TDP2/TTRAP is the major 5′-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage

Journal of Biological Chemistry

Volumn 286, Issue 1, 2011, Pages 403-409

  Zeng, Zhihong ^a   Cortés Ledesma, Felipe ^a   El Khamisy, Sherif F ^a   Caldecott, Keith W ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR AGENTS; CAMPTOTHECINS; CANCER DEVELOPMENT; COVALENTLY BOUND; CYTOTOXIC; DNA DAMAGES; DOUBLE-STRAND BREAKS; DT40 CELL; ETOPOSIDE; HIGHLY SENSITIVE; METHANESULFONATES; PHOSPHODIESTERASE ACTIVITY; PHOSPHODIESTERASES; RECEPTOR-ASSOCIATED PROTEINS; SIGNIFICANT FACTORS; SITE-SPECIFIC; TOPOISOMERASE II; TOPOISOMERASES; VERTEBRATE CELLS;

DNA;

5' TYROSYL DNA PHOSPHODIESTERASE; CAMPTOTHECIN; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; MESYLIC ACID; PHOSPHODIESTERASE; PROTEIN TYROSYL DNA PHOSPHODIESTERASE 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL CYCLE; CELL LINE; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG SENSITIVITY; ENZYME ACTIVITY; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; VERTEBRATE;

ANIMALS; CELL LINE, TUMOR; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; ETOPOSIDE; HUMANS; PHOSPHORIC DIESTER HYDROLASES; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS;

VERTEBRATA;

EID: 78650964114     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.181016     Document Type: Article

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