Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet

Neurology

Volumn 60, Issue 6, 2003, Pages 1026-1029

  Fraser, D D ^a,b   Whiting, S ^a,b   Andrew, R D ^b   Macdonald, E A ^b   Musa Veloso, K ^c   Cunnane, S C ^b,c  

^a CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; HYDROCORTISONE; LIPID; POLYUNSATURATED FATTY ACID;

ADOLESCENT; ANTICONVULSANT ACTIVITY; ARTICLE; BLOOD ANALYSIS; CHILD; CHILD NUTRITION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET THERAPY; DISEASE CONTROL; EPILEPSY; FATTY ACID BLOOD LEVEL; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; KETOGENIC DIET; LIPID ANALYSIS; MALE; METABOLITE; PRIORITY JOURNAL; SEIZURE;

EID: 0037465771     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000049974.74242.C6     Document Type: Article

References (10)

1. Vining EPG. Clinical efficacy of the ketogenic diet. Epilepsy Res 1999;37:181-190.
2. Anderson GD, Rho JM, Bough KJ, et al. Rats fed a ketogenic diet exhibit significantly elevated levels of long chain, polyunsaturated fatty acids. Epilepsia 2001;42(suppl 7):262-263.
3. Dell CA, Likhodii SS, Musa K, et al. Lipid and fatty acid profiles in rats consuming different high-fat ketogenic diets. Lipids 2001;36:373-378.
4. Cunnane SC, Musa K, Ryan MA, et al. Potential role of polyunsaturates in seizure protection achieved with the ketogenic diet. Prostaglandins Leukotrienes Essential Fatty Acids 2002;67:131-135.
5. Yehuda S, Carasso RL, Mostofsky DI. Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. Eur J Pharmacol 1994;254: 193-198.
6. Voskuyl RA, Vreugdenhil M, Kang JX, Leaf A. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur J Pharmacol 1998;341:145-152.
7. Hassan AB, Keene DL, Whiting SE, et al. Ketogenic diet in the treatment of refractory epilepsy in childhood. Pediatr Neurol 1999;21:548-552.
8. Prasad AN, Stafstrom CF, Holmes GL. Alternative epilepsy therapies: the ketogenic diet, immunoglobulins, and steroids. Epilepsia 1996;37:S81-S95.
9. Wang W, Dow KE, Fraser DD. Elevated corticotropin releasing hormone/corticotropin releasing hormone-R1 expression in post-mortem brain obtained from children with generalized epilepsy. Ann Neurol 2001;50:404-409.
10. Raclot T, Groscolas R. Selective mobilization of adipose tissue fatty acids during energy depletion in the rat. J Lipid Res 1995;36:2164-2173.