Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension

Nature Structural and Molecular Biology

Volumn 12, Issue 6, 2005, Pages 554-555

  Fagart, Jérôme ^a   Huyet, Jessica ^a   Pinon, Grégory M ^a   Rochel, Marina ^a   Mayer, Claudine ^b   Rafestin Oblin, Marie Edith ^a  

^a INSERM   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYCORTICOSTERONE; LEUCINE; MINERALOCORTICOID RECEPTOR; MUTANT PROTEIN; PROGESTERONE; LIGAND; RECOMBINANT PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; HYPERTENSION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; AMINO ACID SUBSTITUTION; BINDING SITE; CELL LINE; CHEMISTRY; GENETICS; HUMAN; MUTAGENESIS; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; BINDING SITES; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYPERTENSION; LIGANDS; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, MINERALOCORTICOID; RECOMBINANT PROTEINS;

EID: 22444438401     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb939     Document Type: Article

References (12)

1. Bonvalet, J.P. Kidney Int. Suppl. 65, S49-S56 (1998).
2. Evans, R.M. Science 240, 889-895 (1988).
3. Nagy, L. & Schwabe, J.W. Trends Biochem. Sci. 29, 317-324 (2004).
4. Fagart, J. et al. EMBO J. 17, 3317-3325 (1998).
5. Geller, D.S. et al. Science 289, 119-123 (2000).
6. Brzozowski, A.M. et al. Nature 389, 753-758 (1997).
7. Williams, S.P. & Sigler, P.B. Nature 393, 392-396 (1998).
8. Matias, P.M. et al. J. Biol. Chem. 275, 26164-26171 (2000).
9. Sack, J.S. et al. Proc. Natl. Acad. Sci. USA 98, 4904-4909 (2001).
10. Bledsoe, R.K. et al. Cell 110, 93-105 (2002).
11. Kauppi, B. et al. J. Biol. Chem. 278, 22748-22754 (2003).
12. Pinon, G.M. et al. Mol. Cell. Endocrinol. 217, 181-188 (2004).