Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion

Toxicological Sciences

Volumn 116, Issue 1, 2010, Pages 140-150

  Li, Ching Hao ^a   Cheng, Yu Wen ^b   Liao, Po Lin ^a   Yang, Ya Ting ^a   Kang, Jaw Jou ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Antibiotics; Cell invasion; Chloramphenicol; JNK; Matrix metalloproteinase; Mitochondria stress; PI 3K

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; CHLORAMPHENICOL; CLINDAMYCIN; DOXYCYCLINE; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE 13; OLIGOMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C JUN; PROTEIN INHIBITOR; PROTEIN KINASE B; PROTEIN P85; RIBOSOMAL PROTEIN 70S INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; COLLAGENASE 3; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CANCER CELL; CELL INVASION; CELL STRESS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SOLID TUMOR; UPREGULATION; CHROMATIN IMMUNOPRECIPITATION; DRUG EFFECTS; ENZYME INDUCTION; GENETICS; METABOLISM; MITOCHONDRION; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOXICITY; TUMOR CELL LINE; TUMOR INVASION;

BACTERIA (MICROORGANISMS);

ADENOSINE TRIPHOSPHATE; BASE SEQUENCE; CELL LINE, TUMOR; CHLORAMPHENICOL; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; ENZYME INDUCTION; HUMANS; MAP KINASE KINASE 4; MATRIX METALLOPROTEINASE 13; MITOCHONDRIA; NEOPLASM INVASIVENESS; PHOSPHATIDYLINOSITOL 3-KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 77954358006     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq085     Document Type: Article

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