Calorie restriction in nonhuman primates: Effects on diabetes and cardiovascular disease risk

Toxicological Sciences

Volumn 52, Issue 2 SUPPL., 1999, Pages 41-48

  Lane, M A ^a   Ingram, D K ^a   Roth, G S ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Aging; Biomarkers; Rhesus monkeys; Sulfated dehydroepiandrosterone (DHEAS)

Indexed keywords

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CALORIC RESTRICTION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIABETES MELLITUS; INSULIN SENSITIVITY; LIFESPAN; LONGEVITY; NONHUMAN; OBESITY; RHESUS MONKEY; WEIGHT REDUCTION;

EID: 0033377625     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/52.2.41     Document Type: Article

References (43)

1. Barrett-Conner, E., et al. (1986). A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N. Engl. J. Med. 315, 1519-1524.
2. Barzilai, N., et al. (1998). Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J. Clin. Invest. 101, 1353-1361.
3. Bodkin, N. L., et al. (1995). Long-term dietary restriction in older-aged rhesus monkeys: Effects on insulin resistance. J. Gerontol. Biol. Sci. 50A, B142-147.
4. 1 cholesterol, apo A-I and apo A-II, and increased risk of myocardial infarction. Circulation 85, 222-229.
5. Cefalu, W.T. et al (1997) A study of caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): A potential model for aging research. J. Gerontol. Biol. Sci 52A, B10-19.
6. Cefalu et al (1998) Toxicol Sci. (this symposium issue).
7. Cocchi, D. et al (1995). Effect of long-term dietary restriction on the somatotrophic axis in adult and aged monkeys. Neuroendocrinal. Lett. 17, 181-186.
8. DeAngelis, H. A., et al (1998). Calorie restriction in male rhesus monkeys improves risk factors associated with the insulin resistance syndrome (abstract). Gerontologist 1, 15.
9. Fishbein, L. (1991). Biological Effects of Dietary Restriction. Springer-Verlag, New York.
10. Grossman, A., et al., (1995). Influence of age, sex, and dietary restriction on intracellular free calcium responses of CD4+ lymphocytes in rhesus monkeys (Macaca mulatta). J. Cell. Physiol. 162, 298-303.
11. Hansen, B. C., and Bodkin, N. L. (1993). Primary prevention of diabetes mellitus by prevention of obesity in monkeys. Diabetes. 42, 1809-1813.
12. Hart, R. W., and Neumann, D. A., et al. (1995). Dietary restriction: Implications for the design and interpretation of toxicity and carcinogenicity studies. ILSI Press, Washington, DC.
13. Ingram, D. K., et al. (1990). Dietary restriction and aging: The initiation of a primate study. J. Gerontol., 45, B148-163.
14. Kalant, N., (1988). Effect of diet restriction on glucose metabolism and insulin responsiveness in aging rats. Mech. Ageing Dev. 46, 89-104.
15. Kemnitz, J. W., et al. (1993). Dietary restriction of adult male rhesus monkeys: Design, methodology and preliminary findings from the first year of study. J. Gerontol. Biol Sci. 48, B17-26.
16. Kemnitz, J. W., et al. (1994). Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am. J. Physiol. 266, E540-547.
17. Lane, M. A., et al. (1992). Dietary restriction in nonhuman primates: Progress report on the NIA study. Annn N Y Acad. Sci. 673, 36-45.
18. Lane, M. A., et al. (1995a). Aging and food restriction alters some indices of bone metabolism in male rhesus monkeys (Macaca mulatta). J. Nutr. 125, 1600-1610.
19. Lane, M. A., et al. (1995b). Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory endpoints. Am. J. Physiol. 268, E 941-948.
20. Lane, M. A., et al. (1995c). Energy balance in rhesus monkeys subjected to long-term dietary restriction. J. Gerontol. 50A, B295-302.
21. Lane, M. A., et al. (1996). Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc. Natl. Acad. Sci. U S A 93, 4159-4164.
22. Lane, M. A., et al (1997a). DHEAS: A biomarker of primate aging slowed by calorie restriction. J. Clin. Endo. Metabol. 82, 2093-2096.
23. Lane, M. A., et al. (1997b). Beyond the rodent model: Calorie restriction in rhesus monkeys. AGE 20, 45-56.
24. Lane, M. A., et al. (1999). Calorie restriction in nonhuman primates: Implications for age-related disease risk. J. Anti-Aging Med. 1, 315-325.
25. Ley, C. J., et al. (1992). Sex-and menopause-associated changes in body-fat distribution. Am. J. Clin. Nutr. 53, 1378-1383.
26. Lucia, M. A., et al. (1996). Early changes in glucoregulation during the onset of calorie restriction in female rhesus monkeys. Gerontologist 36(suppl. 1), 1.
27. Masoro, E. J., et al. (1989). Evidence for the glycation theory of aging from the food-restricted rodent model. J. Gerontol. Biol. Sci. 44, B20-22.
28. Masoro, E. J., et al. (1992). Dietary restriction alters characteristics of glucose fuel use. J. Gerontol. Biol. Sci. 47, B202-208.
29. National Research Council (1978). Nutrient Requirements of Laboratory Animals. National Academy of Sciences, Washington, DC.
30. Pendergrass, W. R., et al. (1999). Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta). J. Cell. Physiol. 180, 123-130.
31. Roth, G. S., et al. (1993). Age-related changes in androgen levels of rhesus monkeys subjected to diet restriction. Endocrine J. 1, 227-234.
32. Roth, G. S., et al. (1997). Effect of age and caloric restriction on cutaneous wound closure in rats and monkeys. J. Gerontol. Biol. Sci. 52A(2): B98-B102.
33. Small, M., et al. (1989). Adrenal androgens and insulin-dependent diabetes mellitus. Diabetes Res. 11, 93-95.
34. Svendsen, O. L., et al. (1993a). Relationships and independence of body composition, sex hormones, fat distribution and other cardiovascular risk factors in overweight women. Int. J. Obes. 36, 225-228.
35. Svendsen, O. L. et al. (1993b). Measurement of abdominal and intra-abdominal fat in postmenopausal women by dual-energy x-ray absorptionometry: Comparison with computerized tomography. Int. J. Obes. 17, 45-51.
36. Tilmont, E. M. et al. (1996). Calorie restriction reduces body weight, body fat, and lean mass in rhesus monkeys. Gerontologist 36(suppl.), 19.
37. Verdery R. B., et al. (1997) Caloric restriction increases HDL2 levels in rhesus monkeys (Macaca mulatta) Am. J. Physiol. (Endocrinol. Metab. 36, E714-719.
38. Weed, J. L., et al. (1997). Activity measures in rhesus monkeys on long-term calorie restriction. Physiol. Behav. 62, 97-103.
39. Weindruch, R., and Walford, R., (1988). The Retardation of Aging and Disease by Dietary Restriction. Charles C. Thomas, Springfield, IL.
40. Weindruch, R., et al. (1997). Lymphopenia and reduced mitogen-proliferation in peripheral blood mononudear cell. Aging (Clin. Exp. Res.). 9, 304-308.
41. Weindruch, R., et al. (1998). Toxicol. Sci. (in press).
42. Yu, B. P., (1994). Modulation of Aging Processes by Dietary Restriction. CRC Press, Boca Raton, FL.
43. Zumoff, B., Levin, J., Rosenfeld, R. S., Fukushima, D. K. (1981). Abnormal 24-hour mean plasma concentrations of dehydroisoandrosterone and dehydroisoandrosterone sulfate in women with primary operable breast cancer. Cancer Res. 41(9, Part 1), 3360-3363.