A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor

Journal of Biological Chemistry

Volumn 280, Issue 35, 2005, Pages 31283-31293

  Bledsoe, Randy K ^a   Madauss, Kevin P ^a   Holt, Jason A ^a   Apolito, Christopher J ^a   Lambert, Millard H ^a   Pearce, Kenneth H ^a   Stanley, Thomas B ^a   Stewart, Eugene L ^a   Trump, Ryan P ^a   Willson, Timothy H ^a   Williams, Shawm P ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOCHEMISTRY; CRYSTAL STRUCTURE; MUTAGENESIS;

HORMONE LIGAND; LIGAND-MEDIATED HYDROGEN BOND NETWORK; MINERALOCORTICOID RECEPTOR (MR); S810L MUTANT;

HYDROGEN BONDS;

11 HYDROXYCORTICOSTEROID; ALDOSTERONE; ASPARAGINE; CORTISONE; DEOXYCORTICOSTERONE; FURYLFURAMIDE; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; PROGESTERONE; SPIRONOLACTONE; THREONINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DRUG SELECTIVITY; HORMONAL REGULATION; HYDROGEN BOND; LIGAND BINDING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; STRUCTURE ANALYSIS;

CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, MINERALOCORTICOID; STEROIDS; TRANS-ACTIVATION (GENETICS);

EID: 24744451821     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504098200     Document Type: Article

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