InAKTivation of insulin/IGF-1 signaling by dephosphorylation

Cell Cycle

Volumn 8, Issue 23, 2009, Pages 3878-3884

  Narasimhan, Sri Devi ^a   Mukhopadhyay, Arnab ^b   Tissenbaum, Heidi A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

Akt; B56; C. Elegans; DAF 16; FOXO; Insulin IGF 1 signaling; Lifespan; Metabolism; Phosphorylation; PP2A

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; CHAPERONE; INSULIN; PH DOMAIN LEUCINE RICH REPEAT PROTEIN PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PLECKSTRIN; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN PPTR1; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 1; THREONINE; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

CAENORHABDITIS ELEGANS; DEPHOSPHORYLATION; DIAPAUSE; DROSOPHILA MELANOGASTER; GENE TARGETING; GENETIC EPISTASIS; GENOME; LIPID METABOLISM; LONGEVITY; MAMMAL CELL; NONHUMAN; REVIEW; RNA INTERFERENCE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRESS;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 74849116065     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.23.10072     Document Type: Review

References (64)

1. McConnell JL, Wadzinski BE. Targeting protein serine/threonine phosphatases for drug development. Mol Pharmacol 2009; 75:1249-61.
2. Barford D. Molecular mechanisms of the protein serine/threonine phosphatases. Trends Biochem Sci 1996; 21:407-12.
3. Moorhead GB, Trinkle-Mulcahy L, Ulke-Lemee A. Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol 2007; 8:234-44.
4. Tran HT, Ulke A, Morrice N, Johannes CJ, Moorhead GB. Proteomic characterization of protein phosphatase complexes of the mammalian nucleus. Mol Cell Proteomics 2004; 3:257-65.
5. Virshup DM, Shenolikar S. From promiscuity to precision: protein phosphatases get a makeover. Mol Cell 2009; 33:537-45.
6. Goldstein BJ, Ahmad F, Ding W, Li PM, Zhang WR. Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol Cell Biochem 1998; 182:91-9.
7. Hendriks WJ, Elson A, Harroch S, Stoker AW. Protein tyrosine phosphatases: functional inferences from mouse models and human diseases. FEBS J 2008; 275:816-30.
8. Faux MC, Scott JD. More on target with protein phosphorylation: conferring specificity by location. Trends Biochem Sci 1996; 21:312-5.
9. Barford D, Das AK, Egloff MP. The structure and mechanism of protein phosphatases: insights into catalysis and regulation. Annu Rev Biophys Biomol Struct 1998; 27:133-64.
10. Padmanabhan S, Mukhopadhyay A, Narasimhan S, Tesz G, Czech MP, Tissenbaum HA. A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation. Cell 2009; 136.
11. Vereshchagina N, Ramel MC, Bitoun E, Wilson C. The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila. J Cell Sci 2008; 121:3383-92.
12. Barbieri M, Bonafe M, Franceschi C, Paolisso G. Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab 2003; 285:1064-71.
13. Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 2005; 120:449-60.
14. Antebi A. Genetics of aging in Caenorhabditis elegans. PLoS Genet 2007; 3:1565-71.
15. Wolff S, Dillin A. The trifecta of aging in Caenorhabditis elegans. Exp Gerontol 2006; 41:894-903.
16. Riddle DBT, Meyer B, Priess J. C. elegans II. Cold Spring Harbor: Cold Spring Harbor Press 1997.
17. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997; 277:942-6.
18. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 1997; 389:994-9.
19. Lee RY, Hench J, Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol 2001; 11:1950-7.
20. Lin K, Dorman JB, Rodan A, Kenyon C. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 1997; 278:1319-22.
21. Weinkove D, Halstead JR, Gems D, Divecha N. Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm. BMC Biol 2006; 4:1.
22. Alessi DR, Downes CP. The role of PI 3-kinase in insulin action. Biochim Biophys Acta 1998; 1436:151-64.
23. Toker A, Yoeli-Lerner M. Akt signaling and cancer: surviving but not moving on. Cancer Res 2006; 66:3963-6.
24. Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 1998; 12:2488-98.
25. Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 1999; 18:3024-33.
26. Hertweck M, Gobel C, Baumeister R. C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 2004; 6:577-88.
27. Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 1999; 13:1438-52.
28. Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ, Tissenbaum HA. C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/ FOXO. Mech Ageing Dev 2006; 127:741-7.
29. Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 2003; 424:277-83.
30. Dong MQ, Venable JD, Au N, Xu T, Park SK, Cociorva D, et al. Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science 2007; 317:660-3.
31. Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet 2006; 38:251-7.
32. Maehama T, Dixon JE. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 1999; 9:125-8.
33. Paez J, Sellers WR. PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling. Cancer Treat Res 2003; 115:145-67.
34. Renner O, Blanco-Aparicio C, Carnero A. Genetic modelling of the PTEN/AKT pathway in cancer research. Clin Transl Oncol 2008; 10:618-27.
35. Dorman JB, Albinder B, Shroyer T, Kenyon C. The age-1 and daf-2 Genes Function in a Common Pathway to Control the Lifespan of Caenorhabditis elegans. Genetics 1995; 141:1399-406.
36. Larsen PL, Albert PS, Riddle DL. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 1995; 139:1567-83.
37. Ogg S, Ruvkun G. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Molecular Cell 1998; 2:887-93.
38. Solari F, Bourbon-Piffaut A, Masse I, Payrastre B, Chan AM, Billaud M. The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans. Oncogene 2005; 24:20-7.
39. Van Hoof C, Goris J. PP2A fulfills its promises as tumor suppressor: which subunits are important? Cancer Cell 2004; 5:105-6.
40. Schonthal AH. Role of PP2A in intracellular signal transduction pathways. Front Biosci 1998; 3:1262-73.
41. Sontag E. Protein phosphatase 2A: the Trojan Horse of cellular signaling. Cell Signal 2001; 13:7-16.
42. Goldberg Y. Protein phosphatase 2A: who shall regulate the regulator? Biochem Pharmacol 1999; 57:321-8.
43. Lechward K, Awotunde OS, Swiatek W, Muszynska G. Protein phosphatase 2A: variety of forms and diversity of functions. Acta Biochim Pol 2001; 48:921-33.
44. Janssens V, Longin S, Goris J. PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail). Trends Biochem Sci 2008; 33:113-21.
45. Eichhorn PJ, Creyghton MP, Bernards R. Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta 2009; 1795:1-15.
46. Zdychova J, Komers R. Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications. Physiol Res 2005; 54:1-16.
47. Brazil DP, Yang ZZ, Hemmings BA. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 2004; 29:233-42.
48. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098-101.
49. Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci USA 2005; 102:4494-9.
50. Evans EA, Chen WC, Tan MW. The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans. Aging Cell 2008; 7:879-93.
51. Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth and life span in Caenorhabditis elegans. Genes Dev 2009; 23:496-511.
52. Yang ZZ, Tschopp O, Baudry A, Dummler B, Hynx D, Hemmings BA. Physiological functions of protein kinase B/Akt. Biochem Soc Trans 2004; 32:350-4.
53. Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell 2002; 111:293-303.
54. Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 2005; 20:539-50.
55. Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis and suppresses tumor growth. Mol Cell 2005; 18:13-24.
56. Brognard J, Sierecki E, Gao T, Newton AC. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 2007; 25:917-31.
57. Van Der Heide LP, Hoekman MF, Smidt MP. The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J 2004; 380:297-309.
58. Mukhopadhyay A, Oh SW, Tissenbaum HA. Worming pathways to and from DAF-16/FOXO. Exp Gerontol 2006; 41:928-34.
59. Mattila J, Kallijarvi J, Puig O. RNAi screening for kinases and phosphatases identifies FoxO regulators. Proc Natl Acad Sci USA 2008; 105:14873-8.
60. Salih DA, Brunet A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 2008; 20:126-36.
61. Tremblay ML, Giguere V. Phosphatases at the heart of FoxO metabolic control. Cell Metab 2008; 7:101-3.
62. Srinivasan M, Begum N. Regulation of protein phosphatase 1 and 2A activities by insulin during myogenesis in rat skeletal muscle cells in culture. J Biol Chem 1994; 269:12514-20.
63. Ni YG, Wang N, Cao DJ, Sachan N, Morris DJ, Gerard RD, et al. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci USA 2007; 104:20517-22.
64. Libina N, Berman JR, Kenyon C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 2003; 115:489-502.