An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans

Genetics

Volumn 148, Issue 2, 1998, Pages 703-717

  Tissenbaum, Heidi A ^b   Ruvkun, Gary ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; CAENORHABDITIS ELEGANS; CELL VIABILITY; FERTILITY; GENE MUTATION; INSULIN LIKE ACTIVITY; LIFESPAN; LONGEVITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPRODUCTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; FERTILITY; GENES, HELMINTH; GENOTYPE; HELMINTH PROTEINS; INSULIN; LONGEVITY; MUTATION; RECEPTOR, INSULIN; RECOMBINATION, GENETIC; REPRODUCTION; SIGNAL TRANSDUCTION; TEMPERATURE; TRANSCRIPTION FACTORS; ZYGOTE;

CAENORHABDITIS ELEGANS; INVERTEBRATA; MAMMALIA; NEMATODA;

EID: 0031935425     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. ACCILI, D.,J. DRAGO, E. J. LEE, M. D. JOHNSON, M. H. COOL et al., 1996 Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genetics 12: 106-109.
2. ANDERSON, G. L., 1982 Superoxide dismutase activity in dauerlarvae of C. elegans (Nematoda: Rhabditidae). Can. J. Zool. 60: 288-291.
3. BONFINI, L., E. MIGLIACCIO, G. PELICCI, L. LANFRANCONE and P. G. PELICCI, 1996 Not all Shc's roads lead to Ras. TIBS 247: 257-261.
4. BRENNER, S., 1974 The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
5. CASSADA, R. C., and R. RUSSELL, 1975 The dauer larva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans. Developmental Biology 46: 326-342.
6. CHAPMAN, T, 1992 A cost of mating with males that do not transfer sperm in female Drosophila melanogaster. J. Insect. Physiol. 38: 223-227.
7. CHAPMAN, T., L. F. LIDDLE, J. M. KALB, M. F. WOLFNER and L. PARTRIDGE, 1995 Cost of mating in Drosophila melanogaster females is mediated by male accessory gland products. Nature 373: 241-244.
8. DORMAN, J. B., B. ALBINDER, T. SHROYER and C. KENYON, 1995 The age-1 and daf-2 genes function in a common pathway to control the life span of Caenorhabditis elegans. Genetics 141: 1399-1406.
9. EWBANK, J. J., T. M. BARNES, B. LAKOWSKI, M. LUSSIER, H. BUSSEY et al., 1997 Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science 275: 980-983.
10. FINCH, C., 1990 Longevity, Senescence and the Genome. The University of Chicago Press, Chicago.
11. FRIEDMAN, D. B., and T. E. JOHNSON, 1988a A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118: 75-86.
12. FRIEDMAN, D. B., and T. E. JOHNSON, 1988b Three mutants that extend both mean and maximum life span of the nematode, C. elegans define the age-1 gene. J. Gerontol. 43: B102-109.
13. GEMS, D., and D. R. RIDDLE, 1996 Longevity in Caenorhabditis elegans reduced by mating but not gamete production. Nature 379: 723-725.
14. GOLDEN, J. W., and D, L. RIDDLE, 1984 The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food and temperature. Developmental Biology 102: 368-378.
15. GOTTLIEB, S., and G. RUVKUN, 1994 daf-2, daf-16 and daf-23: genetically interacting genes controlling dauer formation in C. elegans. Genetics 137: 107-120.
16. GUARENTE, L., 1996 Do changes in chromosomes cause aging? Cell 86: 9-12.
17. HARMAN, S. M., and G. B. TALBERT, 1985 Reproductive aging, pp. 457-510 in Handbook of the Biology of Aging, edited by C. E. FINCH and E. L. SCHNEIDER. Van Nostrand-Reinhold, New York.
18. HENGARTNER, M. O., R. E. ELLIS and H. R. HORVITZ, 1992 Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356: 494-499.
19. HUBERT, O., I. MORI, Y. YAMASHITA, H. HONDA, Y. OHSHIMA et al., 1997 Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 19: 345-357.
20. HODGKIN, J., and T. M. BARNES, 1992 More is not better: brood size and population growth in a self-fertilizing nematode. Proc. R. Soc. Lond. Ser B. 246: 19-24.
21. JOSHI, R. L., B. LAMOTHE, N. CORDONNIER, K. MESBAH, E. MONTHIOUX et al., 1996 Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J. 15: 1542-1547.
22. KAHN, C. R., 1994 Insulin action, diabetogenes and the cause of Type II diabetes. Diabetes 43: 1066-1084.
23. KAHN, C. R., and G. C. WEIR, 1994 Joslin's Diabetes Mellitus. Lea & Febiger, Philadelphia.
24. KENNEDY, B. K., N. R. AUSTRIACO, Z. ZHANG and L. GUARENTE, 1995 Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80: 485-496.
25. KENYON, C., 1996 Ponce d'elegans: genetic quest for the fountain of youth. Cell 84: 501-504.
26. KENYON, C., J. CHANG, E. GENSCH, A. RUDNER and R. TABTIANG, 1993 A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
27. KIMURA, K., H. A. TISSENBAUM, Y. LIU and G. RUVKUN, 1997 daf-2, an insulin receptor family member that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946.
28. KLASS, M. R., 1983 A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mechanisms of Ageing and Dev. 22: 279-286.
29. KLASS, M. R., and D. I. HIRSCH, 1976 Nonaging developmental variant of C. elegans. Nature 260: 523-525.
30. KROOK, A., L. BRUETON and S. O'RAHILLY, 1993 Homozygous nonsense mutation in the insulin receptor gene in infant with leprechaunism. The Lancet 342: 277-278.
31. LAKOWSKI, B., and S. HEKIMI, 1996 Determination of life-span in Caenorhabditis elegans by four o'clock genes. Science 272: 1010-1013.
32. LARSEN, P. L., 1993 Aging and resistance to oxidative stress in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 90: 8905-8909.
33. LARSEN, P. L., P. S. ALBERT and D. L. RIDDLE, 1995 Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139: 1567-1583.
34. MALONE, E. A., and J. H. THOMAS, 1994 A screen for non-conditional dauer-constitutive mutations in C. elegans. Genetics 136: 879-886.
35. MALONE, E. A., T. INOUE and J. H. THOMAS, 1996 Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. Genetics 143: 1193-1205.
36. MASORO, E. J., I. SHOMOKAWA and B. P. YU, 1991 Retardation of the aging processes in rats by food restriction. Ann. NY Acad. Sci. 621: 337-352.
37. MORRIS, J. Z., H. A. TISSENBAUM and G. RUVKUN, 1996 A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-539.
38. OGG, S., S. PARADIS, S. GOTTLIEB, G. I. PATTERSON, L. LEE et al., 1997 The DAF-16 Fork head-related transcription factor transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389: 994-999.
39. ORTIZ-LOPEZ, R., H. LI, J. SU, V. GOYTIA and J. F. TOWBIN, 1997 Evidence for a dystrophing missense mutation as a cause of X-linked dilated cardiomyopathy. Circulation 95: 2434-2440.
40. PARTRIDGE, L., and M. FARQUHAR, 1981 Sexual activity reduces life span of male fruitflies. Nature 294: 580-582.
41. PARTRIDGE, L., A. GREEN and K. FOWLER, 1987 Effects of egg-production and of exposure to males on female survival in Drosophila melanogaster. J. Insect. Physiol. 33: 745-749.
42. PERKINS, L. A., E. M. HEDGECOCK, J. N. THOMSEN and J. G. CULOTTI, 1986 Mutant sensory cilia in the nematode Caenorhabditis elegans. Developmental Biology 117: 456-487.
43. QUIRING, R., U. WALLDORF, U. KLOTER and W. J. GEHRING, 1994 Homology of the eyeless gene of Drosophila to the small eye gene in mice and Anitidia in humans. Science 265: 785-789.
44. REN, P., C.-S. LIM, R. JOHNSEN, P. S. ALBERT, D. PILGRIM et al., 1996 Control of C. elegans larval development by neuronal expression of a TGF-b homolog. Science 274: 1389-1391.
45. RIDDLE, D. L., 1988 The dauer larva, pp. 393-412 in The Nematode Caenorhabditis elegans, edited by W. B. WOOD. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
46. RIDDLE, D. L., and P. S. ALBERT, 1997 Genetic and environmental regulation of dauer larva development, pp. 739-768 in C. elegans II, edited by D. L. RIDDLE, T. BLUMENTHAL, B. J. MEYER and J. R. PRIESS. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
47. RIDDLE, D. L., M. M. SWANSON and P. S. ALBERT, 1981 Interacting genes in nematode dauer larva formation. Nature 290: 668-671.
48. SCHACKWITZ, W. S., T. INOUE and J. H. THOMAS, 1996 Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron 17: 719-728.
49. SCHNEIDER, E. L., and J. W. E. ROWE, 1990 Handbook of the Biology of Aging. Academic Press, San Diego.
50. SMITH, J. M., 1958 The effects of temperature and of egg-laying on the longevity of Drosophila subobscura. J. Exp. Biol. 35: 832-842.
51. SOHAL, R. S., and R. WEINRUCH, 1996 Oxidative stress, caloric restriction and aging. Science 273: 59-63.
52. SULSTON, J., and J. HODGKIN, 1988 Methods, pp. 587-602 in The Nematode Caenorhabditis elegans, edited by W. B. WOOD. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
53. SWANSON, M. M., and D. L. RIDDLE, 1981 Critical periods in the development of the Caenorhabditis elegans dauer larva. Developmental Biology 84: 27-40.
54. THOMAS, J. H., 1993 Chemosensory regulation of development in C. elegans. Bioessays 15: 791-797.
55. THOMAS, J. H., D. A, BIRNBY and J. J. VOWELS, 1993 Evidence for parallel processing of sensory information controlling dauer formation in C. elegans. Genetics 134: 1105-1117.
56. VANFLETEREN, J. R., 1993 Oxidative stress and aging in Caenorhabditis elegans. Biochem. J. 292: 605-608.
57. VANFLETEREN, J. R., and A. DE VREESE, 1995 The geronotogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans. FASEB J 9: 1355-1361.
58. VAN VOORHIES, W. A., 1992 Production of sperm and aging in Caenorhabditis elegans. Nature 360: 456-458.
59. VOWELS, J. J., and J. H. THOMAS, 1992 Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130: 105-123.
60. WERIHEIMER, E., S.-P. LU, P. F. BACKELJAUW, M. L. DAVENPORT and S. I. TAYLOR, 1993 Homozygous deletion of the human insulin receptor gene results in leprechaunism. Nature Genetics 5: 71-73.