DNA end resection by CtIP and exonuclease 1 prevents genomic instability

EMBO Reports

Volumn 11, Issue 12, 2010, Pages 962-968

  Eid, Wassim ^a   Steger, Martin ^a,b   El Shemerly, Mahmoud ^a   Ferretti, Lorenza P ^a   Peña Diaz, Javier ^a   König, Christiane ^a   Valtorta, Emanuele ^a   Sartori, Alessandro A ^a   Ferrari, Stefano ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Institute for Clinical and Biomedical Research   (Switzerland)

Author keywords

camptothecin; CtIP; DNA double strand break repair; exonuclease 1

Indexed keywords

BINDING PROTEIN; CAMPTOTHECIN; CTIP PROTEIN; EXONUCLEASE; EXONUCLEASE 1; MRE11 PROTEIN; NIBRIN; RAD50 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME DAMAGE; DNA DAMAGE; DNA REPAIR; DNA STRUCTURE; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENOMIC INSTABILITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PROTEIN INTERACTION;

CARRIER PROTEINS; CELL LINE, TUMOR; CYTOPROTECTION; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA REPAIR ENZYMES; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; EXODEOXYRIBONUCLEASES; GENOMIC INSTABILITY; HEK293 CELLS; HUMANS; NUCLEAR PROTEINS; PROTEIN BINDING; RECOMBINATION, GENETIC;

EID: 78649460650     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2010.157     Document Type: Article

References (32)

1. Adamo A, Collis SJ, Adelman CA, Silva N, Horejsi Z, Ward JD,Martinez-Perez E, Boulton SJ, La Volpe A (2010) Preventingnonhomologous end joining suppresses DNA repair defects of Fanconianemia. Mol Cell 39: 25-35
2. Bassing CH, Swat W, Alt FW (2002) The mechanism and regulation ofchromosomal V(D)J recombination. Cell 109: S45-S55
3. Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J,Lukas J (2006) Spatial organization of the mammalian genome surveillancemachinery in response to DNA strand breaks. J Cell Biol 173: 195-206
4. Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, Pandita TK,Burma S, Khanna KK (2010) Phosphorylation of Exo1 modulateshomologous recombination repair of DNA double-strand breaks. NucleicAcids Res 38: 1821-1831
5. Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S,Meuth M, Curtin NJ, Helleday T (2005) Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) Polymerase. Nature434: 913-917
6. Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV, Weitzman MD(2003) The Mre11 complex is required for ATM activation and the G2/Mcheckpoint. EMBO J 22: 6610-6620
7. Chen BP, Chan DW, Kobayashi J, Burma S, Asaithamby A, Morotomi-Yano K,Botvinick E, Qin J, Chen DJ (2005) Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA doublestrand breaks. J Biol Chem 280: 14709-14715
8. Chen L, Nievera CJ, Lee AY, Wu X (2008) Cell cycle-dependent complexformation of BRCA1-CtIP-MRN is important for DNA double-strandbreak repair. J Biol Chem 283: 7713-7720
9. El-Shemerly M, Janscak P, Hess D, Jiricny J, Ferrari S (2005) Degradation ofhuman exonuclease 1b upon DNA synthesis inhibition. Cancer Res 65:3604-3609
10. Farmer H et al (2005) Targeting the DNA repair defect in BRCA mutant cellsas a therapeutic strategy. Nature 434: 917-921
11. 0-directed mismatch repair. J Biol Chem 284:21536-21544
12. Gravel S, Chapman JR, Magill C, Jackson SP (2008) DNA helicases Sgs1 and BLMpromote DNA double-strand break resection. Genes Dev 22: 2767-2772
13. Helleday T, Petermann E, Lundin C, Hodgson B, Sharma RA (2008) DNArepair pathways as targets for cancer therapy. Nat Rev Cancer 8: 193-204
14. Hoeijmakers JH (2001) Genome maintenance mechanisms for preventingcancer. Nature 411: 366-374
15. 0 exonuclease and flap structure-specific endonucleaseactivities. J Biol Chem 274: 37763-37769
16. Lengsfeld BM, Rattray AJ, Bhaskara V, Ghirlando R, Paull TT (2007) Sae2 is anendonuclease that processes hairpin DNA cooperatively with the Mre11-Rad50-Xrs2 complex. Mol Cell 28: 638-651
17. Lisby M, Barlow JH, Burgess RC, Rothstein R (2004) Choreography of theDNA damage response: spatiotemporal relationships among checkpointand repair proteins. Cell 118: 699-713
18. Mimitou EP, Symington LS (2008) Sae2, Exo1 and Sgs1 collaborate in DNAdouble-strand break processing. Nature 455: 770-774
19. Mimitou EP, Symington LS (2009) DNA end resection: many nucleases makelight work. DNA Repair (Amst) 8: 983-995
20. Misteli T, Soutoglou E (2009) The emerging role of nuclear architecture in DNArepair and genome maintenance. Nat Rev Mol Cell Biol 10: 243-254
21. Niu H, Raynard S, Sung P (2009) Multiplicity of DNA end resectionmachineries in chromosome break repair. Genes Dev 23: 1481-1486
22. Pace P, Mosedale G, Hodskinson MR, Rosado IV, Sivasubramaniam M,Patel KJ (2010) Ku70 corrupts DNA repair in the absence of the Fanconianemia pathway. Science 329: 219-223
23. Pardo B, Gomez-Gonzalez B, Aguilera A (2009) DNA repair in mammaliancells: DNA double-strand break repair: how to fix a broken relationship.Cell Mol Life Sci 66: 1039-1056
24. Pommier Y (2006) Topoisomerase I inhibitors: camptothecins and beyond.Nat Rev Cancer 6: 789-802
25. Sakasai R, Teraoka H, Tibbetts RS (2010) Proteasome inhibition suppressesDNA-dependent protein kinase activation caused by camptothecin. DNARepair (Amst) 9: 76-82
26. Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J,Jackson SP (2007) Human CtIP promotes DNA end resection. Nature450: 509-514
27. Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, Jaspers NG,Raams A, Byrd PJ, Petrini JH, Taylor AM (1999) The DNA double-strandbreak repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99: 577-587
28. Walter J, Cremer T, Miyagawa K, Tashiro S (2003) A new system for laser-UVA-microirradiation of living cells. J Microsc 209: 71-75
29. Whitby MC (2005) Making crossovers during meiosis. Biochem Soc Trans 33: 1451-1455
30. Wyman C, Kanaar R (2006) DNA double-strand break repair: all's well that ends well. Annu Rev Genet 40: 363-383
31. 0-directed human mismatch repair in a purified system. Cell 122: 693-705
32. Zhu Z, Chung WH, Shim EY, Lee SE, Ira G (2008) Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134: 981-994