Nuclear Receptor Coregulators: Judges, Juries, and Executioners of Cellular Regulation

Molecular Cell

Volumn 27, Issue 5, 2007, Pages 691-700

  Lonard, David M ^a   O'Malley, Bert W ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; DNA; GROWTH FACTOR; HISTONE; NUCLEAR RECEPTOR COREPRESSOR; PHOSPHOTRANSFERASE; SIRTUIN; STEROID; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; CELL CULTURE; CELL DIFFERENTIATION; CELL ELONGATION; CELL FUNCTION; CELL METABOLISM; DNA BINDING; ENERGY METABOLISM; GENE EXPRESSION; HOMEOSTASIS; HUMAN; LIPID METABOLISM; MASS SPECTROMETRY; METABOLIC REGULATION; METHYLATION; NONHUMAN; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; RNA SPLICING; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSLATION INITIATION; UBIQUITINATION;

EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MODELS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRESSOR PROTEINS; RNA SPLICING; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 34548252291     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2007.08.012     Document Type: Review

References (100)

1. Anzick S.L., Kononen J., Walker R.L., Azorsa D.O., Tanner M.M., Guan X.Y., Sauter G., Kallioniemi O.P., Trent J.M., and Meltzer P.S. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277 (1997) 965-968
2. Arany Z., Lebrasseur N., Morris C., Smith E., Yang W., Ma Y., Chin S., and Spiegelman B.M. The transcriptional coactivator PGC-1β drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab. 5 (2007) 35-46
3. Baniahmad A., Leng X., Burris T.P., Tsai S.Y., Tsai M.-J., and O'Malley B.W. The tau 4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing. Mol. Cell. Biol. 15 (1995) 76-86
4. Barnes C.J., Vadlamudi R.K., Mishra S.K., Jacobson R.H., Li F., and Kumar R. Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat. Struct. Biol. 10 (2003) 622-628
5. Baur J.A., and Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 5 (2006) 493-506
6. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 (2006) 337-342
7. Berghagen H., Ragnhildstveit E., Krogsrud K., Thuestad G., Apriletti J., and Saatcioglu F. Corepressor SMRT functions as a coactivator for thyroid hormone receptor T3Rα from a negative hormone response element. J. Biol. Chem. 277 (2002) 49517-49522
8. Bertolotti M., Gabbi C., Anzivino C., Mitro N., Godio C., De Fabiani E., Crestani M., Del Puppo M., Ricchi M., Carulli L., et al. Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis. Eur. J. Clin. Invest. 36 (2006) 170-175
9. Blaheta R.A., and Cinatl Jr. J. Anti-tumor mechanisms of valproate: a novel role for an old drug. Med. Res. Rev. 22 (2002) 492-511
10. Boeger H., Bushnell D.A., Davis R., Griesenbeck J., Lorch Y., Strattan J.S., Westover K.D., and Kornberg R.D. Structural basis of eukaryotic gene transcription. FEBS Lett. 579 (2005) 899-903
11. Bordone L., and Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat. Rev. Mol. Cell Biol. 6 (2005) 298-305
12. Bresnick E.H., John S., Berard D.S., LeFebvre P., and Hager G.L. Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate. Proc. Natl. Acad. Sci. USA 87 (1990) 3977-3981
13. Burwinkel B., Wirtenberger M., Klaes R., Schmutzler R.K., Grzybowska E., Forsti A., Frank B., Bermejo J.L., Bugert P., Wappenschmidt B., et al. Association of NCOA3 polymorphisms with breast cancer risk. Clin. Cancer Res. 11 (2005) 2169-2174
14. Carroll J.S., Meyer C.A., Song J., Li W., Geistlinger T.R., Eeckhoute J., Brodsky A.S., Keeton E.K., Fertuck K.C., Hall G.F., et al. Genome-wide analysis of estrogen receptor binding sites. Nat. Genet. 38 (2006) 1289-1297
15. Chen J.D., and Evans R.M. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377 (1995) 454-457
16. Chen H., Lin R.J., Xie W., Wilpitz D., and Evans R.M. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 98 (1999) 675-686
17. Chen J., Kinyamu H.K., and Archer T.K. Changes in attitude, changes in latitude: nuclear receptors remodeling chromatin to regulate transcription. Mol. Endocrinol. 20 (2006) 1-13
18. Coste A., Antal M.C., Chan S., Kastner P., Mark M., O'Malley B.W., and Auwerx J. Absence of the steroid receptor coactivator-3 induces B-cell lymphoma. EMBO J. 25 (2006) 2453-2464
19. Cvoro A., Tzagarakis-Foster C., Tatomer D., Paruthiyil S., Fox M.S., and Leitman D.C. Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol. Cell 21 (2006) 555-564
20. Ek J., Andersen G., Urhammer S.A., Gaede P.H., Drivsholm T., Borch-Johnsen K., Hansen T., and Pedersen O. Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia 44 (2001) 2220-2226
21. Feige J.N., and Auwerx J. Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol. 17 (2007) 292-301
22. Feng Q., Yi P., Wong J., and O'Malley B.W. Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly. Mol. Cell. Biol. 26 (2006) 7846-7857
23. Ge K., Guermah M., Yuan C.X., Ito M., Wallberg A.E., Spiegelman B.M., and Roeder R.G. Transcription coactivator TRAP220 is required for PPARγ 2-stimulated adipogenesis. Nature 417 (2002) 563-567
24. Glass C.K., and Rosenfeld M.G. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14 (2000) 121-141
25. Goodson M., Jonas B.A., and Privalsky M.A. Corepressors: custom tailoring and alterations while you wait. Nucleic Recept. Signal. 3 (2005) e003
26. Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature 444 (2006) 868-874
27. Gupta P., Huq M.D., Khan S.A., Tsai N.P., and Wei L.N. Regulation of co-repressive activity of and HDAC recruitment to RIP140 by site-specific phosphorylation. Mol. Cell. Proteomics 4 (2005) 1776-1784
28. Haigis M.C., Mostoslavsky R., Haigis K.M., Fahie K., Christodoulou D.C., Murphy A.J., Valenzuela D.M., Yancopoulos G.D., Karow M., Blander G., et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126 (2006) 941-954
29. Hamroun D., Kato S., Ishioka C., Claustres M., Beroud C., and Soussi T. The UMD TP53 database and website: update and revisions. Hum. Mutat. 27 (2006) 14-20
30. Han S.J., Jung S.Y., Malovannaya A., Kim T., Lanz R.B., Qin J., and O'Malley B.W. A scoring system for the follow up study of nuclear receptor coactivator complexes. Nucleic Recept. Signal. 4 (2006) e014
31. Handschin C., and Spiegelman B.M. Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr. Rev. 27 (2006) 728-735
32. Hara K., Tobe K., Okada T., Kadowaki H., Akanuma Y., Ito C., Kimura S., and Kadowaki T. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia 45 (2002) 740-743
33. Hassig C.A., and Schreiber S.L. Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs. Curr. Opin. Chem. Biol. 1 (1997) 300-308
34. Heinlein C.A., and Chang C. Androgen receptor (AR) coregulators: an overview. Endocr. Rev. 23 (2002) 175-200
35. Hermanson O., Jepsen K., and Rosenfeld M.G. N-CoR controls differentiation of neural stem cells into astrocytes. Nature 419 (2002) 934-939
36. Horlein A.J., Naar A.M., Heinzel T., Torchia J., Gloss B., Kurokawa R., Ryan A., Kamei Y., Soderstrom M., Glass C.K., et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377 (1995) 387-388
37. Huq M.D., Tsai N.P., Lin Y.P., Higgins L., and Wei L.N. Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation. Nat. Chem. Biol. 3 (2007) 161-165
38. Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
39. Jeong J.W., Kwak I., Lee K.Y., White L.D., Wang X.P., Brunicardi F.C., O'Malley B.W., and DeMayo F.J. The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism. Mol. Endocrinol. 20 (2006) 1138-1152
40. Jonas B.A., and Privalsky M.L. SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J. Biol. Chem. 279 (2004) 54676-54686
41. Jung S.Y., Malovannaya A., Wei J., O'Malley B.W., and Qin J. Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol. Endocrinol. 19 (2005) 2451-2465
42. Kasashima K., Ohta E., Kagawa Y., and Endo H. Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2. J. Biol. Chem. 281 (2006) 36401-36410
43. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127 (2006) 1109-1122
44. Lee D.Y., Teyssier C., Strahl B.D., and Stallcup M.R. Role of protein methylation in regulation of transcription. Endocr. Rev. 26 (2005) 147-170
45. Lee Y.H., Coonrod S.A., Kraus W.L., Jelinek M.A., and Stallcup M.R. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc. Natl. Acad. Sci. USA 102 (2005) 3611-3616
46. Lelliott C.J., Medina-Gomez G., Petrovic N., Kis A., Feldmann H.M., Bjursell M., Parker N., Curtis K., Campbell M., Hu P., et al. Ablation of PGC-1β results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol. 4 (2006) e369 10.1371/journal.pbio.0040369
47. Leonardsson G., Steel J.H., Christian M., Pocock V., Milligan S., Bell J., So P.W., Medina-Gomez G., Vidal-Puig A., White R., and Parker M.G. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc. Natl. Acad. Sci. USA 101 (2004) 8437-8442
48. Lin J., Wu P.H., Tarr P.T., Lindenberg K.S., St-Pierre J., Zhang C.Y., Mootha V.K., Jager S., Vianna C.R., Reznick R.M., et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice. Cell 119 (2004) 121-135
49. Lonard D.M., and O'Malley B.W. Expanding functional diversity of the coactivators. Trends Biochem. Sci. 30 (2005) 126-132
50. Lonard D.M., and O'Malley B.W. The expanding cosmos of nuclear receptor coactivators. Cell 125 (2006) 411-414
51. Lonard D.M., and O'Malley B.W. Nuclear receptor coregulators and human disease. Endocr. Rev. 28 (2007) 575-587
52. Lopez G.N., Turck C.W., Schaufele F., Stallcup M.R., and Kushner P.J. Growth factors signal to steroid receptors through mitogen-activated protein kinase regulation of p160 coactivator activity. J. Biol. Chem. 276 (2001) 22177-22182
53. Louet J.F., Coste A., Amazit L., Tannour-Louet M., Wu R.C., Tsai S.Y., Tsai M.-J., Auwerx J., and O'Malley B.W. Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc. Natl. Acad. Sci. USA 103 (2006) 17868-17873
54. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., and Evans R.M. The nuclear receptor superfamily: the second decade. Cell 83 (1995) 835-839
55. Matsuura T., Sutcliffe J.S., Fang P., Galjaard R.J., Jiang Y.H., Benton C.S., Rommens J.M., and Beaudet A.L. De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. Nat. Genet. 15 (1997) 74-77
56. McKenna N.J., Xu J., Nawaz Z., Tsai S.Y., Tsai M.-J., and O'Malley B.W. Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions. J. Steroid Biochem. Mol. Biol. 69 (1999) 3-12
57. Meng Q., Rayala S.K., Gururaj A.E., Talukder A.H., O'Malley B.W., and Kumar R. Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1. Proc. Natl. Acad. Sci. USA 104 (2007) 5866-5871
58. Metivier R., Penot G., Hubner M.R., Reid G., Brand H., Kos M., and Gannon F. Estrogen receptor-α directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115 (2003) 751-763
59. Mostaqul Huq M.D., Gupta P., Tsai N.P., White R., Parker M.G., and Wei L.N. Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation. EMBO J. 25 (2006) 5094-5104
60. Mostoslavsky R., Chua K.F., Lombard D.B., Pang W.W., Fischer M.R., Gellon L., Liu P., Mostoslavsky G., Franco S., Murphy M.M., et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124 (2006) 315-329
61. Naeem H., Cheng D., Zhao Q., Underhill C., Tini M., Bedford M.T., and Torchia J. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol. Cell. Biol. 27 (2007) 120-134
62. Nawaz Z., Lonard D.M., Smith C.L., Lev-Lehman E., Tsai S.Y., Tsai M.-J., and O'Malley B.W. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol. Cell. Biol. 19 (1999) 1182-1189
63. Onate S.A., Tsai S.Y., Tsai M.-J., and O'Malley B.W. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270 (1995) 1354-1357
64. Petrij F., Giles R.H., Dauwerse H.G., Saris J.J., Hennekam R.C., Masuno M., Tommerup N., van Ommen G.J., Goodman R.H., Peters D.J., et al. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature 376 (1995) 348-351
65. Picard F., Gehin M., Annicotte J., Rocchi S., Champy M.F., O'Malley B.W., Chambon P., and Auwerx J. SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell 111 (2002) 931-941
66. Porcu M., and Chiarugi A. The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends Pharmacol. Sci. 26 (2005) 94-103
67. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., and Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 (1998) 829-839
68. Puigserver P., Rhee J., Lin J., Wu Z., Yoon J.C., Zhang C.Y., Krauss S., Mootha V.K., Lowell B.B., and Spiegelman B.M. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1. Mol. Cell 8 (2001) 971-982
69. Qiu Y., Zhao Y., Becker M., John S., Parekh B.S., Huang S., Hendarwanto A., Martinez E.D., Chen Y., Lu H., et al. HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol. Cell 22 (2006) 669-679
70. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., and Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434 (2005) 113-118
71. Roeder R.G. Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett. 579 (2005) 909-915
72. Rogatsky I., Luecke H.F., Leitman D.C., and Yamamoto K.R. Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc. Natl. Acad. Sci. USA 99 (2002) 16701-16706
73. Rosenfeld M.G., Lunyak V.V., and Glass C.K. Sensors and signals: a coactivator/corepressor/epigenetic code. Genes Dev. 20 (2006) 1405-1428
74. Rowan B.G., Weigel N.L., and O'Malley B.W. Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway. J. Biol. Chem. 275 (2000) 4475-4483
75. Salma N., Xiao H., Mueller E., and Imbalzano A.N. Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor. Mol. Cell. Biol. 24 (2004) 4651-4663
76. Schmidt D., and Muller S. PIAS/SUMO: new partners in transcriptional regulation. Cell. Mol. Life Sci. 60 (2003) 2561-2574
77. Shao W., Keeton E.K., McDonnell D.P., and Brown M. Coactivator AIB1 links estrogen receptor transcriptional activity and stability. Proc. Natl. Acad. Sci. USA 101 (2004) 11599-11604
78. Singh R.R., and Kumar R. Steroid hormone receptor signaling in tumorigenesis. J. Cell. Biochem. 96 (2005) 490-505
79. Stallcup M.R., Kim J.H., Teyssier C., Lee Y.H., Ma H., and Chen D. The roles of protein-protein interactions and protein methylation in transcriptional activation by nuclear receptors and their coactivators. J. Steroid Biochem. Mol. Biol. 85 (2003) 139-145
80. Takeuchi Y., Murata Y., Sadow P., Hayashi Y., Seo H., Xu J., O'Malley B.W., Weiss R.E., and Refetoff S. Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo. Endocrinology 143 (2002) 1346-1352
81. Teyssier C., Ma H., Emter R., Kralli A., and Stallcup M.R. Activation of nuclear receptor coactivator PGC-1α by arginine methylation. Genes Dev. 19 (2005) 1466-1473
82. Thomas M.C., and Chiang C.M. The general transcription machinery and general cofactors. Crit. Rev. Biochem. Mol. Biol. 41 (2006) 105-178
83. Tiefenbach J., Novac N., Ducasse M., Eck M., Melchior F., and Heinzel T. SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription. Mol. Biol. Cell 17 (2006) 1643-1651
84. Tjian R. The biochemistry of transcription in eukaryotes: a paradigm for multisubunit regulatory complexes. Philos. Trans. R. Soc. Lond. B Biol. Sci. 351 (1996) 491-499
85. Treuter E., and Gustafsson J.A. Wrestling rules in transrepression: as easy as SUMO-1, -2, -3?. Mol. Cell 26 (2007) 178-180
86. Tsai M.-J., and O'Malley B.W. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63 (1994) 451-486
87. Vadlamudi R.K., Manavathi B., Singh R.R., Nguyen D., Li F., and Kumar R. An essential role of Pak1 phosphorylation of SHARP in Notch signaling. Oncogene 24 (2005) 4591-4596
88. Vianna C.R., Huntgeburth M., Coppari R., Choi C.S., Lin J., Krauss S., Barbatelli G., Tzameli I., Kim Y.B., Cinti S., et al. Hypomorphic mutation of PGC-1β causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 4 (2006) 453-464
89. Verrotti A., Greco R., Latini G., and Chiarelli F. Endocrine and metabolic changes in epileptic patients receiving valproic acid. J. Pediatr. Endocrinol. Metab. 18 (2005) 423-430
90. Wang Z., Qi C., Krones A., Woodring P., Zhu X., Reddy J.K., Evans R.M., Rosenfeld M.G., and Hunter T. Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab. 3 (2006) 111-122
91. Wu R.C., Qin J., Hashimoto Y., Wong J., Xu J., Tsai S.Y., Tsai M.J., and O'Malley B.W. Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase. Mol. Cell. Biol. 22 (2002) 3549-3561
92. Wu R.C., Qin J., Yi P., Wong J., Tsai S.Y., Tsai M.-J., and O'Malley B.W. Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol. Cell 15 (2004) 937-949
93. Wu R.C., Smith C.L., and O'Malley B.W. Transcriptional regulation by steroid receptor coactivator phosphorylation. Endocr. Rev. 26 (2005) 393-399
94. Wu H., Sun L., Zhang Y., Chen Y., Shi B., Li R., Wang Y., Liang J., Fan D., Wu G., et al. Coordinated regulation of AIB1 transcriptional activity by sumoylation and phosphorylation. J. Biol. Chem. 281 (2006) 21848-21856
95. Wu R.C., Feng Q., Lonard D.M., and O'Malley B.W. SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock. Cell 129 (2007) 1125-1140
96. Yoo E.J., Chung J.J., Choe S.S., Kim K.H., and Kim J.B. Down-regulation of histone deacetylases stimulates adipocyte differentiation. J. Biol. Chem. 281 (2006) 6608-6615
97. Yoon J.C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C.R., Granner D.K., et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413 (2001) 131-138
98. Yu C., York B., Wang S., Feng Q., Xu J., and O'Malley B.W. An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response. Mol. Cell 25 (2007) 765-778
99. Zhang J., Guenther M.G., Carthew R.W., and Lazar M.A. Proteasomal regulation of nuclear receptor corepressor-mediated repression. Genes Dev. 12 (1998) 1775-1780
100. Zhao X., Patton J.R., Ghosh S.K., Fischel-Ghodsian N., Shen L., and Spanjaard R.A. Pus3p- and Pus1p-dependent pseudouridylation of steroid receptor RNA activator controls a functional switch that regulates nuclear receptor signaling. Mol. Endocrinol. 21 (2007) 686-699