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Volumn 263, Issue 2, 2008, Pages 167-178

Mitochondrial dysfunction as a cause of ageing

Author keywords

Ageing; Life span; Mitochondria; Mitochondrial dysfunction; mtDNA; Respiratory chain

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

EID: 38349108752     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2007.01905.x     Document Type: Conference Paper
Times cited : (293)

References (82)
  • 1
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • Kirkwood TB. Understanding the odd science of aging. Cell 2005 120 : 437 47.
    • (2005) Cell , vol.120 , pp. 437-47
    • Kirkwood, T.B.1
  • 2
    • 13844249825 scopus 로고    scopus 로고
    • Is aging programed?
    • Austad SN. Is aging programed? Aging Cell 2004 3 : 249 51.
    • (2004) Aging Cell , vol.3 , pp. 249-51
    • Austad, S.N.1
  • 3
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria?
    • Harman D. The biologic clock: the mitochondria? J Am Geriatr Soc 1972 20 : 145 7.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-7
    • Harman, D.1
  • 4
    • 0033525924 scopus 로고    scopus 로고
    • Oxidative phosphorylation at the fin de siecle
    • Saraste M. Oxidative phosphorylation at the fin de siecle. Science 1999 283 : 1488 93.
    • (1999) Science , vol.283 , pp. 1488-93
    • Saraste, M.1
  • 8
    • 17144429302 scopus 로고    scopus 로고
    • Calorie restriction, SIRT1 and metabolism: Understanding longevity
    • Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 2005 6 : 298 305.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 298-305
    • Bordone, L.1    Guarente, L.2
  • 9
    • 13944253348 scopus 로고    scopus 로고
    • Calorie restriction-the SIR2 connection
    • Guarente L, Picard F. Calorie restriction-the SIR2 connection. Cell 2005 120 : 473 82.
    • (2005) Cell , vol.120 , pp. 473-82
    • Guarente, L.1    Picard, F.2
  • 10
    • 0037130175 scopus 로고    scopus 로고
    • Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    • Lin SJ, Kaeberlein M, Andalis AA et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 2002 418 : 344 8.
    • (2002) Nature , vol.418 , pp. 344-8
    • Lin, S.J.1    Kaeberlein, M.2    Andalis, A.A.3
  • 11
    • 29244489494 scopus 로고    scopus 로고
    • Increased life span due to calorie restriction in respiratory-deficient yeast
    • Kaeberlein M, Hu D, Kerr EO et al. Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 2005 1 : e69.
    • (2005) PLoS Genet , vol.1
    • Kaeberlein, M.1    Hu, D.2    Kerr, E.O.3
  • 12
    • 19344374925 scopus 로고    scopus 로고
    • Sir2-independent life span extension by calorie restriction in yeast
    • Kaeberlein M, Kirkland KT, Fields S, Kennedy BK. Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2004 2 : E296.
    • (2004) PLoS Biol , vol.2
    • Kaeberlein, M.1    Kirkland, K.T.2    Fields, S.3    Kennedy, B.K.4
  • 13
    • 85044703856 scopus 로고    scopus 로고
    • No reduction of metabolic rate in food restricted Caenorhabditis elegans
    • Houthoofd K, Braeckman BP, Lenaerts I et al. No reduction of metabolic rate in food restricted Caenorhabditis elegans. Exp Gerontol 2002 37 : 1359 69.
    • (2002) Exp Gerontol , vol.37 , pp. 1359-69
    • Houthoofd, K.1    Braeckman, B.P.2    Lenaerts, I.3
  • 14
    • 3543062946 scopus 로고    scopus 로고
    • Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster
    • Hulbert AJ, Clancy DJ, Mair W, Braeckman BP, Gems D, Partridge L. Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Exp Gerontol 2004 39 : 1137 43.
    • (2004) Exp Gerontol , vol.39 , pp. 1137-43
    • Hulbert, A.J.1    Clancy, D.J.2    Mair, W.3    Braeckman, B.P.4    Gems, D.5    Partridge, L.6
  • 15
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C. elegans
    • Bishop NA, Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 2007 447 : 545 9.
    • (2007) Nature , vol.447 , pp. 545-9
    • Bishop, N.A.1    Guarente, L.2
  • 16
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006 127 : 1109 22.
    • (2006) Cell , vol.127 , pp. 1109-22
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 17
    • 33947710793 scopus 로고    scopus 로고
    • Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
    • Civitarese AE, Carling S, Heilbronn LK et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med 2007 4 : e76.
    • (2007) PLoS Med , vol.4
    • Civitarese, A.E.1    Carling, S.2    Heilbronn, L.K.3
  • 18
    • 0347579845 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide
    • Nisoli E, Clementi E, Paolucci C et al. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 2003 299 : 896 9.
    • (2003) Science , vol.299 , pp. 896-9
    • Nisoli, E.1    Clementi, E.2    Paolucci, C.3
  • 19
    • 26844558334 scopus 로고    scopus 로고
    • Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
    • Nisoli E, Tonello C, Cardile A et al. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005 310 : 314 7.
    • (2005) Science , vol.310 , pp. 314-7
    • Nisoli, E.1    Tonello, C.2    Cardile, A.3
  • 20
    • 0021056471 scopus 로고
    • A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results
    • Klass MR. A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech Ageing Dev 1983 22 : 279 86.
    • (1983) Mech Ageing Dev , vol.22 , pp. 279-86
    • Klass, M.R.1
  • 21
    • 0023678537 scopus 로고
    • Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene
    • Friedman DB, Johnson TE. Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J Gerontol 1988 43 : B102 9.
    • (1988) J Gerontol , vol.43
    • Friedman, D.B.1    Johnson, T.E.2
  • 22
    • 0037228016 scopus 로고    scopus 로고
    • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    • Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 2003 33 : 40 8.
    • (2003) Nat Genet , vol.33 , pp. 40-8
    • Lee, S.S.1    Lee, R.Y.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5    Ruvkun, G.6
  • 23
    • 0035515923 scopus 로고    scopus 로고
    • Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
    • Feng J, Bussiere F, Hekimi S. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell 2001 1 : 633 44.
    • (2001) Dev Cell , vol.1 , pp. 633-44
    • Feng, J.1    Bussiere, F.2    Hekimi, S.3
  • 24
    • 0037147103 scopus 로고    scopus 로고
    • Rates of behavior and aging specified by mitochondrial function during development
    • Dillin A, Hsu AL, Arantes-Oliveira N et al. Rates of behavior and aging specified by mitochondrial function during development. Science 2002 298 : 2398 401.
    • (2002) Science , vol.298 , pp. 2398-401
    • Dillin, A.1    Hsu, A.L.2    Arantes-Oliveira, N.3
  • 25
    • 0035834789 scopus 로고    scopus 로고
    • A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans
    • Senoo-Matsuda N, Yasuda K, Tsuda M et al. A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans. J Biol Chem 2001 276 : 41553 8.
    • (2001) J Biol Chem , vol.276 , pp. 41553-8
    • Senoo-Matsuda, N.1    Yasuda, K.2    Tsuda, M.3
  • 26
    • 0028950419 scopus 로고
    • Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing
    • Wong A, Boutis P, Hekimi S. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 1995 139 : 1247 59.
    • (1995) Genetics , vol.139 , pp. 1247-59
    • Wong, A.1    Boutis, P.2    Hekimi, S.3
  • 27
    • 0035896557 scopus 로고    scopus 로고
    • Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans
    • Miyadera H, Amino H, Hiraishi A et al. Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans. J Biol Chem 2001 276 : 7713 6.
    • (2001) J Biol Chem , vol.276 , pp. 7713-6
    • Miyadera, H.1    Amino, H.2    Hiraishi, A.3
  • 28
    • 11144245002 scopus 로고    scopus 로고
    • Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1
    • Kayser EB, Sedensky MM, Morgan PG, Hoppel CL. Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1. J Biol Chem 2004 279 : 54479 86.
    • (2004) J Biol Chem , vol.279 , pp. 54479-86
    • Kayser, E.B.1    Sedensky, M.M.2    Morgan, P.G.3    Hoppel, C.L.4
  • 29
    • 2942598255 scopus 로고    scopus 로고
    • The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans
    • Kayser EB, Sedensky MM, Morgan PG. The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans. Mech Ageing Dev 2004 125 : 455 64.
    • (2004) Mech Ageing Dev , vol.125 , pp. 455-64
    • Kayser, E.B.1    Sedensky, M.M.2    Morgan, P.G.3
  • 30
    • 35648947912 scopus 로고    scopus 로고
    • Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
    • Rea SL, Ventura N, Johnson TE. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol 2007 5 : e259.
    • (2007) PLoS Biol , vol.5
    • Rea, S.L.1    Ventura, N.2    Johnson, T.E.3
  • 31
    • 26944501617 scopus 로고    scopus 로고
    • Evolutionary conservation of the clk-1-dependent mechanism of longevity: Loss of mclk1 increases cellular fitness and lifespan in mice
    • Liu X, Jiang N, Hughes B, Bigras E, Shoubridge E, Hekimi S. Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev 2005 19 : 2424 34.
    • (2005) Genes Dev , vol.19 , pp. 2424-34
    • Liu, X.1    Jiang, N.2    Hughes, B.3    Bigras, E.4    Shoubridge, E.5    Hekimi, S.6
  • 32
    • 33847304164 scopus 로고    scopus 로고
    • Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice
    • Dell'agnello C, Leo S, Agostino A et al. Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice. Hum Mol Genet 2007 16 : 431 44.
    • (2007) Hum Mol Genet , vol.16 , pp. 431-44
    • Dell'Agnello, C.1    Leo, S.2    Agostino, A.3
  • 33
    • 0025185977 scopus 로고
    • A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans
    • Ishii N, Takahashi K, Tomita S et al. A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans. Mutat Res 1990 237 : 165 71.
    • (1990) Mutat Res , vol.237 , pp. 165-71
    • Ishii, N.1    Takahashi, K.2    Tomita, S.3
  • 34
    • 0034284973 scopus 로고    scopus 로고
    • Extension of life-span with superoxide dismutase/catalase mimetics
    • Melov S, Ravenscroft J, Malik S et al. Extension of life-span with superoxide dismutase/catalase mimetics. Science 2000 289 : 1567 9.
    • (2000) Science , vol.289 , pp. 1567-9
    • Melov, S.1    Ravenscroft, J.2    Malik, S.3
  • 36
    • 0029587469 scopus 로고
    • Molecular genetic aspects of human mitochondrial disorders
    • Larsson NG, Clayton DA. Molecular genetic aspects of human mitochondrial disorders. Annu Rev Genet 1995 29 : 151 78.
    • (1995) Annu Rev Genet , vol.29 , pp. 151-78
    • Larsson, N.G.1    Clayton, D.A.2
  • 37
    • 0023883150 scopus 로고
    • Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
    • Holt IJ, Harding AE, Morgan-Hughes JA. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 1988 331 : 717 9.
    • (1988) Nature , vol.331 , pp. 717-9
    • Holt, I.J.1    Harding, A.E.2    Morgan-Hughes, J.A.3
  • 38
    • 0024242545 scopus 로고
    • Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy
    • Wallace DC, Singh G, Lott MT et al. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science 1988 242 : 1427 30.
    • (1988) Science , vol.242 , pp. 1427-30
    • Wallace, D.C.1    Singh, G.2    Lott, M.T.3
  • 39
    • 0019978703 scopus 로고
    • Replication of animal mitochondrial DNA
    • Clayton DA. Replication of animal mitochondrial DNA. Cell 1982 28 : 693 705.
    • (1982) Cell , vol.28 , pp. 693-705
    • Clayton, D.A.1
  • 40
    • 0036211772 scopus 로고    scopus 로고
    • Interfibrillar cardiac mitochondrial comples III defects in the aging rat heart
    • Hoppel CL, Moghaddas S, Lesnefsky EJ. Interfibrillar cardiac mitochondrial comples III defects in the aging rat heart. Biogerontology 2002 3 : 41 4.
    • (2002) Biogerontology , vol.3 , pp. 41-4
    • Hoppel, C.L.1    Moghaddas, S.2    Lesnefsky, E.J.3
  • 41
    • 0023944266 scopus 로고
    • Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging
    • Piko L, Hougham AJ, Bulpitt KJ. Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging. Mech Ageing Dev 1988 43 : 279 93.
    • (1988) Mech Ageing Dev , vol.43 , pp. 279-93
    • Piko, L.1    Hougham, A.J.2    Bulpitt, K.J.3
  • 42
    • 0024328562 scopus 로고
    • Multiple populations of deleted mitochondrial DNA detected by a novel gene amplification method
    • Sato W, Tanaka M, Ohno K, Yamamoto T, Takada G, Ozawa T. Multiple populations of deleted mitochondrial DNA detected by a novel gene amplification method. Biochem Biophys Res Commun 1989 162 : 664 72.
    • (1989) Biochem Biophys Res Commun , vol.162 , pp. 664-72
    • Sato, W.1    Tanaka, M.2    Ohno, K.3    Yamamoto, T.4    Takada, G.5    Ozawa, T.6
  • 43
    • 0027021442 scopus 로고
    • Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain
    • Soong NW, Hinton DR, Cortopassi G, Arnheim N. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet 1992 2 : 318 23.
    • (1992) Nat Genet , vol.2 , pp. 318-23
    • Soong, N.W.1    Hinton, D.R.2    Cortopassi, G.3    Arnheim, N.4
  • 45
    • 0024580556 scopus 로고
    • Decline in skeletal muscle mitochondrial respiratory chain function: Possible factor in ageing
    • Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1989 1(8639) : 637 9.
    • (1989) Lancet , vol.1 , Issue.8639 , pp. 637-9
    • Trounce, I.1    Byrne, E.2    Marzuki, S.3
  • 47
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
    • Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989 1(8639) : 642 5.
    • (1989) Lancet , vol.1 , Issue.8639 , pp. 642-5
    • Linnane, A.W.1    Marzuki, S.2    Ozawa, T.3    Tanaka, M.4
  • 48
    • 15944396616 scopus 로고    scopus 로고
    • Mitochondrial encephalomyopathies: An update
    • DiMauro S, Hirano M. Mitochondrial encephalomyopathies: an update. Neuromuscul Disord 2005 15 : 276 86.
    • (2005) Neuromuscul Disord , vol.15 , pp. 276-86
    • Dimauro, S.1    Hirano, M.2
  • 49
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 1999 286 : 774 9.
    • (1999) Science , vol.286 , pp. 774-9
    • Michikawa, Y.1    Mazzucchelli, F.2    Bresolin, N.3    Scarlato, G.4    Attardi, G.5
  • 50
    • 0035957323 scopus 로고    scopus 로고
    • Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication
    • Wang Y, Michikawa Y, Mallidis C et al. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci U S A 2001 98 : 4022 7.
    • (2001) Proc Natl Acad Sci U S a , vol.98 , pp. 4022-7
    • Wang, Y.1    Michikawa, Y.2    Mallidis, C.3
  • 52
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • Trifunovic A, Wredenberg A, Falkenberg M et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004 429 : 417 23.
    • (2004) Nature , vol.429 , pp. 417-23
    • Trifunovic, A.1    Wredenberg, A.2    Falkenberg, M.3
  • 53
    • 29144458899 scopus 로고    scopus 로고
    • Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
    • Trifunovic A, Hansson A, Wredenberg A et al. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci U S A 2005 102 : 17993 8.
    • (2005) Proc Natl Acad Sci U S a , vol.102 , pp. 17993-8
    • Trifunovic, A.1    Hansson, A.2    Wredenberg, A.3
  • 54
    • 0024366601 scopus 로고
    • Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - An age-related phenomenon
    • Mueller-Hocker J. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - an age-related phenomenon. Am J Pathol 1989 134 : 1167 73.
    • (1989) Am J Pathol , vol.134 , pp. 1167-73
    • Mueller-Hocker, J.1
  • 55
    • 0025673968 scopus 로고
    • Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age related alteration
    • Müller-Höcker J. Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age related alteration. J Neurol Sci 1990 100 : 14 21.
    • (1990) J Neurol Sci , vol.100 , pp. 14-21
    • Müller-Höcker, J.1
  • 56
    • 0347600946 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human colonic crypt stem cells
    • Taylor RW, Barron MJ, Borthwick GM et al. Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest 2003 112 : 1351 60.
    • (2003) J Clin Invest , vol.112 , pp. 1351-60
    • Taylor, R.W.1    Barron, M.J.2    Borthwick, G.M.3
  • 59
    • 33646375711 scopus 로고    scopus 로고
    • High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
    • Bender A, Krishnan KJ, Morris CM et al. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 2006 38 : 515 7.
    • (2006) Nat Genet , vol.38 , pp. 515-7
    • Bender, A.1    Krishnan, K.J.2    Morris, C.M.3
  • 60
    • 0036258718 scopus 로고    scopus 로고
    • Ageing muscle: Clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function
    • Fayet G, Jansson M, Sternberg D et al. Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function. Neuromuscul Disord 2002 12 : 484 93.
    • (2002) Neuromuscul Disord , vol.12 , pp. 484-93
    • Fayet, G.1    Jansson, M.2    Sternberg, D.3
  • 62
    • 0015363173 scopus 로고
    • The cellular production of hydrogen peroxide
    • Boveris A, Oshino N, Chance B. The cellular production of hydrogen peroxide. Biochem J 1972 128 : 617 30.
    • (1972) Biochem J , vol.128 , pp. 617-30
    • Boveris, A.1    Oshino, N.2    Chance, B.3
  • 64
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000 29 : 222 30.
    • (2000) Free Radic Biol Med , vol.29 , pp. 222-30
    • Cadenas, E.1    Davies, K.J.2
  • 65
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979 59 : 527 605.
    • (1979) Physiol Rev , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 66
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • St-Pierre J, Buckingham JA, Roebuck SJ, Brand MD. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 2002 277 : 44784 90.
    • (2002) J Biol Chem , vol.277 , pp. 44784-90
    • St-Pierre, J.1    Buckingham, J.A.2    Roebuck, S.J.3    Brand, M.D.4
  • 67
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 2005 120 : 483 95.
    • (2005) Cell , vol.120 , pp. 483-95
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 68
    • 21144434217 scopus 로고    scopus 로고
    • Extension of murine life span by overexpression of catalase targeted to mitochondria
    • Schriner SE, Linford NJ, Martin GM et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005 308 : 1909 11.
    • (2005) Science , vol.308 , pp. 1909-11
    • Schriner, S.E.1    Linford, N.J.2    Martin, G.M.3
  • 69
    • 3242737464 scopus 로고    scopus 로고
    • Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila
    • Miwa S, Riyahi K, Partridge L, Brand MD. Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila. Ann N Y Acad Sci 2004 1019 : 388 91.
    • (2004) Ann N Y Acad Sci , vol.1019 , pp. 388-91
    • Miwa, S.1    Riyahi, K.2    Partridge, L.3    Brand, M.D.4
  • 71
    • 0028827252 scopus 로고
    • Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
    • Li YB, Huang T-T, Carlson EJ et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 1995 11 : 376 81.
    • (1995) Nat Genet , vol.11 , pp. 376-81
    • Li, Y.B.1    Huang, T.-T.2    Carlson, E.J.3
  • 72
    • 12144288373 scopus 로고    scopus 로고
    • Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
    • Van Remmen H, Ikeno Y, Hamilton M et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 2003 16 : 29 37.
    • (2003) Physiol Genomics , vol.16 , pp. 29-37
    • Van Remmen, H.1    Ikeno, Y.2    Hamilton, M.3
  • 73
    • 2942556985 scopus 로고    scopus 로고
    • Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress
    • Van Remmen H, Qi W, Sabia M et al. Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med 2004 36 : 1625 34.
    • (2004) Free Radic Biol Med , vol.36 , pp. 1625-34
    • Van Remmen, H.1    Qi, W.2    Sabia, M.3
  • 74
    • 34748850786 scopus 로고    scopus 로고
    • Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    • Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 2007 6 : 280 93.
    • (2007) Cell Metab , vol.6 , pp. 280-93
    • Schulz, T.J.1    Zarse, K.2    Voigt, A.3    Urban, N.4    Birringer, M.5    Ristow, M.6
  • 75
    • 0027197284 scopus 로고
    • Oxidative stress and ageing in Caenorhabditis elegans
    • Vanfleteren JR. Oxidative stress and ageing in Caenorhabditis elegans. Biochem J 1993 2 : 605 8.
    • (1993) Biochem J , vol.2 , pp. 605-8
    • Vanfleteren, J.R.1
  • 76
    • 33646704229 scopus 로고    scopus 로고
    • Is the mitochondrial free radical theory of aging intact?
    • Sanz A, Pamplona R, Barja G. Is the mitochondrial free radical theory of aging intact? Antioxid Redox Signal 2006 8 : 582 99.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 582-99
    • Sanz, A.1    Pamplona, R.2    Barja, G.3
  • 77
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
    • Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. Jama 2007 297 : 842 57.
    • (2007) Jama , vol.297 , pp. 842-57
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 78
    • 0036903625 scopus 로고    scopus 로고
    • Complex I-mediated reactive oxygen species generation: Modulation by cytochrome c and NAD(P)+ oxidation-reduction state
    • Kushnareva Y, Murphy AN, Andreyev A. Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem J 2002 368 : 545 53.
    • (2002) Biochem J , vol.368 , pp. 545-53
    • Kushnareva, Y.1    Murphy, A.N.2    Andreyev, A.3
  • 79
    • 33846225260 scopus 로고    scopus 로고
    • Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: Implications for hypoxic cell signaling
    • Hoffman DL, Salter JD, Brookes PS. Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling. Am J Physiol 2007 292 : H101 8.
    • (2007) Am J Physiol , vol.292
    • Hoffman, D.L.1    Salter, J.D.2    Brookes, P.S.3
  • 81
    • 22344456832 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
    • Kujoth GC, Hiona A, Pugh TD et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005 309 : 481 4.
    • (2005) Science , vol.309 , pp. 481-4
    • Kujoth, G.C.1    Hiona, A.2    Pugh, T.D.3
  • 82
    • 34250647400 scopus 로고    scopus 로고
    • Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: Implications for aging studies
    • Barja G. Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: implications for aging studies. Rejuvenation research 2007 10 : 215 24.
    • (2007) Rejuvenation Research , vol.10 , pp. 215-24
    • Barja, G.1


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