로고    scopus 로고
    • Creatine and creatinine metabolism
    • Wyss M., and Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol. Rev. 80 (2000) 1107-1213
    • (2000) Physiol. Rev. , vol.80 , pp. 1107-1213
    • Wyss, M.1    Kaddurah-Daouk, R.2
  • 55
    • 0035196365 scopus 로고    scopus 로고
    • Brain activation in normal subjects and in patients affected by mitochondrial disease without clinical central nervous system involvement: a phosphorus magnetic resonance spectroscopy study
    • Rango M., Bozzali M., Prelle A., Scarlato G., and Bresolin N. Brain activation in normal subjects and in patients affected by mitochondrial disease without clinical central nervous system involvement: a phosphorus magnetic resonance spectroscopy study. J. Cereb. Blood Flow Metab. 21 (2001) 85-91
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 85-91
    • Rango, M.1    Bozzali, M.2    Prelle, A.3    Scarlato, G.4    Bresolin, N.5
  • 56
    • 0032822221 scopus 로고    scopus 로고
    • Direct measurement of high-energy phosphate compounds in patients with neuromuscular disease
    • Tarnopolsky M.A., and Parise G. Direct measurement of high-energy phosphate compounds in patients with neuromuscular disease. Muscle Nerve 22 (1999) 1228-1233
    • (1999) Muscle Nerve , vol.22 , pp. 1228-1233
    • Tarnopolsky, M.A.1    Parise, G.2
  • 57
    • 0025968255 scopus 로고
    • In vivo muscle magnetic resonance spectroscopy in the clinical investigation of mitochondrial disease
    • Matthews P.M., Allaire C., Shoubridge E.A., Karpati G., Carpenter S., and Arnold D.L. In vivo muscle magnetic resonance spectroscopy in the clinical investigation of mitochondrial disease. Neurology 41 (1991) 114-120
    • (1991) Neurology , vol.41 , pp. 114-120
    • Matthews, P.M.1    Allaire, C.2    Shoubridge, E.A.3    Karpati, G.4    Carpenter, S.5    Arnold, D.L.6
  • 58
    • 0033822249 scopus 로고    scopus 로고
    • Insights into muscle diseases gained by phosphorus magnetic resonance spectroscopy
    • Argov Z., Lofberg M., and Arnold D.L. Insights into muscle diseases gained by phosphorus magnetic resonance spectroscopy. Muscle Nerve 23 (2000) 1316-1334
    • (2000) Muscle Nerve , vol.23 , pp. 1316-1334
    • Argov, Z.1    Lofberg, M.2    Arnold, D.L.3
  • 60
    • 0037240189 scopus 로고    scopus 로고
    • Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults
    • Brose A., Parise G., and Tarnopolsky M.A. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J. Gerontol. A Biol. Sci. Med. Sci. 58 (2003) 11-19
    • (2003) J. Gerontol. A Biol. Sci. Med. Sci. , vol.58 , pp. 11-19
    • Brose, A.1    Parise, G.2    Tarnopolsky, M.A.3
  • 61
    • 0026722343 scopus 로고
    • Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation
    • Harris R.C., Soderlund K., and Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci. (Lond) 83 (1992) 367-374
    • (1992) Clin. Sci. (Lond) , vol.83 , pp. 367-374
    • Harris, R.C.1    Soderlund, K.2    Hultman, E.3
  • 63
    • 0034875340 scopus 로고    scopus 로고
    • Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis
    • Parise G., Mihic S., MacLennan D., Yarasheski K.E., and Tarnopolsky M.A. Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis. J. Appl. Physiol. 91 (2001) 1041-1047
    • (2001) J. Appl. Physiol. , vol.91 , pp. 1041-1047
    • Parise, G.1    Mihic, S.2    MacLennan, D.3    Yarasheski, K.E.4    Tarnopolsky, M.A.5
  • 64
    • 0032852064 scopus 로고    scopus 로고
    • Increase of total creatine in human brain after oral supplementation of creatine-monohydrate
    • Dechent P., Pouwels P.J., Wilken B., Hanefeld F., and Frahm J. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am. J. Physiol. 277 (1999) R698-704
    • (1999) Am. J. Physiol. , vol.277
    • Dechent, P.1    Pouwels, P.J.2    Wilken, B.3    Hanefeld, F.4    Frahm, J.5
  • 65
    • 0036949481 scopus 로고    scopus 로고
    • Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia
    • Adcock K.H., Nedelcu J., Loenneker T., Martin E., Wallimann T., and Wagner B.P. Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia. Dev. Neurosci. 24 (2002) 382-388
    • (2002) Dev. Neurosci. , vol.24 , pp. 382-388
    • Adcock, K.H.1    Nedelcu, J.2    Loenneker, T.3    Martin, E.4    Wallimann, T.5    Wagner, B.P.6
  • 69
    • 0033767740 scopus 로고    scopus 로고
    • Dietary supplement creatine protects against traumatic brain injury
    • Sullivan P.G., Geiger J.D., Mattson M.P., and Scheff S.W. Dietary supplement creatine protects against traumatic brain injury. Ann. Neurol. 48 (2000) 723-729
    • (2000) Ann. Neurol. , vol.48 , pp. 723-729
    • Sullivan, P.G.1    Geiger, J.D.2    Mattson, M.P.3    Scheff, S.W.4
  • 70
    • 0033152490 scopus 로고    scopus 로고
    • Effects of creatine phosphate on Ca2+ regulation by the sarcoplasmic reticulum in mechanically skinned rat skeletal muscle fibres
    • Duke A.M., and Steele D.S. Effects of creatine phosphate on Ca2+ regulation by the sarcoplasmic reticulum in mechanically skinned rat skeletal muscle fibres. J. Physiol. 517 Pt 2 (1999) 447-458
    • (1999) J. Physiol. , vol.517 , Issue.PART 2 , pp. 447-458
    • Duke, A.M.1    Steele, D.S.2
  • 71
  • 72
    • 0031788804 scopus 로고    scopus 로고
    • Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells
    • Pulido S.M., Passaquin A.C., Leijendekker W.J., Challet C., Wallimann T., and Ruegg U.T. Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells. FEBS Lett. 439 (1998) 357-362
    • (1998) FEBS Lett. , vol.439 , pp. 357-362
    • Pulido, S.M.1    Passaquin, A.C.2    Leijendekker, W.J.3    Challet, C.4    Wallimann, T.5    Ruegg, U.T.6
  • 73
    • 0029993078 scopus 로고    scopus 로고
    • Phosphocreatine-dependent glutamate uptake by synaptic vesicles. A comparison with ATP-dependent glutamate uptake
    • Xu C.J., Klunk W.E., Kanfer J.N., Xiong Q., Miller G., and Pettegrew J.W. Phosphocreatine-dependent glutamate uptake by synaptic vesicles. A comparison with ATP-dependent glutamate uptake. J. Biol. Chem. 271 (1996) 13435-13440
    • (1996) J. Biol. Chem. , vol.271 , pp. 13435-13440
    • Xu, C.J.1    Klunk, W.E.2    Kanfer, J.N.3    Xiong, Q.4    Miller, G.5    Pettegrew, J.W.6
  • 75
    • 0038115294 scopus 로고    scopus 로고
    • Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice
    • Dedeoglu A., Kubilus J.K., Yang L., Ferrante K.L., Hersch S.M., Beal M.F., and Ferrante R.J. Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice. J. Neurochem. 85 (2003) 1359-1367
    • (2003) J. Neurochem. , vol.85 , pp. 1359-1367
    • Dedeoglu, A.1    Kubilus, J.K.2    Yang, L.3    Ferrante, K.L.4    Hersch, S.M.5    Beal, M.F.6    Ferrante, R.J.7
  • 78
    • 0034737380 scopus 로고    scopus 로고
    • Neuroprotective effects of creatine administration against NMDA and malonate toxicity
    • Malcon C., Kaddurah-Daouk R., and Beal M.F. Neuroprotective effects of creatine administration against NMDA and malonate toxicity. Brain Res. 860 (2000) 195-198
    • (2000) Brain Res. , vol.860 , pp. 195-198
    • Malcon, C.1    Kaddurah-Daouk, R.2    Beal, M.F.3
  • 84
    • 0030731246 scopus 로고    scopus 로고
    • A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies
    • Tarnopolsky M.A., Roy B.D., and MacDonald J.R. A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve 20 (1997) 1502-1509
    • (1997) Muscle Nerve , vol.20 , pp. 1502-1509
    • Tarnopolsky, M.A.1    Roy, B.D.2    MacDonald, J.R.3
  • 85
    • 0032859505 scopus 로고    scopus 로고
    • Supplementation with creatine monohydrate in children with mitochondrial encephalomyopathies
    • Borchert A., Wilichowski E., and Hanefeld F. Supplementation with creatine monohydrate in children with mitochondrial encephalomyopathies. Muscle Nerve 22 (1999) 1299-1300
    • (1999) Muscle Nerve , vol.22 , pp. 1299-1300
    • Borchert, A.1    Wilichowski, E.2    Hanefeld, F.3
  • 89
    • 20144387513 scopus 로고    scopus 로고
    • Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebo-controlled, double-blind 31P-MRS crossover study
    • Kornblum C., Schroder R., Muller K., Vorgerd M., Eggers J., Bogdanow M., Papassotiropoulos A., Fabian K., Klockgether T., and Zange J. Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebo-controlled, double-blind 31P-MRS crossover study. Eur. J. Neurol. 12 (2005) 300-309
    • (2005) Eur. J. Neurol. , vol.12 , pp. 300-309
    • Kornblum, C.1    Schroder, R.2    Muller, K.3    Vorgerd, M.4    Eggers, J.5    Bogdanow, M.6    Papassotiropoulos, A.7    Fabian, K.8    Klockgether, T.9    Zange, J.10
  • 91
    • 0037345750 scopus 로고    scopus 로고
    • Statins unmasking a mitochondrial myopathy: a case report and proposed mechanism of disease
    • Diaczok B.J., and Shali R. Statins unmasking a mitochondrial myopathy: a case report and proposed mechanism of disease. South Med. J. 96 (2003) 318-320
    • (2003) South Med. J. , vol.96 , pp. 318-320
    • Diaczok, B.J.1    Shali, R.2
  • 93
    • 0023267038 scopus 로고
    • Clinical improvement after administration of coenzyme Q10 in a patient with mitochondrial encephalomyopathy
    • Goda S., Hamada T., Ishimoto S., Kobayashi T., Goto I., and Kuroiwa Y. Clinical improvement after administration of coenzyme Q10 in a patient with mitochondrial encephalomyopathy. J. Neurol. 234 (1987) 62-63
    • (1987) J. Neurol. , vol.234 , pp. 62-63
    • Goda, S.1    Hamada, T.2    Ishimoto, S.3    Kobayashi, T.4    Goto, I.5    Kuroiwa, Y.6
  • 94
    • 34248175243 scopus 로고    scopus 로고
    • The evidence basis for coenzyme Q therapy in oxidative phosphorylation disease
    • Suppl
    • Haas R.H. The evidence basis for coenzyme Q therapy in oxidative phosphorylation disease. Mitochondrion 7 (2007) S136-145 Suppl
    • (2007) Mitochondrion , vol.7
    • Haas, R.H.1
  • 95
    • 0024561803 scopus 로고
    • Mitochondrial encephalomyopathy (MELAS): pathological study and successful therapy with coenzyme Q10 and idebenone
    • Ihara Y., Namba R., Kuroda S., Sato T., and Shirabe T. Mitochondrial encephalomyopathy (MELAS): pathological study and successful therapy with coenzyme Q10 and idebenone. J. Neurol. Sci. 90 (1989) 263-271
    • (1989) J. Neurol. Sci. , vol.90 , pp. 263-271
    • Ihara, Y.1    Namba, R.2    Kuroda, S.3    Sato, T.4    Shirabe, T.5
  • 97
    • 0029056559 scopus 로고
    • A case of diabetic amyotrophy associated with 3243 mitochondrial tRNA(leu; UUR) mutation and successful therapy with coenzyme Q10
    • Suzuki Y., Kadowaki H., Atsumi Y., Hosokawa K., Katagiri H., Kadowaki T., Oka Y., Uyama K., Mokubo A., Asahina T., et al. A case of diabetic amyotrophy associated with 3243 mitochondrial tRNA(leu; UUR) mutation and successful therapy with coenzyme Q10. Endocr. J. 42 (1995) 141-145
    • (1995) Endocr. J. , vol.42 , pp. 141-145
    • Suzuki, Y.1    Kadowaki, H.2    Atsumi, Y.3    Hosokawa, K.4    Katagiri, H.5    Kadowaki, T.6    Oka, Y.7    Uyama, K.8    Mokubo, A.9    Asahina, T.10
  • 98
    • 3042717908 scopus 로고    scopus 로고
    • Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease
    • Shults C.W., Flint Beal M., Song D., and Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease. Exp. Neurol. 188 (2004) 491-494
    • (2004) Exp. Neurol. , vol.188 , pp. 491-494
    • Shults, C.W.1    Flint Beal, M.2    Song, D.3    Fontaine, D.4
  • 102
    • 0036554660 scopus 로고    scopus 로고
    • Heart hypertrophy and function are improved by idebenone in Friedreich's ataxia
    • Rustin P., Rotig A., Munnich A., and Sidi D. Heart hypertrophy and function are improved by idebenone in Friedreich's ataxia. Free Radic. Res. 36 (2002) 467-469
    • (2002) Free Radic. Res. , vol.36 , pp. 467-469
    • Rustin, P.1    Rotig, A.2    Munnich, A.3    Sidi, D.4
  • 105
    • 0029834971 scopus 로고    scopus 로고
    • Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS
    • Ikejiri Y., Mori E., Ishii K., Nishimoto K., Yasuda M., and Sasaki M. Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS. Neurology 47 (1996) 583-585
    • (1996) Neurology , vol.47 , pp. 583-585
    • Ikejiri, Y.1    Mori, E.2    Ishii, K.3    Nishimoto, K.4    Yasuda, M.5    Sasaki, M.6
  • 110
    • 0025964461 scopus 로고
    • Successful treatment of pure myopathy, associated with complex I deficiency, with riboflavin and carnitine
    • Bernsen P.L., Gabreels F.J., Ruitenbeek W., Sengers R.C., Stadhouders A.M., and Renier W.O. Successful treatment of pure myopathy, associated with complex I deficiency, with riboflavin and carnitine. Arch. Neurol. 48 (1991) 334-338
    • (1991) Arch. Neurol. , vol.48 , pp. 334-338
    • Bernsen, P.L.1    Gabreels, F.J.2    Ruitenbeek, W.3    Sengers, R.C.4    Stadhouders, A.M.5    Renier, W.O.6
  • 112
    • 0028180592 scopus 로고
    • Vitamin-responsive complex I deficiency in a myopathic patient with increased activity of the terminal respiratory chain and lactic acidosis
    • Bakker H.D., Scholte H.R., Jeneson J.A., Busch H.F., Abeling N.G., and van Gennip A.H. Vitamin-responsive complex I deficiency in a myopathic patient with increased activity of the terminal respiratory chain and lactic acidosis. J. Inherit. Metab. Dis. 17 (1994) 196-204
    • (1994) J. Inherit. Metab. Dis. , vol.17 , pp. 196-204
    • Bakker, H.D.1    Scholte, H.R.2    Jeneson, J.A.3    Busch, H.F.4    Abeling, N.G.5    van Gennip, A.H.6
  • 114
    • 0031909628 scopus 로고    scopus 로고
    • Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial
    • Schoenen J., Jacquy J., and Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 50 (1998) 466-470
    • (1998) Neurology , vol.50 , pp. 466-470
    • Schoenen, J.1    Jacquy, J.2    Lenaerts, M.3
  • 116
    • 33846191544 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis
    • Magis D., Ambrosini A., Sandor P., Jacquy J., Laloux P., and Schoenen J. A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache 47 (2007) 52-57
    • (2007) Headache , vol.47 , pp. 52-57
    • Magis, D.1    Ambrosini, A.2    Sandor, P.3    Jacquy, J.4    Laloux, P.5    Schoenen, J.6
  • 117
    • 1842523325 scopus 로고    scopus 로고
    • Cofactor treatment improves ATP synthetic capacity in patients with oxidative phosphorylation disorders
    • Marriage B.J., Clandinin M.T., Macdonald I.M., and Glerum D.M. Cofactor treatment improves ATP synthetic capacity in patients with oxidative phosphorylation disorders. Mol. Genet. Metab. 81 (2004) 263-272
    • (2004) Mol. Genet. Metab. , vol.81 , pp. 263-272
    • Marriage, B.J.1    Clandinin, M.T.2    Macdonald, I.M.3    Glerum, D.M.4
  • 120
    • 0029066771 scopus 로고
    • The treatment of mitochondrial myopathies and encephalomyopathies
    • Peterson P.L. The treatment of mitochondrial myopathies and encephalomyopathies. Biochim. Biophys. Acta 1271 (1995) 275-280
    • (1995) Biochim. Biophys. Acta , vol.1271 , pp. 275-280
    • Peterson, P.L.1


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