-
2
-
-
0019524044
-
Sensory control of dauer larva formation in Caenorhabditis elegans
-
Albert PS, Brown SJ, and Riddle DL. Sensory control of dauer larva formation in Caenorhabditis elegans. J Comp Neurol 198: 435-451, 1981.
-
(1981)
J Comp Neurol
, vol.198
, pp. 435-451
-
-
Albert, P.S.1
Brown, S.J.2
Riddle, D.L.3
-
3
-
-
0347854376
-
Regulation of C. elegans Longevity by specific gustatory and olfactory neurons
-
Alcedo J and Kenyon C. Regulation of C. elegans Longevity by specific gustatory and olfactory neurons. Neuron 41: 45-55, 2004.
-
(2004)
Neuron
, vol.41
, pp. 45-55
-
-
Alcedo, J.1
Kenyon, C.2
-
4
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phos-phorylates and activates protein kinase Balpha
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, and Cohen P. Characterization of a 3-phosphoinositide-dependent protein kinase which phos-phorylates and activates protein kinase Balpha. Curr Biol 7: 261-269, 1997.
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
5
-
-
0033576579
-
Regulation of lifespan by sensory perception in Caenorhabditis elegans
-
Apfeld J and Kenyon C. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402: 804-809, 1999.
-
(1999)
Nature
, vol.402
, pp. 804-809
-
-
Apfeld, J.1
Kenyon, C.2
-
6
-
-
43649107519
-
14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans
-
Araiz C, Chateau MT, and Galas S. 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. Exp Gerontol 43: 505-519, 2008.
-
(2008)
Exp Gerontol
, vol.43
, pp. 505-519
-
-
Araiz, C.1
Chateau, M.T.2
Galas, S.3
-
7
-
-
33846294435
-
FoxOs in tumor suppression and stem cell maintenance
-
Arden KC. FoxOs in tumor suppression and stem cell maintenance. Cell 128: 235-237, 2007.
-
(2007)
Cell
, vol.128
, pp. 235-237
-
-
Arden, K.C.1
-
8
-
-
0142052858
-
Insulin/IGF-I-signaling pathway: An evolutionarily conserved mechanism of longevity from yeast to humans
-
Barbieri M, Bonafe M, Franceschi C, and Paolisso G. Insulin/IGF-I- signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab 285: E1064-E1071, 2003.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Barbieri, M.1
Bonafe, M.2
Franceschi, C.3
Paolisso, G.4
-
9
-
-
0035082093
-
Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans
-
Barsyte D, Lovejoy DA, and Lithgow GJ. Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. FASEB J 15: 627-634, 2001.
-
(2001)
FASEB J
, vol.15
, pp. 627-634
-
-
Barsyte, D.1
Lovejoy, D.A.2
Lithgow, G.J.3
-
10
-
-
33744976074
-
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
-
Berdichevsky A, Viswanathan M, Horvitz HR, and Guarente L. C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125: 1165-1177, 2006.
-
(2006)
Cell
, vol.125
, pp. 1165-1177
-
-
Berdichevsky, A.1
Viswanathan, M.2
Horvitz, H.R.3
Guarente, L.4
-
11
-
-
50849130900
-
Structural basis for DNA recognition by FoxO1 and its regulation by post-translational modification
-
Brent MM, Anand R, and Marmorstein R. Structural basis for DNA recognition by FoxO1 and its regulation by post-translational modification. Structure 16: 1407-1416, 2008.
-
(2008)
Structure
, vol.16
, pp. 1407-1416
-
-
Brent, M.M.1
Anand, R.2
Marmorstein, R.3
-
12
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, and Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868, 1999.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
13
-
-
0037018148
-
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
-
Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, and Yaffe MB. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol 156: 817-828, 2002.
-
(2002)
J Cell Biol
, vol.156
, pp. 817-828
-
-
Brunet, A.1
Kanai, F.2
Stehn, J.3
Xu, J.4
Sarbassova, D.5
Frangioni, J.V.6
Dalal, S.N.7
Decaprio, J.A.8
Greenberg, M.E.9
Yaffe, M.B.10
-
14
-
-
0035135841
-
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
-
Brunet A, Park J, Tran H, Hu LS, Hemmings BA, and Greenberg ME. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 21: 952-965, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 952-965
-
-
Brunet, A.1
Park, J.2
Tran, H.3
Hu, L.S.4
Hemmings, B.A.5
Greenberg, M.E.6
-
15
-
-
0036629251
-
Cell cycle and death control: Long live Forkheads
-
Burgering BM and Kops GJ. Cell cycle and death control: long live Forkheads. Trends Biochem Sci 27: 352-360, 2002.
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 352-360
-
-
Burgering, B.M.1
Kops, G.J.2
-
16
-
-
0035918148
-
Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways
-
Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, and Alexander-Bridges M. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J Biol Chem 276: 13402-13410, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 13402-13410
-
-
Cahill, C.M.1
Tzivion, G.2
Nasrin, N.3
Ogg, S.4
Dore, J.5
Ruvkun, G.6
Alexander-Bridges, M.7
-
17
-
-
23444431611
-
Green Fluorescent protein as a marker for gene expression
-
Chalfie M, Tu Y, Euskirchen G, Ward WW, and Prasher DC. Green Fluorescent protein as a marker for gene expression. Science 263: 802-805, 1994.
-
(1994)
Science
, vol.263
, pp. 802-805
-
-
Chalfie, M.1
Tu, Y.2
Euskirchen, G.3
Ward, W.W.4
Prasher, D.C.5
-
18
-
-
3042750643
-
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
-
Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, Miyagishi M, Nakajima T, and Fukamizu A. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci USA 101: 10042-10047, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10042-10047
-
-
Daitoku, H.1
Hatta, M.2
Matsuzaki, H.3
Aratani, S.4
Ohshima, T.5
Miyagishi, M.6
Nakajima, T.7
Fukamizu, A.8
-
19
-
-
49849093007
-
Unravelling the tumor-suppressive functions of FOXO proteins
-
Dansen TB and Burgering BM. Unravelling the tumor-suppressive functions of FOXO proteins. Trends Cell Biol 18: 421-429, 2008.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 421-429
-
-
Dansen, T.B.1
Burgering, B.M.2
-
20
-
-
0028807085
-
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
-
Dorman JB, Albinder B, Shroyer T, and Kenyon C. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141: 1399-1406, 1995.
-
(1995)
Genetics
, vol.141
, pp. 1399-1406
-
-
Dorman, J.B.1
Albinder, B.2
Shroyer, T.3
Kenyon, C.4
-
21
-
-
69649094479
-
Caenorhabditis elegans pheromones regulate multiple complex behaviors
-
Edison AS. Caenorhabditis elegans pheromones regulate multiple complex behaviors. Curr Opin Neurobiol 19: 378-388, 2009.
-
(2009)
Curr Opin Neurobiol
, vol.19
, pp. 378-388
-
-
Edison, A.S.1
-
22
-
-
18844382368
-
Functional interaction between beta-catenin and FOXO in oxidative stress signaling
-
Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, and Korswagen HC. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308: 1181-1184, 2005.
-
(2005)
Science
, vol.308
, pp. 1181-1184
-
-
Essers, M.A.1
De Vries-Smits, L.M.2
Barker, N.3
Polderman, P.E.4
Burgering, B.M.5
Korswagen, H.C.6
-
23
-
-
11244320393
-
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
-
Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL, and Burgering BM. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 23: 4802-4812, 2004.
-
(2004)
EMBO J
, vol.23
, pp. 4802-4812
-
-
Essers, M.A.1
Weijzen, S.2
De Vries-Smits, A.M.3
Saarloos, I.4
De Ruiter, N.D.5
Bos, J.L.6
Burgering, B.M.7
-
24
-
-
0033057848
-
Heat-shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology
-
Feder ME and Hofmann GE. Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu Rev Physiol 61: 243-282, 1999.
-
(1999)
Annu Rev Physiol
, vol.61
, pp. 243-282
-
-
Feder, M.E.1
Hofmann, G.E.2
-
25
-
-
50049116926
-
C. elegans dauer formation and the molecular basis of plasticity
-
Fielenbach N and Antebi A. C. elegans dauer formation and the molecular basis of plasticity. Genes Dev 22: 2149-2165, 2008.
-
(2008)
Genes Dev
, vol.22
, pp. 2149-2165
-
-
Fielenbach, N.1
Antebi, A.2
-
26
-
-
62449083712
-
Association of FOXO3A variation with human longevity confirmed in German centenarians
-
Flachsbart F, Caliebe A, Kleindorp R, Blanche H, von Eller-Eberstein H, Nikolaus S, Schreiber S, and Nebel A. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci USA 106: 2700-2705, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2700-2705
-
-
Flachsbart, F.1
Caliebe, A.2
Kleindorp, R.3
Blanche, H.4
Von Eller-Eberstein, H.5
Nikolaus, S.6
Schreiber, S.7
Nebel, A.8
-
27
-
-
0023831256
-
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
-
Friedman DB and Johnson TE. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118: 75-86, 1988.
-
(1988)
Genetics
, vol.118
, pp. 75-86
-
-
Friedman, D.B.1
Johnson, T.E.2
-
28
-
-
0034661826
-
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
-
Furuyama T, Nakazawa T, Nakano I, and Mori N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J 349: 629-634, 2000.
-
(2000)
Biochem J
, vol.349
, pp. 629-634
-
-
Furuyama, T.1
Nakazawa, T.2
Nakano, I.3
Mori, N.4
-
29
-
-
0036021375
-
Genetic analysis of tissue aging in Cae-norhabditis elegans: A role for heat-shock factor and bacterial proliferation
-
Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, and Kenyon C. Genetic analysis of tissue aging in Cae-norhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161: 1101-1112, 2002.
-
(2002)
Genetics
, vol.161
, pp. 1101-1112
-
-
Garigan, D.1
Hsu, A.L.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Kenyon, C.6
-
30
-
-
0038047438
-
Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens
-
Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, and Ausubel FM. Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science 300: 1921, 2003.
-
(2003)
Science
, vol.300
, pp. 1921
-
-
Garsin, D.A.1
Villanueva, J.M.2
Begun, J.3
Kim, D.H.4
Sifri, C.D.5
Calderwood, S.B.6
Ruvkun, G.7
Ausubel, F.M.8
-
31
-
-
0034570990
-
Longevity and ageing in parasitic and free-living nematodes
-
Gems D. Longevity and ageing in parasitic and free-living nematodes. Biogerontology 1: 289-307, 2000.
-
(2000)
Biogerontology
, vol.1
, pp. 289-307
-
-
Gems, D.1
-
32
-
-
12344309431
-
Broad spectrum detoxification: The major longevity assurance process regulated by insulin/IGF-1 signaling?
-
Gems D and McElwee JJ. Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling? Mech Ageing Dev 126: 381-387, 2005.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 381-387
-
-
Gems, D.1
McElwee, J.J.2
-
33
-
-
70349668985
-
A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans
-
Ghazi A, Henis-Korenblit S, and Kenyon C. A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet 5: e1000639, 2009.
-
(2009)
PLoS Genet
, vol.5
-
-
Ghazi, A.1
Henis-Korenblit, S.2
Kenyon, C.3
-
34
-
-
34250882745
-
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
-
Ghazi A, Henis-Korenblit S, and Kenyon C. Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci USA 104: 5947-5952, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5947-5952
-
-
Ghazi, A.1
Henis-Korenblit, S.2
Kenyon, C.3
-
35
-
-
34250326302
-
The emerging role of FOXO transcription factors in pancreatic beta cells
-
Glauser DA and Schlegel W. The emerging role of FOXO transcription factors in pancreatic beta cells. J Endocrinol 193: 195-207, 2007.
-
(2007)
J Endocrinol
, vol.193
, pp. 195-207
-
-
Glauser, D.A.1
Schlegel, W.2
-
36
-
-
0020000259
-
A pheromone influences larval development in the nematode Caenorhabditis elegans
-
Golden JW and Riddle DL. A pheromone influences larval development in the nematode Caenorhabditis elegans. Science 218: 578-580, 1982.
-
(1982)
Science
, vol.218
, pp. 578-580
-
-
Golden, J.W.1
Riddle, D.L.2
-
37
-
-
0028334880
-
Daf-2, daf-16, and daf-23: Genetically interacting genes controlling dauer formation in C. elegans
-
Gottlieb S and Ruvkun G. daf-2, daf-16, and daf-23: Genetically interacting genes controlling dauer formation in C. elegans. Genetics 137: 107-120, 1994.
-
(1994)
Genetics
, vol.137
, pp. 107-120
-
-
Gottlieb, S.1
Ruvkun, G.2
-
38
-
-
34848850156
-
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
-
Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, Blanchard D, Gygi SP, and Brunet A. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol 17: 1646-1656, 2007.
-
(2007)
Curr Biol
, vol.17
, pp. 1646-1656
-
-
Greer, E.L.1
Dowlatshahi, D.2
Banko, M.R.3
Villen, J.4
Hoang, K.5
Blanchard, D.6
Gygi, S.P.7
Brunet, A.8
-
40
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin DA and Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 12: 9-22, 2007.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
41
-
-
0035846604
-
Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
-
Henderson ST and Johnson TE. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 11: 1975-1980, 2001.
-
(2001)
Curr Biol
, vol.11
, pp. 1975-1980
-
-
Henderson, S.T.1
Johnson, T.E.2
-
42
-
-
11144355021
-
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
-
Hertweck M, Gobel C, and Baumeister R. C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 6: 577-588, 2004.
-
(2004)
Dev Cell
, vol.6
, pp. 577-588
-
-
Hertweck, M.1
Gobel, C.2
Baumeister, R.3
-
43
-
-
0032782364
-
The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
-
Honda Y and Honda S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J 13: 1385-1393, 1999.
-
(1999)
FASEB J
, vol.13
, pp. 1385-1393
-
-
Honda, Y.1
Honda, S.2
-
44
-
-
0033609291
-
Signals from the reproductive system regulate the lifespan of C. elegans
-
Hsin H and Kenyon C. Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399: 362-366, 1999.
-
(1999)
Nature
, vol.399
, pp. 362-366
-
-
Hsin, H.1
Kenyon, C.2
-
45
-
-
0038701745
-
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
-
Hsu AL, Murphy CT, and Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300: 1142-1145, 2003.
-
(2003)
Science
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
46
-
-
38449105152
-
Dauer
-
Hu PJ. Dauer. WormBook 1-19, 2007.
-
(2007)
WormBook
, pp. 1-19
-
-
Hu, P.J.1
-
47
-
-
13444252337
-
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation
-
Huang H, Regan KM, Wang F, Wang D, Smith DI, Van Deursen JM, and Tindall DJ. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci USA 102: 1649-1654, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1649-1654
-
-
Huang, H.1
Regan, K.M.2
Wang, F.3
Wang, D.4
Smith, D.I.5
Van Deursen, J.M.6
Tindall, D.J.7
-
48
-
-
34548289502
-
Dynamic FoxO transcription factors
-
Huang H and Tindall DJ. Dynamic FoxO transcription factors. J Cell Sci 120: 2479-2487, 2007.
-
(2007)
J Cell Sci
, vol.120
, pp. 2479-2487
-
-
Huang, H.1
Tindall, D.J.2
-
49
-
-
0343729870
-
The Caenorhabditis elegans gonad: A test tube for cell and developmental biology
-
Hubbard EJ and Greenstein D. The Caenorhabditis elegans gonad: a test tube for cell and developmental biology. Dev Dyn 218: 2-22, 2000.
-
(2000)
Dev Dyn
, vol.218
, pp. 2-22
-
-
Hubbard, E.J.1
Greenstein, D.2
-
50
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia K, Chen D, and Riddle DL. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131: 3897-3906, 2004.
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
51
-
-
65949103405
-
Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1
-
Jones KT, Greer ER, Pearce D, and Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol 7: e60, 2009.
-
(2009)
PLoS Biol
, vol.7
-
-
Jones, K.T.1
Greer, E.R.2
Pearce, D.3
Ashrafi, K.4
-
52
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Sacchar-omyces cerevisiae by two different mechanisms
-
Kaeberlein M, McVey M, and Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Sacchar-omyces cerevisiae by two different mechanisms. Genes Dev 13: 2570-2580, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
53
-
-
4544358547
-
Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type i (slow twitch/red muscle) fiber genes, and impaired gly-cemic control
-
Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, Mochida K, Hata T, Matsuda J, Aburatani H, Nishino I, and Ezaki O. Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired gly-cemic control. J Biol Chem 279: 41114-41123, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 41114-41123
-
-
Kamei, Y.1
Miura, S.2
Suzuki, M.3
Kai, Y.4
Mizukami, J.5
Taniguchi, T.6
Mochida, K.7
Hata, T.8
Matsuda, J.9
Aburatani, H.10
Nishino, I.11
Ezaki, O.12
-
54
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon C, Chang J, Gensch E, Rudner A, and Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464, 1993.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
55
-
-
0042030924
-
JNK-interacting protein 1 promotes Akt1 activation
-
Kim AH, Sasaki T, and Chao MV. JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem 278: 29830-29836, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 29830-29836
-
-
Kim, A.H.1
Sasaki, T.2
Chao, M.V.3
-
56
-
-
0030813398
-
Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
Kimura KD, Tissenbaum HA, Liu Y, and Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946, 1997.
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
57
-
-
0028930267
-
Genes that regulate both development and longevity in Caenorhabditis elegans
-
Larsen PL, Albert PS, and Riddle DL. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139: 1567-1583, 1995.
-
(1995)
Genetics
, vol.139
, pp. 1567-1583
-
-
Larsen, P.L.1
Albert, P.S.2
Riddle, D.L.3
-
58
-
-
77951926114
-
Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans
-
Le TT, Duren HM, Slipchenko MN, Hu CD, and Cheng JX. Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans. J Lipid Res 51: 672-677.
-
J Lipid Res
, vol.51
, pp. 672-677
-
-
Le, T.T.1
Duren, H.M.2
Slipchenko, M.N.3
Hu, C.D.4
Cheng, J.X.5
-
59
-
-
0035846601
-
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
-
Lee RY, Hench J, and Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol 11: 1950-1957, 2001.
-
(2001)
Curr Biol
, vol.11
, pp. 1950-1957
-
-
Lee, R.Y.1
Hench, J.2
Ruvkun, G.3
-
60
-
-
0037466652
-
DAF-16 target genes that control C. elegans life-span and metabolism
-
Lee SS, Kennedy S, Tolonen AC, and Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science 300: 644-647, 2003.
-
(2003)
Science
, vol.300
, pp. 644-647
-
-
Lee, S.S.1
Kennedy, S.2
Tolonen, A.C.3
Ruvkun, G.4
-
61
-
-
33646934067
-
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
-
Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, and Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125: 987-1001, 2006.
-
(2006)
Cell
, vol.125
, pp. 987-1001
-
-
Lehtinen, M.K.1
Yuan, Z.2
Boag, P.R.3
Yang, Y.4
Villen, J.5
Becker, E.B.6
Dibacco, S.7
De La Iglesia, N.8
Gygi, S.9
Blackwell, T.K.10
Bonni, A.11
-
62
-
-
54749095200
-
Cae-norhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator
-
Li J, Ebata A, Dong Y, Rizki G, Iwata T, and Lee SS. Cae-norhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol 6: e233, 2008.
-
(2008)
PLoS Biol
, vol.6
-
-
Li, J.1
Ebata, A.2
Dong, Y.3
Rizki, G.4
Iwata, T.5
Lee, S.S.6
-
63
-
-
33845736825
-
The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans
-
Li J, Tewari M, Vidal M, and Lee SS. The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Dev Biol 301: 82-91, 2007.
-
(2007)
Dev Biol
, vol.301
, pp. 82-91
-
-
Li, J.1
Tewari, M.2
Vidal, M.3
Lee, S.S.4
-
64
-
-
33846596646
-
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination
-
Li W, Gao B, Lee SM, Bennett K, and Fang D. RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Dev Cell 12: 235-246, 2007.
-
(2007)
Dev Cell
, vol.12
, pp. 235-246
-
-
Li, W.1
Gao, B.2
Lee, S.M.3
Bennett, K.4
Fang, D.5
-
65
-
-
0345447590
-
Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan
-
DOI 10.1016/S0092-8674(03)00889-4
-
Libina N, Berman JR, and Kenyon C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115: 489-502, 2003. (Pubitemid 37456810)
-
(2003)
Cell
, vol.115
, Issue.4
, pp. 489-502
-
-
Libina, N.1
Berman, J.R.2
Kenyon, C.3
-
66
-
-
0030657540
-
Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin K, Dorman JB, Rodan A, and Kenyon C. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278: 1319-1322, 1997.
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
67
-
-
0034967720
-
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/ IGF-1 and germline signaling
-
Lin K, Hsin H, Libina N, and Kenyon C. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/ IGF-1 and germline signaling. Nat Genet 28: 139-145, 2001.
-
(2001)
Nat Genet
, vol.28
, pp. 139-145
-
-
Lin, K.1
Hsin, H.2
Libina, N.3
Kenyon, C.4
-
68
-
-
0029123058
-
Ther-motolerance and extended life-span conferred by single-gene mutations and induced by thermal stress
-
Lithgow GJ, White TM, Melov S, and Johnson TE. Ther-motolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci USA 92: 7540-7544, 1995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 7540-7544
-
-
Lithgow, G.J.1
White, T.M.2
Melov, S.3
Johnson, T.E.4
-
69
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T and Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
70
-
-
42749086593
-
OutFOXOing disease and disability: The therapeutic potential of targeting FoxO proteins
-
Maiese K, Chong ZZ, and Shang YC. OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins. Trends Mol Med 14: 219-227, 2008.
-
(2008)
Trends Mol Med
, vol.14
, pp. 219-227
-
-
Maiese, K.1
Chong, Z.Z.2
Shang, Y.C.3
-
71
-
-
33748312093
-
Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
-
Matsumoto M, Han S, Kitamura T, and Accili D. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest 116: 2464-2472, 2006.
-
(2006)
J Clin Invest
, vol.116
, pp. 2464-2472
-
-
Matsumoto, M.1
Han, S.2
Kitamura, T.3
Accili, D.4
-
72
-
-
28244483928
-
Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family
-
Matsuzaki H, Ichino A, Hayashi T, Yamamoto T, and Kikkawa U. Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family. J Biochem 138: 485-491, 2005.
-
(2005)
J Biochem
, vol.138
, pp. 485-491
-
-
Matsuzaki, H.1
Ichino, A.2
Hayashi, T.3
Yamamoto, T.4
Kikkawa, U.5
-
73
-
-
0042631524
-
Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
-
McElwee J, Bubb K, and Thomas JH. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2: 111-121, 2003.
-
(2003)
Aging Cell
, vol.2
, pp. 111-121
-
-
McElwee, J.1
Bubb, K.2
Thomas, J.H.3
-
74
-
-
0033595003
-
The PTEN tumor suppressor homolog in Cae-norhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway
-
Mihaylova VT, Borland CZ, Manjarrez L, Stern MJ, and Sun H. The PTEN tumor suppressor homolog in Cae-norhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway. Proc Natl Acad Sci USA 96: 7427-7432, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7427-7432
-
-
Mihaylova, V.T.1
Borland, C.Z.2
Manjarrez, L.3
Stern, M.J.4
Sun, H.5
-
75
-
-
79251557441
-
Regulation of longevity in C. elegans by heat shock factor and molecular chaperones
-
Morley JF and Morimoto RI. Regulation of longevity in C. elegans by heat shock factor and molecular chaperones. Mol Biol Cell, 2003.
-
(2003)
Mol Biol Cell
-
-
Morley, J.F.1
Morimoto, R.I.2
-
76
-
-
0029768753
-
A phosphatidy-linositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
-
Morris JZ, Tissenbaum HA, and Ruvkun G. A phosphatidy-linositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-539, 1996.
-
(1996)
Nature
, vol.382
, pp. 536-539
-
-
Morris, J.Z.1
Tissenbaum, H.A.2
Ruvkun, G.3
-
78
-
-
0035797913
-
The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans
-
Murakami S and Johnson TE. The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. Curr Biol 11: 1517-1523, 2001.
-
(2001)
Curr Biol
, vol.11
, pp. 1517-1523
-
-
Murakami, S.1
Johnson, T.E.2
-
79
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Cae-norhabditis elegans
-
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, and Kenyon C. Genes that act downstream of DAF-16 to influence the lifespan of Cae-norhabditis elegans. Nature 424: 277-283, 2003.
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
80
-
-
74849116065
-
InAKTivation of insulin/IGF-1 signaling by dephosphory-lation
-
Narasimhan SD, Mukhopadhyay A, and Tissenbaum HA. InAKTivation of insulin/IGF-1 signaling by dephosphory-lation. Cell Cycle 8: 3878-3884, 2009.
-
(2009)
Cell Cycle
, vol.8
, pp. 3878-3884
-
-
Narasimhan, S.D.1
Mukhopadhyay, A.2
Tissenbaum, H.A.3
-
82
-
-
12944335299
-
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
-
NasrinN, Ogg S, Cahill CM, Biggs W,Nui S,Dore J, Calvo D, Shi Y, Ruvkun G, and Alexander-Bridges MC. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci USA 97: 10412-10417, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10412-10417
-
-
Nasrinn Ogg, S.1
Cahill, C.M.2
Biggs Wnui Sdore, J.3
Calvo, D.4
Shi, Y.5
Ruvkun, G.6
Alexander-Bridges, M.C.7
-
83
-
-
0037099046
-
Chaperoning signaling pathways: Molecular chaperones as stress-sensing "heat shock" proteins
-
Nollen EA and Morimoto RI. Chaperoning signaling pathways: molecular chaperones as stress-sensing "heat shock" proteins. J Cell Sci 115: 2809-2816, 2002.
-
(2002)
J Cell Sci
, vol.115
, pp. 2809-2816
-
-
Nollen, E.A.1
Morimoto, R.I.2
-
84
-
-
41849104205
-
Structure/function relationships underlying regulation of FOXO transcription factors
-
Obsil T and Obsilova V. Structure/function relationships underlying regulation of FOXO transcription factors. Oncogene 27: 2263-2275, 2008.
-
(2008)
Oncogene
, vol.27
, pp. 2263-2275
-
-
Obsil, T.1
Obsilova, V.2
-
85
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissen-baum HA, and Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389: 994-999, 1997.
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissen-Baum, H.A.6
Ruvkun, G.7
-
86
-
-
0032238299
-
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
-
Ogg S and Ruvkun G. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell 2: 887-893, 1998.
-
(1998)
Mol Cell
, vol.2
, pp. 887-893
-
-
Ogg, S.1
Ruvkun, G.2
-
87
-
-
31744438846
-
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chro-matin immunoprecipitation
-
Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, and Tissenbaum HA. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chro-matin immunoprecipitation. Nat Genet 38: 251-257, 2006.
-
(2006)
Nat Genet
, vol.38
, pp. 251-257
-
-
Oh, S.W.1
Mukhopadhyay, A.2
Dixit, B.L.3
Raha, T.4
Green, M.R.5
Tissenbaum, H.A.6
-
88
-
-
15444371989
-
JNK regulates lifespan in Cae-norhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
-
Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, and Tissenbaum HA. JNK regulates lifespan in Cae-norhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci USA 102: 4494-4499, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 4494-4499
-
-
Oh, S.W.1
Mukhopadhyay, A.2
Svrzikapa, N.3
Jiang, F.4
Davis, R.J.5
Tissenbaum, H.A.6
-
89
-
-
0037418579
-
Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans
-
Ookuma S, Fukuda M, and Nishida E. Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Curr Biol 13: 427-431, 2003.
-
(2003)
Curr Biol
, vol.13
, pp. 427-431
-
-
Ookuma, S.1
Fukuda, M.2
Nishida, E.3
-
90
-
-
13844273087
-
PI3K-Akt pathway: Its functions and alterations in human cancer
-
Osaki M, Oshimura M, et al. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9: 667-676, 2004.
-
(2004)
Apoptosis
, vol.9
, pp. 667-676
-
-
Osaki, M.1
Oshimura, M.2
-
91
-
-
61349123235
-
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation
-
Padmanabhan S, Mukhopadhyay A, Narasimhan SD, Tesz G, Czech MP, and Tissenbaum HA. A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell 136: 939-951, 2009.
-
(2009)
Cell
, vol.136
, pp. 939-951
-
-
Padmanabhan, S.1
Mukhopadhyay, A.2
Narasimhan, S.D.3
Tesz, G.4
Czech, M.P.5
Tissenbaum, H.A.6
-
92
-
-
0033151613
-
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Cae-norhabditis elegans
-
Paradis S, Ailion M, Toker A, Thomas JH, and Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Cae-norhabditis elegans. Genes Dev 13: 1438-1452, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 1438-1452
-
-
Paradis, S.1
Ailion, M.2
Toker, A.3
Thomas, J.H.4
Ruvkun, G.5
-
93
-
-
0038362751
-
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome
-
Plas DR and Thompson CB. Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem 278: 12361-12366, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 12361-12366
-
-
Plas, D.R.1
Thompson, C.B.2
-
94
-
-
0004282618
-
-
Cold Spring Harbor, NY: Cold Spring Harbor Press
-
Riddle D, Blumenthal T, Meyer B, and Priess J. C. Elegans II. Cold Spring Harbor, NY: Cold Spring Harbor Press, 1997.
-
(1997)
C. Elegans II
-
-
Riddle, D.1
Blumenthal, T.2
Meyer, B.3
Priess, J.4
-
95
-
-
0000519995
-
A genetic pathway for dauer larva formation in Caenorhabditis elegans
-
University of Missouri, Columbia
-
Riddle DL. A genetic pathway for dauer larva formation in Caenorhabditis elegans. Stadler Symposia, University of Missouri, Columbia, 1977, pp. 101-120.
-
(1977)
Stadler Symposia
, pp. 101-120
-
-
Riddle, D.L.1
-
96
-
-
0001104583
-
-
C. elegans II, edited by Riddle DL, Blumenthal T, Meyer BJ, and Priess JR. Cold Spring Harbor, NY Cold Spring Harbor Laboratory Press
-
Riddle DL and Albert PS. Genetic and environmental regulation of dauer larva development. In: C. elegans II, edited by Riddle DL, Blumenthal T, Meyer BJ, and Priess JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1997, pp. 739-768.
-
(1997)
Genetic and Environmental Regulation of Dauer Larva Development
, pp. 739-768
-
-
Riddle, D.L.1
Albert, P.S.2
-
97
-
-
0023340731
-
Four genes responsible for a position effect on expression from HML and HMR in Sac-charomyces cerevisiae
-
Rine J and Herskowitz I. Four genes responsible for a position effect on expression from HML and HMR in Sac-charomyces cerevisiae. Genetics 116: 9-22, 1987.
-
(1987)
Genetics
, vol.116
, pp. 9-22
-
-
Rine, J.1
Herskowitz, I.2
-
98
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B and Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 101: 15998-16003, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
99
-
-
0036333737
-
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
-
Scheid MP, Marignani PA, and Woodgett JR. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol 22: 6247-6260, 2002.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6247-6260
-
-
Scheid, M.P.1
Marignani, P.A.2
Woodgett, J.R.3
-
100
-
-
77949434499
-
Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT
-
Singh A, Ye M, Bucur O, Zhu S, Tanya SantosM, Rabinovitz I, Wei W, Gao D, Hahn WC, and Khosravi-Far R. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell 21: 1140-1152, 2010.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 1140-1152
-
-
Singh, A.1
Ye, M.2
Bucur, O.3
Zhu, S.4
Santosm, T.5
Rabinovitz, I.6
Wei, W.7
Gao, D.8
Hahn, W.C.9
Khosravi-Far, R.10
-
101
-
-
61449244533
-
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
-
Soukas AA, Kane EA, Carr CE, Melo JA, and Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev 23: 496-511, 2009.
-
(2009)
Genes Dev
, vol.23
, pp. 496-511
-
-
Soukas, A.A.1
Kane, E.A.2
Carr, C.E.3
Melo, J.A.4
Ruvkun, G.5
-
102
-
-
38449085292
-
Maintenance of C. elegans
-
Stiernagle T. Maintenance of C. elegans. WormBook 1-11, 2006.
-
(2006)
WormBook
, pp. 1-11
-
-
Stiernagle, T.1
-
103
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum HA and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230, 2001.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
104
-
-
0036007110
-
Model organisms as a guide to mammalian aging
-
Tissenbaum HA and Guarente L. Model organisms as a guide to mammalian aging. Dev Cell 2: 9-19, 2002.
-
(2002)
Dev Cell
, vol.2
, pp. 9-19
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
105
-
-
0031935425
-
An insulin-like signaling pathway affects both longevity and reproduction in Cae-norhabditis elegans
-
Tissenbaum HA and Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in Cae-norhabditis elegans. Genetics 148: 703-717, 1998.
-
(1998)
Genetics
, vol.148
, pp. 703-717
-
-
Tissenbaum, H.A.1
Ruvkun, G.2
-
106
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegue E, DePinho RA, and Gilliland DG. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128: 325-339, 2007.
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
Lee, B.H.4
Castrillon, D.H.5
Cullen, D.E.6
McDowell, E.P.7
Lazo-Kallanian, S.8
Williams, I.R.9
Sears, C.10
Armstrong, S.A.11
Passegue, E.12
Depinho, R.A.13
Gilliland, D.G.14
-
107
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulinlike signaling in C. elegans
-
Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, and Blackwell TK. Direct inhibition of the longevity-promoting factor SKN-1 by insulinlike signaling in C. elegans. Cell 132: 1025-1038, 2008.
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
Liu, S.6
Oliveira, R.P.7
Baumeister, R.8
Blackwell, T.K.9
-
108
-
-
4544314719
-
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes
-
Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, and Olefsky JM. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol 24: 8778-8789, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8778-8789
-
-
Ugi, S.1
Imamura, T.2
Maegawa, H.3
Egawa, K.4
Yoshizaki, T.5
Shi, K.6
Obata, T.7
Ebina, Y.8
Kashiwagi, A.9
Olefsky, J.M.10
-
109
-
-
2942726155
-
The ins and outs of FoxO shuttling: Mechanisms of FoxO translo-cation and transcriptional regulation
-
Van Der Heide LP, Hoekman MF, and Smidt MP. The ins and outs of FoxO shuttling: mechanisms of FoxO translo-cation and transcriptional regulation. Biochem J 380: 297-309, 2004.
-
(2004)
Biochem J
, vol.380
, pp. 297-309
-
-
Van Der Heide, L.P.1
Hoekman, M.F.2
Smidt, M.P.3
-
110
-
-
34249281690
-
Stressing the role of FoxO proteins in lifespan and disease
-
Van der Horst A and Burgering BM. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 8: 440-450, 2007.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 440-450
-
-
Van Der Horst, A.1
Burgering, B.M.2
-
111
-
-
61649127812
-
From promiscuity to precision: Protein phosphatases get a makeover
-
Virshup DM and Shenolikar S. From promiscuity to precision: protein phosphatases get a makeover. Mol Cell 33: 537-545, 2009.
-
(2009)
Mol Cell
, vol.33
, pp. 537-545
-
-
Virshup, D.M.1
Shenolikar, S.2
-
112
-
-
25444442080
-
Triple layer control: Phos-phorylation, acetylation and ubiquitination of FOXO proteins
-
Vogt PK, Jiang H, and Aoki M. Triple layer control: phos-phorylation, acetylation and ubiquitination of FOXO proteins. Cell Cycle 4: 908-913, 2005.
-
(2005)
Cell Cycle
, vol.4
, pp. 908-913
-
-
Vogt, P.K.1
Jiang, H.2
Aoki, M.3
-
113
-
-
17044408768
-
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
-
Wang MC, Bohmann D, and Jasper H. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121: 115-125, 2005.
-
(2005)
Cell
, vol.121
, pp. 115-125
-
-
Wang, M.C.1
Bohmann, D.2
Jasper, H.3
-
114
-
-
33746245679
-
C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO
-
Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ, and Tissenbaum HA. C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev 127: 741-747, 2006.
-
(2006)
Mech Ageing Dev
, vol.127
, pp. 741-747
-
-
Wang, Y.1
Oh, S.W.2
Deplancke, B.3
Luo, J.4
Walhout, A.J.5
Tissenbaum, H.A.6
-
115
-
-
63749112313
-
Fat synthesis and adiposity regulation in Cae-norhabditis elegans
-
Watts JL. Fat synthesis and adiposity regulation in Cae-norhabditis elegans. Trends Endocrinol Metab 20: 58-65, 2009.
-
(2009)
Trends Endocrinol Metab
, vol.20
, pp. 58-65
-
-
Watts, J.L.1
-
116
-
-
33645017887
-
Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm
-
Weinkove D, Halstead JR, Gems D, and Divecha N. Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm. BMC Biol 4: 1, 2006.
-
(2006)
BMC Biol
, vol.4
, pp. 1
-
-
Weinkove, D.1
Halstead, J.R.2
Gems, D.3
Divecha, N.4
-
117
-
-
33847754623
-
The JNK signal transduction pathway
-
Weston CR and Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol 19: 142-149, 2007.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 142-149
-
-
Weston, C.R.1
Davis, R.J.2
-
118
-
-
0002221492
-
The structure of the nervous system of the nematode Cae-norhabditis elegans
-
White JG, Southgate E, Thomson JN, and Brenner S. The structure of the nervous system of the nematode Cae-norhabditis elegans. Phil Trans Roy Soc (Lond) B 314: 1-340, 1986.
-
(1986)
Phil Trans Roy Soc (Lond) B
, vol.314
, pp. 1-340
-
-
White, J.G.1
Southgate, E.2
Thomson, J.N.3
Brenner, S.4
-
119
-
-
52949122885
-
FOXO3A genotype is strongly associated with human longevity
-
Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B, and Curb JD. FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci USA 105: 13987-13992, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 13987-13992
-
-
Willcox, B.J.1
Donlon, T.A.2
He, Q.3
Chen, R.4
Grove, J.S.5
Yano, K.6
Masaki, K.H.7
Willcox, D.C.8
Rodriguez, B.9
Curb, J.D.10
-
120
-
-
38449093926
-
The MAP kinase JNK-1 of Caenorhabditis elegans: Location, activation, and influences over temperature-dependent insulinlike signaling, stress responses, and fitness
-
Wolf M, Nunes F, Henkel A, Heinick A, and Paul RJ. The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulinlike signaling, stress responses, and fitness. J Cell Physiol 214: 721-729, 2008.
-
(2008)
J Cell Physiol
, vol.214
, pp. 721-729
-
-
Wolf, M.1
Nunes, F.2
Henkel, A.3
Heinick, A.4
Paul, R.J.5
-
121
-
-
33644750381
-
SMK-1, an essential regulator of DAF-16-mediated longevity
-
Wolff S, Ma H, Burch D, Maciel GA, Hunter T, and Dillin A. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124: 1039-1053, 2006.
-
(2006)
Cell
, vol.124
, pp. 1039-1053
-
-
Wolff, S.1
Ma, H.2
Burch, D.3
MacIel, G.A.4
Hunter, T.5
Dillin, A.6
-
122
-
-
0034613164
-
Regulation of C. elegans life-span by insulinlike signaling in the nervous system
-
Wolkow CA, Kimura KD, Lee MS, and Ruvkun G. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290: 147-150, 2000.
-
(2000)
Science
, vol.290
, pp. 147-150
-
-
Wolkow, C.A.1
Kimura, K.D.2
Lee, M.S.3
Ruvkun, G.4
-
123
-
-
0346668317
-
Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/ insulin-like signaling pathway
-
Wolkow CA, Munoz MJ, Riddle DL, and Ruvkun G. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/ insulin-like signaling pathway. J Biol Chem 277: 49591-49597, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 49591-49597
-
-
Wolkow, C.A.1
Munoz, M.J.2
Riddle, D.L.3
Ruvkun, G.4
-
124
-
-
0004291817
-
-
Cold Spring Harbor NY Cold Spring Harbor Laboratory Press
-
Wood WB. The nematode Caenorhabditis elegans. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1988.
-
(1988)
The Nematode Caenorhabditis Elegans
-
-
Wood, W.B.1
-
125
-
-
43149103684
-
PP2A regulates the pro-apoptotic activity of FOXO1
-
Yan L, Lavin VA, Moser LR, Cui Q, Kanies C, and Yang E. PP2A regulates the pro-apoptotic activity of FOXO1. J Biol Chem 283: 7411-7420, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 7411-7420
-
-
Yan, L.1
Lavin, V.A.2
Moser, L.R.3
Cui, Q.4
Kanies, C.5
Yang, E.6
-
126
-
-
72949109772
-
Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling
-
Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, Patel H, and Mobbs CV. Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biol 7: e1000245, 2009.
-
(2009)
PLoS Biol
, vol.7
-
-
Zhang, M.1
Poplawski, M.2
Yen, K.3
Cheng, H.4
Bloss, E.5
Zhu, X.6
Patel, H.7
Mobbs, C.V.8
|