메뉴 건너뛰기




Volumn 3, Issue 2, 2011, Pages 78-88

To live or to die: A matter of processing damaged DNA termini in neurons

Author keywords

Aprataxin; DNA repair; Neuron; TDP1; Topoisomerase

Indexed keywords

ALBUMIN; ALPHA FETOPROTEIN; APRATAXIN; ATAXIA OCULOMOTOR APRAXIA 1 PROTEIN; ATAXIA OCULOMOTOR APRAXIA 2 PROTEIN; ATAXIN 1; CULLIN; CULLIN 4B; DNA TOPOISOMERASE; HELICASE; MITOCHONDRIAL DNA; PHOSPHOPROTEIN PHOSPHATASE; POLYNUCLEOTIDE KINASE PHOSPHATASE; PROTEIN; RNA HELICASE; SENATAXIN; SPINOCEREBELLAR ATAXIA WITH AXONAL NEUROPATHY 1 PROTEIN; TYROSYL DNA PHOSPHODIESTERASE 1; UNCLASSIFIED DRUG;

EID: 79551513593     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201000114     Document Type: Review
Times cited : (42)

References (113)
  • 3
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • Audebert M, Salles B, Calsou P (2004) Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem 279: 55117- 55126
    • (2004) J Biol Chem , vol.279 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 4
    • 77749270650 scopus 로고    scopus 로고
    • Yeast Tdp1 regulates the fidelity of nonhomologous end joining
    • Bahmed K, Nitiss KC, Nitiss JL (2010) Yeast Tdp1 regulates the fidelity of nonhomologous end joining. Proc Natl Acad Sci USA 107: 4057- 4062
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4057-4062
    • Bahmed, K.1    Nitiss, K.C.2    Nitiss, J.L.3
  • 5
    • 77957233906 scopus 로고    scopus 로고
    • A tyrosyl DNA phosphodiesterase 1 from kinetoplastid parasite Leishmania donovani (LdTdp1) capable of removing topo I-DNA covalent complexes
    • Banerjee B, Roy A, Sen N, Majumder HK (2010) A tyrosyl DNA phosphodiesterase 1 from kinetoplastid parasite Leishmania donovani (LdTdp1) capable of removing topo I-DNA covalent complexes. Mol Microbiol 78: 119- 137
    • (2010) Mol Microbiol , vol.78 , pp. 119-137
    • Banerjee, B.1    Roy, A.2    Sen, N.3    Majumder, H.K.4
  • 6
    • 0032585526 scopus 로고    scopus 로고
    • Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
    • Barnes DE, Stamp G, Rosewell I, Denzel A, Lindahl T (1998) Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr Biol 8: 1395- 1398
    • (1998) Curr Biol , vol.8 , pp. 1395-1398
    • Barnes, D.E.1    Stamp, G.2    Rosewell, I.3    Denzel, A.4    Lindahl, T.5
  • 9
    • 0025335205 scopus 로고
    • Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription
    • Bendixen C, Thomsen B, Alsner J, Westergaard O (1990) Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription. Biochemistry 29: 5613- 5619
    • (1990) Biochemistry , vol.29 , pp. 5613-5619
    • Bendixen, C.1    Thomsen, B.2    Alsner, J.3    Westergaard, O.4
  • 10
    • 77950229880 scopus 로고    scopus 로고
    • Neural mechanisms of ageing and cognitive decline
    • Bishop NA, Lu T, Yankner BA (2010) Neural mechanisms of ageing and cognitive decline. Nature 464: 529- 535
    • (2010) Nature , vol.464 , pp. 529-535
    • Bishop, N.A.1    Lu, T.2    Yankner, B.A.3
  • 13
    • 0018787368 scopus 로고
    • X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution
    • Bradley MO, Kohn KW (1979) X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution. Nucleic Acids Res 7: 793- 804
    • (1979) Nucleic Acids Res , vol.7 , pp. 793-804
    • Bradley, M.O.1    Kohn, K.W.2
  • 14
    • 0033835634 scopus 로고    scopus 로고
    • A new X linked mental retardation (XLMR) syndrome with short stature, small testes, muscle wasting, and tremor localises to Xq24-q25
    • Cabezas DA, Slaugh R, Abidi F, Arena JF, Stevenson RE, Schwartz CE, Lubs HA (2000) A new X linked mental retardation (XLMR) syndrome with short stature, small testes, muscle wasting, and tremor localises to Xq24-q25. J Med Genet 37: 663- 668
    • (2000) J Med Genet , vol.37 , pp. 663-668
    • Cabezas, D.A.1    Slaugh, R.2    Abidi, F.3    Arena, J.F.4    Stevenson, R.E.5    Schwartz, C.E.6    Lubs, H.A.7
  • 15
    • 48249095920 scopus 로고    scopus 로고
    • Single-strand break repair and genetic disease
    • Caldecott KW (2008) Single-strand break repair and genetic disease. Nat Rev Genet 9: 619- 631
    • (2008) Nat Rev Genet , vol.9 , pp. 619-631
    • Caldecott, K.W.1
  • 17
    • 0034923502 scopus 로고    scopus 로고
    • DNA topoisomerases: structure, function, and mechanism
    • Champoux JJ (2001) DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem 70: 369- 413
    • (2001) Annu Rev Biochem , vol.70 , pp. 369-413
    • Champoux, J.J.1
  • 18
    • 0037013895 scopus 로고    scopus 로고
    • Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining
    • Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M, West SC (2002) Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J 21: 2827- 2832
    • (2002) EMBO J , vol.21 , pp. 2827-2832
    • Chappell, C.1    Hanakahi, L.A.2    Karimi-Busheri, F.3    Weinfeld, M.4    West, S.C.5
  • 20
    • 0026004662 scopus 로고
    • Two distinct human DNA diesterases that hydrolyze 3'-blocking deoxyribose fragments from oxidized DNA
    • Chen DS, Herman T, Demple B (1991) Two distinct human DNA diesterases that hydrolyze 3'-blocking deoxyribose fragments from oxidized DNA. Nucleic Acids Res 19: 5907- 5914
    • (1991) Nucleic Acids Res , vol.19 , pp. 5907-5914
    • Chen, D.S.1    Herman, T.2    Demple, B.3
  • 21
    • 77951916582 scopus 로고    scopus 로고
    • TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage
    • Chiang SC, Carroll J, El-Khamisy SF (2010) TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage. Cell Cycle 9: 588- 595
    • (2010) Cell Cycle , vol.9 , pp. 588-595
    • Chiang, S.C.1    Carroll, J.2    El-Khamisy, S.F.3
  • 23
    • 1242339593 scopus 로고    scopus 로고
    • Repair of DNA covalently linked to protein
    • Connelly JC, Leach DR (2004) Repair of DNA covalently linked to protein. Mol Cell 13: 307- 316
    • (2004) Mol Cell , vol.13 , pp. 307-316
    • Connelly, J.C.1    Leach, D.R.2
  • 24
    • 0025674177 scopus 로고
    • Detection of a specific mitochondrial DNA deletion in tissues of older humans
    • Cortopassi GA, Arnheim N (1990) Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res 18: 6927- 6933
    • (1990) Nucleic Acids Res , vol.18 , pp. 6927-6933
    • Cortopassi, G.A.1    Arnheim, N.2
  • 25
    • 44849118274 scopus 로고    scopus 로고
    • Two DNA-binding and nick recognition modules in human DNA ligase III
    • Cotner-Gohara E, Kim IK, Tomkinson AE, Ellenberger T (2008) Two DNA-binding and nick recognition modules in human DNA ligase III. J Biol Chem 283: 10764- 10772
    • (2008) J Biol Chem , vol.283 , pp. 10764-10772
    • Cotner-Gohara, E.1    Kim, I.K.2    Tomkinson, A.E.3    Ellenberger, T.4
  • 27
    • 77952582291 scopus 로고    scopus 로고
    • Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair
    • Daley JM, Wilson TE, Ramotar D (2010) Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair. DNA Repair (Amst) 9: 690- 699
    • (2010) DNA Repair (Amst) , vol.9 , pp. 690-699
    • Daley, J.M.1    Wilson, T.E.2    Ramotar, D.3
  • 29
    • 79551570800 scopus 로고    scopus 로고
    • Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria
    • Das BB, Dexheimer TS, Maddali K, Pommier Y (2010) Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria. Proc Natl Acad Sci 107: 19790- 19795
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 19790-19795
    • Das, B.B.1    Dexheimer, T.S.2    Maddali, K.3    Pommier, Y.4
  • 33
    • 34548535219 scopus 로고    scopus 로고
    • TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks
    • El-Khamisy SF, Hartsuiker E, Caldecott KW (2007) TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks. DNA Repair (Amst) 6: 1485- 1495
    • (2007) DNA Repair (Amst) , vol.6 , pp. 1485-1495
    • El-Khamisy, S.F.1    Hartsuiker, E.2    Caldecott, K.W.3
  • 34
    • 67349107467 scopus 로고    scopus 로고
    • Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin
    • El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ, Caldecott KW (2009) Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. DNA Repair (Amst) 8: 760- 766
    • (2009) DNA Repair (Amst) , vol.8 , pp. 760-766
    • El-Khamisy, S.F.1    Katyal, S.2    Patel, P.3    Ju, L.4    McKinnon, P.J.5    Caldecott, K.W.6
  • 35
    • 33750195046 scopus 로고    scopus 로고
    • Mitochondrial DNA clonality in the dock: can surveillance swing the case
    • Elson JL, Lightowlers RN (2006) Mitochondrial DNA clonality in the dock: can surveillance swing the case? Trends Genet 22: 603- 607
    • (2006) Trends Genet , vol.22 , pp. 603-607
    • Elson, J.L.1    Lightowlers, R.N.2
  • 36
    • 34250001115 scopus 로고    scopus 로고
    • BRCA2 is required for neurogenesis and suppression of medulloblastoma
    • Frappart PO, Lee Y, Lamont J, McKinnon PJ (2007) BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26: 2732- 2742
    • (2007) EMBO J , vol.26 , pp. 2732-2742
    • Frappart, P.O.1    Lee, Y.2    Lamont, J.3    McKinnon, P.J.4
  • 39
    • 74249102052 scopus 로고    scopus 로고
    • Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice
    • Goula AV, Berquist BR, Wilson DM, III, Wheeler VC, Trottier Y, Merienne K (2009) Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice. PLoS Genet 5: e1000749
    • (2009) PLoS Genet , vol.5
    • Goula, A.V.1    Berquist, B.R.2    Wilson III, D.M.3    Wheeler, V.C.4    Trottier, Y.5    Merienne, K.6
  • 40
    • 79551536942 scopus 로고    scopus 로고
    • Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease
    • in press) PMID: 20708822
    • Gredilla R, Weissman L, Yang JL, Bohr VA, Stevnsner T (2010) Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease. Neurobiol Aging (in press) PMID: 20708822
    • (2010) Neurobiol Aging
    • Gredilla, R.1    Weissman, L.2    Yang, J.L.3    Bohr, V.A.4    Stevnsner, T.5
  • 43
    • 78149442129 scopus 로고    scopus 로고
    • MRE11 function in response to topoisomerase poisons is independent of its function in double-strand break Repair in Saccharomyces cerevisiae
    • Hamilton NK, Maizels N (2010) MRE11 function in response to topoisomerase poisons is independent of its function in double-strand break Repair in Saccharomyces cerevisiae. PLoS One 5: e15387
    • (2010) PLoS One , vol.5
    • Hamilton, N.K.1    Maizels, N.2
  • 44
    • 70349978979 scopus 로고    scopus 로고
    • Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage
    • Harris JL, Jakob B, Taucher-Scholz G, Dianov GL, Becherel OJ, Lavin MF (2009) Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage. Hum Mol Genet 18: 4102- 4117
    • (2009) Hum Mol Genet , vol.18 , pp. 4102-4117
    • Harris, J.L.1    Jakob, B.2    Taucher-Scholz, G.3    Dianov, G.L.4    Becherel, O.J.5    Lavin, M.F.6
  • 47
    • 0023883150 scopus 로고
    • Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
    • Holt IJ, Harding AE, Morgan-Hughes JA (1988) Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 331: 717- 719
    • (1988) Nature , vol.331 , pp. 717-719
    • Holt, I.J.1    Harding, A.E.2    Morgan-Hughes, J.A.3
  • 50
    • 34248157719 scopus 로고    scopus 로고
    • APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks
    • Iles N, Rulten S, El-Khamisy SF, Caldecott KW (2007) APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol Cell Biol 27: 3793- 3803
    • (2007) Mol Cell Biol , vol.27 , pp. 3793-3803
    • Iles, N.1    Rulten, S.2    El-Khamisy, S.F.3    Caldecott, K.W.4
  • 51
    • 0037178839 scopus 로고    scopus 로고
    • Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1
    • Inamdar KV, Pouliot JJ, Zhou T, Lees-Miller SP, Rasouli-Nia A, Povirk LF (2002) Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1. J Biol Chem 277: 27162- 27168
    • (2002) J Biol Chem , vol.277 , pp. 27162-27168
    • Inamdar, K.V.1    Pouliot, J.J.2    Zhou, T.3    Lees-Miller, S.P.4    Rasouli-Nia, A.5    Povirk, L.F.6
  • 52
    • 0035834150 scopus 로고    scopus 로고
    • The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily
    • Interthal H, Pouliot JJ, Champoux JJ (2001) The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily. Proc Natl Acad Sci USA 98: 12009- 12014
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12009-12014
    • Interthal, H.1    Pouliot, J.J.2    Champoux, J.J.3
  • 53
    • 21844437071 scopus 로고    scopus 로고
    • SCAN1 mutant Tdp1 accumulates the enzyme-DNA intermediate and causes camptothecin hypersensitivity
    • Interthal H, Chen HJ, Kehl-Fie TE, Zotzmann J, Leppard JB, Champoux JJ (2005a) SCAN1 mutant Tdp1 accumulates the enzyme-DNA intermediate and causes camptothecin hypersensitivity. EMBO J 24: 2224- 2233
    • (2005) EMBO J , vol.24 , pp. 2224-2233
    • Interthal, H.1    Chen, H.J.2    Kehl-Fie, T.E.3    Zotzmann, J.4    Leppard, J.B.5    Champoux, J.J.6
  • 54
    • 27744521320 scopus 로고    scopus 로고
    • Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages
    • Interthal H, Chen HJ, Champoux JJ (2005b) Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages. J Biol Chem 280: 36518- 36528
    • (2005) J Biol Chem , vol.280 , pp. 36518-36528
    • Interthal, H.1    Chen, H.J.2    Champoux, J.J.3
  • 55
    • 0033588161 scopus 로고    scopus 로고
    • Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage
    • Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW, Lasko DD (1999) Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage. J Biol Chem 274: 24176- 24186
    • (1999) J Biol Chem , vol.274 , pp. 24176-24186
    • Jilani, A.1    Ramotar, D.2    Slack, C.3    Ong, C.4    Yang, X.M.5    Scherer, S.W.6    Lasko, D.D.7
  • 57
    • 36248984333 scopus 로고    scopus 로고
    • TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo
    • Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW, McKinnon PJ (2007) TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J 26: 4720- 4731
    • (2007) EMBO J , vol.26 , pp. 4720-4731
    • Katyal, S.1    el-Khamisy, S.F.2    Russell, H.R.3    Li, Y.4    Ju, L.5    Caldecott, K.W.6    McKinnon, P.J.7
  • 59
    • 33744937625 scopus 로고    scopus 로고
    • Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities
    • Kijas AW, Harris JL, Harris JM, Lavin MF (2006) Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities. J Biol Chem 281: 13939- 13948
    • (2006) J Biol Chem , vol.281 , pp. 13939-13948
    • Kijas, A.W.1    Harris, J.L.2    Harris, J.M.3    Lavin, M.F.4
  • 64
    • 33645460107 scopus 로고    scopus 로고
    • Mitochondrial disease: powerhouse of disease
    • Lane N (2006) Mitochondrial disease: powerhouse of disease. Nature 440: 600- 602
    • (2006) Nature , vol.440 , pp. 600-602
    • Lane, N.1
  • 66
    • 70349673605 scopus 로고    scopus 로고
    • A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage
    • Ledesma FC, El Khamisy, SF, Zuma MC, Osborn K, Caldecott KW. (2009) A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature 461: 674- 678
    • (2009) Nature , vol.461 , pp. 674-678
    • Ledesma, F.C.1    El Khamisy, S.F.2    Zuma, M.C.3    Osborn, K.4    Caldecott, K.W.5
  • 67
    • 0033610079 scopus 로고    scopus 로고
    • Gene expression profile of aging and its retardation by caloric restriction
    • Lee CK, Klopp RG, Weindruch R, Prolla TA (1999) Gene expression profile of aging and its retardation by caloric restriction. Science 285: 1390- 1393
    • (1999) Science , vol.285 , pp. 1390-1393
    • Lee, C.K.1    Klopp, R.G.2    Weindruch, R.3    Prolla, T.A.4
  • 69
    • 0942268166 scopus 로고    scopus 로고
    • DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
    • Lehmann AR (2003) DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Biochimie 85: 1101- 1111
    • (2003) Biochimie , vol.85 , pp. 1101-1111
    • Lehmann, A.R.1
  • 70
    • 0026572276 scopus 로고
    • Hereditary disorders including mitochondrial diseases
    • Lightowlers RN (1992) Hereditary disorders including mitochondrial diseases. Curr Opin Neurol Neurosurg 5: 368- 374
    • (1992) Curr Opin Neurol Neurosurg , vol.5 , pp. 368-374
    • Lightowlers, R.N.1
  • 72
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G (1999) Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286: 774- 779
    • (1999) Science , vol.286 , pp. 774-779
    • Michikawa, Y.1    Mazzucchelli, F.2    Bresolin, N.3    Scarlato, G.4    Attardi, G.5
  • 73
    • 0020505366 scopus 로고
    • Role of metabolic rate and DNA-repair in Drosophila aging: implications for the mitochondrial mutation theory of aging
    • Miquel J, Binnard R, Fleming JE (1983) Role of metabolic rate and DNA-repair in Drosophila aging: implications for the mitochondrial mutation theory of aging. Exp Gerontol 18: 167- 171
    • (1983) Exp Gerontol , vol.18 , pp. 167-171
    • Miquel, J.1    Binnard, R.2    Fleming, J.E.3
  • 75
    • 1642268993 scopus 로고    scopus 로고
    • The effect of donor age on the processing of UV-damaged DNA by cultured human cells: reduced DNA repair capacity and increased DNA mutability
    • Moriwaki S, Ray S, Tarone RE, Kraemer KH, Grossman L (1996) The effect of donor age on the processing of UV-damaged DNA by cultured human cells: reduced DNA repair capacity and increased DNA mutability. Mutat Res 364: 117- 123
    • (1996) Mutat Res , vol.364 , pp. 117-123
    • Moriwaki, S.1    Ray, S.2    Tarone, R.E.3    Kraemer, K.H.4    Grossman, L.5
  • 76
    • 15044357229 scopus 로고    scopus 로고
    • The novel human gene aprataxin is directly involved in DNA single-strand-break repair
    • Mosesso P, Piane M, Palitti F, Pepe G, Penna S, Chessa L (2005) The novel human gene aprataxin is directly involved in DNA single-strand-break repair. Cell Mol Life Sci 62: 485- 491
    • (2005) Cell Mol Life Sci , vol.62 , pp. 485-491
    • Mosesso, P.1    Piane, M.2    Palitti, F.3    Pepe, G.4    Penna, S.5    Chessa, L.6
  • 80
    • 0036182026 scopus 로고    scopus 로고
    • Mitochondrial involvement in Parkinson's disease
    • Orth M, Schapira AH (2002) Mitochondrial involvement in Parkinson's disease. Neurochem Int 40: 533- 541
    • (2002) Neurochem Int , vol.40 , pp. 533-541
    • Orth, M.1    Schapira, A.H.2
  • 83
    • 0030698003 scopus 로고    scopus 로고
    • Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects
    • Pourquier P, Pilon AA, Kohlhagen G, Mazumder A, Sharma A, Pommier Y (1997) Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects. J Biol Chem 272: 26441- 26447
    • (1997) J Biol Chem , vol.272 , pp. 26441-26447
    • Pourquier, P.1    Pilon, A.A.2    Kohlhagen, G.3    Mazumder, A.4    Sharma, A.5    Pommier, Y.6
  • 84
    • 34248215322 scopus 로고    scopus 로고
    • Actions of aprataxin in multiple DNA repair pathways
    • Rass U, Ahel I, West SC (2007a) Actions of aprataxin in multiple DNA repair pathways. J Biol Chem 282: 9469- 9474
    • (2007) J Biol Chem , vol.282 , pp. 9469-9474
    • Rass, U.1    Ahel, I.2    West, S.C.3
  • 85
    • 34548614799 scopus 로고    scopus 로고
    • Defective DNA repair and neurodegenerative disease
    • Rass U, Ahel I, West SC (2007b) Defective DNA repair and neurodegenerative disease. Cell 130: 991- 1004
    • (2007) Cell , vol.130 , pp. 991-1004
    • Rass, U.1    Ahel, I.2    West, S.C.3
  • 87
    • 36849017921 scopus 로고    scopus 로고
    • Mitochondrial structure and function in the untreated Jackson toxic milk (tx-j) mouse, a model for Wilson disease
    • Roberts EA, Robinson BH, Yang S (2008) Mitochondrial structure and function in the untreated Jackson toxic milk (tx-j) mouse, a model for Wilson disease. Mol Genet Metab 93: 54- 65
    • (2008) Mol Genet Metab , vol.93 , pp. 54-65
    • Roberts, E.A.1    Robinson, B.H.2    Yang, S.3
  • 88
    • 20444419381 scopus 로고    scopus 로고
    • Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin
    • Seidle HF, Bieganowski P, Brenner C (2005) Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin. J Biol Chem 280: 20927- 20931
    • (2005) J Biol Chem , vol.280 , pp. 20927-20931
    • Seidle, H.F.1    Bieganowski, P.2    Brenner, C.3
  • 90
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT, (2002) An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci 22: 7006- 7015
    • (2002) J Neurosci , vol.22 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6    Cookson, M.R.7    Greenamyre, J.T.8
  • 91
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • Shrivastav M, De Haro LP, Nickoloff JA (2008) Regulation of DNA double-strand break repair pathway choice. Cell Res 18: 134- 147
    • (2008) Cell Res , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 93
    • 69449101422 scopus 로고    scopus 로고
    • Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation
    • Suraweera A, Lim Y, Woods R, Birrell GW, Nasim T, Becherel OJ, Lavin MF (2009) Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Hum Mol Genet 18: 3384- 3396
    • (2009) Hum Mol Genet , vol.18 , pp. 3384-3396
    • Suraweera, A.1    Lim, Y.2    Woods, R.3    Birrell, G.W.4    Nasim, T.5    Becherel, O.J.6    Lavin, M.F.7
  • 97
    • 33846639529 scopus 로고    scopus 로고
    • Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor
    • Tarpey PS, Raymond FL, O'Meara S, Edkins S, Teague J, Butler A, Dicks E, Stevens C, Tofts C, Avis T, et al (2007) Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am J Hum Genet 80: 345- 352
    • (2007) Am J Hum Genet , vol.80 , pp. 345-352
    • Tarpey, P.S.1    Raymond, F.L.2    O'Meara, S.3    Edkins, S.4    Teague, J.5    Butler, A.6    Dicks, E.7    Stevens, C.8    Tofts, C.9    Avis, T.10
  • 98
    • 0034666329 scopus 로고    scopus 로고
    • The DNA ligase III zinc finger stimulates binding to DNA secondary structure and promotes end joining
    • Taylor RM, Whitehouse CJ, Caldecott KW (2000) The DNA ligase III zinc finger stimulates binding to DNA secondary structure and promotes end joining. Nucleic Acids Res 28: 3558- 3563
    • (2000) Nucleic Acids Res , vol.28 , pp. 3558-3563
    • Taylor, R.M.1    Whitehouse, C.J.2    Caldecott, K.W.3
  • 99
    • 2942562564 scopus 로고    scopus 로고
    • Mitochondrial disorders: prevalence, myths and advances
    • Thorburn DR (2004) Mitochondrial disorders: prevalence, myths and advances. J Inherit Metab Dis 27: 349- 362
    • (2004) J Inherit Metab Dis , vol.27 , pp. 349-362
    • Thorburn, D.R.1
  • 102
    • 0036085460 scopus 로고    scopus 로고
    • Cellular roles of DNA topoisomerases: a molecular perspective
    • Wang JC (2002) Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol 3: 430- 440
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 430-440
    • Wang, J.C.1
  • 104
    • 77953176342 scopus 로고    scopus 로고
    • When powerhouses fail
    • Westly E (2010) When powerhouses fail. Nat Med 16: 625- 627
    • (2010) Nat Med , vol.16 , pp. 625-627
    • Westly, E.1
  • 106
    • 0029053881 scopus 로고
    • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
    • Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL (1995) An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14: 1105- 1116
    • (1995) Neuron , vol.14 , pp. 1105-1116
    • Wong, P.C.1    Pardo, C.A.2    Borchelt, D.R.3    Lee, M.K.4    Copeland, N.G.5    Jenkins, N.A.6    Sisodia, S.S.7    Cleveland, D.W.8    Price, D.L.9
  • 108
    • 78650964114 scopus 로고    scopus 로고
    • TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage
    • in press)
    • Zeng Z, Cortes-Ledesma F, El-Khamisy SF, Caldecott KW (2011) TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. J Biol Chem (in press)
    • (2011) J Biol Chem
    • Zeng, Z.1    Cortes-Ledesma, F.2    El-Khamisy, S.F.3    Caldecott, K.W.4
  • 109
    • 54849425967 scopus 로고    scopus 로고
    • Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA
    • Zhang H, Pommier Y (2008) Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA. Biochemistry 47: 11196- 11203
    • (2008) Biochemistry , vol.47 , pp. 11196-11203
    • Zhang, H.1    Pommier, Y.2
  • 110
    • 13744253911 scopus 로고    scopus 로고
    • Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)
    • Zhou T, Lee JW, Tatavarthi H, Lupski JR, Valerie K, Povirk LF (2005) Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1). Nucleic Acids Res 33: 289- 297
    • (2005) Nucleic Acids Res , vol.33 , pp. 289-297
    • Zhou, T.1    Lee, J.W.2    Tatavarthi, H.3    Lupski, J.R.4    Valerie, K.5    Povirk, L.F.6
  • 112
    • 33847216248 scopus 로고    scopus 로고
    • Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation
    • Zou Y, Liu Q, Chen B, Zhang X, Guo C, Zhou H, Li J, Gao G, Guo Y, Yan C, et al (2007) Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. Am J Hum Genet 80: 561- 566
    • (2007) Am J Hum Genet , vol.80 , pp. 561-566
    • Zou, Y.1    Liu, Q.2    Chen, B.3    Zhang, X.4    Guo, C.5    Zhou, H.6    Li, J.7    Gao, G.8    Guo, Y.9    Yan, C.10
  • 113
    • 70450225328 scopus 로고    scopus 로고
    • Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression
    • Zou Y, Mi J, Cui J, Lu D, Zhang X, Guo C, Gao G, Liu Q, Chen B, Shao C, et al (2009) Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. J Biol Chem 284: 33320- 33332
    • (2009) J Biol Chem , vol.284 , pp. 33320-33332
    • Zou, Y.1    Mi, J.2    Cui, J.3    Lu, D.4    Zhang, X.5    Guo, C.6    Gao, G.7    Liu, Q.8    Chen, B.9    Shao, C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.