The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 47, 2008, Pages 18390-18395

  Sablin, Elena P ^a   Woods, April ^a   Krylova, Irina N ^a   Hwang, Peter ^a   Ingraham, Holly A ^a   Fletterick, Robert J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Dax 1; LRH 1; Nuclear receptor; Regulation; Structure

Indexed keywords

LIVER RECEPTOR HOMOLOG 1; NUCLEAR RECEPTOR DAX 1;

ARTICLE; CONGENITAL ADRENAL HYPOPLASIA; DIMERIZATION; DISEASE ASSOCIATION; ENDOCRINE DISEASE; GENE MUTATION; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN TARGETING; REPRESSOR GENE; TRANSCRIPTION REGULATION;

DIMERIZATION; DNA-BINDING PROTEINS; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

EID: 57449090890     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808936105     Document Type: Article

References (52)

1. Lalli E, Sassone-Corsi P (2003) DAX-1, an unusual orphan nuclear receptor at the crossroads of steroidogenic function and sexual differentiation. Mol Endocrinol 17:1445-1453.
2. Bardoni B, et al. (1994) A dosage-sensitive locus at chromosome Xp21 is involved in male to female sex reversal. Nat Genet 7:497-501.
3. Lin L, et al. (2006) Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: Ten years' experience. J Clin Endocrinol Metab 91:3048-3054.
4. Ito M, Yu R, Jameson JL (1997) DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita. Mol Cell Biol 17:1476-1483.
5. Crawford PA, Dorn C, Sadovsky Y, Milbrandt J (1998) Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1. Mol Cell Biol 18:2949-2956.
6. Nachtigal MW, et al. (1998) Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. Cell 93:445-454.
7. Song KH, et al. (2004) The atypical orphan nuclear receptorDAX1interacts with orphan nuclear receptor Nur77 and represses its transactivation. Mol Endocrinol 18:1920-1940.
8. Park YY, et al. (2005) An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRgamma. Nucleic Acids Res 33:6756-6768.
9. Zhang H, Thomsen JS, Johansson L, Gustafsson JA, Treuter E (2000) DAX-1 functions as an LXXLL-containing corepressor for activated estrogen receptors. J Biol Chem 275:39855-39859.
10. Holter E, et al. (2002) Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX1. Mol Endocrinol 16:515-528.
11. Agoulnik IU, et al. (2003) Repressors of androgen and progesterone receptor action. J Biol Chem 278:31136-31148.
12. Suzuki T, Kasahara M, Yoshioka H, Morohashi K, Umesono K (2003) LXXLL-related motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1. Mol Cell Biol 23:238-249.
13. Fayard E, Auwerx J, Schoonjans K (2004) LRH-1: An orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol 14:250-260.
14. Niakan KK, et al. (2006) Novel role for the orphan nuclear receptor DAX1 in embryogenesis, different from steroidogenesis. Mol Gen Metabol 88:261-271.
15. Wang J, et al. (2006) A protein interaction network for pluripotency of embryonic stem cells. Nature 444:364-368.
16. Zanaria E, et al. (1994) An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature 372:635-641.
17. Kawajiri K, et al. (2003) Role of the LXXLL-motif and activation function 2 domain in subcellular localization of DAX-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1). Mol Endocrinol 17:994-1004.
18. Lalli E, et al. (1997)Atranscriptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita. Mol Endocrinol 11:1950-1960.
19. Altincicek B, et al. (2000) Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. J Biol Chem 275:7662-7667.
20. Zazopoulos E, Lalli E, Stocco DM, Sassone-Corsi P (1997) DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis. Nature 390:311-315.
21. Nitta M, Ku S, Brown C, Okamoto AY, Shan B (1999) CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc Natl Acad Sci USA 96:6660-6665.
22. del Castillo-Olivares A, Gil G (2000) Alpha 1-fetoprotein transcription factor is required for the expression of sterol 12alpha-hydroxylase, the specific enzyme for cholic acid synthesis: Potential role in the bile acid-mediated regulation of gene transcription. J Biol Chem 275:17793-17799.
23. Luo Y, Liang CP, Tall AR (2001) The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J Biol Chem 276:24767-24773.
24. Schoonjans K, et al. (2002) Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. EMBO Rep 3:1181-1187.
25. Clyne CD, Speed CJ, Zhou J, Simpson ER (2002) Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J Biol Chem 277:20591-20597.
26. Liu DL, et al. (2003) Expression and functional analysis of liver receptor homologue-1 as a potential steroidogenic factor in rat ovary. Biol Reprod 69:508-517.
27. Mendelson CR, Jiang B, Shelton JM, Richardson JA, Hinshelwood MM (2005) Transcriptional regulation of aromatase in placenta and ovary. J Steroid Biochem Mol Biol 95:25-33.
28. Hinshelwood MM, Shelton JM, Richardson JA, Mendelson CR (2005) Temporal and spatial expression of liver receptor homologue-1 (LRH-1) during embryogenesis suggests a potential role in gonadal development. Dev Dyn 234:159-168.
29. Gu P, et al. (2005) Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Mol Cell Biol 25:3492-3505.
30. Ueda H, Sun GC, Murata T, Hirose S (1992) A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal long-terminal repeat-binding protein. Mol Cell Biol 12:5667-5672.
31. Solomon IH, et al. (2005) Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. J Mol Biol 354:1091-1102.
32. Val P, et al. (2004) Adrenocorticotropin/3-′, 5′--cyclic AMP-mediated transcription of the scavenger akr1-b7 gene in adrenocortical cells is dependent on three functionally distinct steroidogenic factor-1-responsive elements. Endocrinology 145:508-518.
33. Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA (2003) A novel structural element accounts for the constitutive activity of the orphan nuclear receptor, LRH-1. Mol Cell 11:1575-1585.
34. Krylova IN, et al. (2005) Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell 120:343-355.
35. Li Y, et al. (2005) Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. Proc Natl Acad Sci U S A 102:9505-9510.
36. Ortlund EA, et al. (2005) Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol 12:357-363.
37. Wang W, et al. (2005) The crystal structures of human steroidogenic factor-1 and liver receptor homogue-1. Proc Natl Acad Sci USA 102:7505-7510.
38. Lee YK, Choi YH, Chua SS, Park YJ, Moore DD (2006) Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. J Biol Chem 281:7850-7855.
39. Yu FQ, et al. (2005) Activation of the p38MPAK pathway by follicle-stimulating hormone regulates steroidogenesis in granulosa cells differentially. J Endocrinol 186:85-96.
40. Kim JW, Peng N, Rainey WE, Carr BR, Attia GR (2004) The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3b-hydroxysteroid dehydrogenase type II. J Clin Endocrinol Metab 89:3042-3047.
41. Kim JW, Havelock JC, Carr BR, Attia GR (2005) Liver receptor homolog-1 regulates the expression of steroidogenic acute regulatory protein in human granulosa cells. J Clin Endocrinol Metab 90:1678-1685.
42. Peng N, Kim JW, Rainey WE, Carr BR, Attia G (2003) The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3b-hydroxysteroid dehydrogenase type II. J Clin Endocrinol Metab 88:6020-6028.
43. Darimont BD, et al. (1998) Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev 12:3343-3356.
44. Fujino T, et al. (2003) In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association. J Steroid Biochem Mol Biol 87:247-252.
45. Moore JM, et al. (2004) Quantitative proteomics of the thyroid hormone receptorcoregulator interactions. J Biol Chem 279:27584-27590.
46. Lehmann SG, Sassone-Corsi P (2002) X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein. Proc Natl Acad Sci USA 99:8225-8230.
47. Park YY, et al. (2004) Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1. Mol Endocrinol 18:1082-1095.
48. Shiau AK, et al. (1998) The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95:927-937.
49. Glass CK, Rosenfeld MG (2000) The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14:121-141.
50. Lenmann S, Wurtz JM, Renaud JP, Sassone-Corsi P, Lalli E (2003) Structure-function analyses reveal the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients. Hum Mol Genet 12:1063-1072.
51. Iyer AK, Zhang YH, McCabe ER (2006) Dosage-sensitive sex-reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers. Mol Endocrinol 20:2326-2342.
52. Huang Z, Park JI, Watson DS, Hwang P, Szoka FC (2006) Facile synthesis of multivalent nitrilotriacetic acid (NTA) and NTA conjugates for analytical and drug delivery applications. Bioconjug Chem 17:1592-1600.