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Volumn 1410, Issue 2, 1999, Pages 171-182

Mitochondrial involvement in Alzheimer's disease

Author keywords

Aging; Alzheimer; Deletion; Hippocampus; Mitochondrial encephalomyopathy; Mitochondrion; mtDNA; Neuritic plaque; Neurofibrillary tangle; Neuropathology; Oxidative phosphorylation; Oxidative stress; Point mutation; Reactive oxygen species; Respiratory chain

Indexed keywords

CELL NUCLEUS DNA; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

EID: 0033028516     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2728(98)00165-0     Document Type: Review
Times cited : (150)

References (96)
  • 2
    • 0022616654 scopus 로고
    • Alzheimer's disease
    • R. Katzman, Alzheimer's disease, New Engl. J. Med. 314 (1986) 964-973.
    • (1986) New Engl. J. Med. , vol.314 , pp. 964-973
    • Katzman, R.1
  • 6
    • 0026587335 scopus 로고
    • Mitochondrial genetics: A paradigm for aging and degenerative diseases?
    • D.C. Wallace, Mitochondrial genetics: a paradigm for aging and degenerative diseases?, Science 256 (1992) 628-632.
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace, D.C.1
  • 7
    • 0029125857 scopus 로고
    • Aging, energy, and oxidative stress in neurodegenerative diseases
    • M.F. Beal, Aging, energy, and oxidative stress in neurodegenerative diseases, Ann. Neurol. 38 (1995) 357-366.
    • (1995) Ann. Neurol. , vol.38 , pp. 357-366
    • Beal, M.F.1
  • 8
    • 0029743756 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in neurodegeneration
    • A.H.V. Schapira, Oxidative stress and mitochondrial dysfunction in neurodegeneration, Curr. Opin. Neurol. 9 (1996) 260-264.
    • (1996) Curr. Opin. Neurol. , vol.9 , pp. 260-264
    • Schapira, A.H.V.1
  • 9
    • 0021077610 scopus 로고
    • Senile dementia of the Alzheimer type
    • R.D. Terry, R. Katzman, Senile dementia of the Alzheimer type, Ann. Neurol. 14 (1983) 497-506.
    • (1983) Ann. Neurol. , vol.14 , pp. 497-506
    • Terry, R.D.1    Katzman, R.2
  • 10
    • 0007352889 scopus 로고
    • Alzheimer's disease: Cell specific pathology isolates the hippocampal formation
    • B.T. Hyman, A.R. Damasio, G.W. Van Hoesen, C.L. Barnes, Alzheimer's disease: cell specific pathology isolates the hippocampal formation, Science 298 (1984) 83-95.
    • (1984) Science , vol.298 , pp. 83-95
    • Hyman, B.T.1    Damasio, A.R.2    Van Hoesen, G.W.3    Barnes, C.L.4
  • 11
    • 0025807752 scopus 로고
    • Paralbumin-immunoreactive neurons in the neocortex are resistant to degeneration in Alzheimer disease
    • P.R. Hof, K. Cox, W.G. Young, M.R. Celio, J. Rogers, J.H. Morrison, Paralbumin-immunoreactive neurons in the neocortex are resistant to degeneration in Alzheimer disease, J. Neuropathol. Exp. Neurol. 50 (1991) 451-462.
    • (1991) J. Neuropathol. Exp. Neurol. , vol.50 , pp. 451-462
    • Hof, P.R.1    Cox, K.2    Young, W.G.3    Celio, M.R.4    Rogers, J.5    Morrison, J.H.6
  • 12
    • 0025969656 scopus 로고
    • Neocortical neuronal subpopulations labeled by a monoclonal antibody to calbindin exhibit differential vulnerability in Alzheimer's disease
    • P.R. Hof, J.H. Morrison, Neocortical neuronal subpopulations labeled by a monoclonal antibody to calbindin exhibit differential vulnerability in Alzheimer's disease, Exp. Neurol. 111 (1991) 293-301.
    • (1991) Exp. Neurol. , vol.111 , pp. 293-301
    • Hof, P.R.1    Morrison, J.H.2
  • 13
    • 0026032039 scopus 로고
    • Cortical and subcortical patterns of synaptophysin-like immunoreactivity in Alzheimer's disease
    • E. Masliah, R.D. Terry, M. Alford, R. De Teresa, L.A. Hansen, Cortical and subcortical patterns of synaptophysin-like immunoreactivity in Alzheimer's disease, Am. J. Pathol. 138 (1991) 235-246.
    • (1991) Am. J. Pathol. , vol.138 , pp. 235-246
    • Masliah, E.1    Terry, R.D.2    Alford, M.3    De Teresa, R.4    Hansen, L.A.5
  • 14
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • R.D. Terry, E. Masliah, D.P. Salmon, N. Butters, R. De Teresa, R. Hill, L.A. Hansen, R. Katzman, Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment, Ann. Neurol. 30 (1991) 572-580.
    • (1991) Ann. Neurol. , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    De Teresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 15
    • 0022535539 scopus 로고
    • Perforant pathway changes and the memory impairment of Alzheimer's disease
    • B.T. Hyman, G.W. Van Hoesen, L.J. Kromer, A.R. Damasio, Perforant pathway changes and the memory impairment of Alzheimer's disease, Ann. Neurol. 20 (1986) 472-481.
    • (1986) Ann. Neurol. , vol.20 , pp. 472-481
    • Hyman, B.T.1    Van Hoesen, G.W.2    Kromer, L.J.3    Damasio, A.R.4
  • 16
    • 0024842108 scopus 로고
    • The three-dimensional organization of the hippocampal formation: A review of anatomical data
    • D.G. Amaral, M.P. Witter, The three-dimensional organization of the hippocampal formation: a review of anatomical data, Neuroscience 31 (1989) 571-591.
    • (1989) Neuroscience , vol.31 , pp. 571-591
    • Amaral, D.G.1    Witter, M.P.2
  • 17
    • 0025107676 scopus 로고
    • Memory-related neural systems in Alzheimer's disease: An anatomic study
    • B.T. Hyman, G.W. Van Hoesen, A.R. Damasio, Memory-related neural systems in Alzheimer's disease: an anatomic study, Neurology 40 (1990) 1721-1730.
    • (1990) Neurology , vol.40 , pp. 1721-1730
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3
  • 20
    • 2642567981 scopus 로고    scopus 로고
    • Mitochondrial encephalomyopathies
    • R.N. Rosenberg, S.B. Prusiner, S. DiMauro, R.L. Barchi (Eds.), Butterworth-Heinemann, Boston
    • S. DiMauro, E. Bonilla, Mitochondrial encephalomyopathies, in: R.N. Rosenberg, S.B. Prusiner, S. DiMauro, R.L. Barchi (Eds.), The Molecular and Genetic Basis of Neurological Disease, Butterworth-Heinemann, Boston, pp. 189-200.
    • The Molecular and Genetic Basis of Neurological Disease , pp. 189-200
    • DiMauro, S.1    Bonilla, E.2
  • 21
    • 0024596946 scopus 로고
    • A direct repeat is a hotspot for large-scale deletions of human mitochondrial DNA
    • E.A. Schon, R. Rizzuto, C.T. Moraes, H. Nakase, M. Zeviani, S. DiMauro, A direct repeat is a hotspot for large-scale deletions of human mitochondrial DNA, Science 244 (1989) 346-349.
    • (1989) Science , vol.244 , pp. 346-349
    • Schon, E.A.1    Rizzuto, R.2    Moraes, C.T.3    Nakase, H.4    Zeviani, M.5    DiMauro, S.6
  • 23
    • 0025373850 scopus 로고
    • Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: Implications for pathogenesis
    • H. Nakase, C.T. Moraes, R. Rizzuto, A. Lombes, S. DiMauro, E. A. Schon, Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: implications for pathogenesis, Am. J. Hum. Genet. 46 (1990) 418-427.
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 418-427
    • Nakase, H.1    Moraes, C.T.2    Rizzuto, R.3    Lombes, A.4    DiMauro, S.5    Schon, E.A.6
  • 25
    • 0025674177 scopus 로고
    • Detection of a specific mitochondrial DNA deletion in tissues of older humans
    • G.A. Cortopassi, N. Arnheim, Detection of a specific mitochondrial DNA deletion in tissues of older humans, Nucleic Acids Res. 18 (1990) 6927-6933.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 6927-6933
    • Cortopassi, G.A.1    Arnheim, N.2
  • 26
    • 0026471872 scopus 로고
    • Accumulation of deletions in human mitochondrial DNA during normal aging: Analysis by quantitative PCR
    • S. Simonetti, X. Chen, S. DiMauro, E.A. Schon, Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR, Biochim. Biophys. Acta 1180 (1992) 113-122.
    • (1992) Biochim. Biophys. Acta , vol.1180 , pp. 113-122
    • Simonetti, S.1    Chen, X.2    DiMauro, S.3    Schon, E.A.4
  • 27
    • 0026532722 scopus 로고
    • Multiple mitochondrial DNA deletions in an elderly human individual
    • C. Zhang, A. Baumer, R.J. Maxwell, A.W. Linnane, P. Nagley, Multiple mitochondrial DNA deletions in an elderly human individual, FEBS Lett. 297 (1992) 34-38.
    • (1992) FEBS Lett. , vol.297 , pp. 34-38
    • Zhang, C.1    Baumer, A.2    Maxwell, R.J.3    Linnane, A.W.4    Nagley, P.5
  • 28
    • 0002557105 scopus 로고
    • Accumulation of mitochondrial DNA deletions in organisms with various lifespans
    • X. Chen, S. Simonetti, S. DiMauro, E.A. Schon, Accumulation of mitochondrial DNA deletions in organisms with various lifespans, Bull. Mol. Biol. Med. 18 (1993) 57-66.
    • (1993) Bull. Mol. Biol. Med. , vol.18 , pp. 57-66
    • Chen, X.1    Simonetti, S.2    DiMauro, S.3    Schon, E.A.4
  • 29
    • 0029741431 scopus 로고    scopus 로고
    • Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging
    • F. Pallotti, X. Chen, E. Bonilla, E.A. Schon, Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging, Am. J. Hum. Genet. 59 (1996) 591-602.
    • (1996) Am. J. Hum. Genet. , vol.59 , pp. 591-602
    • Pallotti, F.1    Chen, X.2    Bonilla, E.3    Schon, E.A.4
  • 31
    • 0027021442 scopus 로고
    • Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain
    • N.W. Soong, D.R. Hinton, G. Cortopassi, N. Arnheim, Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain, Nature Genet. 2 (1992) 318-323.
    • (1992) Nature Genet. , vol.2 , pp. 318-323
    • Soong, N.W.1    Hinton, D.R.2    Cortopassi, G.3    Arnheim, N.4
  • 32
    • 0019301990 scopus 로고
    • Free radical theory of aging: Origin of life, evolution and aging
    • D. Harman, Free radical theory of aging: origin of life, evolution and aging, Age 3 (1980) 100-102.
    • (1980) Age , vol.3 , pp. 100-102
    • Harman, D.1
  • 33
    • 33646796790 scopus 로고
    • Free radical theory of aging: A hypothesis on pathogenesis of senile dementia of the Alzheimer's type
    • D. Harman, Free radical theory of aging: a hypothesis on pathogenesis of senile dementia of the Alzheimer's type, Age 16 (1993) 23-30.
    • (1993) Age , vol.16 , pp. 23-30
    • Harman, D.1
  • 34
    • 0025041392 scopus 로고
    • Involvement of free radicals in dementia of the Alzheimer type: A hypothesis
    • I. Volicer, P.B. Crino, Involvement of free radicals in dementia of the Alzheimer type: a hypothesis, Neurobiol. Aging 11 (1990) 567-571.
    • (1990) Neurobiol. Aging , vol.11 , pp. 567-571
    • Volicer, I.1    Crino, P.B.2
  • 35
    • 0029145084 scopus 로고
    • Are oxygen free radicals involved in Alzheimer's disease?
    • G. Benzi, A. Moretti, Are oxygen free radicals involved in Alzheimer's disease?, Neurobiol. Aging 16 (1995) 661-674.
    • (1995) Neurobiol. Aging , vol.16 , pp. 661-674
    • Benzi, G.1    Moretti, A.2
  • 36
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate and neurodegenerative disorders
    • J.T. Coyle, P. Puttfarcken, Oxidative stress, glutamate and neurodegenerative disorders, Science 262 (1993) 689-695.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 39
    • 0029073455 scopus 로고
    • Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease
    • M.A. Lovell, W.D. Ehman, S.M. Butler, W.R. Markesbery, Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease, Neurology 45 (1995) 1594-1601.
    • (1995) Neurology , vol.45 , pp. 1594-1601
    • Lovell, M.A.1    Ehman, W.D.2    Butler, S.M.3    Markesbery, W.R.4
  • 40
    • 0028065142 scopus 로고
    • Analyses of microtubule-associated protein tau glycation in paired helical filaments
    • M.D. Ledesma, P. Boney, C. Colaco, J. Avila, Analyses of microtubule-associated protein tau glycation in paired helical filaments, J. Biol. Chem. 269 (1994) 21614-21619.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21614-21619
    • Ledesma, M.D.1    Boney, P.2    Colaco, C.3    Avila, J.4
  • 43
    • 0029902166 scopus 로고    scopus 로고
    • Evidence for neuronal oxidative damage in Alzheimer's disease
    • P.F. Good, P. Werner, A. Hsu, C.W. Olanow, D.P. Perl, Evidence for neuronal oxidative damage in Alzheimer's disease, Am. J. Pathol. 149 (1996) 21-28.
    • (1996) Am. J. Pathol. , vol.149 , pp. 21-28
    • Good, P.F.1    Werner, P.2    Hsu, A.3    Olanow, C.W.4    Perl, D.P.5
  • 46
    • 0028180518 scopus 로고
    • A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer's disease
    • K. Hensley, M.J. Carney, M.P. Mattson, M. Aksenova, M. Karris, R. A. Floyd, D.A. Butterfield, A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer's disease, Proc. Natl. Acad. Sci. USA 91 (1994) 3270-3274.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3270-3274
    • Hensley, K.1    Carney, M.J.2    Mattson, M.P.3    Aksenova, M.4    Karris, M.5    Floyd, R.A.6    Butterfield, D.A.7
  • 47
    • 0028908516 scopus 로고
    • Direct evidence of oxidative injury produced by the Alzheimer β-amyloid peptide (1-40) in cultured hippocampal neurons
    • M.E. Harris, K. Hensley, D.A. Butterfield, R.A. Leedle, J.M. Carney, Direct evidence of oxidative injury produced by the Alzheimer β-amyloid peptide (1-40) in cultured hippocampal neurons, Exp. Neurol. 131 (1995) 193-202.
    • (1995) Exp. Neurol. , vol.131 , pp. 193-202
    • Harris, M.E.1    Hensley, K.2    Butterfield, D.A.3    Leedle, R.A.4    Carney, J.M.5
  • 49
    • 0029671441 scopus 로고    scopus 로고
    • Transfer of β-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle
    • V. Askanas, J. McFerrin, S. Baque, R.B. Alvarez, E. Sarkozi, W.K. Engel, Transfer of β-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle, Proc. Natl. Acad. Sci. USA 93 (1996) 1314-1319.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1314-1319
    • Askanas, V.1    McFerrin, J.2    Baque, S.3    Alvarez, R.B.4    Sarkozi, E.5    Engel, W.K.6
  • 51
    • 0028152717 scopus 로고
    • Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
    • P. Mecocci, U. MacGarvey, M.F. Beal, Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease, Ann. Neurol. 36 (1994) 747-751.
    • (1994) Ann. Neurol. , vol.36 , pp. 747-751
    • Mecocci, P.1    MacGarvey, U.2    Beal, M.F.3
  • 54
    • 0028008696 scopus 로고
    • Clinical deterioration in probable Alzheimer's disease correlates with progressive metabolic impairment of association areas
    • R. Mielke, K. Herholz, M. Grond, J. Kessler, W.D. Heiss, Clinical deterioration in probable Alzheimer's disease correlates with progressive metabolic impairment of association areas, Dementia 5 (1994) 36-41.
    • (1994) Dementia , vol.5 , pp. 36-41
    • Mielke, R.1    Herholz, K.2    Grond, M.3    Kessler, J.4    Heiss, W.D.5
  • 55
    • 0021969443 scopus 로고
    • Alzheimer's disease: Anterior-posterior and lateral hemispheric alterations in cortical glucose utilization
    • R.P. Friedland, T.F. Budinger, E. Koss, B.A. Ober, Alzheimer's disease: anterior-posterior and lateral hemispheric alterations in cortical glucose utilization, Neurosci. Lett. 33 (1985) 235-240.
    • (1985) Neurosci. Lett. , vol.33 , pp. 235-240
    • Friedland, R.P.1    Budinger, T.F.2    Koss, E.3    Ober, B.A.4
  • 56
    • 0022523469 scopus 로고
    • Neocortical metabolic abnormalities precede nonmemory cognitive deficits in early Alzheimer's-type dementia
    • J.V. Haxby, C.L. Grady, R. Duara, N. Schlageter, G. Berg, S.I. Rapoport, Neocortical metabolic abnormalities precede nonmemory cognitive deficits in early Alzheimer's-type dementia, Arch. Neurol. 43 (1986) 882-885.
    • (1986) Arch. Neurol. , vol.43 , pp. 882-885
    • Haxby, J.V.1    Grady, C.L.2    Duara, R.3    Schlageter, N.4    Berg, G.5    Rapoport, S.I.6
  • 58
    • 0029055772 scopus 로고
    • Cytochrome c oxidase in Alzheimer's disease brain
    • W.D. Parker, J.K. Parks, Cytochrome c oxidase in Alzheimer's disease brain, Neurology 45 (1995) 482-486.
    • (1995) Neurology , vol.45 , pp. 482-486
    • Parker, W.D.1    Parks, J.K.2
  • 60
    • 0028110234 scopus 로고
    • Cortical cytochrome oxidase activity is reduced in Alzheimer's disease
    • E.M. Mutisya, A.C. Bowling, M.F. Beal, Cortical cytochrome oxidase activity is reduced in Alzheimer's disease, J. Neurochem. 63 (1994) 2179-2184.
    • (1994) J. Neurochem. , vol.63 , pp. 2179-2184
    • Mutisya, E.M.1    Bowling, A.C.2    Beal, M.F.3
  • 61
    • 0028948660 scopus 로고
    • Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases
    • P. Chagnon, C. Betard, Y. Robitaille, A. Cholette, D. Gauvreau, Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases, Mol. Neurosci. 6 (1995) 711-715.
    • (1995) Mol. Neurosci. , vol.6 , pp. 711-715
    • Chagnon, P.1    Betard, C.2    Robitaille, Y.3    Cholette, A.4    Gauvreau, D.5
  • 62
    • 0027420891 scopus 로고
    • Functional alterations in Alzheimer's disease: Diminution of cytochrome oxidase in the hippocampal formation
    • N.A. Simonian, B.T. Hyman, Functional alterations in Alzheimer's disease: diminution of cytochrome oxidase in the hippocampal formation, J. Neuropathol. Exp. Neurol. 52 (1993) 580-585.
    • (1993) J. Neuropathol. Exp. Neurol. , vol.52 , pp. 580-585
    • Simonian, N.A.1    Hyman, B.T.2
  • 63
    • 0028023533 scopus 로고
    • Functional alterations in Alzheimer's disease: Selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation
    • N.A. Simonian, B.T. Hyman, Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation, J. Neuropathol. Exp. Neurol. 53 (1994) 508-512.
    • (1994) J. Neuropathol. Exp. Neurol. , vol.53 , pp. 508-512
    • Simonian, N.A.1    Hyman, B.T.2
  • 64
    • 0022000397 scopus 로고
    • Immunocytological demonstration of cytochrome c oxidase with an immunoperoxidase method
    • C.D. Bedetti, Immunocytological demonstration of cytochrome c oxidase with an immunoperoxidase method, J. Histochem. Cytochem. 33 (1985) 446-452.
    • (1985) J. Histochem. Cytochem. , vol.33 , pp. 446-452
    • Bedetti, C.D.1
  • 65
    • 0027405664 scopus 로고
    • Mitochondrial and nuclear gene expression for cytochrome oxidase subunits are disproportionally regulated by functional activity in neurons
    • R.F. Hevner, M.T.T. Wong-Riley, Mitochondrial and nuclear gene expression for cytochrome oxidase subunits are disproportionally regulated by functional activity in neurons, J. Neurosci. 13 (1993) 1805-1819.
    • (1993) J. Neurosci. , vol.13 , pp. 1805-1819
    • Hevner, R.F.1    Wong-Riley, M.T.T.2
  • 66
    • 0029985675 scopus 로고    scopus 로고
    • Nuclear respiratory factors and the pathways of nuclear-mitochondrial interactions
    • R.C. Scarpulla, Nuclear respiratory factors and the pathways of nuclear-mitochondrial interactions, Trends Cardiovasc. Med. 6 (1996) 39-45.
    • (1996) Trends Cardiovasc. Med. , vol.6 , pp. 39-45
    • Scarpulla, R.C.1
  • 67
    • 0028869597 scopus 로고
    • 0 ATP-synthase defects in Alzheimer's disease revealed by blue native polyacrylamide gel electrophoresis
    • 0 ATP-synthase defects in Alzheimer's disease revealed by blue native polyacrylamide gel electrophoresis, Eur. J. Biochem. 227 (1995) 916-921.
    • (1995) Eur. J. Biochem. , vol.227 , pp. 916-921
    • Schagger, H.1    Ohm, T.G.2
  • 68
    • 0021813419 scopus 로고
    • An immunohistochemical study of pyruvate dehydrogenase deficit in Alzheimer's disease brain
    • K.F.R. Sheu, Y.T. Kim, J.P. Blass, M.E. Weksler, An immunohistochemical study of pyruvate dehydrogenase deficit in Alzheimer's disease brain, Ann. Neurol. 17 (1985) 444-449.
    • (1985) Ann. Neurol. , vol.17 , pp. 444-449
    • Sheu, K.F.R.1    Kim, Y.T.2    Blass, J.P.3    Weksler, M.E.4
  • 69
    • 0027332651 scopus 로고
    • Brain α-ketoglutarate dehydrogenase activity in Alzheimer's disease
    • F. Mastrogiacomo, C. Bergeron, S.J. Kish, Brain α-ketoglutarate dehydrogenase activity in Alzheimer's disease, J. Neurochem. 6 (1993) 2007-2014.
    • (1993) J. Neurochem. , vol.6 , pp. 2007-2014
    • Mastrogiacomo, F.1    Bergeron, C.2    Kish, S.J.3
  • 70
    • 0030296713 scopus 로고    scopus 로고
    • Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease
    • K. Chandrasekaran, K. Hatanpää, D.R. Brady, S.I. Rapoport, Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease, Exp. Neurol. 142 (1996) 80-88.
    • (1996) Exp. Neurol. , vol.142 , pp. 80-88
    • Chandrasekaran, K.1    Hatanpää, K.2    Brady, D.R.3    Rapoport, S.I.4
  • 71
    • 0030498070 scopus 로고    scopus 로고
    • Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer's disease
    • S.I. Rapoport, K. Hatanpää, D.R. Brady, K. Chandrasekaran, Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer's disease, Neurodegeneration 5 (1996) 473-476.
    • (1996) Neurodegeneration , vol.5 , pp. 473-476
    • Rapoport, S.I.1    Hatanpää, K.2    Brady, D.R.3    Chandrasekaran, K.4
  • 73
    • 0031036773 scopus 로고    scopus 로고
    • Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer's disease
    • K. Chandrasekaran, K. Hatanpää, S.I. Rapoport, D.R. Brady, Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer's disease, Mol. Brain Res. 44 (1997) 99-104.
    • (1997) Mol. Brain Res. , vol.44 , pp. 99-104
    • Chandrasekaran, K.1    Hatanpää, K.2    Rapoport, S.I.3    Brady, D.R.4
  • 74
    • 0027215961 scopus 로고
    • A mitochondrial DNA deletion in normally aging and in Alzheimer brain tissue
    • B.J. Blanchard, T. Park, W.J. Fripp, L.S. Lerman, V.M. Ingram, A mitochondrial DNA deletion in normally aging and in Alzheimer brain tissue, Neuroreport 4 (1993) 799-802.
    • (1993) Neuroreport , vol.4 , pp. 799-802
    • Blanchard, B.J.1    Park, T.2    Fripp, W.J.3    Lerman, L.S.4    Ingram, V.M.5
  • 75
    • 0029101854 scopus 로고
    • Decreased cytochrome-c oxidase activity and lack of age-related accumulation of mitochondrial DNA deletions in the brains of schizophrenics
    • L. Cavelier, E.E. Jazin, I. Eriksson, J. Prince, U. Bave, L. Oreland, U. Gyllenstein, Decreased cytochrome-c oxidase activity and lack of age-related accumulation of mitochondrial DNA deletions in the brains of schizophrenics, Genomics 29 (1995) 217-224.
    • (1995) Genomics , vol.29 , pp. 217-224
    • Cavelier, L.1    Jazin, E.E.2    Eriksson, I.3    Prince, J.4    Bave, U.5    Oreland, L.6    Gyllenstein, U.7
  • 76
    • 0030016323 scopus 로고    scopus 로고
    • Increased risk of dementia in mothers of Alzheimer's disease cases: Evidence for maternal inheritance
    • S.D. Edland, J.M. Silverman, E.R. Peskind, D. Tsuang, E. Wijsman, J.C. Morris, Increased risk of dementia in mothers of Alzheimer's disease cases: evidence for maternal inheritance, Neurology 47 (1996) 254-256.
    • (1996) Neurology , vol.47 , pp. 254-256
    • Edland, S.D.1    Silverman, J.M.2    Peskind, E.R.3    Tsuang, D.4    Wijsman, E.5    Morris, J.C.6
  • 78
    • 0026672905 scopus 로고
    • Is a point mutation in the mitochondrial ND2 gene associated with Alzheimer's disease?
    • V. Petruzzella, X. Chen, E.A. Schon, Is a point mutation in the mitochondrial ND2 gene associated with Alzheimer's disease?, Biochim. Biophys. Res. Commun. 186 (1992) 491-497.
    • (1992) Biochim. Biophys. Res. Commun. , vol.186 , pp. 491-497
    • Petruzzella, V.1    Chen, X.2    Schon, E.A.3
  • 79
    • 0027935035 scopus 로고
    • No association of mutations at nucleotide 5460 of mitochondrial NADH dehydrogenase with Alzheimer's disease
    • S. Kösel, R. Egensperger, P. Mehraein, M.B. Graeber, No association of mutations at nucleotide 5460 of mitochondrial NADH dehydrogenase with Alzheimer's disease, Biochem. Biophys. Res. Commun. 203 (1994) 745-759.
    • (1994) Biochem. Biophys. Res. Commun. , vol.203 , pp. 745-759
    • Kösel, S.1    Egensperger, R.2    Mehraein, P.3    Graeber, M.B.4
  • 81
    • 0029965659 scopus 로고    scopus 로고
    • Investigations on the point mutations at nt 5460 of the mtDNA in different neurodegenerative and neuromuscular diseases
    • B. Janetzky, C. Schmid, F. Bischof, L. Frolich, W. Gsell, R.N. Kalaria, P. Riederer, H. Reichmann, Investigations on the point mutations at nt 5460 of the mtDNA in different neurodegenerative and neuromuscular diseases, Eur. Neurol. 36 (1996) 149-153.
    • (1996) Eur. Neurol. , vol.36 , pp. 149-153
    • Janetzky, B.1    Schmid, C.2    Bischof, F.3    Frolich, L.4    Gsell, W.5    Kalaria, R.N.6    Riederer, P.7    Reichmann, H.8
  • 84
    • 0029091194 scopus 로고
    • A mitochondrial DNA clone is associated with increased risk for Alzheimer disease
    • T. Hutchin, G. Cortopassi, A mitochondrial DNA clone is associated with increased risk for Alzheimer disease, Proc. Natl. Acad. Sci. USA 92 (1995) 6892-6895.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6892-6895
    • Hutchin, T.1    Cortopassi, G.2
  • 85
    • 0028843809 scopus 로고
    • No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant
    • M.A. Wragg, C.J. Talbot, J.C. Morris, C.L. Lendon, A.M. Goate, No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant, Neurosci. Lett. 201 (1995) 107-110.
    • (1995) Neurosci. Lett. , vol.201 , pp. 107-110
    • Wragg, M.A.1    Talbot, C.J.2    Morris, J.C.3    Lendon, C.L.4    Goate, A.M.5
  • 86
    • 0031584966 scopus 로고    scopus 로고
    • Mitochondrial tRNA(Gln) and tRNA(Thr) gene variants in Parkinson's disease
    • U. Mayr-Wohlfart, G. Rodel, A. Henneberg, Mitochondrial tRNA(Gln) and tRNA(Thr) gene variants in Parkinson's disease, Eur. J. Med. Res. 2 (1997) 111-113.
    • (1997) Eur. J. Med. Res. , vol.2 , pp. 111-113
    • Mayr-Wohlfart, U.1    Rodel, G.2    Henneberg, A.3
  • 89
    • 0031449003 scopus 로고    scopus 로고
    • Apparent mtDNA heteroplasmy in Alzheimer disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes
    • M. Hirano, A. Shtilbans, R. Mayeux, M.M. Davidson, S. DiMauro, J.A. Knowles, E.A. Schon, Apparent mtDNA heteroplasmy in Alzheimer disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes, Proc. Natl. Acad. Sci. USA 94 (1997) 14894-14899.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14894-14899
    • Hirano, M.1    Shtilbans, A.2    Mayeux, R.3    Davidson, M.M.4    DiMauro, S.5    Knowles, J.A.6    Schon, E.A.7
  • 90
    • 0031464288 scopus 로고    scopus 로고
    • Ancient mtDNA sequences in the human nuclear genome: A potential source of errors in identifying pathogenic mutations
    • D.C. Wallace, C. Stugard, D. Murdock, T. Schurr, M.D. Brown, Ancient mtDNA sequences in the human nuclear genome: a potential source of errors in identifying pathogenic mutations, Proc. Natl. Acad. Sci. USA 94 (1997) 14900-14905.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14900-14905
    • Wallace, D.C.1    Stugard, C.2    Murdock, D.3    Schurr, T.4    Brown, M.D.5
  • 91
    • 0024448458 scopus 로고
    • Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation
    • M.P. King, G. Attardi, Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation, Science 246 (1989) 500-503.
    • (1989) Science , vol.246 , pp. 500-503
    • King, M.P.1    Attardi, G.2
  • 92
    • 0026573082 scopus 로고
    • Leu(UUR) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes
    • Leu(UUR) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes, Mol. Cell Biol. 12 (1992) 480-490.
    • (1992) Mol. Cell Biol. , vol.12 , pp. 480-490
    • King, M.P.1    Koga, Y.2    Davidson, M.3    Schon, E.A.4
  • 93
    • 0029800941 scopus 로고    scopus 로고
    • Creation and characterization of mitochondrial DNA-depleted cell lines with 'neuronal-like' properties
    • S.W. Miller, P.A. Trimmer, W.D. Parker, R.E. Davis, Creation and characterization of mitochondrial DNA-depleted cell lines with 'neuronal-like' properties, J. Neurochem. 67 (1996) 1897-1907.
    • (1996) J. Neurochem. , vol.67 , pp. 1897-1907
    • Miller, S.W.1    Trimmer, P.A.2    Parker, W.D.3    Davis, R.E.4
  • 95
    • 0030923869 scopus 로고    scopus 로고
    • Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease
    • J.P. Sheehan, R.H. Swerdlow, S.W. Miller, R.E. Davis, J.K. Parks, W.D. Parker, J.B. Tuttle, Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease, J. Neurosci. 17 (1997) 4612-4622.
    • (1997) J. Neurosci. , vol.17 , pp. 4612-4622
    • Sheehan, J.P.1    Swerdlow, R.H.2    Miller, S.W.3    Davis, R.E.4    Parks, J.K.5    Parker, W.D.6    Tuttle, J.B.7
  • 96
    • 0031843532 scopus 로고    scopus 로고
    • Cybrids in Alzheimer's disease: A cellular model of the disease?
    • E.A. Schon, E.A. Shoubridge, C.T. Moraes, Cybrids in Alzheimer's disease: a cellular model of the disease? (letter), Neurology 51 (1998) 326-327.
    • (1998) Neurology , vol.51 , pp. 326-327
    • Schon, E.A.1    Shoubridge, E.A.2    Moraes, C.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.