Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines

Brain

Volumn 127, Issue 10, 2004, Pages 2183-2192

  Beretta, Simone ^a   Mattavelli, Laura ^a,b   Sala, Gessica ^a   Tremolizzo, Lucio ^a,b   Schapira, Anthony H V ^e,f   Martinuzzi, Andrea ^c   Carelli, Valerio ^d   Ferrarese, Carlo ^a,b,c  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c SCIENTIFIC INSTITUTE   (Italy)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cybrids; EAAT1; Glutamate transport; Leber hereditary optic neuropathy; Reactive oxygen species

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); EXCITATORY AMINO ACID TRANSPORTER 1; GLUTAMIC ACID DERIVATIVE; HYDROGEN PEROXIDE; ROTENONE; UNCOUPLING PROTEIN;

ARTICLE; BIOCHEMISTRY; CELL DEGENERATION; CELL LINE; CELL TYPE; CONTROLLED STUDY; CYBRID; CYTOTOXICITY; EXTRACHROMOSOMAL INHERITANCE; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; HUMAN; HUMAN CELL; HYPOTHESIS; LEBER HEREDITARY OPTIC NEUROPATHY; MITOCHONDRION; NERVE CELL; NUCLEOTIDE SEQUENCE; OPTIC NERVE; OSTEOSARCOMA; PRIORITY JOURNAL; RETINA; RETINA GANGLION CELL; DRUG EFFECT; ENERGY METABOLISM; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

AMINO ACID TRANSPORT SYSTEM X-AG; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; DNA, MITOCHONDRIAL; ENERGY METABOLISM; EXCITATORY AMINO ACID TRANSPORTER 1; GLUTAMATES; HUMANS; HYDROGEN PEROXIDE; MUTATION; OPTIC ATROPHY, HEREDITARY, LEBER; REACTIVE OXYGEN SPECIES; ROTENONE; UNCOUPLING AGENTS;

EID: 4944263224     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/awh258     Document Type: Article

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