Linking the Rb and Polycomb pathways

Molecular Cell

Volumn 8, Issue 3, 2001, Pages 557-568

  Dahiya, Anjali ^a   Wong, Sharon ^a   Gonzalo, Susana ^a   Gavin, Mark ^a   Dean, Douglas C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; RETINOBLASTOMA PROTEIN;

ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GENE REPRESSION; HUMAN; HUMAN CELL; MITOSIS; MITOSIS INHIBITION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

EID: 0034785586     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00346-X     Document Type: Article

References (69)

1. A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes
2. Reversal of terminal differentiation and control of DNA replication: Cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication
3. The E2F transcription factor is a cellular target for the RB protein
4. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
5. Domains A and B in the Rb pocket interact to form a transcriptional repressor motif
6. The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif
7. Role of the LXCXE binding site in Rb function
8. The cyclin-dependent protein kinases and the control of cell division
9. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
10. The cell cycle and the retinoblastoma protein family
11. E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control
12. Regulation of cyclin E transcription by E2Fs and retinoblastoma protein
13. Functions of mammalian Polycomb group and trithorax group related genes
14. The Rb/E2F pathway: Expanding roles and emerging paradigms
15. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
16. bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis
17. E2F is required to prevent inappropriate S-phase entry of mammalian cells
18. Cyclin A expression is under negative transcriptional control during the cell cycle
19. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
20. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
21. Requirement of cyclin E-Cdk2 inhibition in p16(INK4a)-mediated growth suppression
22. The Polycomb and trithorax group proteins of Drosophila: Trans-regulators of homeotic gene function
23. The murine SNF5/INI1 chromatin remodelling factor is essential for embryonic development and tumor suppression
24. Inhibition of DNA synthesis by RB: Effects on G1/S transition and S-phase progression
25. RB-dependent S-phase response to DNA damage
26. Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system
27. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
28. Functional antagonism of the Polycomb-group genes eed and Bmi1 in hemopoietic cell proliferation
29. A gene complex controlling segmentation in Drosophila
30. lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48
31. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
32. p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: Molecular mechanisms and implications for oncogenesis
33. Rb interacts with histone deacetylase to repress transcription
34. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
35. Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
36. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor
37. Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)
38. Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein
39. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor
40. E2f: A link between the Rb tumor suppressor protein and viral oncoproteins
41. Regulation of the cyclin E gene by transcription factor E2F1
42. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein
43. Polycombing the genome: PcG, trxG, and chromatin silencing
44. ZEB represses transcription through interaction with the corepressor CtBP
45. Ring1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity
46. Ring1 is associated with the polycomb group protein complex and acts as a transcriptional repressor
47. Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis
48. Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond
49. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
50. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins
51. Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest
52. Inhibitors of mammalian G1 cyclin-dependent kinases
53. CDK inhibitors: Positive and negative regulators of G1-phase progression
54. A genetic screen for modifiers of E2F in Drosophila melanogaster
55. Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest
56. BRG-1 is required for RB-mediated cell cycle arrest
57. Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins
58. Xenopus embryonic E2F is required for the formation of ventral and posterior cell fates during early embryogenesis
59. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
60. RB and hbrm cooperate to repress the activation functions of E2F1
61. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
62. Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status
63. The retinoblastoma protein and cell cycle control
64. Retinoblastoma protein switches the E2F site from positive to negative element
65. Mechanism of active transcriptional repression by the retinoblastoma protein
66. Target gene specificity of E2F and pocket protein family members in living cells
67. BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
68. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFβ, and contact inhibition
69. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF