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Volumn 94, Issue C, 2011, Pages 129-169

RB1, Development, and Cancer

Author keywords

Chromatin; Differentiation; Epigenetics; Retinoblastoma; Stem cells

Indexed keywords

RETINOBLASTOMA PROTEIN;

EID: 79551490353     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-380916-2.00005-X     Document Type: Book
Times cited : (143)

References (244)
  • 1
    • 3142768347 scopus 로고    scopus 로고
    • Chromatin regulates origin activity in Drosophila follicle cells
    • Aggarwal B.D., Calvi B.R. Chromatin regulates origin activity in Drosophila follicle cells. Nature 2004, 430:372-376.
    • (2004) Nature , vol.430 , pp. 372-376
    • Aggarwal, B.D.1    Calvi, B.R.2
  • 3
    • 70749128701 scopus 로고    scopus 로고
    • RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation
    • Amato A., Lentini L., Schillaci T., Iovino F., Di Leonardo A. RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation. BMC Cell Biol. 2009, 10:79.
    • (2009) BMC Cell Biol. , vol.10 , pp. 79
    • Amato, A.1    Lentini, L.2    Schillaci, T.3    Iovino, F.4    Di Leonardo, A.5
  • 6
    • 0345060052 scopus 로고    scopus 로고
    • Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo
    • Balsitis S.J., Sage J., Duensing S., Munger K., Jacks T., Lambert P.F. Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo. Mol. Cell. Biol. 2003, 23:9094-9103.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 9094-9103
    • Balsitis, S.J.1    Sage, J.2    Duensing, S.3    Munger, K.4    Jacks, T.5    Lambert, P.F.6
  • 7
    • 16244378910 scopus 로고    scopus 로고
    • Control of cell proliferation in the Drosophila eye by Notch signaling
    • Baonza A., Freeman M. Control of cell proliferation in the Drosophila eye by Notch signaling. Dev. Cell 2005, 8:529-539.
    • (2005) Dev. Cell , vol.8 , pp. 529-539
    • Baonza, A.1    Freeman, M.2
  • 8
    • 0034719409 scopus 로고    scopus 로고
    • Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function
    • Barrientes S., Cooke C., Goodrich D.W. Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function. Oncogene 2000, 19:562-570.
    • (2000) Oncogene , vol.19 , pp. 562-570
    • Barrientes, S.1    Cooke, C.2    Goodrich, D.W.3
  • 9
    • 18144378722 scopus 로고    scopus 로고
    • Retinoblastoma and the related pocket protein p107 act as coactivators of neuroD1 to enhance gene transcription
    • Batsche E., Moschopoulos P., Desroches J., Bilodeau S., Drouin J. Retinoblastoma and the related pocket protein p107 act as coactivators of neuroD1 to enhance gene transcription. J. Biol. Chem. 2005, 280:16088-16095.
    • (2005) J. Biol. Chem. , vol.280 , pp. 16088-16095
    • Batsche, E.1    Moschopoulos, P.2    Desroches, J.3    Bilodeau, S.4    Drouin, J.5
  • 10
    • 33750463354 scopus 로고    scopus 로고
    • MES-4: An autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line
    • Bender L.B., Suh J., Carroll C.R., Fong Y., Fingerman I.M., Briggs S.D., Cao R., Zhang Y., Reinke V., Strome S. MES-4: An autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Development 2006, 133:3907-3917.
    • (2006) Development , vol.133 , pp. 3907-3917
    • Bender, L.B.1    Suh, J.2    Carroll, C.R.3    Fong, Y.4    Fingerman, I.M.5    Briggs, S.D.6    Cao, R.7    Zhang, Y.8    Reinke, V.9    Strome, S.10
  • 14
    • 33947246502 scopus 로고    scopus 로고
    • Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
    • Binne U.K., Classon M.K., Dick F.A., Wei W., Rape M., Kaelin W.G., Naar A.M., Dyson N.J. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat. Cell Biol. 2007, 9:225-232.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 225-232
    • Binne, U.K.1    Classon, M.K.2    Dick, F.A.3    Wei, W.4    Rape, M.5    Kaelin, W.G.6    Naar, A.M.7    Dyson, N.J.8
  • 15
    • 77955911829 scopus 로고    scopus 로고
    • Arabidopsis retinoblastoma-related is required for stem cell maintenance, cell differentiation, and lateral organ production
    • 22, 1792-1811
    • Borghi L., Gutzat R., Futterer J., Laizet Y.h., Hennig L., Gruissem W. Arabidopsis retinoblastoma-related is required for stem cell maintenance, cell differentiation, and lateral organ production. Plant Cell 2010, 22, 1792-1811.
    • (2010) Plant Cell
    • Borghi, L.1    Gutzat, R.2    Futterer, J.3    Laizet, Y.4    Hennig, L.5    Gruissem, W.6
  • 16
    • 0035092886 scopus 로고    scopus 로고
    • DNA replication control through interaction of E2F-RB and the origin recognition complex
    • Bosco G., Du W., Orr-Weaver T.L. DNA replication control through interaction of E2F-RB and the origin recognition complex. Nat. Cell Biol. 2001, 3:289-295.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 289-295
    • Bosco, G.1    Du, W.2    Orr-Weaver, T.L.3
  • 17
    • 0035169269 scopus 로고    scopus 로고
    • Lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans
    • Boxem M., van den Heuvel S. lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans. Development 2001, 128:4349-4359.
    • (2001) Development , vol.128 , pp. 4349-4359
    • Boxem, M.1    van den Heuvel, S.2
  • 18
    • 0037018845 scopus 로고    scopus 로고
    • C. elegans class B synthetic multivulva genes act in G(1) regulation
    • Boxem M., van den Heuvel S. C. elegans class B synthetic multivulva genes act in G(1) regulation. Curr. Biol. 2002, 12:906-911.
    • (2002) Curr. Biol. , vol.12 , pp. 906-911
    • Boxem, M.1    van den Heuvel, S.2
  • 20
    • 0032931991 scopus 로고    scopus 로고
    • Cumulative effect of phosphorylation of pRB on regulation of E2F activity
    • Brown V.D., Phillips R.A., Gallie B.L. Cumulative effect of phosphorylation of pRB on regulation of E2F activity. Mol. Cell. Biol. 1999, 19:3246-3256.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3246-3256
    • Brown, V.D.1    Phillips, R.A.2    Gallie, B.L.3
  • 21
    • 77952387813 scopus 로고    scopus 로고
    • Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding
    • Burke J.R., Deshong A.J., Pelton J.G., Rubin S.M. Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding. J. Biol. Chem. 2010, 285:16286-16293.
    • (2010) J. Biol. Chem. , vol.285 , pp. 16286-16293
    • Burke, J.R.1    Deshong, A.J.2    Pelton, J.G.3    Rubin, S.M.4
  • 22
    • 50149120366 scopus 로고    scopus 로고
    • Cellular mechanisms of tumour suppression by the retinoblastoma gene
    • Burkhart D.L., Sage J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat. Rev. Cancer 2008, 8:671-682.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 671-682
    • Burkhart, D.L.1    Sage, J.2
  • 24
    • 0035265833 scopus 로고    scopus 로고
    • Dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development
    • Ceol C.J., Horvitz H.R. dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. Mol. Cell 2001, 7:461-473.
    • (2001) Mol. Cell , vol.7 , pp. 461-473
    • Ceol, C.J.1    Horvitz, H.R.2
  • 27
    • 41149159603 scopus 로고    scopus 로고
    • Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp
    • Chau C.M., Deng Z., Kang H., Lieberman P.M. Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp. J. Virol. 2008, 82:3428-3437.
    • (2008) J. Virol. , vol.82 , pp. 3428-3437
    • Chau, C.M.1    Deng, Z.2    Kang, H.3    Lieberman, P.M.4
  • 28
    • 0030031409 scopus 로고    scopus 로고
    • Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
    • Chen P.L., Riley D.J., Chen-Kiang S., Lee W.H. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 1996, 93:465-469.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 465-469
    • Chen, P.L.1    Riley, D.J.2    Chen-Kiang, S.3    Lee, W.H.4
  • 29
    • 0029830342 scopus 로고    scopus 로고
    • Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
    • Chen P.L., Riley D.J., Chen Y., Lee W.H. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 1996, 10:2794-2804.
    • (1996) Genes Dev. , vol.10 , pp. 2794-2804
    • Chen, P.L.1    Riley, D.J.2    Chen, Y.3    Lee, W.H.4
  • 30
    • 2942574955 scopus 로고    scopus 로고
    • Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma
    • Chen D., Livne-bar I., Vanderluit J.L., Slack R.S., Agochiya M., Bremner R. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell 2004, 5:539-551.
    • (2004) Cancer Cell , vol.5 , pp. 539-551
    • Chen, D.1    Livne-bar, I.2    Vanderluit, J.L.3    Slack, R.S.4    Agochiya, M.5    Bremner, R.6
  • 32
    • 70350518233 scopus 로고    scopus 로고
    • Emerging roles of E2Fs in cancer: An exit from cell cycle control
    • Chen H.Z., Tsai S.Y., Leone G. Emerging roles of E2Fs in cancer: An exit from cell cycle control. Nat. Rev. Cancer 2009, 9:785-797.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 785-797
    • Chen, H.Z.1    Tsai, S.Y.2    Leone, G.3
  • 33
    • 66349139380 scopus 로고    scopus 로고
    • Proliferation and cell fate establishment during Arabidopsis male gametogenesis depends on the Retinoblastoma protein
    • Chen Z., Hafidh S., Poh S.H., Twell D., Berger F. Proliferation and cell fate establishment during Arabidopsis male gametogenesis depends on the Retinoblastoma protein. Proc. Natl. Acad. Sci. USA 2009, 106:7257-7262.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 7257-7262
    • Chen, Z.1    Hafidh, S.2    Poh, S.H.3    Twell, D.4    Berger, F.5
  • 37
    • 0035835827 scopus 로고    scopus 로고
    • P107 and p130: Versatile proteins with interesting pockets
    • Classon M., Dyson N. p107 and p130: Versatile proteins with interesting pockets. Exp. Cell Res. 2001, 264:135-147.
    • (2001) Exp. Cell Res. , vol.264 , pp. 135-147
    • Classon, M.1    Dyson, N.2
  • 38
    • 0036037189 scopus 로고    scopus 로고
    • The retinoblastoma family: Twins or distant cousins?
    • (reviews 3012)
    • Claudio P.P., Tonini T., Giordano A. The retinoblastoma family: Twins or distant cousins?. Genome Biol. 2002, 3. (reviews 3012).
    • (2002) Genome Biol. , vol.3
    • Claudio, P.P.1    Tonini, T.2    Giordano, A.3
  • 39
    • 0015749593 scopus 로고
    • A general theory of carcinogenesis
    • Comings D.E. A general theory of carcinogenesis. Proc. Natl. Acad. Sci. USA 1973, 70:3324-3328.
    • (1973) Proc. Natl. Acad. Sci. USA , vol.70 , pp. 3324-3328
    • Comings, D.E.1
  • 40
    • 0031019197 scopus 로고    scopus 로고
    • Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
    • Connell-Crowley L., Harper J.W., Goodrich D.W. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol. Biol. Cell 1997, 8:287-301.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 287-301
    • Connell-Crowley, L.1    Harper, J.W.2    Goodrich, D.W.3
  • 42
    • 42949129074 scopus 로고    scopus 로고
    • Many roads lead to oncogene-induced senescence
    • Courtois-Cox S., Jones S.L., Cichowski K. Many roads lead to oncogene-induced senescence. Oncogene 2008, 27:2801-2809.
    • (2008) Oncogene , vol.27 , pp. 2801-2809
    • Courtois-Cox, S.1    Jones, S.L.2    Cichowski, K.3
  • 45
    • 59649101100 scopus 로고    scopus 로고
    • AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development
    • Dasgupta B., Milbrandt J., Dasgupta B., Milbrandt J. AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev. Cell 2009, 16:256-270.
    • (2009) Dev. Cell , vol.16 , pp. 256-270
    • Dasgupta, B.1    Milbrandt, J.2    Dasgupta, B.3    Milbrandt, J.4
  • 46
    • 0037113944 scopus 로고    scopus 로고
    • Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis
    • Day K.C., McCabe M.T., Zhao X., Wang Y., Davis J.N., Phillips J., Von Geldern M., Ried T., KuKuruga M.A., Cunha G.R., Hayward S.W., Day M.L. Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis. J. Biol. Chem. 2002, 277:44475-44484.
    • (2002) J. Biol. Chem. , vol.277 , pp. 44475-44484
    • Day, K.C.1    McCabe, M.T.2    Zhao, X.3    Wang, Y.4    Davis, J.N.5    Phillips, J.6    Von Geldern, M.7    Ried, T.8    KuKuruga, M.A.9    Cunha, G.R.10    Hayward, S.W.11    Day, M.L.12
  • 49
    • 0141927097 scopus 로고    scopus 로고
    • PRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities
    • Dick F.A., Dyson N. pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Mol. Cell 2003, 12:639-649.
    • (2003) Mol. Cell , vol.12 , pp. 639-649
    • Dick, F.A.1    Dyson, N.2
  • 50
    • 0033970464 scopus 로고    scopus 로고
    • Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain
    • Du W. Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain. Development 2000, 127:367-379.
    • (2000) Development , vol.127 , pp. 367-379
    • Du, W.1
  • 51
    • 0033558346 scopus 로고    scopus 로고
    • The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis
    • Du W., Dyson N. The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J. 1999, 18:916-925.
    • (1999) EMBO J. , vol.18 , pp. 916-925
    • Du, W.1    Dyson, N.2
  • 54
    • 0029044951 scopus 로고
    • The transcription factor E2F is required for S phase during Drosophila embryogenesis
    • Duronio R.J., O'Farrell P.H., Xie J.E., Brook A., Dyson N. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 1995, 9:1445-1455.
    • (1995) Genes Dev. , vol.9 , pp. 1445-1455
    • Duronio, R.J.1    O'Farrell, P.H.2    Xie, J.E.3    Brook, A.4    Dyson, N.5
  • 55
    • 0027936686 scopus 로고
    • Differential regulation of E2F transactivation by cyclin/cdk2 complexes
    • Dynlacht B.D., Flores O., Lees J.A., Harlow E. Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev. 1994, 8:1772-1786.
    • (1994) Genes Dev. , vol.8 , pp. 1772-1786
    • Dynlacht, B.D.1    Flores, O.2    Lees, J.A.3    Harlow, E.4
  • 56
    • 3042640434 scopus 로고    scopus 로고
    • Plant retinoblastoma homologues control nuclear proliferation in the female gametophyte
    • Ebel C., Mariconti L., Gruissem W. Plant retinoblastoma homologues control nuclear proliferation in the female gametophyte. Nature 2004, 429:776-780.
    • (2004) Nature , vol.429 , pp. 776-780
    • Ebel, C.1    Mariconti, L.2    Gruissem, W.3
  • 57
    • 0029015262 scopus 로고
    • Promoter-dependent photocross-linking of the acidic transcriptional activator E2F-1 to the TATA-binding protein
    • Emili A., Ingles C.J. Promoter-dependent photocross-linking of the acidic transcriptional activator E2F-1 to the TATA-binding protein. J. Biol. Chem. 1995, 270:13674-13680.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13674-13680
    • Emili, A.1    Ingles, C.J.2
  • 59
    • 0037083918 scopus 로고    scopus 로고
    • Fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen
    • Fay D.S., Keenan S., Han M. fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Genes Dev. 2002, 16:503-517.
    • (2002) Genes Dev. , vol.16 , pp. 503-517
    • Fay, D.S.1    Keenan, S.2    Han, M.3
  • 60
    • 0037150653 scopus 로고    scopus 로고
    • Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans
    • Fong Y., Bender L., Wang W., Strome S. Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans. Science 2002, 296:2235-2238.
    • (2002) Science , vol.296 , pp. 2235-2238
    • Fong, Y.1    Bender, L.2    Wang, W.3    Strome, S.4
  • 61
    • 0022506980 scopus 로고
    • A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
    • Friend S.H., Bernards R., Rogelj S., Weinberg R.A., Rapaport J.M., Albert D.M., Dryja T.P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986, 323:643-646.
    • (1986) Nature , vol.323 , pp. 643-646
    • Friend, S.H.1    Bernards, R.2    Rogelj, S.3    Weinberg, R.A.4    Rapaport, J.M.5    Albert, D.M.6    Dryja, T.P.7
  • 62
    • 2942722811 scopus 로고    scopus 로고
    • Molecular mechanisms of E2F-dependent activation and pRB-mediated repression
    • Frolov M.V., Dyson N.J. Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J. Cell Sci. 2004, 117:2173-2181.
    • (2004) J. Cell Sci. , vol.117 , pp. 2173-2181
    • Frolov, M.V.1    Dyson, N.J.2
  • 63
  • 65
    • 33748039091 scopus 로고    scopus 로고
    • Involvement of RB gene family in tumor angiogenesis
    • Gabellini C., Del Bufalo D., Zupi G. Involvement of RB gene family in tumor angiogenesis. Oncogene 2006, 25:5326-5332.
    • (2006) Oncogene , vol.25 , pp. 5326-5332
    • Gabellini, C.1    Del Bufalo, D.2    Zupi, G.3
  • 66
    • 0038322038 scopus 로고    scopus 로고
    • The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding
    • Gladden A.B., Diehl J.A. The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding. J. Biol. Chem. 2003, 278:9754-9760.
    • (2003) J. Biol. Chem. , vol.278 , pp. 9754-9760
    • Gladden, A.B.1    Diehl, J.A.2
  • 68
    • 0242380343 scopus 로고    scopus 로고
    • How the other half lives, the amino-terminal domain of the retinoblastoma tumor suppressor protein
    • Goodrich D.W. How the other half lives, the amino-terminal domain of the retinoblastoma tumor suppressor protein. J. Cell. Physiol. 2003, 197:169-180.
    • (2003) J. Cell. Physiol. , vol.197 , pp. 169-180
    • Goodrich, D.W.1
  • 69
    • 33748075785 scopus 로고    scopus 로고
    • The retinoblastoma tumor-suppressor gene, the exception that proves the rule
    • Goodrich D.W. The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene 2006, 25:5233-5243.
    • (2006) Oncogene , vol.25 , pp. 5233-5243
    • Goodrich, D.W.1
  • 70
    • 0026058874 scopus 로고
    • The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle
    • Goodrich D.W., Wang N.P., Qian Y.W., Lee E.Y., Lee W.H. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 1991, 67:293-302.
    • (1991) Cell , vol.67 , pp. 293-302
    • Goodrich, D.W.1    Wang, N.P.2    Qian, Y.W.3    Lee, E.Y.4    Lee, W.H.5
  • 71
    • 28444433734 scopus 로고    scopus 로고
    • Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes
    • Grishok A., Sharp P.A. Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proc. Natl. Acad. Sci. USA 2005, 102:17360-17365.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 17360-17365
    • Grishok, A.1    Sharp, P.A.2
  • 72
    • 0027499060 scopus 로고
    • Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
    • Gu W., Schneider J.W., Condorelli G., Kaushal S., Mahdavi V., Nadal-Ginard B. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 1993, 72:309-324.
    • (1993) Cell , vol.72 , pp. 309-324
    • Gu, W.1    Schneider, J.W.2    Condorelli, G.3    Kaushal, S.4    Mahdavi, V.5    Nadal-Ginard, B.6
  • 73
    • 27744563251 scopus 로고    scopus 로고
    • Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells
    • Guo J., Sheng G., Warner B.W. Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells. J. Biol. Chem. 2005, 280:35992-35998.
    • (2005) J. Biol. Chem. , vol.280 , pp. 35992-35998
    • Guo, J.1    Sheng, G.2    Warner, B.W.3
  • 74
    • 58649106915 scopus 로고    scopus 로고
    • Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine
    • Guo J., Longshore S., Nair R., Warner B.W. Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine. J. Biol. Chem. 2009, 284:134-140.
    • (2009) J. Biol. Chem. , vol.284 , pp. 134-140
    • Guo, J.1    Longshore, S.2    Nair, R.3    Warner, B.W.4
  • 75
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: Mirage or reality?
    • Gupta P.B., Chaffer C.L., Weinberg R.A. Cancer stem cells: Mirage or reality?. Nat. Med. 2009, 15:1010-1012.
    • (2009) Nat. Med. , vol.15 , pp. 1010-1012
    • Gupta, P.B.1    Chaffer, C.L.2    Weinberg, R.A.3
  • 77
    • 0027520469 scopus 로고
    • The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro
    • Hagemeier C., Cook A., Kouzarides T. The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro. Nucleic Acids Res. 1993, 21:4998-5004.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 4998-5004
    • Hagemeier, C.1    Cook, A.2    Kouzarides, T.3
  • 78
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • Halazonetis T.D., Gorgoulis V.G., Bartek J. An oncogene-induced DNA damage model for cancer development. Science 2008, 319:1352-1355.
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 80
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 81
    • 33947177072 scopus 로고    scopus 로고
    • Developmentally regulated histone modifications in Drosophila follicle cells: Initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation
    • Hartl T., Boswell C., Orr-Weaver T.L., Bosco G. Developmentally regulated histone modifications in Drosophila follicle cells: Initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation. Chromosoma 2007, 116:197-214.
    • (2007) Chromosoma , vol.116 , pp. 197-214
    • Hartl, T.1    Boswell, C.2    Orr-Weaver, T.L.3    Bosco, G.4
  • 82
    • 35648942123 scopus 로고    scopus 로고
    • Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture
    • Hassler M., Singh S., Yue W.W., Luczynski M., Lakbir R., Sanchez-Sanchez F., Bader T., Pearl L.H., Mittnacht S. Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. Mol. Cell 2007, 28:371-385.
    • (2007) Mol. Cell , vol.28 , pp. 371-385
    • Hassler, M.1    Singh, S.2    Yue, W.W.3    Luczynski, M.4    Lakbir, R.5    Sanchez-Sanchez, F.6    Bader, T.7    Pearl, L.H.8    Mittnacht, S.9
  • 83
    • 0026652346 scopus 로고
    • A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
    • Helin K., Lees J.A., Vidal M., Dyson N., Harlow E., Fattaey A. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 1992, 70:337-350.
    • (1992) Cell , vol.70 , pp. 337-350
    • Helin, K.1    Lees, J.A.2    Vidal, M.3    Dyson, N.4    Harlow, E.5    Fattaey, A.6
  • 84
    • 68049097008 scopus 로고    scopus 로고
    • Epigenetic dynamics of stem cells and cell lineage commitment: Digging Waddington's canal
    • Hemberger M., Dean W., Reik W. Epigenetic dynamics of stem cells and cell lineage commitment: Digging Waddington's canal. Nat. Rev. Mol. Cell Biol. 2009, 10:526-537.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 526-537
    • Hemberger, M.1    Dean, W.2    Reik, W.3
  • 86
    • 0029909105 scopus 로고    scopus 로고
    • Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts
    • Herrera R.E., Chen F., Weinberg R.A. Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts. Proc. Natl. Acad. Sci. USA 1996, 93:11510-11515.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11510-11515
    • Herrera, R.E.1    Chen, F.2    Weinberg, R.A.3
  • 87
    • 0026802989 scopus 로고
    • Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
    • Hinds P.W., Mittnacht S., Dulic V., Arnold A., Reed S.I., Weinberg R.A. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 1992, 70:993-1006.
    • (1992) Cell , vol.70 , pp. 993-1006
    • Hinds, P.W.1    Mittnacht, S.2    Dulic, V.3    Arnold, A.4    Reed, S.I.5    Weinberg, R.A.6
  • 88
    • 0037073753 scopus 로고    scopus 로고
    • Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis
    • Hou S.T., Xie X., Baggley A., Park D.S., Chen G., Walker T. Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis. J. Biol. Chem. 2002, 277:48764-48770.
    • (2002) J. Biol. Chem. , vol.277 , pp. 48764-48770
    • Hou, S.T.1    Xie, X.2    Baggley, A.3    Park, D.S.4    Chen, G.5    Walker, T.6
  • 91
    • 0028303223 scopus 로고
    • The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein
    • Iavarone A., Garg P., Lasorella A., Hsu J., Israel M.A. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev. 1994, 8:1270-1284.
    • (1994) Genes Dev. , vol.8 , pp. 1270-1284
    • Iavarone, A.1    Garg, P.2    Lasorella, A.3    Hsu, J.4    Israel, M.A.5
  • 92
    • 11144248047 scopus 로고    scopus 로고
    • Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
    • Iavarone A., King E.R., Dai X.M., Leone G., Stanley E.R., Lasorella A. Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature 2004, 432:1040-1045.
    • (2004) Nature , vol.432 , pp. 1040-1045
    • Iavarone, A.1    King, E.R.2    Dai, X.M.3    Leone, G.4    Stanley, E.R.5    Lasorella, A.6
  • 93
    • 33947540326 scopus 로고    scopus 로고
    • The female gametophyte and the endosperm control cell proliferation and differentiation of the seed coat in Arabidopsis
    • Ingouff M., Jullien P.E., Berger F. The female gametophyte and the endosperm control cell proliferation and differentiation of the seed coat in Arabidopsis. Plant Cell 2006, 18:3491-3501.
    • (2006) Plant Cell , vol.18 , pp. 3491-3501
    • Ingouff, M.1    Jullien, P.E.2    Berger, F.3
  • 94
    • 34247199852 scopus 로고    scopus 로고
    • Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage
    • Inoue Y., Kitagawa M., Taya Y. Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007, 26:2083-2093.
    • (2007) EMBO J. , vol.26 , pp. 2083-2093
    • Inoue, Y.1    Kitagawa, M.2    Taya, Y.3
  • 95
    • 33750220492 scopus 로고    scopus 로고
    • RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts
    • Iovino F., Lentini L., Amato A., Di Leonardo A. RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts. Mol. Cancer 2006, 5:38.
    • (2006) Mol. Cancer , vol.5 , pp. 38
    • Iovino, F.1    Lentini, L.2    Amato, A.3    Di Leonardo, A.4
  • 97
    • 0034949169 scopus 로고    scopus 로고
    • Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis
    • Ishida S., Huang E., Zuzan H., Spang R., Leone G., West M., Nevins J.R. Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol. Cell. Biol. 2001, 21:4684-4699.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4684-4699
    • Ishida, S.1    Huang, E.2    Zuzan, H.3    Spang, R.4    Leone, G.5    West, M.6    Nevins, J.R.7
  • 101
    • 4944252223 scopus 로고    scopus 로고
    • An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant
    • Ji P., Jiang H., Rekhtman K., Bloom J., Ichetovkin M., Pagano M., Zhu L. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol. Cell 2004, 16:47-58.
    • (2004) Mol. Cell , vol.16 , pp. 47-58
    • Ji, P.1    Jiang, H.2    Rekhtman, K.3    Bloom, J.4    Ichetovkin, M.5    Pagano, M.6    Zhu, L.7
  • 102
    • 0037033802 scopus 로고    scopus 로고
    • Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma
    • Jiang Z., Zacksenhaus E. Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma. J. Cell Biol. 2002, 156:185-198.
    • (2002) J. Cell Biol. , vol.156 , pp. 185-198
    • Jiang, Z.1    Zacksenhaus, E.2
  • 106
    • 0032739015 scopus 로고    scopus 로고
    • Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
    • Ketting R.F., Haverkamp T.H., van Luenen H.G., Plasterk R.H. Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD. Cell 1999, 99:133-141.
    • (1999) Cell , vol.99 , pp. 133-141
    • Ketting, R.F.1    Haverkamp, T.H.2    van Luenen, H.G.3    Plasterk, R.H.4
  • 107
    • 0030996584 scopus 로고    scopus 로고
    • Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box
    • Kim H.Y., Cho Y. Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box. Nat. Struct. Biol. 1997, 4:390-395.
    • (1997) Nat. Struct. Biol. , vol.4 , pp. 390-395
    • Kim, H.Y.1    Cho, Y.2
  • 108
    • 0026719682 scopus 로고
    • Retinoblastoma gene product activates expression of the human TGF-beta 2 gene through transcription factor ATF-2
    • Kim S.J., Wagner S., Liu F., O'Reilly M.A., Robbins P.D., Green M.R. Retinoblastoma gene product activates expression of the human TGF-beta 2 gene through transcription factor ATF-2. Nature 1992, 358:331-334.
    • (1992) Nature , vol.358 , pp. 331-334
    • Kim, S.J.1    Wagner, S.2    Liu, F.3    O'Reilly, M.A.4    Robbins, P.D.5    Green, M.R.6
  • 109
    • 0035863048 scopus 로고    scopus 로고
    • Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen
    • Kim H.Y., Ahn B.Y., Cho Y. Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen. EMBO J. 2001, 20:295-304.
    • (2001) EMBO J. , vol.20 , pp. 295-304
    • Kim, H.Y.1    Ahn, B.Y.2    Cho, Y.3
  • 110
    • 34247563433 scopus 로고    scopus 로고
    • Transcriptome profiling of the C. elegans Rb ortholog reveals diverse developmental roles
    • Kirienko N.V., Fay D.S. Transcriptome profiling of the C. elegans Rb ortholog reveals diverse developmental roles. Dev. Biol. 2007, 305:674-684.
    • (2007) Dev. Biol. , vol.305 , pp. 674-684
    • Kirienko, N.V.1    Fay, D.S.2
  • 112
    • 0029924241 scopus 로고    scopus 로고
    • Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites
    • Knudsen E.S., Wang J.Y.J. Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J. Biol. Chem. 1996, 271:8313-8320.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8313-8320
    • Knudsen, E.S.1    Wang, J.Y.J.2
  • 113
    • 0030849455 scopus 로고    scopus 로고
    • Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation
    • Knudsen E.S., Wang J.Y.J. Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol. Cell. Biol. 1997, 17:5771-5783.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5771-5783
    • Knudsen, E.S.1    Wang, J.Y.J.2
  • 115
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson A.G. Mutation and cancer: Statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 1971, 68:820-823.
    • (1971) Proc. Natl. Acad. Sci. USA , vol.68 , pp. 820-823
    • Knudson, A.G.1
  • 116
    • 24344442345 scopus 로고    scopus 로고
    • E2F-Rb complexes regulating transcription of genes important for differentiation and development
    • Korenjak M., Brehm A., Korenjak M., Brehm A. E2F-Rb complexes regulating transcription of genes important for differentiation and development. Curr. Opin. Genet. Dev. 2005, 15:520-527.
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 520-527
    • Korenjak, M.1    Brehm, A.2    Korenjak, M.3    Brehm, A.4
  • 118
    • 0021262921 scopus 로고
    • Retinoblastoma-origin from a primitive neuroectodermal cell?
    • Kyritsis A.P., Tsokos M., Triche T.J., Chader G.J. Retinoblastoma-origin from a primitive neuroectodermal cell?. Nature 1984, 307:471-473.
    • (1984) Nature , vol.307 , pp. 471-473
    • Kyritsis, A.P.1    Tsokos, M.2    Triche, T.J.3    Chader, G.J.4
  • 119
    • 0032849352 scopus 로고    scopus 로고
    • RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins
    • Lai A., Lee J.M., Yang W.M., DeCaprio J.A., Kaelin W.G., Seto E., Branton P.E. RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. Mol. Cell. Biol. 1999, 19:6632-6641.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6632-6641
    • Lai, A.1    Lee, J.M.2    Yang, W.M.3    DeCaprio, J.A.4    Kaelin, W.G.5    Seto, E.6    Branton, P.E.7
  • 120
    • 0035076249 scopus 로고    scopus 로고
    • RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest
    • Lai A., Kennedy B.K., Barbie D.A., Bertos N.R., Yang X.J., Theberge M.C., Tsai S.C., Seto E., Zhang Y., Kuzmichev A., Lane W.S., Reinberg D., et al. RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Mol. Cell. Biol. 2001, 21:2918-2932.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 2918-2932
    • Lai, A.1    Kennedy, B.K.2    Barbie, D.A.3    Bertos, N.R.4    Yang, X.J.5    Theberge, M.C.6    Tsai, S.C.7    Seto, E.8    Zhang, Y.9    Kuzmichev, A.10    Lane, W.S.11    Reinberg, D.12
  • 122
    • 0035979992 scopus 로고    scopus 로고
    • E2F transcriptional activation requires TRRAP and GCN5 cofactors
    • Lang S.E., McMahon S.B., Cole M.D., Hearing P. E2F transcriptional activation requires TRRAP and GCN5 cofactors. J. Biol. Chem. 2001, 276:32627-32634.
    • (2001) J. Biol. Chem. , vol.276 , pp. 32627-32634
    • Lang, S.E.1    McMahon, S.B.2    Cole, M.D.3    Hearing, P.4
  • 124
    • 33746035661 scopus 로고    scopus 로고
    • P14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation
    • Leduc C., Claverie P., Eymin B., Col E., Khochbin S., Brambilla E., Gazzeri S. p14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation. Oncogene 2006, 25:4147-4154.
    • (2006) Oncogene , vol.25 , pp. 4147-4154
    • Leduc, C.1    Claverie, P.2    Eymin, B.3    Col, E.4    Khochbin, S.5    Brambilla, E.6    Gazzeri, S.7
  • 125
    • 0037115601 scopus 로고    scopus 로고
    • Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor
    • Lee C.C.J.H. Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev. 2002, 16:3199-3212.
    • (2002) Genes Dev. , vol.16 , pp. 3199-3212
    • Lee, C.C.J.H.1
  • 126
    • 0023106062 scopus 로고
    • Human retinoblastoma susceptibility gene: Cloning, identification, and sequence
    • Lee W.H., Bookstein R., Hong F., Young L.J., Shew J.Y., Lee E.Y.H.P. Human retinoblastoma susceptibility gene: Cloning, identification, and sequence. Science 1987, 235:1394-1399.
    • (1987) Science , vol.235 , pp. 1394-1399
    • Lee, W.H.1    Bookstein, R.2    Hong, F.3    Young, L.J.4    Shew, J.Y.5    Lee, E.Y.H.P.6
  • 127
    • 0026744563 scopus 로고
    • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
    • Lee E.Y., Chang C.Y., Hu N., Wang Y.C., Lai C.C., Herrup K., Lee W.H. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 1992, 359:288-294.
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.Y.1    Chang, C.Y.2    Hu, N.3    Wang, Y.C.4    Lai, C.C.5    Herrup, K.6    Lee, W.H.7
  • 128
    • 2642601106 scopus 로고    scopus 로고
    • Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7
    • Lee J.O., Russo A.A., Pavletich N.P. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 1998, 391:859-865.
    • (1998) Nature , vol.391 , pp. 859-865
    • Lee, J.O.1    Russo, A.A.2    Pavletich, N.P.3
  • 130
    • 0036118561 scopus 로고    scopus 로고
    • Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4
    • Leng X., Noble M., Adams P.D., Qin J., Harper J.W. Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol. Cell. Biol. 2002, 22:2242-2254.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2242-2254
    • Leng, X.1    Noble, M.2    Adams, P.D.3    Qin, J.4    Harper, J.W.5
  • 131
    • 0035914347 scopus 로고    scopus 로고
    • MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14
    • Leung J.K., Berube N., Venable S., Ahmed S., Timchenko N., Pereira-Smith O.M. MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. J. Biol. Chem. 2001, 276:39171-39178.
    • (2001) J. Biol. Chem. , vol.276 , pp. 39171-39178
    • Leung, J.K.1    Berube, N.2    Venable, S.3    Ahmed, S.4    Timchenko, N.5    Pereira-Smith, O.M.6
  • 132
    • 35948959373 scopus 로고    scopus 로고
    • Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor
    • Liu X., Marmorstein R. Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. Genes Dev. 2007, 21:2711-2716.
    • (2007) Genes Dev. , vol.21 , pp. 2711-2716
    • Liu, X.1    Marmorstein, R.2
  • 134
    • 74149083175 scopus 로고    scopus 로고
    • PRb, a local chromatin organizer with global possibilities
    • Longworth M.S., Dyson N.J. pRb, a local chromatin organizer with global possibilities. Chromosoma 2009, 119:1-11.
    • (2009) Chromosoma , vol.119 , pp. 1-11
    • Longworth, M.S.1    Dyson, N.J.2
  • 135
    • 42149095961 scopus 로고    scopus 로고
    • RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3
    • Longworth M.S., Herr A., Ji J.Y., Dyson N.J. RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev. 2008, 22:1011-1024.
    • (2008) Genes Dev. , vol.22 , pp. 1011-1024
    • Longworth, M.S.1    Herr, A.2    Ji, J.Y.3    Dyson, N.J.4
  • 136
    • 0032553424 scopus 로고    scopus 로고
    • Differential regulation of androgen and glucocorticoid receptors by retinoblastoma protein
    • Lu J., Danielsen M. Differential regulation of androgen and glucocorticoid receptors by retinoblastoma protein. J. Biol. Chem. 1998, 273:31528-31533.
    • (1998) J. Biol. Chem. , vol.273 , pp. 31528-31533
    • Lu, J.1    Danielsen, M.2
  • 138
    • 0032549001 scopus 로고    scopus 로고
    • Rb interacts with histone deacetylase to repress transcription
    • Luo R.X., Postigo A.A., Dean D.C. Rb interacts with histone deacetylase to repress transcription. Cell 1998, 92:463-473.
    • (1998) Cell , vol.92 , pp. 463-473
    • Luo, R.X.1    Postigo, A.A.2    Dean, D.C.3
  • 139
    • 0034460363 scopus 로고    scopus 로고
    • A novel Rb- and p300-binding protein inhibits transactivation by MyoD
    • MacLellan W.R., Xiao G., Abdellatif M., Schneider M.D. A novel Rb- and p300-binding protein inhibits transactivation by MyoD. Mol. Cell. Biol. 2000, 20:8903-8915.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8903-8915
    • MacLellan, W.R.1    Xiao, G.2    Abdellatif, M.3    Schneider, M.D.4
  • 140
    • 52549128786 scopus 로고    scopus 로고
    • The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system
    • Macleod K.F. The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system. Nat. Rev. Cancer 2008, 8:769-781.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 769-781
    • Macleod, K.F.1
  • 143
    • 77649208749 scopus 로고    scopus 로고
    • Cancer stem cells: A reality, a myth, a fuzzy concept or a misnomer? An analysis
    • Maenhaut C., Dumont J.E., Roger P.P., van Staveren W.C. Cancer stem cells: A reality, a myth, a fuzzy concept or a misnomer? An analysis. Carcinogenesis 2010, 31:149-158.
    • (2010) Carcinogenesis , vol.31 , pp. 149-158
    • Maenhaut, C.1    Dumont, J.E.2    Roger, P.P.3    van Staveren, W.C.4
  • 145
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres M., Barbacid M. To cycle or not to cycle: A critical decision in cancer. Nat. Rev. Cancer 2001, 1:222-231.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 146
    • 77954522274 scopus 로고    scopus 로고
    • Loss of pRB causes centromere dysfunction and chromosomal instability
    • Manning A.L., Longworth M.S., Dyson N.J. Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev. 2010, 24:1364-1376.
    • (2010) Genes Dev. , vol.24 , pp. 1364-1376
    • Manning, A.L.1    Longworth, M.S.2    Dyson, N.J.3
  • 148
    • 0042977676 scopus 로고    scopus 로고
    • Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence
    • Marino S., Hoogervoorst D., Brandner S., Berns A. Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence. Development 2003, 130:3359-3368.
    • (2003) Development , vol.130 , pp. 3359-3368
    • Marino, S.1    Hoogervoorst, D.2    Brandner, S.3    Berns, A.4
  • 152
    • 37549016756 scopus 로고    scopus 로고
    • Specific in vivo roles for E2Fs in differentiation and development
    • McClellan K.A., Slack R.S., McClellan K.A., Slack R.S. Specific in vivo roles for E2Fs in differentiation and development. Cell Cycle 2007, 6:2917-2927.
    • (2007) Cell Cycle , vol.6 , pp. 2917-2927
    • McClellan, K.A.1    Slack, R.S.2    McClellan, K.A.3    Slack, R.S.4
  • 153
    • 0033578386 scopus 로고    scopus 로고
    • A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor
    • Meloni A.R., Smith E.J., Nevins J.R. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc. Natl. Acad. Sci. USA 1999, 96:9574-9579.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9574-9579
    • Meloni, A.R.1    Smith, E.J.2    Nevins, J.R.3
  • 154
    • 0141523025 scopus 로고    scopus 로고
    • Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model
    • Meuwissen R., Linn S.C., Linnoila R.I., Zevenhoven J., Mooi W.J., Berns A. Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell 2003, 4:181-189.
    • (2003) Cancer Cell , vol.4 , pp. 181-189
    • Meuwissen, R.1    Linn, S.C.2    Linnoila, R.I.3    Zevenhoven, J.4    Mooi, W.J.5    Berns, A.6
  • 157
    • 61349117970 scopus 로고    scopus 로고
    • Genetics and epigenetics: Stability and plasticity during cellular differentiation
    • Mohn F., Schubeler D. Genetics and epigenetics: Stability and plasticity during cellular differentiation. Trends Genet. 2009, 25:129-136.
    • (2009) Trends Genet. , vol.25 , pp. 129-136
    • Mohn, F.1    Schubeler, D.2
  • 158
    • 77953158267 scopus 로고    scopus 로고
    • Progenitor stem cell marker expression by pulmonary carcinomas
    • Moreira A.L., Gonen M., Rekhtman N., Downey R.J. Progenitor stem cell marker expression by pulmonary carcinomas. Mod. Pathol. 2010, 23:889-895.
    • (2010) Mod. Pathol. , vol.23 , pp. 889-895
    • Moreira, A.L.1    Gonen, M.2    Rekhtman, N.3    Downey, R.J.4
  • 159
    • 0034964014 scopus 로고    scopus 로고
    • Retinoblastoma protein partners
    • Morris E.J., Dyson N.J. Retinoblastoma protein partners. Adv. Cancer Res. 2001, 82:1-54.
    • (2001) Adv. Cancer Res. , vol.82 , pp. 1-54
    • Morris, E.J.1    Dyson, N.J.2
  • 160
    • 75149172476 scopus 로고    scopus 로고
    • Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction
    • Mukherjee P., Winter S.L., Alexandrow M.G., Mukherjee P., Winter S.L., Alexandrow M.G. Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction. Mol. Cell. Biol. 2010, 30:845-856.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 845-856
    • Mukherjee, P.1    Winter, S.L.2    Alexandrow, M.G.3    Mukherjee, P.4    Winter, S.L.5    Alexandrow, M.G.6
  • 164
    • 33746752125 scopus 로고    scopus 로고
    • A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation
    • Narita M., Narita M., Krizhanovsky V., Nunez S., Chicas A., Hearn S.A., Myers M.P., Lowe S.W. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 2006, 126:503-514.
    • (2006) Cell , vol.126 , pp. 503-514
    • Narita, M.1    Narita, M.2    Krizhanovsky, V.3    Nunez, S.4    Chicas, A.5    Hearn, S.A.6    Myers, M.P.7    Lowe, S.W.8
  • 165
    • 0141841682 scopus 로고    scopus 로고
    • Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of p38 and cyclin-dependent kinases
    • Nath N., Wang S., Betts V., Knudsen E., Chellappan S. Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of p38 and cyclin-dependent kinases. Oncogene 2003, 22:5986-5994.
    • (2003) Oncogene , vol.22 , pp. 5986-5994
    • Nath, N.1    Wang, S.2    Betts, V.3    Knudsen, E.4    Chellappan, S.5
  • 166
    • 24344507918 scopus 로고    scopus 로고
    • Role of the retinoblastoma tumor suppressor protein in cellular differentiation
    • Nguyen D.X., McCance D.J. Role of the retinoblastoma tumor suppressor protein in cellular differentiation. J. Cell. Biochem. 2005, 94:870-879.
    • (2005) J. Cell. Biochem. , vol.94 , pp. 870-879
    • Nguyen, D.X.1    McCance, D.J.2
  • 168
    • 0029960519 scopus 로고    scopus 로고
    • Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
    • Novitch B.G., Mulligan G.J., Jacks T., Lassar A.B. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J. Cell Biol. 1996, 135:441-456.
    • (1996) J. Cell Biol. , vol.135 , pp. 441-456
    • Novitch, B.G.1    Mulligan, G.J.2    Jacks, T.3    Lassar, A.B.4
  • 169
    • 0033529030 scopus 로고    scopus 로고
    • PRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation
    • Novitch B.G., Spicer D.B., Kim P.S., Cheung W.L., Lassar A.B. pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation. Curr. Biol. 1999, 9:449-459.
    • (1999) Curr. Biol. , vol.9 , pp. 449-459
    • Novitch, B.G.1    Spicer, D.B.2    Kim, P.S.3    Cheung, W.L.4    Lassar, A.B.5
  • 170
    • 34249290037 scopus 로고    scopus 로고
    • The lin-35/Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegans
    • Ouellet J., Roy R. The lin-35/Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegans. BMC Dev. Biol. 2007, 7:38.
    • (2007) BMC Dev. Biol. , vol.7 , pp. 38
    • Ouellet, J.1    Roy, R.2
  • 171
    • 0035265832 scopus 로고    scopus 로고
    • The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/MAPK signaling
    • Page B.D., Guedes S., Waring D., Priess J.R. The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/MAPK signaling. Mol. Cell 2001, 7:451-460.
    • (2001) Mol. Cell , vol.7 , pp. 451-460
    • Page, B.D.1    Guedes, S.2    Waring, D.3    Priess, J.R.4
  • 172
    • 18944364763 scopus 로고    scopus 로고
    • Interplay between the retinoblastoma protein and LEK1 specifies stem cells toward the cardiac lineage
    • Papadimou E., Menard C., Grey C., Puceat M. Interplay between the retinoblastoma protein and LEK1 specifies stem cells toward the cardiac lineage. EMBO J. 2005, 24:1750-1761.
    • (2005) EMBO J. , vol.24 , pp. 1750-1761
    • Papadimou, E.1    Menard, C.2    Grey, C.3    Puceat, M.4
  • 173
    • 0032735881 scopus 로고    scopus 로고
    • Regulation of postembryonic G(1) cell cycle progression in Caenorhabditis elegans by a cyclin D/CDK-like complex
    • Park M., Krause M.W. Regulation of postembryonic G(1) cell cycle progression in Caenorhabditis elegans by a cyclin D/CDK-like complex. Development 1999, 126:4849-4860.
    • (1999) Development , vol.126 , pp. 4849-4860
    • Park, M.1    Krause, M.W.2
  • 174
    • 0030690423 scopus 로고    scopus 로고
    • Modular organization of the E2F1 activation domain and its interaction with general transcription factors TBP and TFIIH
    • Pearson A., Greenblatt J. Modular organization of the E2F1 activation domain and its interaction with general transcription factors TBP and TFIIH. Oncogene 1997, 15:2643-2658.
    • (1997) Oncogene , vol.15 , pp. 2643-2658
    • Pearson, A.1    Greenblatt, J.2
  • 176
    • 49649121765 scopus 로고    scopus 로고
    • E2F1 regulates autophagy and the transcription of autophagy genes
    • Polager S., Ofir M., Ginsberg D. E2F1 regulates autophagy and the transcription of autophagy genes. Oncogene 2008, 27:4860-4864.
    • (2008) Oncogene , vol.27 , pp. 4860-4864
    • Polager, S.1    Ofir, M.2    Ginsberg, D.3
  • 177
    • 41549149451 scopus 로고    scopus 로고
    • Cellular senescence in vivo: A barrier to tumorigenesis
    • Prieur A., Peeper D.S. Cellular senescence in vivo: A barrier to tumorigenesis. Curr. Opin. Cell Biol. 2008, 20:150-155.
    • (2008) Curr. Opin. Cell Biol. , vol.20 , pp. 150-155
    • Prieur, A.1    Peeper, D.S.2
  • 178
    • 0028856782 scopus 로고
    • Dual retinoblastoma-binding proteins with properties related to a negative regulator of Ras in yeast
    • Qian Y.W., Lee E.Y. Dual retinoblastoma-binding proteins with properties related to a negative regulator of Ras in yeast. J. Biol. Chem. 1995, 270:25507-25513.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25507-25513
    • Qian, Y.W.1    Lee, E.Y.2
  • 179
    • 0027320814 scopus 로고
    • A retinoblastoma-binding protein related to a negative regulator of Ras in yeast
    • Qian Y.W., Wang Y.C., Hollingsworth R.E., Jones D., Ling N., Lee E.Y. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 1993, 364:648-652.
    • (1993) Nature , vol.364 , pp. 648-652
    • Qian, Y.W.1    Wang, Y.C.2    Hollingsworth, R.E.3    Jones, D.4    Ling, N.5    Lee, E.Y.6
  • 180
    • 0037080483 scopus 로고    scopus 로고
    • E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints
    • Ren B., Cam H., Takahashi Y., Volkert T., Terragni J., Young R.A., Dynlacht B.D. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev. 2002, 16:245-256.
    • (2002) Genes Dev. , vol.16 , pp. 245-256
    • Ren, B.1    Cam, H.2    Takahashi, Y.3    Volkert, T.4    Terragni, J.5    Young, R.A.6    Dynlacht, B.D.7
  • 181
    • 0033919595 scopus 로고    scopus 로고
    • DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
    • Robertson K.D., Ait-Si-Ali S., Yokochi T., Wade P.A., Jones P.L., Wolffe A.P. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat. Genet. 2000, 25:338-342.
    • (2000) Nat. Genet. , vol.25 , pp. 338-342
    • Robertson, K.D.1    Ait-Si-Ali, S.2    Yokochi, T.3    Wade, P.A.4    Jones, P.L.5    Wolffe, A.P.6
  • 182
    • 0033118363 scopus 로고    scopus 로고
    • ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP
    • Royzman I., Austin R.J., Bosco G., Bell S.P., Orr-Weaver T.L. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Genes Dev. 1999, 13:827-840.
    • (1999) Genes Dev. , vol.13 , pp. 827-840
    • Royzman, I.1    Austin, R.J.2    Bosco, G.3    Bell, S.P.4    Orr-Weaver, T.L.5
  • 183
    • 28944437358 scopus 로고    scopus 로고
    • Structure of the Rb C-terminal domain bound to E2F1-DP1: A mechanism for phosphorylation-induced E2F release
    • Rubin S.M., Gall A.-L., Zheng N., Pavletich N.P. Structure of the Rb C-terminal domain bound to E2F1-DP1: A mechanism for phosphorylation-induced E2F release. Cell 2005, 123:1093-1106.
    • (2005) Cell , vol.123 , pp. 1093-1106
    • Rubin, S.M.1    Gall, A.-L.2    Zheng, N.3    Pavletich, N.P.4
  • 184
    • 3042813439 scopus 로고    scopus 로고
    • Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis
    • Ruiz S., Santos M., Segrelles C., Leis H., Jorcano J.L., Berns A., Paramio J.M., Vooijs M. Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development 2004, 131:2737-2748.
    • (2004) Development , vol.131 , pp. 2737-2748
    • Ruiz, S.1    Santos, M.2    Segrelles, C.3    Leis, H.4    Jorcano, J.L.5    Berns, A.6    Paramio, J.M.7    Vooijs, M.8
  • 186
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • Sage J., Miller A.L., Perez-Mancera P.A., Wysocki J.M., Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 2003, 424:223-228.
    • (2003) Nature , vol.424 , pp. 223-228
    • Sage, J.1    Miller, A.L.2    Perez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5
  • 188
    • 0029064774 scopus 로고
    • Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping
    • Saijo M., Sakai Y., Kishino T., Niikawa N., Matsuura Y., Morino K., Tamai K., Taya Y. Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping. Genomics 1995, 27:511-519.
    • (1995) Genomics , vol.27 , pp. 511-519
    • Saijo, M.1    Sakai, Y.2    Kishino, T.3    Niikawa, N.4    Matsuura, Y.5    Morino, K.6    Tamai, K.7    Taya, Y.8
  • 191
    • 0028339957 scopus 로고
    • Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells
    • Schneider J.W., Gu W., Zhu L., Mahdavi V., Nadal-Ginard B. Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science 1994, 264:1467-1471.
    • (1994) Science , vol.264 , pp. 1467-1471
    • Schneider, J.W.1    Gu, W.2    Zhu, L.3    Mahdavi, V.4    Nadal-Ginard, B.5
  • 192
    • 0026484975 scopus 로고
    • Molecular cloning of cellular genes encoding retinoblastoma- associated proteins: Identification of a gene with properties of the transcription factor E2F
    • Shan B., Zhu X., Chen P.L., Durfee T., Yang Y., Sharp D., Lee W.H. Molecular cloning of cellular genes encoding retinoblastoma- associated proteins: Identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 1992, 12:5620-5631.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5620-5631
    • Shan, B.1    Zhu, X.2    Chen, P.L.3    Durfee, T.4    Yang, Y.5    Sharp, D.6    Lee, W.H.7
  • 194
    • 0036835483 scopus 로고    scopus 로고
    • The plant E2F-Rb pathway and epigenetic control
    • Shen W.H. The plant E2F-Rb pathway and epigenetic control. Trends Plant Sci. 2002, 7:505-511.
    • (2002) Trends Plant Sci. , vol.7 , pp. 505-511
    • Shen, W.H.1
  • 195
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr C.J., McCormick F. The RB and p53 pathways in cancer. Cancer Cell 2002, 2:103-112.
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 196
    • 33847638915 scopus 로고    scopus 로고
    • Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics
    • Siddiqui H., Fox S.R., Gunawardena R.W., Knudsen E.S. Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics. J. Cell. Physiol. 2007, 211:131-137.
    • (2007) J. Cell. Physiol. , vol.211 , pp. 131-137
    • Siddiqui, H.1    Fox, S.R.2    Gunawardena, R.W.3    Knudsen, E.S.4
  • 197
    • 0345306117 scopus 로고    scopus 로고
    • Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi
    • Sijen T., Plasterk R.H. Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi. Nature 2003, 426:310-314.
    • (2003) Nature , vol.426 , pp. 310-314
    • Sijen, T.1    Plasterk, R.H.2
  • 198
    • 0028986413 scopus 로고
    • A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor
    • Singh P., Coe J., Hong W. A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. Nature 1995, 374:562-565.
    • (1995) Nature , vol.374 , pp. 562-565
    • Singh, P.1    Coe, J.2    Hong, W.3
  • 201
    • 0031945518 scopus 로고    scopus 로고
    • Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7
    • Sterner J.M., Dew-Knight S., Musahl C., Kornbluth S., Horowitz J.M. Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. Mol. Cell. Biol. 1998, 18:2748-2757.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2748-2757
    • Sterner, J.M.1    Dew-Knight, S.2    Musahl, C.3    Kornbluth, S.4    Horowitz, J.M.5
  • 202
    • 0029995309 scopus 로고    scopus 로고
    • Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins
    • Strober B.E., Dunaief J.L., Guha, Goff S.P. Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins. Mol. Cell. Biol. 1996, 16:1576-1583.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1576-1583
    • Strober, B.E.1    Dunaief, J.L.2    Guha3    Goff, S.P.4
  • 203
    • 0037154156 scopus 로고    scopus 로고
    • Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
    • Suzuma K., Takahara N., Suzuma I., Isshiki K., Ueki K., Leitges M., Aiello L.P., King G.L. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc. Natl. Acad. Sci. USA 2002, 99(2):721-726.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , Issue.2 , pp. 721-726
    • Suzuma, K.1    Takahara, N.2    Suzuma, I.3    Isshiki, K.4    Ueki, K.5    Leitges, M.6    Aiello, L.P.7    King, G.L.8
  • 204
    • 18244402890 scopus 로고    scopus 로고
    • Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro
    • Takaki T., Fukasawa K., Suzuki-Takahashi I., Semba K., Kitagawa M., Taya Y., Hirai H. Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro. J. Biochem. 2005, 137:381-386.
    • (2005) J. Biochem. , vol.137 , pp. 381-386
    • Takaki, T.1    Fukasawa, K.2    Suzuki-Takahashi, I.3    Semba, K.4    Kitagawa, M.5    Taya, Y.6    Hirai, H.7
  • 206
    • 0026329868 scopus 로고
    • Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering
    • Templeton D.J., Park S.H., Lanier L., Weinberg R.A. Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering. Proc. Natl. Acad. Sci. USA 1991, 88:3033-3037.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3033-3037
    • Templeton, D.J.1    Park, S.H.2    Lanier, L.3    Weinberg, R.A.4
  • 207
    • 0034840594 scopus 로고    scopus 로고
    • The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation
    • Thomas D.M., Carty S.A., Piscopo D.M., Lee J.S., Wang W.F., Forrester W.C., Hinds P.W. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol. Cell 2001, 8:303-316.
    • (2001) Mol. Cell , vol.8 , pp. 303-316
    • Thomas, D.M.1    Carty, S.A.2    Piscopo, D.M.3    Lee, J.S.4    Wang, W.F.5    Forrester, W.C.6    Hinds, P.W.7
  • 211
    • 0032159103 scopus 로고    scopus 로고
    • Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
    • Tsai K.Y., Hu Y., Macleod K.F., Crowley D., Yamasaki L., Jacks T. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 1998, 2:293-304.
    • (1998) Mol. Cell , vol.2 , pp. 293-304
    • Tsai, K.Y.1    Hu, Y.2    Macleod, K.F.3    Crowley, D.4    Yamasaki, L.5    Jacks, T.6
  • 215
    • 0034811677 scopus 로고    scopus 로고
    • Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase
    • Vandel L., Nicolas E., Vaute O., Ferreira R., Ait-Si-Ali S., Trouche D. Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase. Mol. Cell. Biol. 2001, 21:6484-6494.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6484-6494
    • Vandel, L.1    Nicolas, E.2    Vaute, O.3    Ferreira, R.4    Ait-Si-Ali, S.5    Trouche, D.6
  • 217
    • 0037079677 scopus 로고    scopus 로고
    • Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases
    • Vaute O., Nicolas E., Vandel L., Trouche D. Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic Acids Res. 2002, 30:475-481.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 475-481
    • Vaute, O.1    Nicolas, E.2    Vandel, L.3    Trouche, D.4
  • 219
    • 0032500170 scopus 로고    scopus 로고
    • Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse
    • Vooijs M., van d.V., te R.H., Berns A. Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse. Oncogene 1998, 17:1-12.
    • (1998) Oncogene , vol.17 , pp. 1-12
    • Vooijs, M.1    van, D.2    te, R.H.3    Berns, A.4
  • 220
    • 23144462374 scopus 로고    scopus 로고
    • Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
    • Wang D., Kennedy S., Conte D., Kim J.K., Gabel H.W., Kamath R.S., Mello C.C., Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature 2005, 436:593-597.
    • (2005) Nature , vol.436 , pp. 593-597
    • Wang, D.1    Kennedy, S.2    Conte, D.3    Kim, J.K.4    Gabel, H.W.5    Kamath, R.S.6    Mello, C.C.7    Ruvkun, G.8
  • 222
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell 1995, 81:323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 223
    • 0027429964 scopus 로고
    • A c-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle
    • Welch P.J., Wang J.Y.J. A c-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 1993, 75:779-790.
    • (1993) Cell , vol.75 , pp. 779-790
    • Welch, P.J.1    Wang, J.Y.J.2
  • 225
    • 4644257541 scopus 로고    scopus 로고
    • Rb family proteins differentially regulate distinct cell lineages during epithelial development
    • Wikenheiser-Brokamp K.A. Rb family proteins differentially regulate distinct cell lineages during epithelial development. Development 2004, 131:4299-4310.
    • (2004) Development , vol.131 , pp. 4299-4310
    • Wikenheiser-Brokamp, K.A.1
  • 229
    • 0034910622 scopus 로고    scopus 로고
    • Molecular genetics of small cell lung carcinoma
    • Wistuba I.I., Gazdar A.F., Minna J.D. Molecular genetics of small cell lung carcinoma. Semin. Oncol. 2001, 28:3-13.
    • (2001) Semin. Oncol. , vol.28 , pp. 3-13
    • Wistuba, I.I.1    Gazdar, A.F.2    Minna, J.D.3
  • 230
    • 35748949600 scopus 로고    scopus 로고
    • Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
    • Wong S., Weber J.D. Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem. J. 2007, 407:451-460.
    • (2007) Biochem. J. , vol.407 , pp. 451-460
    • Wong, S.1    Weber, J.D.2
  • 233
    • 0035059136 scopus 로고    scopus 로고
    • Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation
    • Xia X., Cheng A., Lessor T., Zhang Y., Hamburger A.W. Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation. J. Cell. Physiol. 2001, 187:209-217.
    • (2001) J. Cell. Physiol. , vol.187 , pp. 209-217
    • Xia, X.1    Cheng, A.2    Lessor, T.3    Zhang, Y.4    Hamburger, A.W.5
  • 237
    • 0345598896 scopus 로고    scopus 로고
    • Distinct and nonoverlapping roles for pRB and cyclin D: Cyclin-dependent kinases 4/6 activity in melanocyte survival
    • Yu B.D., Becker-Hapak M., Snyder E.L., Vooijs M., Denicourt C., Dowdy S.F. Distinct and nonoverlapping roles for pRB and cyclin D: Cyclin-dependent kinases 4/6 activity in melanocyte survival. Proc. Natl. Acad. Sci. USA 2003, 100:14881-14886.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 14881-14886
    • Yu, B.D.1    Becker-Hapak, M.2    Snyder, E.L.3    Vooijs, M.4    Denicourt, C.5    Dowdy, S.F.6
  • 238
    • 0029819994 scopus 로고    scopus 로고
    • PRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis
    • Zacksenhaus E., Jiang Z., Chung D., Marth J.D., Phillips R.A., Gallie B.L. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev. 1996, 10:3051-3064.
    • (1996) Genes Dev. , vol.10 , pp. 3051-3064
    • Zacksenhaus, E.1    Jiang, Z.2    Chung, D.3    Marth, J.D.4    Phillips, R.A.5    Gallie, B.L.6
  • 239
    • 0030918714 scopus 로고    scopus 로고
    • Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases
    • Zarkowska T., Mittnacht S. Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 1997, 272:12738-12746.
    • (1997) J. Biol. Chem. , vol.272 , pp. 12738-12746
    • Zarkowska, T.1    Mittnacht, S.2
  • 242
    • 0036569924 scopus 로고    scopus 로고
    • Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability
    • Zheng L., Flesken-Nikitin A., Chen P.L., Lee W.H. Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability. Cancer Res. 2002, 62:2498-2502.
    • (2002) Cancer Res. , vol.62 , pp. 2498-2502
    • Zheng, L.1    Flesken-Nikitin, A.2    Chen, P.L.3    Lee, W.H.4
  • 244
    • 34250822389 scopus 로고    scopus 로고
    • Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts
    • Zhou Z., Flesken-Nikitin A., Nikitin A.Y. Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts. Cancer Res. 2007, 67:5683-5690.
    • (2007) Cancer Res. , vol.67 , pp. 5683-5690
    • Zhou, Z.1    Flesken-Nikitin, A.2    Nikitin, A.Y.3


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