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Volumn 14, Issue 5, 2008, Pages 219-227

OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXO;

EID: 42749086593     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2008.03.002     Document Type: Review
Times cited : (152)

References (90)
  • 1
    • 18844434370 scopus 로고    scopus 로고
    • Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease
    • Chong Z.Z., et al. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog. Neurobiol. 75 (2005) 207-246
    • (2005) Prog. Neurobiol. , vol.75 , pp. 207-246
    • Chong, Z.Z.1
  • 2
    • 36448967502 scopus 로고    scopus 로고
    • Sly as a FOXO: new paths with Forkhead signaling in the brain
    • Maiese K., et al. Sly as a FOXO: new paths with Forkhead signaling in the brain. Curr. Neurovasc. Res. 4 (2007) 295-302
    • (2007) Curr. Neurovasc. Res. , vol.4 , pp. 295-302
    • Maiese, K.1
  • 3
    • 30444442827 scopus 로고    scopus 로고
    • Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain
    • Hoekman M.F., et al. Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain. Gene Expr. Patterns 6 (2006) 134-140
    • (2006) Gene Expr. Patterns , vol.6 , pp. 134-140
    • Hoekman, M.F.1
  • 4
    • 36549065662 scopus 로고    scopus 로고
    • FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis
    • Jagani Z., et al. FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis. Biochim. Biophys. Acta 1785 (2008) 63-84
    • (2008) Biochim. Biophys. Acta , vol.1785 , pp. 63-84
    • Jagani, Z.1
  • 5
    • 35548930209 scopus 로고    scopus 로고
    • The emerging roles of forkhead box (Fox) proteins in cancer
    • Myatt S.S., and Lam E.W. The emerging roles of forkhead box (Fox) proteins in cancer. Nat. Rev. Cancer 7 (2007) 847-859
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 847-859
    • Myatt, S.S.1    Lam, E.W.2
  • 6
    • 34249281690 scopus 로고    scopus 로고
    • Stressing the role of FoxO proteins in lifespan and disease
    • van der Horst A., and Burgering B.M. Stressing the role of FoxO proteins in lifespan and disease. Nat. Rev. Mol. Cell Biol. 8 (2007) 440-450
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 440-450
    • van der Horst, A.1    Burgering, B.M.2
  • 7
    • 33746069404 scopus 로고    scopus 로고
    • In control of biology: of mice, men and Foxes
    • Wijchers P.J., et al. In control of biology: of mice, men and Foxes. Biochem. J. 397 (2006) 233-246
    • (2006) Biochem. J. , vol.397 , pp. 233-246
    • Wijchers, P.J.1
  • 8
    • 0035019007 scopus 로고    scopus 로고
    • Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
    • Biggs III W.H., et al. Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm. Genome 12 (2001) 416-425
    • (2001) Mamm. Genome , vol.12 , pp. 416-425
    • Biggs III, W.H.1
  • 9
    • 34548289502 scopus 로고    scopus 로고
    • Dynamic FoxO transcription factors
    • Huang H., and Tindall D.J. Dynamic FoxO transcription factors. J. Cell Sci. 120 (2007) 2479-2487
    • (2007) J. Cell Sci. , vol.120 , pp. 2479-2487
    • Huang, H.1    Tindall, D.J.2
  • 10
    • 2942726155 scopus 로고    scopus 로고
    • The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation
    • Van Der Heide L.P., et al. The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem. J. 380 (2004) 297-309
    • (2004) Biochem. J. , vol.380 , pp. 297-309
    • Van Der Heide, L.P.1
  • 11
    • 0034661826 scopus 로고    scopus 로고
    • Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
    • Furuyama T., et al. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349 (2000) 629-634
    • (2000) Biochem. J. , vol.349 , pp. 629-634
    • Furuyama, T.1
  • 12
    • 1542267804 scopus 로고    scopus 로고
    • Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    • Hosaka T., et al. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 2975-2980
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 2975-2980
    • Hosaka, T.1
  • 13
    • 0038152845 scopus 로고    scopus 로고
    • Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
    • Castrillon D.H., et al. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301 (2003) 215-218
    • (2003) Science , vol.301 , pp. 215-218
    • Castrillon, D.H.1
  • 14
    • 33846538095 scopus 로고    scopus 로고
    • Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a
    • Liu L., et al. Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a. Development 134 (2007) 199-209
    • (2007) Development , vol.134 , pp. 199-209
    • Liu, L.1
  • 15
    • 4143129696 scopus 로고    scopus 로고
    • Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a
    • Lin L., et al. Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 21 (2004) 203-213
    • (2004) Immunity , vol.21 , pp. 203-213
    • Lin, L.1
  • 16
    • 20944443597 scopus 로고    scopus 로고
    • Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis
    • Jonsson H., et al. Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis. Nat. Med. 11 (2005) 666-671
    • (2005) Nat. Med. , vol.11 , pp. 666-671
    • Jonsson, H.1
  • 17
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Tothova Z., et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128 (2007) 325-339
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1
  • 18
    • 34249882777 scopus 로고    scopus 로고
    • Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    • Miyamoto K., et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 1 (2007) 101-112
    • (2007) Cell Stem Cell , vol.1 , pp. 101-112
    • Miyamoto, K.1
  • 19
    • 85047695408 scopus 로고    scopus 로고
    • Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells
    • Mahmud D.L., et al. Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene 21 (2002) 1556-1562
    • (2002) Oncogene , vol.21 , pp. 1556-1562
    • Mahmud, D.L.1
  • 20
    • 11244333356 scopus 로고    scopus 로고
    • New avenues of exploration for erythropoietin
    • Maiese K., et al. New avenues of exploration for erythropoietin. J. Am. Med. Assoc. 293 (2005) 90-95
    • (2005) J. Am. Med. Assoc. , vol.293 , pp. 90-95
    • Maiese, K.1
  • 21
    • 34248230733 scopus 로고    scopus 로고
    • Differential regulation of Foxo3a target genes in erythropoiesis
    • Bakker W.J., et al. Differential regulation of Foxo3a target genes in erythropoiesis. Mol. Cell. Biol. 27 (2007) 3839-3854
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3839-3854
    • Bakker, W.J.1
  • 22
    • 18044362169 scopus 로고    scopus 로고
    • Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival
    • Srinivasan S., et al. Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival. Mol. Cell. Neurosci. 29 (2005) 107-119
    • (2005) Mol. Cell. Neurosci. , vol.29 , pp. 107-119
    • Srinivasan, S.1
  • 23
    • 34547444891 scopus 로고    scopus 로고
    • Mechanisitic insights into diabetes mellitus and oxidative stress
    • Maiese K., et al. Mechanisitic insights into diabetes mellitus and oxidative stress. Curr. Med. Chem. 14 (2007) 1729-1738
    • (2007) Curr. Med. Chem. , vol.14 , pp. 1729-1738
    • Maiese, K.1
  • 24
    • 33847146814 scopus 로고    scopus 로고
    • Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus
    • Maiese K., et al. Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr. Neurovasc. Res. 4 (2007) 63-71
    • (2007) Curr. Neurovasc. Res. , vol.4 , pp. 63-71
    • Maiese, K.1
  • 25
    • 7244231007 scopus 로고    scopus 로고
    • CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice
    • Fallarino F., et al. CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J. Exp. Med. 200 (2004) 1051-1062
    • (2004) J. Exp. Med. , vol.200 , pp. 1051-1062
    • Fallarino, F.1
  • 26
    • 34548349302 scopus 로고    scopus 로고
    • Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver
    • Matsumoto M., et al. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver. Cell Metab. 6 (2007) 208-216
    • (2007) Cell Metab. , vol.6 , pp. 208-216
    • Matsumoto, M.1
  • 27
    • 33845262863 scopus 로고    scopus 로고
    • Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease
    • Kato M., et al. Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease. J. Am. Soc. Nephrol. 17 (2006) 3325-3335
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 3325-3335
    • Kato, M.1
  • 28
    • 34547797469 scopus 로고    scopus 로고
    • Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling
    • Chong Z.Z., et al. Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling. Curr. Neurovasc. Res. 4 (2007) 194-204
    • (2007) Curr. Neurovasc. Res. , vol.4 , pp. 194-204
    • Chong, Z.Z.1
  • 29
    • 32444450603 scopus 로고    scopus 로고
    • GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway
    • Anitha M., et al. GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway. J. Clin. Invest. 116 (2006) 344-356
    • (2006) J. Clin. Invest. , vol.116 , pp. 344-356
    • Anitha, M.1
  • 30
    • 1842475551 scopus 로고    scopus 로고
    • Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors
    • Kwon H.S., et al. Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. Diabetes 53 (2004) 899-910
    • (2004) Diabetes , vol.53 , pp. 899-910
    • Kwon, H.S.1
  • 31
    • 12144258472 scopus 로고    scopus 로고
    • HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients
    • Kino T., et al. HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients. Diabetes 54 (2005) 23-31
    • (2005) Diabetes , vol.54 , pp. 23-31
    • Kino, T.1
  • 32
    • 0038061606 scopus 로고    scopus 로고
    • Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain
    • Maiese K., and Chong Z.Z. Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain. Trends Pharmacol. Sci. 24 (2003) 228-232
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 228-232
    • Maiese, K.1    Chong, Z.Z.2
  • 33
    • 0037112090 scopus 로고    scopus 로고
    • Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles
    • Furuyama T., et al. Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles. Microsc. Res. Tech. 59 (2002) 331-334
    • (2002) Microsc. Res. Tech. , vol.59 , pp. 331-334
    • Furuyama, T.1
  • 34
    • 26944461217 scopus 로고    scopus 로고
    • Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
    • Puig O., and Tjian R. Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev. 19 (2005) 2435-2446
    • (2005) Genes Dev. , vol.19 , pp. 2435-2446
    • Puig, O.1    Tjian, R.2
  • 35
    • 4544358547 scopus 로고    scopus 로고
    • Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
    • Kamei Y., et al. Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J. Biol. Chem. 279 (2004) 41114-41123
    • (2004) J. Biol. Chem. , vol.279 , pp. 41114-41123
    • Kamei, Y.1
  • 36
    • 29044433048 scopus 로고    scopus 로고
    • Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity
    • Chong Z.Z., et al. Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity. Curr. Neurovasc. Res. 2 (2005) 387-399
    • (2005) Curr. Neurovasc. Res. , vol.2 , pp. 387-399
    • Chong, Z.Z.1
  • 37
    • 34147100616 scopus 로고    scopus 로고
    • Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways
    • Chong Z.Z., et al. Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. Cell. Signal. 19 (2007) 1150-1162
    • (2007) Cell. Signal. , vol.19 , pp. 1150-1162
    • Chong, Z.Z.1
  • 38
    • 18544372447 scopus 로고    scopus 로고
    • Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity
    • Smith W.W., et al. Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. J. Cell Biol. 169 (2005) 331-339
    • (2005) J. Cell Biol. , vol.169 , pp. 331-339
    • Smith, W.W.1
  • 39
    • 18844382368 scopus 로고    scopus 로고
    • Functional interaction between beta-catenin and FOXO in oxidative stress signaling
    • Essers M.A., et al. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 (2005) 1181-1184
    • (2005) Science , vol.308 , pp. 1181-1184
    • Essers, M.A.1
  • 40
    • 37349057933 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis
    • Nakamura T., and Sakamoto K. Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis. Mol. Cell. Endocrinol. 281 (2008) 47-55
    • (2008) Mol. Cell. Endocrinol. , vol.281 , pp. 47-55
    • Nakamura, T.1    Sakamoto, K.2
  • 41
    • 33645993568 scopus 로고    scopus 로고
    • Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation
    • Won C.K., et al. Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation. Neurosci. Lett. 398 (2006) 39-43
    • (2006) Neurosci. Lett. , vol.398 , pp. 39-43
    • Won, C.K.1
  • 42
    • 33646775275 scopus 로고    scopus 로고
    • Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-Catenin during oxidative stress
    • Chong Z.Z., et al. Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-Catenin during oxidative stress. Curr. Neurovasc. Res. 3 (2006) 107-117
    • (2006) Curr. Neurovasc. Res. , vol.3 , pp. 107-117
    • Chong, Z.Z.1
  • 43
    • 3042730681 scopus 로고    scopus 로고
    • The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential
    • Chong Z.Z., et al. The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential. J. Cereb. Blood Flow Metab. 24 (2004) 728-743
    • (2004) J. Cereb. Blood Flow Metab. , vol.24 , pp. 728-743
    • Chong, Z.Z.1
  • 44
    • 34047234725 scopus 로고    scopus 로고
    • Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity
    • Chong Z.Z., and Maiese K. Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity. Br. J. Pharmacol. 150 (2007) 839-850
    • (2007) Br. J. Pharmacol. , vol.150 , pp. 839-850
    • Chong, Z.Z.1    Maiese, K.2
  • 45
    • 0036328592 scopus 로고    scopus 로고
    • FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling
    • Zheng W.H., et al. FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling. J. Neurochem. 80 (2002) 1049-1061
    • (2002) J. Neurochem. , vol.80 , pp. 1049-1061
    • Zheng, W.H.1
  • 46
    • 12944294341 scopus 로고    scopus 로고
    • Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK
    • Barthélémy C., et al. Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK. BMC Neurosci. 5 (2004) 48
    • (2004) BMC Neurosci. , vol.5 , pp. 48
    • Barthélémy, C.1
  • 47
    • 33847077943 scopus 로고    scopus 로고
    • FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
    • Obexer P., et al. FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ. 14 (2007) 534-547
    • (2007) Cell Death Differ. , vol.14 , pp. 534-547
    • Obexer, P.1
  • 48
    • 33745163907 scopus 로고    scopus 로고
    • Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a
    • You H., et al. Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 9051-9056
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 9051-9056
    • You, H.1
  • 49
    • 0037178789 scopus 로고    scopus 로고
    • FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress
    • Furukawa-Hibi Y., et al. FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. J. Biol. Chem. 277 (2002) 26729-26732
    • (2002) J. Biol. Chem. , vol.277 , pp. 26729-26732
    • Furukawa-Hibi, Y.1
  • 50
    • 34347357584 scopus 로고    scopus 로고
    • Induction of Mxi1-SR{alpha} by FOXO3a contributes to repression of Myc-dependent gene expression
    • Delpuech O., et al. Induction of Mxi1-SR{alpha} by FOXO3a contributes to repression of Myc-dependent gene expression. Mol. Cell. Biol. 27 (2007) 4917-4930
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 4917-4930
    • Delpuech, O.1
  • 51
    • 35548932785 scopus 로고    scopus 로고
    • Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosis-inducing ligand
    • Kikuchi S., et al. Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosis-inducing ligand. Cancer Sci. 98 (2007) 1949-1958
    • (2007) Cancer Sci. , vol.98 , pp. 1949-1958
    • Kikuchi, S.1
  • 52
    • 33646893537 scopus 로고    scopus 로고
    • Growth, differentiation, and malignant transformation of pre-B cells mediated by inducible activation of v-Abl oncogene
    • Jacobsen E.A., et al. Growth, differentiation, and malignant transformation of pre-B cells mediated by inducible activation of v-Abl oncogene. J. Immunol. 176 (2006) 6831-6838
    • (2006) J. Immunol. , vol.176 , pp. 6831-6838
    • Jacobsen, E.A.1
  • 53
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 (2004) 2011-2015
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1
  • 54
    • 0042355359 scopus 로고    scopus 로고
    • Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation
    • Kang J.Q., et al. Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation. Mol. Pharmacol. 64 (2003) 557-569
    • (2003) Mol. Pharmacol. , vol.64 , pp. 557-569
    • Kang, J.Q.1
  • 55
    • 33746910279 scopus 로고    scopus 로고
    • Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB
    • Li F., et al. Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB. Curr. Neurovasc. Res. 3 (2006) 187-201
    • (2006) Curr. Neurovasc. Res. , vol.3 , pp. 187-201
    • Li, F.1
  • 56
    • 33751206845 scopus 로고    scopus 로고
    • The negative regulators Foxj1 and Foxo3a are up-regulated by a peptide that inhibits systemic lupus erythematosus-associated T cell responses
    • Sela U., et al. The negative regulators Foxj1 and Foxo3a are up-regulated by a peptide that inhibits systemic lupus erythematosus-associated T cell responses. Eur. J. Immunol. 36 (2006) 2971-2980
    • (2006) Eur. J. Immunol. , vol.36 , pp. 2971-2980
    • Sela, U.1
  • 57
    • 33846998653 scopus 로고    scopus 로고
    • Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells
    • Hur E.M., et al. Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat. Immunol. 8 (2007) 74-83
    • (2007) Nat. Immunol. , vol.8 , pp. 74-83
    • Hur, E.M.1
  • 58
    • 33645999375 scopus 로고    scopus 로고
    • Cell life versus cell longevity: the mysteries surrounding the NAD(+) precursor nicotinamide
    • Li F., et al. Cell life versus cell longevity: the mysteries surrounding the NAD(+) precursor nicotinamide. Curr. Med. Chem. 13 (2006) 883-895
    • (2006) Curr. Med. Chem. , vol.13 , pp. 883-895
    • Li, F.1
  • 59
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum H.A., and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410 (2001) 227-230
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 60
    • 10844236451 scopus 로고    scopus 로고
    • Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
    • Nemoto S., et al. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306 (2004) 2105-2108
    • (2004) Science , vol.306 , pp. 2105-2108
    • Nemoto, S.1
  • 61
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • Motta M.C., et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 116 (2004) 551-563
    • (2004) Cell , vol.116 , pp. 551-563
    • Motta, M.C.1
  • 62
    • 24744469490 scopus 로고    scopus 로고
    • SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
    • Kobayashi Y., et al. SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress. Int. J. Mol. Med. 16 (2005) 237-243
    • (2005) Int. J. Mol. Med. , vol.16 , pp. 237-243
    • Kobayashi, Y.1
  • 63
    • 3142742707 scopus 로고    scopus 로고
    • FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
    • van der Horst A., et al. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J. Biol. Chem. 279 (2004) 28873-28879
    • (2004) J. Biol. Chem. , vol.279 , pp. 28873-28879
    • van der Horst, A.1
  • 64
    • 14644409780 scopus 로고    scopus 로고
    • Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts
    • Kyoung Kim H., et al. Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts. J. Gerontol. A Biol. Sci. Med. Sci. 60 (2005) 4-9
    • (2005) J. Gerontol. A Biol. Sci. Med. Sci. , vol.60 , pp. 4-9
    • Kyoung Kim, H.1
  • 65
    • 39449118273 scopus 로고    scopus 로고
    • Exercise training promotes SIRT1 activity in aged rats
    • Ferrara N., et al. Exercise training promotes SIRT1 activity in aged rats. Rejuvenation Res. 11 (2008) 139-150
    • (2008) Rejuvenation Res. , vol.11 , pp. 139-150
    • Ferrara, N.1
  • 66
    • 33845967865 scopus 로고    scopus 로고
    • Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats
    • Li M., et al. Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats. J. Biol. Chem. 281 (2006) 40429-40439
    • (2006) J. Biol. Chem. , vol.281 , pp. 40429-40439
    • Li, M.1
  • 67
    • 0842263745 scopus 로고    scopus 로고
    • Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
    • Miyauchi H., et al. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J. 23 (2004) 212-220
    • (2004) EMBO J. , vol.23 , pp. 212-220
    • Miyauchi, H.1
  • 68
    • 33846295218 scopus 로고    scopus 로고
    • FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
    • Paik J.H., et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128 (2007) 309-323
    • (2007) Cell , vol.128 , pp. 309-323
    • Paik, J.H.1
  • 69
    • 31544445749 scopus 로고    scopus 로고
    • Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt
    • Sunters A., et al. Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. Cancer Res. 66 (2006) 212-220
    • (2006) Cancer Res. , vol.66 , pp. 212-220
    • Sunters, A.1
  • 70
    • 35148859334 scopus 로고    scopus 로고
    • Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate
    • Eddy S.F., et al. Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate. Cancer Res. 67 (2007) 9018-9023
    • (2007) Cancer Res. , vol.67 , pp. 9018-9023
    • Eddy, S.F.1
  • 71
    • 0037033005 scopus 로고    scopus 로고
    • FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer
    • Modur V., et al. FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J. Biol. Chem. 277 (2002) 47928-47937
    • (2002) J. Biol. Chem. , vol.277 , pp. 47928-47937
    • Modur, V.1
  • 72
    • 17144430994 scopus 로고    scopus 로고
    • The progression of LNCaP human prostate cancer cells to androgen independence involves decreased FOXO3a expression and reduced p27KIP1 promoter transactivation
    • Lynch R.L., et al. The progression of LNCaP human prostate cancer cells to androgen independence involves decreased FOXO3a expression and reduced p27KIP1 promoter transactivation. Mol. Cancer Res. 3 (2005) 163-169
    • (2005) Mol. Cancer Res. , vol.3 , pp. 163-169
    • Lynch, R.L.1
  • 73
    • 34547135737 scopus 로고    scopus 로고
    • Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3, 3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
    • Li Y., et al. Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3, 3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J. Biol. Chem. 282 (2007) 21542-21550
    • (2007) J. Biol. Chem. , vol.282 , pp. 21542-21550
    • Li, Y.1
  • 74
    • 25844486505 scopus 로고    scopus 로고
    • Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells
    • Yang L., et al. Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells. J. Biol. Chem. 280 (2005) 33558-33565
    • (2005) J. Biol. Chem. , vol.280 , pp. 33558-33565
    • Yang, L.1
  • 75
    • 35948946952 scopus 로고    scopus 로고
    • Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a
    • Ticchioni M., et al. Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a. Oncogene 26 (2007) 7081-7091
    • (2007) Oncogene , vol.26 , pp. 7081-7091
    • Ticchioni, M.1
  • 76
    • 33846510345 scopus 로고    scopus 로고
    • Latent protein LANA2 from Kaposi's sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOXO3a transcription factor
    • Munoz-Fontela C., et al. Latent protein LANA2 from Kaposi's sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOXO3a transcription factor. J. Virol. 81 (2007) 1511-1516
    • (2007) J. Virol. , vol.81 , pp. 1511-1516
    • Munoz-Fontela, C.1
  • 77
    • 12144290140 scopus 로고    scopus 로고
    • Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin
    • Arimoto-Ishida E., et al. Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin. Endocrinology 145 (2004) 2014-2022
    • (2004) Endocrinology , vol.145 , pp. 2014-2022
    • Arimoto-Ishida, E.1
  • 78
    • 0037016065 scopus 로고    scopus 로고
    • Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    • Chong Z.Z., et al. Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation 106 (2002) 2973-2979
    • (2002) Circulation , vol.106 , pp. 2973-2979
    • Chong, Z.Z.1
  • 79
    • 11144308859 scopus 로고    scopus 로고
    • Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury
    • Chong Z.Z., et al. Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury. Histol. Histopathol. 20 (2005) 299-315
    • (2005) Histol. Histopathol. , vol.20 , pp. 299-315
    • Chong, Z.Z.1
  • 80
    • 11144357466 scopus 로고    scopus 로고
    • IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu M.C., et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117 (2004) 225-237
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.1
  • 81
    • 0037458622 scopus 로고    scopus 로고
    • Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells
    • Leong M.L., et al. Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J. Biol. Chem. 278 (2003) 5871-5882
    • (2003) J. Biol. Chem. , vol.278 , pp. 5871-5882
    • Leong, M.L.1
  • 82
    • 33646934067 scopus 로고    scopus 로고
    • A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
    • Lehtinen M.K., et al. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125 (2006) 987-1001
    • (2006) Cell , vol.125 , pp. 987-1001
    • Lehtinen, M.K.1
  • 83
    • 33750152602 scopus 로고    scopus 로고
    • Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure
    • Watkins W.J., et al. Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure. Fertil. Steril. 86 (2006) 1518-1521
    • (2006) Fertil. Steril. , vol.86 , pp. 1518-1521
    • Watkins, W.J.1
  • 84
    • 34547408400 scopus 로고    scopus 로고
    • Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue
    • Ludikhuize J., et al. Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue. Arthritis Rheum. 56 (2007) 2180-2191
    • (2007) Arthritis Rheum. , vol.56 , pp. 2180-2191
    • Ludikhuize, J.1
  • 85
    • 36849073263 scopus 로고    scopus 로고
    • Altered FOXO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients
    • Kuo C.C., and Lin S.C. Altered FOXO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. Mol. Med. 13 (2007) 561-566
    • (2007) Mol. Med. , vol.13 , pp. 561-566
    • Kuo, C.C.1    Lin, S.C.2
  • 86
    • 33748130877 scopus 로고    scopus 로고
    • Polymorphisms in FOXO gene family and association analysis with BMI
    • Kim J.R., et al. Polymorphisms in FOXO gene family and association analysis with BMI. Obesity (Silver Spring). 14 (2006) 188-193
    • (2006) Obesity (Silver Spring). , vol.14 , pp. 188-193
    • Kim, J.R.1
  • 87
    • 33847182471 scopus 로고    scopus 로고
    • Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age
    • Kuningas M., et al. Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. Eur. J. Hum. Genet. 15 (2007) 294-301
    • (2007) Eur. J. Hum. Genet. , vol.15 , pp. 294-301
    • Kuningas, M.1
  • 88
    • 33846898211 scopus 로고    scopus 로고
    • The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling
    • Bosque A., et al. The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling. Blood 109 (2007) 1627-1635
    • (2007) Blood , vol.109 , pp. 1627-1635
    • Bosque, A.1
  • 89
    • 4644354580 scopus 로고    scopus 로고
    • Expression and intracellular localization of FKHRL1 in mammary gland neoplasms
    • Jin G.S., et al. Expression and intracellular localization of FKHRL1 in mammary gland neoplasms. Acta Med. Okayama 58 (2004) 197-205
    • (2004) Acta Med. Okayama , vol.58 , pp. 197-205
    • Jin, G.S.1
  • 90
    • 33751165468 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of FKHRL1 triple mutant efficiently induces apoptosis in melanoma cells
    • Gomez-Gutierrez J.G., et al. Adenovirus-mediated gene transfer of FKHRL1 triple mutant efficiently induces apoptosis in melanoma cells. Cancer Biol. Ther. 5 (2006) 875-883
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 875-883
    • Gomez-Gutierrez, J.G.1


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