Nuclear-receptor interactions on DNA-response elements

Trends in Biochemical Sciences

Volumn 26, Issue 6, 2001, Pages 384-390

  Khorasanizadeh, Sepideh ^a   Rastinejad, Fraydoon ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; DNA BINDING PROTEIN; TRANSCRIPTION FACTOR;

BINDING SITE; DIMERIZATION; DNA BINDING; DNA RESPONSIVE ELEMENT; DNA SEQUENCE; PRIORITY JOURNAL; RECEPTOR AFFINITY; REVIEW; TRANSCRIPTION REGULATION;

BINDING SITES; DIMERIZATION; DNA; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0035369335     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(01)01800-X     Document Type: Review

References (52)

1. The nuclear receptor superfamily: The second decade
2. The RXR heterodimers and orphan receptors
3. Orphan receptors: In search of a unifying hypothesis for activation
4. Determinants of target gene specificity for RORα1: Monomeric DNA binding by an orphan nuclear receptor
5. The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction
6. Characterization and DNA-binding properties of GRF, a novel monomeric binding orphan receptor related to GCNF and betaFTZ-F1
7. The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat
8. The patterns of binding of RAR, RXR, and TR homo- and heterodimers to direct repeats are dictated by the binding specificities of the DNA binding domains
9. The dimerization interfaces formed between the DNA binding domains of RXR, RAR, and TR determine the binding specificity and polarity of the full-length receptors to direct repeats
10. Determinants for selective RAR and TR recognition of direct repeat HREs
11. Regulation of retinoid signaling by receptor polarity and allosteric control of ligand binding
12. Polarity-specific activities of retinoic acid receptors determined by a co-repressor
13. Identification of a conserved region required for hormone-dependent transcriptional activation by steroid hormone receptors
14. Characterization of the ligand-dependent transactivation by steroid hormone receptors
15. Activation function 2 (AF2) of retinoic acid receptor and 9-cis retinoic acid receptor: Presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element
16. Functional analysis of a transactivation domain in the thyroid hormone receptor
17. Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains
18. Asymmetry in the PPARγ/RXRα crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
19. Structure and specificity of nuclear receptor-coactivator interactions
20. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
21. Coactivator and corepressor complexes in nuclear receptor function
22. Nuclear receptor cofactors as chromatin remodelers
23. Nuclear-receptor ligands and ligand-binding domains
24. The nuclear receptor ligand-binding domain: Structure and function
25. Structural determinants of DNA-binding specificity by steroid receptors
26. The basis for half-site specificity explored through a non-cognate steroid receptor-DNA complex
27. Differences in DNA binding characteristics of the androgen and glucocorticoid receptors can determine hormone-specific responses
28. Nuclear receptor coactivators facilitate vitamin D receptor homodimer action on direct repeat hormone response elements
29. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
30. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
31. The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate among their response elements
32. Structural determinants of nuclear receptor assembly on DNA direct repeats
33. Structural basis of RXR-DNA interactions
34. Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1
35. Structural elements of an orphan nuclear receptor-DNA complex
36. DNA-binding mechanism of the monomeric orphan receptor NGFI-B
37. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain
38. Determinants of DNA-sequence specificity of the androgen, progesterone, and glucocorticoid receptors: Evidence for differential steroid receptor response elements
39. Millisecond to microsecond time scale dynamics of the retinoid X and retinoic acid receptor DNA-binding domains and dimeric complex formation
40. DNA-induced conformational changes are the basis for cooperative dimerization by the DNA binding domain of the retinoid X receptor
41. Retinoid X receptor and its partners in the nuclear receptor family
42. Molecular mechanisms of cell-type determination in budding yeast
43. Crystal structure of the MATa1/MATα2 homeodomain heterodimer bound to DNA
44. A short, diordered protein region mediates interactions between the homeodomain of the yeast α2 protein and MCM1 protein
45. Crystal structure of the yeast MATα2/MCM1/DNA ternary complex
46. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation
47. Structure of a DNA-bound ultrabithorax-extradenticle homeodomain complex
48. Transcription factors: The right combination for the DNA lock
49. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
50. Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation
51. Structure of a HAP1-DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein
52. Interdomain communication regulating ligand binding by PPAR-γ