RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest

Molecular and Cellular Biology

Volumn 21, Issue 8, 2001, Pages 2918-2932

  Lai, A ^a   Kennedy, B K ^a   Barbie, D A ^a   Bertos, N R ^a   Xiang Jiao Yang, ^a   Theberge, M C ^a   Shih Chang Tsai, ^a   Seto, E ^a   Zhang, Y ^a   Kuzmichev, A ^a   Lane, W S ^a   Reinberg, D ^a   Harlow, E ^a   Branton, P E ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; HISTONE DEACETYLASE; PROTEIN; PROTEIN MSIN3; PROTEIN RBP1; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL NUCLEUS; CELLULAR DISTRIBUTION; CHROMATIN STRUCTURE; COMPLEX FORMATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE; CELL NUCLEUS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F4 TRANSCRIPTION FACTOR; HISTONE DEACETYLASES; HUMANS; INTERPHASE; MACROMOLECULAR SUBSTANCES; MODELS, BIOLOGICAL; RECOMBINANT FUSION PROTEINS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS;

EID: 0035076249     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.8.2918-2932.2001     Document Type: Article

References (71)

1. The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter
2. Histone deacetylases: Transcriptional repression with SINers and NuRDs
3. E2F: A nodal point in cell cycle regulation
4. Global transcription regulators of eukaryotes
5. Retinoblastoma protein meets chromatin
6. Retinoblastoma protein recruits histone deacetylase to repress transcription
7. Direct transcriptional repression by pRB and its reversal by specific cyclins
8. HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex
9. Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function
10. Characterization of an E2F-p130 complex formed during growth arrest
11. Role of the LXCXE binding site in Rb function
12. Characterization of monoclonal antibodies raised against p300: Both p300 and CBP are present in intracellular TBP complexes
13. Cell cycle regulation of the human cdc2 gene
14. Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells
15. Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins
16. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
17. The regulation of E2F by pRB-family proteins
18. Characterization of a human RPD3 ortholog, HDAC3
19. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein
20. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes
21. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase
22. E2F-1 mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product
23. Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene
24. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression
25. E2F is required to prevent inappropriate S-phase entry of mammalian cells
26. Regulation of cell proliferation by the E2F transcription factors
27. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein
28. Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression
29. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
30. Identification of distinct roles for separate E1A domains in disruption of E2F complexes
31. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression
32. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters
33. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product
34. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
35. Nuclear organization of DNA replication in primary mammalian cells
36. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
37. Histone acetylases and deacetylases in cell proliferation
38. SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors
39. RBPI recruits both histone deacetylase-dependent and -independent repression activities to retinobtastoma family proteins
40. RBP1 induces growth arrest by repression of E2F-dependent transcription
41. Rb interacts with histone deacetylase to repress transcription
42. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
43. Regulation of E2F1 activity by acetylation
44. HDAC4 deacetylase associates with and represses the MEF2 transcription factor
45. Toward an understanding of the functional complexity of the E2F and retinoblastoma families
46. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
47. Regulation of the cyclin E gene by transcription factor E2F1
48. Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites
49. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast
50. Mechanism of transcriptional repression of E2F by the retinoblastoma tumor suppressor protein
51. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
52. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
53. Fundamentally different logic of gene regulation in eukaryotes and prokaryotes
54. A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae
55. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
56. Viral ski inhibits retinoblastoma protein (Rb)mediated transcriptional repression in a dominant negative fashion
57. RB and hbrm cooperate to repress the activation functions of E2F1
58. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
59. A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase
60. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor
61. Retinoblastoma protein switches the E2F site from positive to negative element
62. Mechanism of active transcriptional repression by the retinoblastoma protein
63. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle
64. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
65. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3
66. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family
67. Active transcriptional repression by the Rb-E2F complex mediates Gl arrest triggered by p16INK4A, TGF-β, and contact inhibition
68. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities
69. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
70. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex
71. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex