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Volumn 69, Issue 2, 2011, Pages 65-75

Mitochondrial response to controlled nutrition in health and disease

Author keywords

Aging; Ketogenic diet; Mitochondria; Mitochondrial diseases; Nutrition; Oxidative phosphorylation

Indexed keywords

ACETYLCYSTEINE; AMYLOID BETA PROTEIN; ARGININE; ASCORBIC ACID; CARNITINE; CREATINE; FLAVOPROTEIN; MENADIOL SODIUM PHOSPHATE; METHIONINE; MITOCHONDRIAL DNA; NICOTINAMIDE; NUTRACEUTICAL; REACTIVE OXYGEN METABOLITE; RIBOFLAVIN; SIRTUIN 1; SUCCINIC ACID; THIAMINE; UBIDECARENONE; UNCOUPLING PROTEIN 2;

EID: 79551631857     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2010.00363.x     Document Type: Editorial
Times cited : (45)

References (125)
  • 1
    • 0004207650 scopus 로고
    • Mitochondria
    • New York: Plenum Press;
    • Tzagoloff A. Mitochondria. New York: Plenum Press; 1982.
    • (1982)
    • Tzagoloff, A.1
  • 2
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298-300.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 3
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • Trifunovic A, Wredenberg A, Falkenberg M, etal. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004;429:417-423.
    • (2004) Nature , vol.429 , pp. 417-423
    • Trifunovic, A.1    Wredenberg, A.2    Falkenberg, M.3
  • 4
    • 29144458899 scopus 로고    scopus 로고
    • Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
    • Trifunovic A, Hansson A, Wredenberg A, etal. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci USA. 2005;102:17993-17998.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17993-17998
    • Trifunovic, A.1    Hansson, A.2    Wredenberg, A.3
  • 5
    • 77955380974 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice
    • Hiona A, Sanz A, Kujoth GC, etal. Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS ONE. 2010;5:e11468.
    • (2010) PLoS ONE , vol.5
    • Hiona, A.1    Sanz, A.2    Kujoth, G.C.3
  • 6
    • 12144288373 scopus 로고    scopus 로고
    • Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
    • Van Remmen H, Ikeno Y, Hamilton M, etal. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics. 2003;16:29-37.
    • (2003) Physiol Genomics , vol.16 , pp. 29-37
    • Van Remmen, H.1    Ikeno, Y.2    Hamilton, M.3
  • 8
    • 35648947912 scopus 로고    scopus 로고
    • Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
    • Rea SL, Ventura N, Johnson TE. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol. 2007;5:e259.
    • (2007) PLoS Biol , vol.5
    • Rea, S.L.1    Ventura, N.2    Johnson, T.E.3
  • 9
    • 13944269026 scopus 로고    scopus 로고
    • Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways
    • Walker G, Houthoofd K, Vanfleteren JR, Gems D. Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways. Mech Ageing Dev. 2005;126:929-937.
    • (2005) Mech Ageing Dev , vol.126 , pp. 929-937
    • Walker, G.1    Houthoofd, K.2    Vanfleteren, J.R.3    Gems, D.4
  • 10
    • 0002458132 scopus 로고
    • The effect of retarded growth upon the length of life span and upon the ultimate body size
    • McCay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of life span and upon the ultimate body size. J Nutr. 1935;10:63-79.
    • (1935) J Nutr , vol.10 , pp. 63-79
    • McCay, C.M.1    Crowell, M.F.2    Maynard, L.A.3
  • 11
    • 67650439330 scopus 로고    scopus 로고
    • Caloric restriction delays disease onset and mortality in rhesus monkeys
    • Colman RJ, Anderson RM, Johnson SC, etal. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009;325:201-204.
    • (2009) Science , vol.325 , pp. 201-204
    • Colman, R.J.1    Anderson, R.M.2    Johnson, S.C.3
  • 12
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span - from yeast to humans
    • Fontana L, Partridge L, Longo VD. Extending healthy life span - from yeast to humans. Science. 2010;328:321-326.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 13
    • 0035403165 scopus 로고    scopus 로고
    • Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart
    • Gredilla R, Sanz A, Lopez-Torres M, Barja G. Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart. Faseb J. 2001;15:1589-1591.
    • (2001) Faseb J , vol.15 , pp. 1589-1591
    • Gredilla, R.1    Sanz, A.2    Lopez-Torres, M.3    Barja, G.4
  • 14
    • 0037130175 scopus 로고    scopus 로고
    • Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    • Lin SJ, Kaeberlein M, Andalis AA, etal. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature. 2002;418:344-348.
    • (2002) Nature , vol.418 , pp. 344-348
    • Lin, S.J.1    Kaeberlein, M.2    Andalis, A.A.3
  • 15
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C. elegans
    • Bishop NA, Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature. 2007;447:545-549.
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 16
    • 0034703217 scopus 로고    scopus 로고
    • Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    • Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science. 2000;289:2126-2128.
    • (2000) Science , vol.289 , pp. 2126-2128
    • Lin, S.J.1    Defossez, P.A.2    Guarente, L.3
  • 17
    • 71849105308 scopus 로고    scopus 로고
    • The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction
    • Bamps S, Wirtz J, Savory FR, Lake D, Hope IA. The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction. Mech Ageing Dev. 2009;130:762-770.
    • (2009) Mech Ageing Dev , vol.130 , pp. 762-770
    • Bamps, S.1    Wirtz, J.2    Savory, F.R.3    Lake, D.4    Hope, I.A.5
  • 18
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA. 2004;101:15998-16003.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 19
    • 3142740860 scopus 로고    scopus 로고
    • Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    • Cohen HY, Miller C, Bitterman KJ, etal. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004;305:390-392.
    • (2004) Science , vol.305 , pp. 390-392
    • Cohen, H.Y.1    Miller, C.2    Bitterman, K.J.3
  • 20
    • 26844558334 scopus 로고    scopus 로고
    • Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
    • Nisoli E, Tonello C, Cardile A, etal. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science. 2005;310:314-317.
    • (2005) Science , vol.310 , pp. 314-317
    • Nisoli, E.1    Tonello, C.2    Cardile, A.3
  • 21
    • 0347128279 scopus 로고    scopus 로고
    • Calorie restriction extends yeast life span by lowering the level of NADH
    • Lin SJ, Ford E, Haigis M, Liszt G, Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 2004;18:12-16.
    • (2004) Genes Dev , vol.18 , pp. 12-16
    • Lin, S.J.1    Ford, E.2    Haigis, M.3    Liszt, G.4    Guarente, L.5
  • 22
    • 34548627517 scopus 로고    scopus 로고
    • Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
    • Yang H, Yang T, Baur JA, etal. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 2007;130:1095-1107.
    • (2007) Cell , vol.130 , pp. 1095-1107
    • Yang, H.1    Yang, T.2    Baur, J.A.3
  • 23
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005;1:361-370.
    • (2005) Cell Metab , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 24
    • 77952547233 scopus 로고    scopus 로고
    • Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
    • Imai S, Guarente L. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci. 2010;31:212-220.
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 212-220
    • Imai, S.1    Guarente, L.2
  • 25
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005;434:113-118.
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 26
    • 46249100836 scopus 로고    scopus 로고
    • Tissue-specific regulation of SIRT1 by calorie restriction
    • Chen D, Bruno J, Easlon E, etal. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 2008;22:1753-1757.
    • (2008) Genes Dev , vol.22 , pp. 1753-1757
    • Chen, D.1    Bruno, J.2    Easlon, E.3
  • 27
    • 33244486764 scopus 로고    scopus 로고
    • Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
    • Bordone L, Motta MC, Picard F, etal. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 2006;4:e31.
    • (2006) PLoS Biol , vol.4
    • Bordone, L.1    Motta, M.C.2    Picard, F.3
  • 28
    • 33746824192 scopus 로고    scopus 로고
    • Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    • Qin W, Yang T, Ho L, etal. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006;281:21745-21754.
    • (2006) J Biol Chem , vol.281 , pp. 21745-21754
    • Qin, W.1    Yang, T.2    Ho, L.3
  • 29
    • 42349085704 scopus 로고    scopus 로고
    • Sirt1 contributes critically to the redox-dependent fate of neural progenitors
    • Prozorovski T, Schulze-Topphoff U, Glumm R, etal. Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat Cell Biol. 2008;10:385-394.
    • (2008) Nat Cell Biol , vol.10 , pp. 385-394
    • Prozorovski, T.1    Schulze-Topphoff, U.2    Glumm, R.3
  • 30
    • 54049158932 scopus 로고    scopus 로고
    • Brain SIRT1: anatomical distribution and regulation by energy availability
    • Ramadori G, Lee CE, Bookout AL, etal. Brain SIRT1: anatomical distribution and regulation by energy availability. J Neurosci. 2008;28:9989-9996.
    • (2008) J Neurosci , vol.28 , pp. 9989-9996
    • Ramadori, G.1    Lee, C.E.2    Bookout, A.L.3
  • 31
    • 33947710793 scopus 로고    scopus 로고
    • Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
    • Civitarese AE, Carling S, Heilbronn LK, etal. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 2007;4:e76.
    • (2007) PLoS Med , vol.4
    • Civitarese, A.E.1    Carling, S.2    Heilbronn, L.K.3
  • 32
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging
    • Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA. 2009;106:20405-20410.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20405-20410
    • Wenz, T.1    Rossi, S.G.2    Rotundo, R.L.3    Spiegelman, B.M.4    Moraes, C.T.5
  • 33
    • 0030729851 scopus 로고    scopus 로고
    • High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
    • Korshunov SS, Skulachev VP, Starkov AA. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 1997;416:15-18.
    • (1997) FEBS Lett , vol.416 , pp. 15-18
    • Korshunov, S.S.1    Skulachev, V.P.2    Starkov, A.A.3
  • 34
    • 0036965865 scopus 로고    scopus 로고
    • Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells
    • Duval C, Negre-Salvayre A, Dogilo A, Salvayre R, Penicaud L, Casteilla L. Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells. Biochem Cell Biol. 2002;80:757-764.
    • (2002) Biochem Cell Biol , vol.80 , pp. 757-764
    • Duval, C.1    Negre-Salvayre, A.2    Dogilo, A.3    Salvayre, R.4    Penicaud, L.5    Casteilla, L.6
  • 35
    • 0031832185 scopus 로고    scopus 로고
    • Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?
    • Samec S, Seydoux J, Dulloo AG. Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB J. 1998;12:715-724.
    • (1998) FASEB J , vol.12 , pp. 715-724
    • Samec, S.1    Seydoux, J.2    Dulloo, A.G.3
  • 36
    • 0036320408 scopus 로고    scopus 로고
    • Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women
    • Harper ME, Dent R, Monemdjou S, etal. Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women. Diabetes. 2002;51:2459-2466.
    • (2002) Diabetes , vol.51 , pp. 2459-2466
    • Harper, M.E.1    Dent, R.2    Monemdjou, S.3
  • 37
    • 77954534139 scopus 로고    scopus 로고
    • Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria
    • Toime LJ, Brand MD. Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria. Free Radic Biol Med. 2010;49(4):606-611.
    • (2010) Free Radic Biol Med , vol.49 , Issue.4 , pp. 606-611
    • Toime, L.J.1    Brand, M.D.2
  • 38
    • 38349108752 scopus 로고    scopus 로고
    • Mitochondrial dysfunction as a cause of ageing
    • Trifunovic A, Larsson NG. Mitochondrial dysfunction as a cause of ageing. J Intern Med. 2008;263:167-178.
    • (2008) J Intern Med , vol.263 , pp. 167-178
    • Trifunovic, A.1    Larsson, N.G.2
  • 39
    • 75149128169 scopus 로고    scopus 로고
    • The life span-prolonging effect of sirtuin-1 is mediated by autophagy
    • Morselli E, Maiuri MC, Markaki M, etal. The life span-prolonging effect of sirtuin-1 is mediated by autophagy. Autophagy. 2010;6:186-188.
    • (2010) Autophagy , vol.6 , pp. 186-188
    • Morselli, E.1    Maiuri, M.C.2    Markaki, M.3
  • 40
    • 77950806433 scopus 로고    scopus 로고
    • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    • Hirschey MD, Shimazu T, Goetzman E, etal. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010;464:121-125.
    • (2010) Nature , vol.464 , pp. 121-125
    • Hirschey, M.D.1    Shimazu, T.2    Goetzman, E.3
  • 41
    • 33744534981 scopus 로고    scopus 로고
    • Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage
    • Sanz A, Caro P, Sanchez JG, Barja G. Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage. Ann N Y Acad Sci. 2006;1067:200-209.
    • (2006) Ann N Y Acad Sci , vol.1067 , pp. 200-209
    • Sanz, A.1    Caro, P.2    Sanchez, J.G.3    Barja, G.4
  • 42
    • 33845635647 scopus 로고    scopus 로고
    • Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage
    • Sanz A, Gomez J, Caro P, Barja G. Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage. J Bioenerg Biomembr. 2006;38:327-333.
    • (2006) J Bioenerg Biomembr , vol.38 , pp. 327-333
    • Sanz, A.1    Gomez, J.2    Caro, P.3    Barja, G.4
  • 43
    • 72949117234 scopus 로고    scopus 로고
    • Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
    • Grandison RC, Piper MD, Partridge L. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature. 2009;462:1061-1064.
    • (2009) Nature , vol.462 , pp. 1061-1064
    • Grandison, R.C.1    Piper, M.D.2    Partridge, L.3
  • 44
    • 33745597874 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection
    • Pamplona R, Barja G. Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection. Biochim Biophys Acta. 2006;1757:496-508.
    • (2006) Biochim Biophys Acta , vol.1757 , pp. 496-508
    • Pamplona, R.1    Barja, G.2
  • 45
    • 49449112344 scopus 로고    scopus 로고
    • Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction possible implications for humans
    • Lopez-Torres M, Barja G. Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction possible implications for humans. Biochim Biophys Acta. 2008;1780:1337-1347.
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 1337-1347
    • Lopez-Torres, M.1    Barja, G.2
  • 46
    • 13844256455 scopus 로고    scopus 로고
    • Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liver
    • Sanz A, Caro P, Barja G. Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liver. J Bioenerg Biomembr. 2004;36:545-552.
    • (2004) J Bioenerg Biomembr , vol.36 , pp. 545-552
    • Sanz, A.1    Caro, P.2    Barja, G.3
  • 47
    • 33745970444 scopus 로고    scopus 로고
    • Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins
    • Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona R, Barja G. Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins. FASEB J. 2006;20:1064-1073.
    • (2006) FASEB J , vol.20 , pp. 1064-1073
    • Sanz, A.1    Caro, P.2    Ayala, V.3    Portero-Otin, M.4    Pamplona, R.5    Barja, G.6
  • 48
    • 34548418947 scopus 로고    scopus 로고
    • Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver
    • Gomez J, Caro P, Naudi A, Portero-Otin M, Pamplona R, Barja G. Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver. Biogerontology. 2007;8:555-566.
    • (2007) Biogerontology , vol.8 , pp. 555-566
    • Gomez, J.1    Caro, P.2    Naudi, A.3    Portero-Otin, M.4    Pamplona, R.5    Barja, G.6
  • 49
    • 33646776442 scopus 로고    scopus 로고
    • Toxicity of methionine in humans
    • Garlick PJ. Toxicity of methionine in humans. J Nutr. 2006;136(Suppl 6):S1722-S1725.
    • (2006) J Nutr , vol.136 , Issue.6 SUPPL
    • Garlick, P.J.1
  • 50
    • 69449103947 scopus 로고    scopus 로고
    • Inherited disorders in the conversion of methionine to homocysteine
    • Baric I. Inherited disorders in the conversion of methionine to homocysteine. J Inherit Metab Dis. 2009;32:459-471.
    • (2009) J Inherit Metab Dis , vol.32 , pp. 459-471
    • Baric, I.1
  • 52
    • 0037046185 scopus 로고    scopus 로고
    • Resting oxygen consumption and in vivo ADP are increased in myopathy due to complex I deficiency
    • Roef MJ, Reijngoud DJ, Jeneson JA, Berger R, de Meer K. Resting oxygen consumption and in vivo ADP are increased in myopathy due to complex I deficiency. Neurology. 2002;58:1088-1093.
    • (2002) Neurology , vol.58 , pp. 1088-1093
    • Roef, M.J.1    Reijngoud, D.J.2    Jeneson, J.A.3    Berger, R.4    de Meer, K.5
  • 53
    • 35548999739 scopus 로고    scopus 로고
    • Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes
    • Pospisilik JA, Knauf C, Joza N, etal. Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell. 2007;131:476-491.
    • (2007) Cell , vol.131 , pp. 476-491
    • Pospisilik, J.A.1    Knauf, C.2    Joza, N.3
  • 54
    • 58149376277 scopus 로고    scopus 로고
    • Mitochondrial energy production correlates with the age-related BMI
    • Wortmann SB, Zweers-van Essen H, Rodenburg RJ, etal. Mitochondrial energy production correlates with the age-related BMI. Pediatr Res. 2009;65:103-108.
    • (2009) Pediatr Res , vol.65 , pp. 103-108
    • Wortmann, S.B.1    Zweers-van Essen, H.2    Rodenburg, R.J.3
  • 56
  • 57
    • 0036157127 scopus 로고    scopus 로고
    • Triacylglycerol infusion improves exercise endurance in patients with mitochondrial myopathy due to complex I deficiency
    • Roef MJ, de Meer K, Reijngoud DJ, etal. Triacylglycerol infusion improves exercise endurance in patients with mitochondrial myopathy due to complex I deficiency. Am J Clin Nutr. 2002;75:237-244.
    • (2002) Am J Clin Nutr , vol.75 , pp. 237-244
    • Roef, M.J.1    de Meer, K.2    Reijngoud, D.J.3
  • 58
    • 0006132932 scopus 로고    scopus 로고
    • Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
    • Kliewer SA, Sundseth SS, Jones SA, etal. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci USA. 1997;94:4318-4323.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4318-4323
    • Kliewer, S.A.1    Sundseth, S.S.2    Jones, S.A.3
  • 59
    • 45549089279 scopus 로고    scopus 로고
    • High-fat diets cause insulin resistance despite an increase in muscle mitochondria
    • Hancock CR, Han DH, Chen M, etal. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc Natl Acad Sci U S A. 2008;105:7815-7820.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 7815-7820
    • Hancock, C.R.1    Han, D.H.2    Chen, M.3
  • 60
    • 62949137030 scopus 로고    scopus 로고
    • Ketogenic diets: evidence for short- and long-term efficacy
    • Kossoff EH, Rho JM. Ketogenic diets: evidence for short- and long-term efficacy. Neurotherapeutics. 2009;6:406-414.
    • (2009) Neurotherapeutics , vol.6 , pp. 406-414
    • Kossoff, E.H.1    Rho, J.M.2
  • 61
    • 33846212708 scopus 로고    scopus 로고
    • Safe and effective use of the ketogenic diet in children with epilepsy and mitochondrial respiratory chain complex defects
    • Kang HC, Lee YM, Kim HD, Lee JS, Slama A. Safe and effective use of the ketogenic diet in children with epilepsy and mitochondrial respiratory chain complex defects. Epilepsia. 2007;48:82-88.
    • (2007) Epilepsia , vol.48 , pp. 82-88
    • Kang, H.C.1    Lee, Y.M.2    Kim, H.D.3    Lee, J.S.4    Slama, A.5
  • 64
    • 60749090581 scopus 로고    scopus 로고
    • The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
    • Maalouf M, Rho JM, Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev. 2009;59:293-315.
    • (2009) Brain Res Rev , vol.59 , pp. 293-315
    • Maalouf, M.1    Rho, J.M.2    Mattson, M.P.3
  • 65
    • 33746848935 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
    • Bough KJ, Wetherington J, Hassel B, etal. Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann Neurol. 2006;60:223-235.
    • (2006) Ann Neurol , vol.60 , pp. 223-235
    • Bough, K.J.1    Wetherington, J.2    Hassel, B.3
  • 66
    • 44549083390 scopus 로고    scopus 로고
    • Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets?
    • Masino SA, Geiger JD. Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets? Trends Neurosci. 2008;31:273-278.
    • (2008) Trends Neurosci , vol.31 , pp. 273-278
    • Masino, S.A.1    Geiger, J.D.2
  • 67
    • 33846852428 scopus 로고    scopus 로고
    • Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation
    • Maalouf M, Sullivan PG, Davis L, Kim DY, Rho JM. Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience. 2007;145:256-264.
    • (2007) Neuroscience , vol.145 , pp. 256-264
    • Maalouf, M.1    Sullivan, P.G.2    Davis, L.3    Kim, D.Y.4    Rho, J.M.5
  • 68
    • 9144268527 scopus 로고    scopus 로고
    • Ketogenic treatment reduces deleted mitochondrial DNAs in cultured human cells
    • Santra S, Gilkerson RW, Davidson M, Schon EA. Ketogenic treatment reduces deleted mitochondrial DNAs in cultured human cells. Ann Neurol. 2004;56:662-669.
    • (2004) Ann Neurol , vol.56 , pp. 662-669
    • Santra, S.1    Gilkerson, R.W.2    Davidson, M.3    Schon, E.A.4
  • 69
    • 0036236378 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor alpha-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain
    • Cullingford TE, Dolphin CT, Sato H. The peroxisome proliferator-activated receptor alpha-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain. Neuropharmacology. 2002;42:724-730.
    • (2002) Neuropharmacology , vol.42 , pp. 724-730
    • Cullingford, T.E.1    Dolphin, C.T.2    Sato, H.3
  • 70
    • 0036281644 scopus 로고    scopus 로고
    • The ketogenic diet upregulates expression of the gene encoding the key ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in rat brain
    • Cullingford TE, Eagles DA, Sato H. The ketogenic diet upregulates expression of the gene encoding the key ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in rat brain. Epilepsy Res. 2002;49:99-107.
    • (2002) Epilepsy Res , vol.49 , pp. 99-107
    • Cullingford, T.E.1    Eagles, D.A.2    Sato, H.3
  • 71
  • 72
    • 0033524415 scopus 로고    scopus 로고
    • Ligand selectivity of the peroxisome proliferator-activated receptor alpha
    • Lin Q, Ruuska SE, Shaw NS, Dong D, Noy N. Ligand selectivity of the peroxisome proliferator-activated receptor alpha. Biochemistry. 1999;38:185-190.
    • (1999) Biochemistry , vol.38 , pp. 185-190
    • Lin, Q.1    Ruuska, S.E.2    Shaw, N.S.3    Dong, D.4    Noy, N.5
  • 73
    • 77952485613 scopus 로고    scopus 로고
    • Ketogenic diet slows down mitochondrial myopathy progression in mice
    • Ahola-Erkkila S, Carroll CJ, Peltola-Mjosund K, etal. Ketogenic diet slows down mitochondrial myopathy progression in mice. Hum Mol Genet. 2010;19:1974-1984.
    • (2010) Hum Mol Genet , vol.19 , pp. 1974-1984
    • Ahola-Erkkila, S.1    Carroll, C.J.2    Peltola-Mjosund, K.3
  • 74
    • 65449133905 scopus 로고    scopus 로고
    • PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders
    • Srivastava S, Diaz F, Iommarini L, Aure K, Lombes A, Moraes CT. PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders. Hum Mol Genet. 2009;18:1805-1812.
    • (2009) Hum Mol Genet , vol.18 , pp. 1805-1812
    • Srivastava, S.1    Diaz, F.2    Iommarini, L.3    Aure, K.4    Lombes, A.5    Moraes, C.T.6
  • 75
    • 50049118173 scopus 로고    scopus 로고
    • Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype
    • Wenz T, Diaz F, Spiegelman BM, Moraes CT. Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab. 2008;8:249-256.
    • (2008) Cell Metab , vol.8 , pp. 249-256
    • Wenz, T.1    Diaz, F.2    Spiegelman, B.M.3    Moraes, C.T.4
  • 76
    • 42049114658 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components
    • Bastin J, Aubey F, Rotig A, Munnich A, Djouadi F. Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components. J Clin Endocrinol Metab. 2008;93:1433-1441.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1433-1441
    • Bastin, J.1    Aubey, F.2    Rotig, A.3    Munnich, A.4    Djouadi, F.5
  • 77
    • 0034730011 scopus 로고    scopus 로고
    • Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency
    • Rotig A, Appelkvist EL, Geromel V, etal. Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency. Lancet. 2000;356:391-395.
    • (2000) Lancet , vol.356 , pp. 391-395
    • Rotig, A.1    Appelkvist, E.L.2    Geromel, V.3
  • 78
    • 1842523325 scopus 로고    scopus 로고
    • Cofactor treatment improves ATP synthetic capacity in patients with oxidative phosphorylation disorders
    • Marriage BJ, Clandinin MT, Macdonald IM, Glerum DM. Cofactor treatment improves ATP synthetic capacity in patients with oxidative phosphorylation disorders. Mol Genet Metab. 2004;81:263-272.
    • (2004) Mol Genet Metab , vol.81 , pp. 263-272
    • Marriage, B.J.1    Clandinin, M.T.2    Macdonald, I.M.3    Glerum, D.M.4
  • 79
    • 76349123010 scopus 로고    scopus 로고
    • Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade
    • Kerr DS. Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade. Mol Genet Metab. 2009;99:246-255.
    • (2009) Mol Genet Metab , vol.99 , pp. 246-255
    • Kerr, D.S.1
  • 81
    • 0031253821 scopus 로고    scopus 로고
    • Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia
    • Rotig A, de Lonlay P, Chretien D, etal. Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nat Genet. 1997;17:215-217.
    • (1997) Nat Genet , vol.17 , pp. 215-217
    • Rotig, A.1    de Lonlay, P.2    Chretien, D.3
  • 82
    • 34548606803 scopus 로고    scopus 로고
    • Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial
    • Di Prospero NA, Baker A, Jeffries N, Fischbeck KH. Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial. Lancet Neurol. 2007;6:878-886.
    • (2007) Lancet Neurol , vol.6 , pp. 878-886
    • Di Prospero, N.A.1    Baker, A.2    Jeffries, N.3    Fischbeck, K.H.4
  • 83
    • 70349330674 scopus 로고    scopus 로고
    • Prolonged intake of coenzyme Q10 impairs cognitive functions in mice
    • Sumien N, Heinrich KR, Shetty RA, Sohal RS, Forster MJ. Prolonged intake of coenzyme Q10 impairs cognitive functions in mice. J Nutr. 2009;139:1926-1932.
    • (2009) J Nutr , vol.139 , pp. 1926-1932
    • Sumien, N.1    Heinrich, K.R.2    Shetty, R.A.3    Sohal, R.S.4    Forster, M.J.5
  • 84
    • 0021449807 scopus 로고
    • 31P NMR study of improvement in oxidative phosphorylation by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle
    • Eleff S, Kennaway NG, Buist NR, etal. 31P NMR study of improvement in oxidative phosphorylation by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle. Proc Natl Acad Sci USA. 1984;81:3529-3533.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 3529-3533
    • Eleff, S.1    Kennaway, N.G.2    Buist, N.R.3
  • 85
    • 0033619147 scopus 로고    scopus 로고
    • Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA
    • Andreu AL, Hanna MG, Reichmann H, etal. Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA. N Engl J Med. 1999;341:1037-1044.
    • (1999) N Engl J Med , vol.341 , pp. 1037-1044
    • Andreu, A.L.1    Hanna, M.G.2    Reichmann, H.3
  • 86
    • 0030731246 scopus 로고    scopus 로고
    • A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies
    • Tarnopolsky MA, Roy BD, MacDonald JR. A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve. 1997;20:1502-1509.
    • (1997) Muscle Nerve , vol.20 , pp. 1502-1509
    • Tarnopolsky, M.A.1    Roy, B.D.2    MacDonald, J.R.3
  • 87
    • 0034642154 scopus 로고    scopus 로고
    • A placebo-controlled crossover trial of creatine in mitochondrial diseases
    • Klopstock T, Querner V, Schmidt F, etal. A placebo-controlled crossover trial of creatine in mitochondrial diseases. Neurology. 2000;55:1748-1751.
    • (2000) Neurology , vol.55 , pp. 1748-1751
    • Klopstock, T.1    Querner, V.2    Schmidt, F.3
  • 89
    • 0024246260 scopus 로고
    • Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblasts
    • Treem WR, Stanley CA, Finegold DN, Hale DE, Coates PM. Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblasts. N Engl J Med. 1988;319:1331-1336.
    • (1988) N Engl J Med , vol.319 , pp. 1331-1336
    • Treem, W.R.1    Stanley, C.A.2    Finegold, D.N.3    Hale, D.E.4    Coates, P.M.5
  • 90
    • 0033955887 scopus 로고    scopus 로고
    • Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: a common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation
    • Infante JP, Huszagh VA. Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: a common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation. FEBS Lett. 2000;468:1-5.
    • (2000) FEBS Lett , vol.468 , pp. 1-5
    • Infante, J.P.1    Huszagh, V.A.2
  • 91
    • 0029135075 scopus 로고
    • CPEO and carnitine deficiency overlapping in MELAS syndrome
    • Hsu CC, Chuang YH, Tsai JL, etal. CPEO and carnitine deficiency overlapping in MELAS syndrome. Acta Neurol Scand. 1995;92:252-255.
    • (1995) Acta Neurol Scand , vol.92 , pp. 252-255
    • Hsu, C.C.1    Chuang, Y.H.2    Tsai, J.L.3
  • 92
    • 0023270881 scopus 로고
    • Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy
    • Ohama E, Ohara S, Ikuta F, Tanaka K, Nishizawa M, Miyatake T. Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy. Acta Neuropathol. 1987;74:226-233.
    • (1987) Acta Neuropathol , vol.74 , pp. 226-233
    • Ohama, E.1    Ohara, S.2    Ikuta, F.3    Tanaka, K.4    Nishizawa, M.5    Miyatake, T.6
  • 93
    • 13844321746 scopus 로고    scopus 로고
    • L-arginine improves the symptoms of strokelike episodes in MELAS
    • Koga Y, Akita Y, Nishioka J, etal. L-arginine improves the symptoms of strokelike episodes in MELAS. Neurology. 2005;64:710-712.
    • (2005) Neurology , vol.64 , pp. 710-712
    • Koga, Y.1    Akita, Y.2    Nishioka, J.3
  • 95
    • 70450247586 scopus 로고    scopus 로고
    • Expressing the alternative oxidase complements cytochrome c oxidase deficiency in human cells
    • Dassa EP, Dufour E, Goncalves S, etal. Expressing the alternative oxidase complements cytochrome c oxidase deficiency in human cells. EMBO Mol Med. 2009;1:30-36.
    • (2009) EMBO Mol Med , vol.1 , pp. 30-36
    • Dassa, E.P.1    Dufour, E.2    Goncalves, S.3
  • 97
    • 76149121171 scopus 로고    scopus 로고
    • Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis
    • Acin-Perez R, Hoyos B, Zhao F, etal. Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. FASEB J. 2010;24:627-636.
    • (2010) FASEB J , vol.24 , pp. 627-636
    • Acin-Perez, R.1    Hoyos, B.2    Zhao, F.3
  • 99
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med. 2004;350:664-671.
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 100
    • 34249681435 scopus 로고    scopus 로고
    • Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes
    • Szendroedi J, Schmid AI, Chmelik M, etal. Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes. PLoS Med. 2007;4:e154.
    • (2007) PLoS Med , vol.4
    • Szendroedi, J.1    Schmid, A.I.2    Chmelik, M.3
  • 101
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes. 2002;51:2944-2950.
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 103
    • 31044433308 scopus 로고    scopus 로고
    • Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
    • Morino K, Petersen KF, Dufour S, etal. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest. 2005;115:3587-3593.
    • (2005) J Clin Invest , vol.115 , pp. 3587-3593
    • Morino, K.1    Petersen, K.F.2    Dufour, S.3
  • 104
  • 105
    • 34249720640 scopus 로고    scopus 로고
    • Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes
    • Mogensen M, Sahlin K, Fernstrom M, etal. Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes. 2007;56:1592-1599.
    • (2007) Diabetes , vol.56 , pp. 1592-1599
    • Mogensen, M.1    Sahlin, K.2    Fernstrom, M.3
  • 107
    • 58149379936 scopus 로고    scopus 로고
    • Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance
    • Suppl
    • Holloszy JO. Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance. Am J Clin Nutr. 2009;89(Suppl):S463-S466.
    • (2009) Am J Clin Nutr , vol.89
    • Holloszy, J.O.1
  • 108
    • 50949116173 scopus 로고    scopus 로고
    • Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function
    • Hammer S, Snel M, Lamb HJ, etal. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. J Am Coll Cardiol. 2008;52:1006-1012.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1006-1012
    • Hammer, S.1    Snel, M.2    Lamb, H.J.3
  • 109
    • 34547596186 scopus 로고    scopus 로고
    • Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes
    • Toledo FG, Menshikova EV, Ritov VB, etal. Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes. 2007;56:2142-2147.
    • (2007) Diabetes , vol.56 , pp. 2142-2147
    • Toledo, F.G.1    Menshikova, E.V.2    Ritov, V.B.3
  • 110
    • 0033377625 scopus 로고    scopus 로고
    • Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk
    • Lane MA, Ingram DK, Roth GS. Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk. Toxicol Sci. 1999;52(Suppl 2):41-48.
    • (1999) Toxicol Sci , vol.52 , Issue.2 SUPPL , pp. 41-48
    • Lane, M.A.1    Ingram, D.K.2    Roth, G.S.3
  • 111
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, etal. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337-342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 112
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z, etal. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127:1109-1122.
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 114
    • 52749091816 scopus 로고    scopus 로고
    • SirT1 gain of function increases energy efficiency and prevents diabetes in mice
    • Banks AS, Kon N, Knight C, etal. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 2008;8:333-341.
    • (2008) Cell Metab , vol.8 , pp. 333-341
    • Banks, A.S.1    Kon, N.2    Knight, C.3
  • 115
    • 55549110913 scopus 로고    scopus 로고
    • Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes
    • De Feyter HM, Lenaers E, Houten SM, etal. Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes. FASEB J. 2008;22:3947-3955.
    • (2008) FASEB J , vol.22 , pp. 3947-3955
    • De Feyter, H.M.1    Lenaers, E.2    Houten, S.M.3
  • 117
    • 39149135842 scopus 로고    scopus 로고
    • Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding
    • Hoeks J, Briede JJ, de Vogel J, etal. Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding. FEBS Lett. 2008;582:510-516.
    • (2008) FEBS Lett , vol.582 , pp. 510-516
    • Hoeks, J.1    Briede, J.J.2    de Vogel, J.3
  • 118
    • 33749041269 scopus 로고    scopus 로고
    • Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance
    • Wredenberg A, Freyer C, Sandstrom ME, etal. Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance. Biochem Biophys Res Commun. 2006;350:202-207.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 202-207
    • Wredenberg, A.1    Freyer, C.2    Sandstrom, M.E.3
  • 119
    • 34548133215 scopus 로고    scopus 로고
    • Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease
    • 2nd.
    • Atamna H, Frey WH 2nd. Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease. Mitochondrion. 2007;7:297-310.
    • (2007) Mitochondrion , vol.7 , pp. 297-310
    • Atamna, H.1    Frey, W.H.2
  • 120
    • 77953666757 scopus 로고    scopus 로고
    • Parkinson's disease mutations in PINK1 result in decreased complex I activity and deficient synaptic function
    • Morais VA, Verstreken P, Roethig A, etal. Parkinson's disease mutations in PINK1 result in decreased complex I activity and deficient synaptic function. EMBO Mol Med. 2009;1:99-111.
    • (2009) EMBO Mol Med , vol.1 , pp. 99-111
    • Morais, V.A.1    Verstreken, P.2    Roethig, A.3
  • 121
    • 19944427435 scopus 로고    scopus 로고
    • Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
    • Maswood N, Young J, Tilmont E, etal. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci U S A. 2004;101:18171-18176.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 18171-18176
    • Maswood, N.1    Young, J.2    Tilmont, E.3
  • 122
    • 20144386977 scopus 로고    scopus 로고
    • Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alz-heimer's disease
    • Wang J, Ho L, Qin W, etal. Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alz-heimer's disease. FASEB J. 2005;19:659-661.
    • (2005) FASEB J , vol.19 , pp. 659-661
    • Wang, J.1    Ho, L.2    Qin, W.3
  • 123
    • 70149092727 scopus 로고    scopus 로고
    • Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice
    • Mouton PR, Chachich ME, Quigley C, Spangler E, Ingram DK. Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice. Neurosci Lett. 2009;464:184-187.
    • (2009) Neurosci Lett , vol.464 , pp. 184-187
    • Mouton, P.R.1    Chachich, M.E.2    Quigley, C.3    Spangler, E.4    Ingram, D.K.5
  • 124
    • 34447308268 scopus 로고    scopus 로고
    • SIRT1 deacetylase protects against neurodegeneration in models for Alz-heimer's disease and amyotrophic lateral sclerosis
    • Kim D, Nguyen MD, Dobbin MM, etal. SIRT1 deacetylase protects against neurodegeneration in models for Alz-heimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007;26:3169-3179.
    • (2007) EMBO J , vol.26 , pp. 3169-3179
    • Kim, D.1    Nguyen, M.D.2    Dobbin, M.M.3
  • 125
    • 33845942205 scopus 로고    scopus 로고
    • Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
    • Okawara M, Katsuki H, Kurimoto E, Shibata H, Kume T, Akaike A. Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochem Pharmacol. 2007;73:550-560.
    • (2007) Biochem Pharmacol , vol.73 , pp. 550-560
    • Okawara, M.1    Katsuki, H.2    Kurimoto, E.3    Shibata, H.4    Kume, T.5    Akaike, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.