The Rb tumor suppressor is required for stress erythropoiesis

EMBO Journal

Volumn 23, Issue 21, 2004, Pages 4319-4329

  Spike, Benjamin T ^a   Dirlam, Alexandra ^a   Dibling, Benjamin C ^a   Marvin, James ^a   Williams, Bart O ^b   Jacks, Tyler ^c,d   Macleod, Kay F ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b VAN ANDEL RESEARCH INSTITUTE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Howard Hughes Institute   (United States)

Author keywords

Cell cycle; Enucleation; Erythropoiesis; Homeostasis; pRb

Indexed keywords

RETINOBLASTOMA PROTEIN;

ANEMIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; ERYTHROBLAST; ERYTHROCYTE; ERYTHROPOIESIS; GENE INACTIVATION; GENE TARGETING; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PLACENTA DISORDER; PRIORITY JOURNAL; RB GENE; STRESS; STRESS ERYTHROPOIESIS; TUMOR SUPPRESSOR GENE;

ANEMIA, APLASTIC; ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CELL NUCLEUS; CELLS, CULTURED; CHIMERA; EMBRYO; ERYTHROBLASTS; ERYTHROCYTES; ERYTHROPOIESIS; GENE SILENCING; HUMANS; LIVER; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; RETINOBLASTOMA PROTEIN;

ANIMALIA;

EID: 9144223727     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600432     Document Type: Article

References (28)

1. Bauer A, Tronche F, Wessely O, Kellendonk C, Reichardt HM, Steinlein P, Schutz G, Beug H (1999) The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev 13: 2996-3002
2. Bianchi L, Tacchini L, Cairo G (1999) HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation. Nucleic Adds Res 27: 4223-4227
3. Broudy VC, Lin NL, Priestley GV, Nocka K, Wolf NS (1996) Interaction of stem cell factor and its receptor c-kit mediates lodgement and acute expansion of hematopoietic cells in the murine spleen. Blood 88: 75-81
4. Clark AJ, Doyle KM, Humbert PO (2004) Cell intrinsic functions of pRb in erythropoiesis. Blood 104: 1324-1326
5. Clarke AR, Maandag ER, van Roon M, van der Lugt NMT, van der Valk M, Hooper ML, Berns A, te Riele H (1992) Requirement for a functional Rb-1 gene in murine development. Nature 359: 328-330
6. D'Andrea AD, Grompe M (2003) The Fanconi anemia/BRCA pathway. Nat Rev Cancer 3: 23-34
7. Esposito F, Russo L, Russo T, Cimino F (2000) Retinoblastoma protein dephosphorylation is an early event of cellular response to pro-oxidant conditions. FEBS Lett 470: 211-215
8. Ferguson KL, Vanderluit JL, Hebert JM, McIntosh WC, Tibbo E, MacLaurin JG, Park DS, Wallace VA, Vooijs M, McConnell SK, Slack RS (2002) Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J 21: 3337-3346
9. Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of aging. Nature 408: 239-247
10. Godin I, Cumano A (2002) The Hare and the tortoise: an embryonic haematopoietic race. Nat Rev Immunol 2: 593-604
11. Harrington EA, Bruce JL, Harlow E, Dyson N (1998) pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci USA 95: 11945-11950
12. Jacks T, Fazeli A, Schmidt E, Bronson R, Goodell M, Weinberg R (1992) Effects of an Rb mutation in the mouse. Nature 359: 295-300
13. Kina T, Ikuta K, Takayama E, Wada K, Majumdar A, Weissman IL, Katsura Y (2000) The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br J Haematol 109: 280-287
14. Lee EY-HP, Chang C-Y, Hu N, Wang Y-CJ, Lai C-C, Herrup K, Lee W-H (1992) Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359: 288-295
15. Lipinski M, Macleod KF, Crowley D, Mullaney T, Jacks T (2001) Cell-autonomous and non-cell autonomous developmental functions of the retinoblastoma tumor suppressor gene in vivo. EMBO J 20: 3402-3413
16. Macleod K, Hu Y, Jacks T (1996) Loss of Rb activates both p53-dependent and -independent cell death pathways in the developing mouse nervous system. EMBO J 15: 6178-6188
17. Macpherson D, Sage J, Crowley D, Trumpp A, Bronson RT, Jacks T (2003) Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol 23: 1044-1053
18. Marino S, Vooijs M, van der Gulden H, Jonkers J, Berns A (2000) Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 14: 994-1004
19. Morgenbesser SD, Williams BO, Jacks T, DePinho RA (1994) p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371: 72-74
20. O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA (2003) A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Gen. 33: 497-501
21. Polager S, Kalma Y, Berkovich E, Ginsberg D (2002) E2Fs upregulate expression of genes involved in DNA replication, DNA repair and mitosis. Oncogene 21: 437-446
22. Robanus-Maandag EC, van der Valk M, Vlaar M, Feltkamp C, O'Brien J, van Roon M, van der Lugt N, Berns A, te Riele H (1994) Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. EMBO J 13: 4260-4268
23. Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF (2001) Ineffective erythropoiesis in Stat5a-/-5b-/-mice due to decreased survival of early erythroblasts. Blood 98: 3261-3273
24. Whyatt D, Grosveld F (2002) Cell-autonomous function of the retinoblastoma tumor suppressor protein: new interpretations of old phenotypes. EMBO Reports 3: 130-135
25. Whyatt D, Lindeboom F, Karis A, Ferreira R, Milot E, Hendriks R, de Bruijn M, Langeveld A, Gribnau J, Grosveld F, Philipsen S (2000) An intrinsic but cell-nonautonomous defect in GATA-1 over-expressing mouse erythroid cells. Nature 406: 519-523
26. Williams BO, Schmitt EM, Remington L, Bronson RT, Albert DM, Weinberg RA, Jacks T (1994) Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J 13: 4251-4259
27. Wu L, de Bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y, Opavska J, Wilson P, Thompson JC, Ostrowski MC, Rosol TJ, Woollett LA, Weinstein M, Cross JC, Robinson ML, Leone G (2003) Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 421: 942-947
28. Zacksenhaus E, Jiang Z, Chung D, Marth JD, Philips RA, Gallie BL (1996) pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev 10: 3051-3064