Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

Nature

Volumn 434, Issue 7029, 2005, Pages 108-113

  El Khamisy, Sherif F ^a   Saifi, Gulam M ^b   Weinfeld, Michael ^c   Johansson, Fredrik ^d   Helleday, Thomas ^d,e   Lupski, James R ^b   Caldecott, Keith W ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c CROSS CANCER INSTITUTE   (Canada)

^d STOCKHOLM UNIVERSITY   (Sweden)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; COMPLEXATION; DISEASE CONTROL; DNA; ENZYMES; NEUROLOGY; TUMORS;

NEURONS; SINGLE-STRAND BREAK REPAIR (SSBR); SPINOCEREBELLAR DISEASE WITH AXONAL NEUROPATHY-1 (SCAN1); TYROSYL PHOSPHODIESTERASE 1 (TDP1);

GENETIC ENGINEERING;

ATAXIN 1; DNA TOPOISOMERASE; PHOSPHODIESTERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; SINGLE STRANDED DNA; TYROSYLPHOSPHODIESTERASE 1; UNCLASSIFIED DRUG; CAMPTOTHECIN; DNA LIGASE III; MULTIPROTEIN COMPLEX; TDP1 PROTEIN, HUMAN; TYROSYL DNA PHOSPHODIESTERASE; TYROSYL-DNA PHOSPHODIESTERASE;

BIOLOGY;

ARTICLE; CATALYSIS; COMET ASSAY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; GENE MUTATION; GENETIC STABILITY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; MITOSIS; OXIDATIVE STRESS; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SPINOCEREBELLAR ATAXIA WITH AXONAL NEUROPATHY 1; SPINOCEREBELLAR DEGENERATION; CELL LINE; CHEMISTRY; DNA DAMAGE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; MUTATION; NERVE FIBER; PATHOLOGY; PHYSIOLOGY; PROTEIN BINDING;

ATAXIA; EUKARYOTA;

AXONS; CAMPTOTHECIN; CATALYSIS; CELL LINE; COMET ASSAY; DNA DAMAGE; DNA LIGASES; DNA REPAIR; DNA REPLICATION; DNA TOPOISOMERASES, TYPE I; DNA, SINGLE-STRANDED; HUMANS; MULTIPROTEIN COMPLEXES; MUTATION; OXIDATIVE STRESS; PHOSPHORIC DIESTER HYDROLASES; PROTEIN BINDING; SPINOCEREBELLAR ATAXIAS;

EID: 14544268980     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03314     Document Type: Article

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