Early stage ethambutol optic neuropathy: Retinal nerve fiber layer and optical coherence tomography

European Journal of Ophthalmology

Volumn 19, Issue 3, 2009, Pages 466-469

  Kim, Ungsoo ^a   Hwang, Jeong Min ^b  

^a Konyang University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

Author keywords

Ethambutol; Optical coherence tomography; Retinal nerve fiber layer thickness; Toxic optic neuropathy

Indexed keywords

ETHAMBUTOL; TUBERCULOSTATIC AGENT;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CLINICAL ARTICLE; COLOR VISION DEFECT; CONTROLLED STUDY; DISEASE SEVERITY; DRUG WITHDRAWAL; FEMALE; HEMIANOPIA; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG TUBERCULOSIS; MALE; NERVE FIBER; NEUROOPHTHALMOLOGY; OPTIC NERVE DISEASE; OPTIC NERVE FIBER; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA NERVE CELL; RETINAL NERVE FIBER LAYER THICKNESS; TREATMENT DURATION; TUBERCULOUS MENINGITIS; VISUAL ACUITY; VISUAL FIELD; VISUAL FIELD DEFECT; VISUAL IMPAIRMENT; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; MIDDLE AGED; PATHOLOGY; RETINA GANGLION CELL;

AGED; AGED, 80 AND OVER; ANTITUBERCULAR AGENTS; ETHAMBUTOL; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE FIBERS; OPTIC NERVE DISEASES; RETINAL GANGLION CELLS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 66149107410     PISSN: 11206721     EISSN: None     Source Type: Journal    
DOI: 10.1177/112067210901900323     Document Type: Article

References (9)

1. Carr RE, Henkind P. Ocular manifestations of ethambutol, toxic amblyopia after administration of an experimental antituberculous drug. Arch Ophthalmol 1962; 67: 566-71.
2. Barron GJ, Tepper L, Iovine G. Ocular toxicity from ethambutol. Am J Ophthalmol 1974; 77: 256-60.
3. Chan RY, Kwok AK. Ocular toxicity of ethambutol. Hong Kong Med J 2006; 12: 56-60.
4. Savini G, Barboni P, Valentino ML, et al. Retinal nerve fiber layer evaluation by optical coherence tomography in unaffected carriers with Leber's hereditary optic neuropathy mutations. Ophthalmology 2005; 112: 127-31.
5. Qi X, Lewin AS, Hauswirth WW, Guy J. Optic neuropathy induced by reductions in mitochondrial superoxide dismutase. Invest Ophthalmol Vis Sci 2003; 44: 1088-96.
6. Zoumalan CI, Agarwal M, Sadun AA. Optical coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathy. Graefes Arch Clin Exp Ophthalmol 2005; 243: 410-6.
7. Heng JE, Vorwerk CK, Lessell E, Zurakowski D, Levin LA, Dreyer EB. Ethambutol is toxic to retinal ganglion cells via an excitotoxic pathway. Invest Ophthalmol Vis Sci 1999; 40: 190-6.
8. Sadun AA, Win PH, Ross-Cisneros FN, Walker SO, Carelli V. Leber's hereditary optic neuropathy differentially affects smaller axons in the optic nerve. Trans Am Ophthalmol Soc 2000; 98: 223-32.
9. Chai SJ, Foroozan R. Decreased retinal nerve fibre layer thickness detected by optical coherence tomography in patients with ethambutol-induced optic neuropathy. Br J Ophthalmol 2007; 91: 895-7.