Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3

Molecular Cell

Volumn 9, Issue 2, 2002, Pages 303-313

  Greschik, Holger ^a   Wurtz, Jean Marie ^a   Sanglier, Sarah ^b   Bourguet, William ^a   Van Dorsselaer, Alain ^b   Moras, Dino ^a   Renaud, Jean Paul ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b Ecole Europeenne de Chimie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RELATED RECEPTOR 3; LIGAND; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CONTROLLED STUDY; LIGAND BINDING; NONHUMAN; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ANALYSIS; TRANSCRIPTION INITIATION;

ANIMALIA;

EID: 0036187372     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00444-6     Document Type: Article

References (42)

1. Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects
2. BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites
3. The ERR-1 orphan receptor is a transcriptional activator expressed during bone development
4. Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains
5. Crystallography & NMR system: A new software for macromolecular structure determination
6. Molecular basis of agonism and antagonism in the oestrogen receptor
7. Molecular basis for the constitutive activity of estrogen-related receptor α-1
8. Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR
9. 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ
10. Bayesian statistical analysis of protein side chain rotamer preferences
11. Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
12. Orphan nuclear receptors: From gene to function
13. Identification of a new class of steroid hormone receptors
14. Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors
15. The coregulator exchange in transcriptional functions of nuclear receptors
16. Functional analysis of retinoid Z receptor β, a brain-specific nuclear orphan receptor
17. Human ERRgamma, a third member of the estrogen-related receptor receptor (ERR) subfamily of orphan nuclear receptors: Tissue-specific isoforms are expressed during development and in the adult
18. Hormone-independent transcriptional activation and coactivator binding by novel orphan receptor ERR3
19. Improved methods for building protein models in electron density maps and the location of errors in these models
20. Detection, delineation, measurement and display of cavities in macromolecular structures
21. The PPARs and PXRs: Nuclear xenobiotic receptors that define novel hormone signaling pathways
22. Estrogen receptor interaction with co-activators and co-repressors
23. Procheck. A program to produce both detailed plots and schematic plots of protein structures
24. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
25. AMoRe: An automated package for molecular replacement
26. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
27. Processing of X-ray diffraction data collected in oscillation mode
28. Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis
29. Structural studies on nuclear receptors
30. Nuclear hormone receptor coregulators in action: Diversity for shared tasks
31. Comparative protein modelling by satisfaction of spatial restraints
32. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction with tamoxifen
33. X-ray structure of the orphan nuclear receptor RORβ ligand-binding domain in the active conformation
34. Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta
35. Role reversal: New insights from new ligands for the xenobiotic receptor CAR
36. The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR
37. Transcriptional activities of the orphan nuclear receptor ERR alpha (estrogen-related receptor receptor-alpha)
38. Transcriptional targets shared by estrogen-related receptor receptors (ERRs) and estrogen receptor (ER) alpha, but not ERbeta
39. Nuclear orphan receptors: The search for novel ligands and signaling pathways
40. A canonical structure for the ligand-binding domain of nuclear receptors
41. Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2
42. Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor α-1 orphan receptor