Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase

Molecular and Cellular Biology

Volumn 21, Issue 19, 2001, Pages 6484-6494

  Vandel, L ^a   Nicolas, E ^a   Vaute, O ^a   Ferreira, R ^a   Ait Si Ali, S ^a   Trouch, D ^a  

^a Université Paul Sabatier   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; METHYLTRANSFERASE; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ARTICLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; HETEROCHROMATIN; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PROCESSING; TRANSCRIPTION REGULATION;

CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; HELA CELLS; HETEROCHROMATIN; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; JURKAT CELLS; METHYLTRANSFERASES; MODELS, GENETIC; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034811677     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.19.6484-6494.2001     Document Type: Article

References (56)

1. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31
2. Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A
3. Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation
4. Selective recognition of methylated lysine 9 on histone H3 by the HPI chromo domain
5. Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern
6. Retinoblastoma protein recruits histone deacetylase to repress transcription
7. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
8. An activity get assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei
9. Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function
10. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation
11. Domains A and B in the Rb pocket interact to form a transcriptional repressor motif
12. The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif
13. Nuclear compartments and gene regulation
14. Role of the LXCXE binding site in Rb function
15. The HP1 protein family: Getting a grip on chromatin
16. E2F-1 functions in mice to promote apoptosis and suppress proliferation
17. Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)
18. DNA methyltransferase Dnmtl associates with histone deacetylase activity
19. Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth
20. Yeast heterochromatin: Regulation of its assembly and inheritance by histones
21. The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro
22. Rb function in cell-cycle regulation and apoptosis
23. Cyclin A-kinase regulation of E2F-I DNA binding function underlies suppression of an S phase checkpoint
24. Roles of histone acetyltransferases and deacetylases in gene regulation
25. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
26. E2F and the molecular mechanisms of early cellcycle control.
27. A possible involvement of TIFI alpha and TIFI beta in the epigenetic control of transcription by nuclear receptoRS
28. Chromatin components as part of a putative transcriptional repressing complex
29. Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14
30. Rb interacts with histone deacetylase to repress transcription
31. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
32. HP1 gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes
33. An E2F-like repressor of transcription
34. The E2F transcription factors: Key regulators of cell proliferation
35. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
36. DNA methylation and chromatin modification
37. RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein
38. Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIFI family
39. Isolation and characterization of suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression
40. The restriction point and control of cell proliferation
41. Regulation of chromatin structure by site-specific histone H3 methyltransferases
42. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
43. Active repression and E2F inhibition by pRB are biochemically distinguishable
44. Transcriptional repression and growth suppression by the p107 pocket protein
45. The language of covalent histone modifications
46. Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases
47. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
48. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex
49. E2F-6, a member of the E2F family that can behave as a transcriptional repressor
50. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var) 3-9 combines domains of antagonistic regulators of homeotic gene complexes
51. Physical association between the histone acetyl transferase CBP and a histone methyl transferase
52. A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase
53. Histone acetylation: Chromatin in action
54. Mechanism of active transcriptional repression by the retinoblastoma protein
55. Retinoblastoma protein switches the E2F site from positive to negative element
56. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities