Structural and functional insights into nuclear receptor signaling

Advanced Drug Delivery Reviews

Volumn 62, Issue 13, 2010, Pages 1218-1226

  Jin, Lihua ^a,b   Li, Yong ^b  

^a XIAMEN UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Cofactor recruitment; Crystal structure; Ligand binding domain; Ligand recognition; Nuclear receptor

Indexed keywords

BOUND LIGANDS; COACTIVATORS; COFACTORS; CONFORMATIONAL FLEXIBILITY; CONSERVED REGIONS; COREPRESSORS; DNA-BINDING DOMAIN; LIGAND BINDING; LIGAND BINDING AFFINITY; LIGAND BINDING DOMAIN; LIGAND RECOGNITION; MOLECULAR BASIS; NUCLEAR RECEPTORS; SEQUENCE IDENTITY; STRUCTURAL COMPARISON; TRANSCRIPTIONAL ACTIVATIONS; TRANSCRIPTIONAL FACTORS;

BINDING ENERGY; CRYSTAL STRUCTURE; TRANSCRIPTION FACTORS;

LIGANDS;

ANTIDIABETIC AGENT; ANTILEUKEMIC AGENT; CELL NUCLEUS RECEPTOR; CELL NUCLEUS RECEPTOR BLOCKING AGENT; CELL NUCLEUS RECEPTOR STIMULATING AGENT; DEACYLCORTIVAZOL; DNA BINDING PROTEIN; ESTROGEN RELATED RECEPTOR ALPHA; GLUCOCORTICOID; INDEGLITAZAR; NUCLEAR RECEPTOR COREPRESSOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PREGNANE X RECEPTOR; RECEPTOR BLOCKING AGENT; RETINOID X RECEPTOR ALPHA; ROSIGLITAZONE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SR 12813; UNCLASSIFIED DRUG;

ACUTE LEUKEMIA; ALPHA HELIX; AMINO TERMINAL SEQUENCE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHILDHOOD LEUKEMIA; CRYSTAL STRUCTURE; DIABETES MELLITUS; DRUG RESEARCH; DRUG SYNTHESIS; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

CELL NUCLEUS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; NUCLEAR RECEPTOR COACTIVATORS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 78649324289     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2010.08.007     Document Type: Review

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