A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 4, 2007, Pages 1607-1614

  Chalasani, Madhavi Latha ^a   Radha, Vegesna ^b   Gupta, Vijay ^b   Agarwal, Neeraj ^c   Balasubramanian, Dorairajan ^a   Swarup, Ghanshyam ^b  

^a L V PRASAD EYE INSTITUTE   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^c UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; MANGANESE SUPEROXIDE DISMUTASE; MUTANT PROTEIN; OPTINEURIN; REACTIVE OXYGEN METABOLITE; TROLOX C; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID; CHROMAN DERIVATIVE; OPTN PROTEIN, HUMAN; TRANSCRIPTION FACTOR IIIA;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL STRAIN COS1; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC TRANSFECTION; GLAUCOMA; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; WESTERN BLOTTING; ANIMAL; APOPTOSIS; CERCOPITHECUS; CULTURE TECHNIQUE; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; MUTATION; OXIDATIVE STRESS; PATHOLOGY; PLASMID;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHROMANS; COS CELLS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLAUCOMA; HELA CELLS; HUMANS; MUTATION; OXIDATIVE STRESS; PLASMIDS; RATS; REACTIVE OXYGEN SPECIES; RETINAL GANGLION CELLS; TRANSCRIPTION FACTOR TFIIIA; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34248402037     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-0834     Document Type: Article

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