-
1
-
-
13944262937
-
Understanding the odd science of aging
-
Kirkwood TB. Understanding the odd science of aging. Cell 2005 120 : 437 47.
-
(2005)
Cell
, vol.120
, pp. 437-47
-
-
Kirkwood, T.B.1
-
2
-
-
13844249825
-
Is aging programed?
-
Austad SN. Is aging programed? Aging Cell 2004 3 : 249 51.
-
(2004)
Aging Cell
, vol.3
, pp. 249-51
-
-
Austad, S.N.1
-
3
-
-
0015319592
-
The biologic clock: The mitochondria?
-
Harman D. The biologic clock: the mitochondria? J Am Geriatr Soc 1972 20 : 145 7.
-
(1972)
J Am Geriatr Soc
, vol.20
, pp. 145-7
-
-
Harman, D.1
-
4
-
-
0033525924
-
Oxidative phosphorylation at the fin de siecle
-
Saraste M. Oxidative phosphorylation at the fin de siecle. Science 1999 283 : 1488 93.
-
(1999)
Science
, vol.283
, pp. 1488-93
-
-
Saraste, M.1
-
5
-
-
0034520923
-
The rotary mechanism of ATP synthase
-
Stock D, Gibbons C, Arechaga I, Leslie AG, Walker JE. The rotary mechanism of ATP synthase. Curr Opin Struct Biol 2000 10 : 672 9.
-
(2000)
Curr Opin Struct Biol
, vol.10
, pp. 672-9
-
-
Stock, D.1
Gibbons, C.2
Arechaga, I.3
Leslie, A.G.4
Walker, J.E.5
-
6
-
-
33745605166
-
Uncoupling proteins: A role in protection against reactive oxygen species-or not?
-
Cannon B, Shabalina IG, Kramarova TV, Petrovic N, Nedergaard J. Uncoupling proteins: a role in protection against reactive oxygen species-or not? Biochim Biophys Acta 2006 1757 : 449 58.
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 449-58
-
-
Cannon, B.1
Shabalina, I.G.2
Kramarova, T.V.3
Petrovic, N.4
Nedergaard, J.5
-
8
-
-
17144429302
-
Calorie restriction, SIRT1 and metabolism: Understanding longevity
-
Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 2005 6 : 298 305.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 298-305
-
-
Bordone, L.1
Guarente, L.2
-
9
-
-
13944253348
-
Calorie restriction-the SIR2 connection
-
Guarente L, Picard F. Calorie restriction-the SIR2 connection. Cell 2005 120 : 473 82.
-
(2005)
Cell
, vol.120
, pp. 473-82
-
-
Guarente, L.1
Picard, F.2
-
10
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
Lin SJ, Kaeberlein M, Andalis AA et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 2002 418 : 344 8.
-
(2002)
Nature
, vol.418
, pp. 344-8
-
-
Lin, S.J.1
Kaeberlein, M.2
Andalis, A.A.3
-
11
-
-
29244489494
-
Increased life span due to calorie restriction in respiratory-deficient yeast
-
Kaeberlein M, Hu D, Kerr EO et al. Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 2005 1 : e69.
-
(2005)
PLoS Genet
, vol.1
-
-
Kaeberlein, M.1
Hu, D.2
Kerr, E.O.3
-
13
-
-
85044703856
-
No reduction of metabolic rate in food restricted Caenorhabditis elegans
-
Houthoofd K, Braeckman BP, Lenaerts I et al. No reduction of metabolic rate in food restricted Caenorhabditis elegans. Exp Gerontol 2002 37 : 1359 69.
-
(2002)
Exp Gerontol
, vol.37
, pp. 1359-69
-
-
Houthoofd, K.1
Braeckman, B.P.2
Lenaerts, I.3
-
14
-
-
3543062946
-
Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster
-
Hulbert AJ, Clancy DJ, Mair W, Braeckman BP, Gems D, Partridge L. Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Exp Gerontol 2004 39 : 1137 43.
-
(2004)
Exp Gerontol
, vol.39
, pp. 1137-43
-
-
Hulbert, A.J.1
Clancy, D.J.2
Mair, W.3
Braeckman, B.P.4
Gems, D.5
Partridge, L.6
-
15
-
-
34249891333
-
Two neurons mediate diet-restriction-induced longevity in C. elegans
-
Bishop NA, Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 2007 447 : 545 9.
-
(2007)
Nature
, vol.447
, pp. 545-9
-
-
Bishop, N.A.1
Guarente, L.2
-
16
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M, Argmann C, Gerhart-Hines Z et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006 127 : 1109 22.
-
(2006)
Cell
, vol.127
, pp. 1109-22
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
-
17
-
-
33947710793
-
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
-
Civitarese AE, Carling S, Heilbronn LK et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med 2007 4 : e76.
-
(2007)
PLoS Med
, vol.4
-
-
Civitarese, A.E.1
Carling, S.2
Heilbronn, L.K.3
-
18
-
-
0347579845
-
Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide
-
Nisoli E, Clementi E, Paolucci C et al. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 2003 299 : 896 9.
-
(2003)
Science
, vol.299
, pp. 896-9
-
-
Nisoli, E.1
Clementi, E.2
Paolucci, C.3
-
19
-
-
26844558334
-
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
-
Nisoli E, Tonello C, Cardile A et al. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005 310 : 314 7.
-
(2005)
Science
, vol.310
, pp. 314-7
-
-
Nisoli, E.1
Tonello, C.2
Cardile, A.3
-
20
-
-
0021056471
-
A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results
-
Klass MR. A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech Ageing Dev 1983 22 : 279 86.
-
(1983)
Mech Ageing Dev
, vol.22
, pp. 279-86
-
-
Klass, M.R.1
-
21
-
-
0023678537
-
Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene
-
Friedman DB, Johnson TE. Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J Gerontol 1988 43 : B102 9.
-
(1988)
J Gerontol
, vol.43
-
-
Friedman, D.B.1
Johnson, T.E.2
-
22
-
-
0037228016
-
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
-
Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 2003 33 : 40 8.
-
(2003)
Nat Genet
, vol.33
, pp. 40-8
-
-
Lee, S.S.1
Lee, R.Y.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Ruvkun, G.6
-
23
-
-
0035515923
-
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
-
Feng J, Bussiere F, Hekimi S. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell 2001 1 : 633 44.
-
(2001)
Dev Cell
, vol.1
, pp. 633-44
-
-
Feng, J.1
Bussiere, F.2
Hekimi, S.3
-
24
-
-
0037147103
-
Rates of behavior and aging specified by mitochondrial function during development
-
Dillin A, Hsu AL, Arantes-Oliveira N et al. Rates of behavior and aging specified by mitochondrial function during development. Science 2002 298 : 2398 401.
-
(2002)
Science
, vol.298
, pp. 2398-401
-
-
Dillin, A.1
Hsu, A.L.2
Arantes-Oliveira, N.3
-
25
-
-
0035834789
-
A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans
-
Senoo-Matsuda N, Yasuda K, Tsuda M et al. A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans. J Biol Chem 2001 276 : 41553 8.
-
(2001)
J Biol Chem
, vol.276
, pp. 41553-8
-
-
Senoo-Matsuda, N.1
Yasuda, K.2
Tsuda, M.3
-
26
-
-
0028950419
-
Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing
-
Wong A, Boutis P, Hekimi S. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 1995 139 : 1247 59.
-
(1995)
Genetics
, vol.139
, pp. 1247-59
-
-
Wong, A.1
Boutis, P.2
Hekimi, S.3
-
27
-
-
0035896557
-
Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans
-
Miyadera H, Amino H, Hiraishi A et al. Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans. J Biol Chem 2001 276 : 7713 6.
-
(2001)
J Biol Chem
, vol.276
, pp. 7713-6
-
-
Miyadera, H.1
Amino, H.2
Hiraishi, A.3
-
28
-
-
11144245002
-
Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1
-
Kayser EB, Sedensky MM, Morgan PG, Hoppel CL. Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1. J Biol Chem 2004 279 : 54479 86.
-
(2004)
J Biol Chem
, vol.279
, pp. 54479-86
-
-
Kayser, E.B.1
Sedensky, M.M.2
Morgan, P.G.3
Hoppel, C.L.4
-
29
-
-
2942598255
-
The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans
-
Kayser EB, Sedensky MM, Morgan PG. The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans. Mech Ageing Dev 2004 125 : 455 64.
-
(2004)
Mech Ageing Dev
, vol.125
, pp. 455-64
-
-
Kayser, E.B.1
Sedensky, M.M.2
Morgan, P.G.3
-
30
-
-
35648947912
-
Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
-
Rea SL, Ventura N, Johnson TE. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol 2007 5 : e259.
-
(2007)
PLoS Biol
, vol.5
-
-
Rea, S.L.1
Ventura, N.2
Johnson, T.E.3
-
31
-
-
26944501617
-
Evolutionary conservation of the clk-1-dependent mechanism of longevity: Loss of mclk1 increases cellular fitness and lifespan in mice
-
Liu X, Jiang N, Hughes B, Bigras E, Shoubridge E, Hekimi S. Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev 2005 19 : 2424 34.
-
(2005)
Genes Dev
, vol.19
, pp. 2424-34
-
-
Liu, X.1
Jiang, N.2
Hughes, B.3
Bigras, E.4
Shoubridge, E.5
Hekimi, S.6
-
32
-
-
33847304164
-
Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice
-
Dell'agnello C, Leo S, Agostino A et al. Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice. Hum Mol Genet 2007 16 : 431 44.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 431-44
-
-
Dell'Agnello, C.1
Leo, S.2
Agostino, A.3
-
33
-
-
0025185977
-
A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans
-
Ishii N, Takahashi K, Tomita S et al. A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans. Mutat Res 1990 237 : 165 71.
-
(1990)
Mutat Res
, vol.237
, pp. 165-71
-
-
Ishii, N.1
Takahashi, K.2
Tomita, S.3
-
34
-
-
0034284973
-
Extension of life-span with superoxide dismutase/catalase mimetics
-
Melov S, Ravenscroft J, Malik S et al. Extension of life-span with superoxide dismutase/catalase mimetics. Science 2000 289 : 1567 9.
-
(2000)
Science
, vol.289
, pp. 1567-9
-
-
Melov, S.1
Ravenscroft, J.2
Malik, S.3
-
36
-
-
0029587469
-
Molecular genetic aspects of human mitochondrial disorders
-
Larsson NG, Clayton DA. Molecular genetic aspects of human mitochondrial disorders. Annu Rev Genet 1995 29 : 151 78.
-
(1995)
Annu Rev Genet
, vol.29
, pp. 151-78
-
-
Larsson, N.G.1
Clayton, D.A.2
-
37
-
-
0023883150
-
Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
-
Holt IJ, Harding AE, Morgan-Hughes JA. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 1988 331 : 717 9.
-
(1988)
Nature
, vol.331
, pp. 717-9
-
-
Holt, I.J.1
Harding, A.E.2
Morgan-Hughes, J.A.3
-
38
-
-
0024242545
-
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy
-
Wallace DC, Singh G, Lott MT et al. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science 1988 242 : 1427 30.
-
(1988)
Science
, vol.242
, pp. 1427-30
-
-
Wallace, D.C.1
Singh, G.2
Lott, M.T.3
-
39
-
-
0019978703
-
Replication of animal mitochondrial DNA
-
Clayton DA. Replication of animal mitochondrial DNA. Cell 1982 28 : 693 705.
-
(1982)
Cell
, vol.28
, pp. 693-705
-
-
Clayton, D.A.1
-
40
-
-
0036211772
-
Interfibrillar cardiac mitochondrial comples III defects in the aging rat heart
-
Hoppel CL, Moghaddas S, Lesnefsky EJ. Interfibrillar cardiac mitochondrial comples III defects in the aging rat heart. Biogerontology 2002 3 : 41 4.
-
(2002)
Biogerontology
, vol.3
, pp. 41-4
-
-
Hoppel, C.L.1
Moghaddas, S.2
Lesnefsky, E.J.3
-
41
-
-
0023944266
-
Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging
-
Piko L, Hougham AJ, Bulpitt KJ. Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging. Mech Ageing Dev 1988 43 : 279 93.
-
(1988)
Mech Ageing Dev
, vol.43
, pp. 279-93
-
-
Piko, L.1
Hougham, A.J.2
Bulpitt, K.J.3
-
42
-
-
0024328562
-
Multiple populations of deleted mitochondrial DNA detected by a novel gene amplification method
-
Sato W, Tanaka M, Ohno K, Yamamoto T, Takada G, Ozawa T. Multiple populations of deleted mitochondrial DNA detected by a novel gene amplification method. Biochem Biophys Res Commun 1989 162 : 664 72.
-
(1989)
Biochem Biophys Res Commun
, vol.162
, pp. 664-72
-
-
Sato, W.1
Tanaka, M.2
Ohno, K.3
Yamamoto, T.4
Takada, G.5
Ozawa, T.6
-
43
-
-
0027021442
-
Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain
-
Soong NW, Hinton DR, Cortopassi G, Arnheim N. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet 1992 2 : 318 23.
-
(1992)
Nat Genet
, vol.2
, pp. 318-23
-
-
Soong, N.W.1
Hinton, D.R.2
Cortopassi, G.3
Arnheim, N.4
-
44
-
-
0027017232
-
Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age
-
Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, Wallace DC. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat Genet 1992 2 : 324 9.
-
(1992)
Nat Genet
, vol.2
, pp. 324-9
-
-
Corral-Debrinski, M.1
Horton, T.2
Lott, M.T.3
Shoffner, J.M.4
Beal, M.F.5
Wallace, D.C.6
-
45
-
-
0024580556
-
Decline in skeletal muscle mitochondrial respiratory chain function: Possible factor in ageing
-
Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1989 1(8639) : 637 9.
-
(1989)
Lancet
, vol.1
, Issue.8639
, pp. 637-9
-
-
Trounce, I.1
Byrne, E.2
Marzuki, S.3
-
46
-
-
0024980878
-
Liver mitochondrial respiratory functions decline with age
-
Yen T-C, Chen Y-S, King K-L, Yeh S-H, Wei Y-H. Liver mitochondrial respiratory functions decline with age. Biochem Biophys Res Commun 1989 165 : 994 1003.
-
(1989)
Biochem Biophys Res Commun
, vol.165
, pp. 994-1003
-
-
Yen, T.-C.1
Chen, Y.-S.2
King, K.-L.3
Yeh, S.-H.4
Wei, Y.-H.5
-
47
-
-
0024541837
-
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
-
Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989 1(8639) : 642 5.
-
(1989)
Lancet
, vol.1
, Issue.8639
, pp. 642-5
-
-
Linnane, A.W.1
Marzuki, S.2
Ozawa, T.3
Tanaka, M.4
-
48
-
-
15944396616
-
Mitochondrial encephalomyopathies: An update
-
DiMauro S, Hirano M. Mitochondrial encephalomyopathies: an update. Neuromuscul Disord 2005 15 : 276 86.
-
(2005)
Neuromuscul Disord
, vol.15
, pp. 276-86
-
-
Dimauro, S.1
Hirano, M.2
-
49
-
-
0033595684
-
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
-
Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 1999 286 : 774 9.
-
(1999)
Science
, vol.286
, pp. 774-9
-
-
Michikawa, Y.1
Mazzucchelli, F.2
Bresolin, N.3
Scarlato, G.4
Attardi, G.5
-
50
-
-
0035957323
-
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication
-
Wang Y, Michikawa Y, Mallidis C et al. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci U S A 2001 98 : 4022 7.
-
(2001)
Proc Natl Acad Sci U S a
, vol.98
, pp. 4022-7
-
-
Wang, Y.1
Michikawa, Y.2
Mallidis, C.3
-
52
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A, Wredenberg A, Falkenberg M et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004 429 : 417 23.
-
(2004)
Nature
, vol.429
, pp. 417-23
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
-
53
-
-
29144458899
-
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
-
Trifunovic A, Hansson A, Wredenberg A et al. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci U S A 2005 102 : 17993 8.
-
(2005)
Proc Natl Acad Sci U S a
, vol.102
, pp. 17993-8
-
-
Trifunovic, A.1
Hansson, A.2
Wredenberg, A.3
-
54
-
-
0024366601
-
Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - An age-related phenomenon
-
Mueller-Hocker J. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - an age-related phenomenon. Am J Pathol 1989 134 : 1167 73.
-
(1989)
Am J Pathol
, vol.134
, pp. 1167-73
-
-
Mueller-Hocker, J.1
-
55
-
-
0025673968
-
Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age related alteration
-
Müller-Höcker J. Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age related alteration. J Neurol Sci 1990 100 : 14 21.
-
(1990)
J Neurol Sci
, vol.100
, pp. 14-21
-
-
Müller-Höcker, J.1
-
56
-
-
0347600946
-
Mitochondrial DNA mutations in human colonic crypt stem cells
-
Taylor RW, Barron MJ, Borthwick GM et al. Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest 2003 112 : 1351 60.
-
(2003)
J Clin Invest
, vol.112
, pp. 1351-60
-
-
Taylor, R.W.1
Barron, M.J.2
Borthwick, G.M.3
-
57
-
-
0035112849
-
Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age
-
Cottrell DA, Blakely EL, Johnson MA, Ince PG, Borthwick GM, Turnbull DM. Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age. Neurobiol Aging 2001 22 : 265 72.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 265-72
-
-
Cottrell, D.A.1
Blakely, E.L.2
Johnson, M.A.3
Ince, P.G.4
Borthwick, G.M.5
Turnbull, D.M.6
-
58
-
-
0036408915
-
The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease
-
Cottrell DA, Borthwick GM, Johnson MA, Ince PG, Turnbull DM. The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease. Neuropathol Appl Neurobiol 2002 28 : 390 6.
-
(2002)
Neuropathol Appl Neurobiol
, vol.28
, pp. 390-6
-
-
Cottrell, D.A.1
Borthwick, G.M.2
Johnson, M.A.3
Ince, P.G.4
Turnbull, D.M.5
-
59
-
-
33646375711
-
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
-
Bender A, Krishnan KJ, Morris CM et al. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 2006 38 : 515 7.
-
(2006)
Nat Genet
, vol.38
, pp. 515-7
-
-
Bender, A.1
Krishnan, K.J.2
Morris, C.M.3
-
60
-
-
0036258718
-
Ageing muscle: Clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function
-
Fayet G, Jansson M, Sternberg D et al. Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function. Neuromuscul Disord 2002 12 : 484 93.
-
(2002)
Neuromuscul Disord
, vol.12
, pp. 484-93
-
-
Fayet, G.1
Jansson, M.2
Sternberg, D.3
-
62
-
-
0015363173
-
The cellular production of hydrogen peroxide
-
Boveris A, Oshino N, Chance B. The cellular production of hydrogen peroxide. Biochem J 1972 128 : 617 30.
-
(1972)
Biochem J
, vol.128
, pp. 617-30
-
-
Boveris, A.1
Oshino, N.2
Chance, B.3
-
64
-
-
0033796250
-
Mitochondrial free radical generation, oxidative stress, and aging
-
Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000 29 : 222 30.
-
(2000)
Free Radic Biol Med
, vol.29
, pp. 222-30
-
-
Cadenas, E.1
Davies, K.J.2
-
65
-
-
0018776894
-
Hydroperoxide metabolism in mammalian organs
-
Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979 59 : 527 605.
-
(1979)
Physiol Rev
, vol.59
, pp. 527-605
-
-
Chance, B.1
Sies, H.2
Boveris, A.3
-
66
-
-
0037160091
-
Topology of superoxide production from different sites in the mitochondrial electron transport chain
-
St-Pierre J, Buckingham JA, Roebuck SJ, Brand MD. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 2002 277 : 44784 90.
-
(2002)
J Biol Chem
, vol.277
, pp. 44784-90
-
-
St-Pierre, J.1
Buckingham, J.A.2
Roebuck, S.J.3
Brand, M.D.4
-
67
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 2005 120 : 483 95.
-
(2005)
Cell
, vol.120
, pp. 483-95
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
68
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, Linford NJ, Martin GM et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005 308 : 1909 11.
-
(2005)
Science
, vol.308
, pp. 1909-11
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
-
69
-
-
3242737464
-
Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila
-
Miwa S, Riyahi K, Partridge L, Brand MD. Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila. Ann N Y Acad Sci 2004 1019 : 388 91.
-
(2004)
Ann N Y Acad Sci
, vol.1019
, pp. 388-91
-
-
Miwa, S.1
Riyahi, K.2
Partridge, L.3
Brand, M.D.4
-
70
-
-
0034006162
-
Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice
-
Huang TT, Carlson EJ, Gillespie AM, Shi Y, Epstein CJ. Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. J Gerontol A Biol Sci Med Sci 2000 55 : B5 9.
-
(2000)
J Gerontol a Biol Sci Med Sci
, vol.55
-
-
Huang, T.T.1
Carlson, E.J.2
Gillespie, A.M.3
Shi, Y.4
Epstein, C.J.5
-
71
-
-
0028827252
-
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
-
Li YB, Huang T-T, Carlson EJ et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 1995 11 : 376 81.
-
(1995)
Nat Genet
, vol.11
, pp. 376-81
-
-
Li, Y.B.1
Huang, T.-T.2
Carlson, E.J.3
-
72
-
-
12144288373
-
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
-
Van Remmen H, Ikeno Y, Hamilton M et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 2003 16 : 29 37.
-
(2003)
Physiol Genomics
, vol.16
, pp. 29-37
-
-
Van Remmen, H.1
Ikeno, Y.2
Hamilton, M.3
-
73
-
-
2942556985
-
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress
-
Van Remmen H, Qi W, Sabia M et al. Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med 2004 36 : 1625 34.
-
(2004)
Free Radic Biol Med
, vol.36
, pp. 1625-34
-
-
Van Remmen, H.1
Qi, W.2
Sabia, M.3
-
74
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
-
Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 2007 6 : 280 93.
-
(2007)
Cell Metab
, vol.6
, pp. 280-93
-
-
Schulz, T.J.1
Zarse, K.2
Voigt, A.3
Urban, N.4
Birringer, M.5
Ristow, M.6
-
75
-
-
0027197284
-
Oxidative stress and ageing in Caenorhabditis elegans
-
Vanfleteren JR. Oxidative stress and ageing in Caenorhabditis elegans. Biochem J 1993 2 : 605 8.
-
(1993)
Biochem J
, vol.2
, pp. 605-8
-
-
Vanfleteren, J.R.1
-
76
-
-
33646704229
-
Is the mitochondrial free radical theory of aging intact?
-
Sanz A, Pamplona R, Barja G. Is the mitochondrial free radical theory of aging intact? Antioxid Redox Signal 2006 8 : 582 99.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 582-99
-
-
Sanz, A.1
Pamplona, R.2
Barja, G.3
-
77
-
-
33847378451
-
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
-
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. Jama 2007 297 : 842 57.
-
(2007)
Jama
, vol.297
, pp. 842-57
-
-
Bjelakovic, G.1
Nikolova, D.2
Gluud, L.L.3
Simonetti, R.G.4
Gluud, C.5
-
78
-
-
0036903625
-
Complex I-mediated reactive oxygen species generation: Modulation by cytochrome c and NAD(P)+ oxidation-reduction state
-
Kushnareva Y, Murphy AN, Andreyev A. Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem J 2002 368 : 545 53.
-
(2002)
Biochem J
, vol.368
, pp. 545-53
-
-
Kushnareva, Y.1
Murphy, A.N.2
Andreyev, A.3
-
79
-
-
33846225260
-
Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: Implications for hypoxic cell signaling
-
Hoffman DL, Salter JD, Brookes PS. Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling. Am J Physiol 2007 292 : H101 8.
-
(2007)
Am J Physiol
, vol.292
-
-
Hoffman, D.L.1
Salter, J.D.2
Brookes, P.S.3
-
80
-
-
0035957398
-
Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
-
Wang J, Silva J, Gustafsson CM, Rustin P, Larsson NG. Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc Natl Acad Sci USA 2001 98 : 4038 43.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4038-43
-
-
Wang, J.1
Silva, J.2
Gustafsson, C.M.3
Rustin, P.4
Larsson, N.G.5
-
81
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
Kujoth GC, Hiona A, Pugh TD et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005 309 : 481 4.
-
(2005)
Science
, vol.309
, pp. 481-4
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
-
82
-
-
34250647400
-
Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: Implications for aging studies
-
Barja G. Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: implications for aging studies. Rejuvenation research 2007 10 : 215 24.
-
(2007)
Rejuvenation Research
, vol.10
, pp. 215-24
-
-
Barja, G.1
|