메뉴 건너뛰기




Volumn 25, Issue 5, 2010, Pages 669-680

The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis

Author keywords

Differentiation; Hematopoietic stem cells; PI3K Akt mTOR; Proliferation; Signal transduction

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

EID: 77953043118     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (33)

References (123)
  • 1
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi K., Traver D., Miyamoto T. and Weissman I.L. (2000). A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193-197.
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 2
    • 0037229714 scopus 로고    scopus 로고
    • Overexpression of AKT2/protein kinase B, leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
    • Arboleda M.J., Lyons J.F., Kabbinavar F.F., Bray M.R., Snow B.E., Ayala R., Danino M., Karlan B.Y. and Slamon D.J. (2003). Overexpression of AKT2/protein kinase B, leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res. 63, 196-206.
    • (2003) Cancer Res. , vol.63 , pp. 196-206
    • Arboleda, M.J.1    Lyons, J.F.2    Kabbinavar, F.F.3    Bray, M.R.4    Snow, B.E.5    Ayala, R.6    Danino, M.7    Karlan, B.Y.8    Slamon, D.J.9
  • 3
    • 22144464506 scopus 로고    scopus 로고
    • Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor
    • Arcasoy M.O. and Jiang X. (2005). Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor. Br. J. Haematol. 130, 121-129.
    • (2005) Br. J. Haematol. , vol.130 , pp. 121-129
    • Arcasoy, M.O.1    Jiang, X.2
  • 4
    • 39749141485 scopus 로고    scopus 로고
    • The regulation and function of Class III PI3Ks: Novel roles for Vps34
    • Backer J.M. (2008). The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem. J. 410, 1-17.
    • (2008) Biochem. J. , vol.410 , pp. 1-17
    • Backer, J.M.1
  • 5
    • 1542781732 scopus 로고    scopus 로고
    • Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B
    • Bae S.S., Cho H., Mu J. and Birnbaum M.J. (2003). Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J. Biol. Chem. 278, 49530-49536.
    • (2003) J. Biol. Chem. , vol.278 , pp. 49530-49536
    • Bae, S.S.1    Cho, H.2    Mu, J.3    Birnbaum, M.J.4
  • 6
    • 35348850734 scopus 로고    scopus 로고
    • Hematopoietic cytokine receptor signaling
    • Baker S.J., Rane S.G. and Reddy E.P. (2007). Hematopoietic cytokine receptor signaling. Oncogene 26, 6724-6737.
    • (2007) Oncogene , vol.26 , pp. 6724-6737
    • Baker, S.J.1    Rane, S.G.2    Reddy, E.P.3
  • 8
    • 34047095297 scopus 로고    scopus 로고
    • The two TORCs and Akt
    • Bhaskar P.T. and Hay N. (2007). The two TORCs and Akt. Dev. Cell 12, 487-502.
    • (2007) Dev. Cell , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 9
  • 12
    • 63749119765 scopus 로고    scopus 로고
    • PIKKing on PKB: Regulation of PKB activity by phosphorylation
    • Bozulic L. and Hemmings B.A. (2009). PIKKing on PKB: regulation of PKB activity by phosphorylation. Curr. Opin. Cell Biol. 21, 256-261.
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 256-261
    • Bozulic, L.1    Hemmings, B.A.2
  • 13
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signalling: AKTion on multiple fronts
    • Brazil D.P., Yang Z.Z. and Hemmings B.A. (2004). Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 29, 233-242.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 233-242
    • Brazil, D.P.1    Yang, Z.Z.2    Hemmings, B.A.3
  • 14
    • 47249105677 scopus 로고    scopus 로고
    • PHLiPPing the switch on Akt and protein kinase C signaling
    • Brognard J. and Newton A.C. (2008). PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol. Metab. 19, 223-230.
    • (2008) Trends Endocrinol. Metab. , vol.19 , pp. 223-230
    • Brognard, J.1    Newton, A.C.2
  • 18
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Chen C., Liu Y., Liu R., Ikenoue T., Guan K.L., Liu Y. and Zheng P. (2008). TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 205, 2397-2408.
    • (2008) J. Exp. Med. , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Liu, Y.6    Zheng, P.7
  • 19
    • 65349114832 scopus 로고    scopus 로고
    • Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia
    • Crazzolara R., Cisterne A., Thien M., Hewson J., Baraz R., Bradstock K.F. and Bendall L.J. (2009). Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia. Blood 113, 3297-3306.
    • (2009) Blood , vol.113 , pp. 3297-3306
    • Crazzolara, R.1    Cisterne, A.2    Thien, M.3    Hewson, J.4    Baraz, R.5    Bradstock, K.F.6    Bendall, L.J.7
  • 20
    • 33748313080 scopus 로고    scopus 로고
    • Membrane and juxtamembrane targeting by PH and PTB domains
    • DiNitto J.P. and Lambright D.G. (2006). Membrane and juxtamembrane targeting by PH and PTB domains. Biochim. Biophys. Acta 1761, 850-867.
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 850-867
    • DiNitto, J.P.1    Lambright, D.G.2
  • 21
    • 0035377208 scopus 로고    scopus 로고
    • Establishment of normal, terminally differentiating mouse erythroid progenitors: Molecular characterization by cDNA arrays
    • Dolznig H., Boulme F., Stangl K., Deiner E.M., Mikulits W., Beug H. and Mullner E.W. (2001). Establishment of normal, terminally differentiating mouse erythroid progenitors: molecular characterization by cDNA arrays. FASEB J. 15, 1442-1444.
    • (2001) FASEB J. , vol.15 , pp. 1442-1444
    • Dolznig, H.1    Boulme, F.2    Stangl, K.3    Deiner, E.M.4    Mikulits, W.5    Beug, H.6    Mullner, E.W.7
  • 22
    • 1342321750 scopus 로고    scopus 로고
    • PI 3-kinase, Akt and cell survival
    • Downward J. (2004). PI 3-kinase, Akt and cell survival. Semin. Cell Dev. Biol. 15, 177-182.
    • (2004) Semin. Cell Dev. Biol. , vol.15 , pp. 177-182
    • Downward, J.1
  • 23
    • 33645505599 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is required for thrombopoietin-induced proliferation of megakaryocyte progenitors
    • Drayer A.L., Olthof S.G. and Vellenga E. (2006). Mammalian target of rapamycin is required for thrombopoietin-induced proliferation of megakaryocyte progenitors. Stem Cells 24, 105-114.
    • (2006) Stem Cells , vol.24 , pp. 105-114
    • Drayer, A.L.1    Olthof, S.G.2    Vellenga, E.3
  • 25
    • 62749096589 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms
    • Dunlop E.A. and Tee A.R. (2009). Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms. Cell. Signal. 21, 827-835.
    • (2009) Cell. Signal. , vol.21 , pp. 827-835
    • Dunlop, E.A.1    Tee, A.R.2
  • 27
    • 55549126786 scopus 로고    scopus 로고
    • Erythropoietins: A common mechanism of action
    • Elliott S., Pham E. and Macdougall I.C. (2008). Erythropoietins: a common mechanism of action. Exp. Hematol. 36, 1573-1584.
    • (2008) Exp. Hematol. , vol.36 , pp. 1573-1584
    • Elliott, S.1    Pham, E.2    Macdougall, I.C.3
  • 28
    • 0037385088 scopus 로고    scopus 로고
    • Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand
    • Engstrom M., Karlsson R. and Jonsson J.I. (2003). Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand. Exp. Hematol. 31, 316-323.
    • (2003) Exp. Hematol. , vol.31 , pp. 316-323
    • Engstrom, M.1    Karlsson, R.2    Jonsson, J.I.3
  • 30
    • 34548359244 scopus 로고    scopus 로고
    • PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
    • Fonseca B.D., Smith E.M., Lee V.H., MacKintosh C. and Proud C.G. (2007). PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J. Biol. Chem. 282, 24514-24524.
    • (2007) J. Biol. Chem. , vol.282 , pp. 24514-24524
    • Fonseca, B.D.1    Smith, E.M.2    Lee, V.H.3    MacKintosh, C.4    Proud, C.G.5
  • 31
    • 54949109808 scopus 로고    scopus 로고
    • PI3K/Akt: Getting it right matters
    • Franke T.F. (2008). PI3K/Akt: getting it right matters. Oncogene 27, 6473-6488.
    • (2008) Oncogene , vol.27 , pp. 6473-6488
    • Franke, T.F.1
  • 32
    • 35348875999 scopus 로고    scopus 로고
    • Transcriptional control of granulocyte and monocyte development
    • Friedman A.D. (2007). Transcriptional control of granulocyte and monocyte development. Oncogene 26, 6816-6828.
    • (2007) Oncogene , vol.26 , pp. 6816-6828
    • Friedman, A.D.1
  • 33
    • 61849126233 scopus 로고    scopus 로고
    • Fine tuning the immune response with PI3K
    • Fruman D.A. and Bismuth G. (2009). Fine tuning the immune response with PI3K. Immunol. Rev. 228, 253-272.
    • (2009) Immunol. Rev. , vol.228 , pp. 253-272
    • Fruman, D.A.1    Bismuth, G.2
  • 37
    • 0035860718 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors
    • Geddis A.E., Fox N.E. and Kaushansky K. (2001). Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors. J, Biol, Chem. 276, 34473-34479.
    • (2001) J, Biol, Chem. , vol.276 , pp. 34473-34479
    • Geddis, A.E.1    Fox, N.E.2    Kaushansky, K.3
  • 38
    • 67650713694 scopus 로고    scopus 로고
    • Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells
    • Geest C.R., Zwartkruis F.J., Vellenga E., Coffer P.J. and Buitenhuis M. (2009). Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells. Haematologica 94, 901-910.
    • (2009) Haematologica , vol.94 , pp. 901-910
    • Geest, C.R.1    Zwartkruis, F.J.2    Vellenga, E.3    Coffer, P.J.4    Buitenhuis, M.5
  • 39
    • 33344458617 scopus 로고    scopus 로고
    • AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation
    • Ghaffari S., Kitidis C., Zhao W., Marinkovic D., Fleming M.D., Luo B., Marszalek J. and Lodish H.F. (2006). AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. Blood 107, 1888-1891.
    • (2006) Blood , vol.107 , pp. 1888-1891
    • Ghaffari, S.1    Kitidis, C.2    Zhao, W.3    Marinkovic, D.4    Fleming, M.D.5    Luo, B.6    Marszalek, J.7    Lodish, H.F.8
  • 40
    • 53449102851 scopus 로고    scopus 로고
    • Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation
    • Grech G., Blazquez-Domingo M., Kolbus A., Bakker W.J., Mullner E.W., Beug H. and von Lindern M. (2008). Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation. Blood 112, 2750-2760.
    • (2008) Blood , vol.112 , pp. 2750-2760
    • Grech, G.1    Blazquez-Domingo, M.2    Kolbus, A.3    Bakker, W.J.4    Mullner, E.W.5    Beug, H.6    Von Lindern, M.7
  • 41
    • 27844497945 scopus 로고    scopus 로고
    • FOXO transcription factors at the interface between longevity and tumor suppression
    • Greer E.L. and Brunet A. (2005). FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24, 7410-7425.
    • (2005) Oncogene , vol.24 , pp. 7410-7425
    • Greer, E.L.1    Brunet, A.2
  • 45
    • 0018181261 scopus 로고
    • Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging
    • Harrison D.E., Astle C.M. and Delaittre J.A. (1978). Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging. J. Exp. Med. 147, 1526-1531.
    • (1978) J. Exp. Med. , vol.147 , pp. 1526-1531
    • Harrison, D.E.1    Astle, C.M.2    Delaittre, J.A.3
  • 46
    • 13044269652 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis
    • Haseyama Y., Sawada K., Oda A., Koizumi K., Takano H., Tarumi T., Nishio M., Handa M., Ikeda Y. and Koike T. (1999). Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis. Blood 94,1568-1577.
    • (1999) Blood , vol.94 , pp. 1568-1577
    • Haseyama, Y.1    Sawada, K.2    Oda, A.3    Koizumi, K.4    Takano, H.5    Tarumi, T.6    Nishio, M.7    Handa, M.8    Ikeda, Y.9    Koike, T.10
  • 47
    • 63849140348 scopus 로고    scopus 로고
    • SHIP is required for a functional hematopoietic stem cell niche
    • Hazen A.L., Smith M.J., Desponts C., Winter O., Moser K. and Kerr W.G. (2009). SHIP is required for a functional hematopoietic stem cell niche. Blood 113, 2924-2933.
    • (2009) Blood , vol.113 , pp. 2924-2933
    • Hazen, A.L.1    Smith, M.J.2    Desponts, C.3    Winter, O.4    Moser, K.5    Kerr, W.G.6
  • 48
    • 0242495010 scopus 로고    scopus 로고
    • Homeostasis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice
    • Helgason C.D., Antonchuk J., Bodner C. and Humphries R.K. (2003). Homeostasis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice. Blood 102, 3541-3547.
    • (2003) Blood , vol.102 , pp. 3541-3547
    • Helgason, C.D.1    Antonchuk, J.2    Bodner, C.3    Humphries, R.K.4
  • 49
    • 45449106335 scopus 로고    scopus 로고
    • KIT associated intracellular tyrosines play an essential role in EpoR co-signaling
    • Hong L., Ramdas B., Chen J., Harris C., Wojchowski D.M. and Kapur R. (2008). KIT associated intracellular tyrosines play an essential role in EpoR co-signaling. Cell. Signal. 20, 1513-1520.
    • (2008) Cell. Signal. , vol.20 , pp. 1513-1520
    • Hong, L.1    Ramdas, B.2    Chen, J.3    Harris, C.4    Wojchowski, D.M.5    Kapur, R.6
  • 50
    • 0041305909 scopus 로고    scopus 로고
    • Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
    • Hong S.P., Leiper F.C., Woods A., Carling D. and Carlson M. (2003). Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc. Natl. Acad. Sci. USA 100, 8839-8843.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8839-8843
    • Hong, S.P.1    Leiper, F.C.2    Woods, A.3    Carling, D.4    Carlson, M.5
  • 51
    • 46449127430 scopus 로고    scopus 로고
    • Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells
    • Horn S., Bergholz U., Jucker M., McCubrey J.A., Trumper L., Stocking C. and Basecke J. (2008). Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells. Oncogene 27, 4096-4106.
    • (2008) Oncogene , vol.27 , pp. 4096-4106
    • Horn, S.1    Bergholz, U.2    Jucker, M.3    McCubrey, J.A.4    Trumper, L.5    Stocking, C.6    Basecke, J.7
  • 52
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang J. and Manning B.D. (2009). A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem. Soc. Trans. 37, 217-222.
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 53
    • 35548932909 scopus 로고    scopus 로고
    • Hematopoietic stem cells: Generation and self-renewal
    • Huang X., Cho S. and Spangrude G.J. (2007). Hematopoietic stem cells: generation and self-renewal. Cell Death Differ. 14, 1851-1859.
    • (2007) Cell Death Differ. , vol.14 , pp. 1851-1859
    • Huang, X.1    Cho, S.2    Spangrude, G.J.3
  • 55
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto E., Loewith R., Schmidt A., Lin S., Ruegg M.A., Hall A. and Hall M.N. (2004). Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6    Hall, M.N.7
  • 56
    • 35548936968 scopus 로고    scopus 로고
    • A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
    • Jang Y.Y. and Sharkis S.J. (2007). A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 110, 3056-3063.
    • (2007) Blood , vol.110 , pp. 3056-3063
    • Jang, Y.Y.1    Sharkis, S.J.2
  • 58
    • 63749106157 scopus 로고    scopus 로고
    • Should individual PI3 kinase isoforms be targeted in cancer?
    • Jia S., Roberts T.M. and Zhao J.J. (2009). Should individual PI3 kinase isoforms be targeted in cancer? Curr. Opin. Cell Biol. 21, 199-208.
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 199-208
    • Jia, S.1    Roberts, T.M.2    Zhao, J.J.3
  • 59
    • 23844462873 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation
    • Kadri Z., Maouche-Chretien L., Rooke H.M., Orkin S.H., Romeo P.H., Mayeux P., Leboulch P. and Chretien S. (2005). Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Mol. Cell. Biol. 25, 7412-7422.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 7412-7422
    • Kadri, Z.1    Maouche-Chretien, L.2    Rooke, H.M.3    Orkin, S.H.4    Romeo, P.H.5    Mayeux, P.6    Leboulch, P.7    Chretien, S.8
  • 61
    • 0034254446 scopus 로고    scopus 로고
    • A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction
    • Kashii Y., Uchida M., Kirito K., Tanaka M., Nishijima K., Toshima M., Ando T., Koizumi K., Endoh T., Sawada K., Momoi M., Miura Y., Ozawa K. and Komatsu N. (2000). A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction. Blood 96, 941-949.
    • (2000) Blood , vol.96 , pp. 941-949
    • Kashii, Y.1    Uchida, M.2    Kirito, K.3    Tanaka, M.4    Nishijima, K.5    Toshima, M.6    Ando, T.7    Koizumi, K.8    Endoh, T.9    Sawada, K.10    Momoi, M.11    Miura, Y.12    Ozawa, K.13    Komatsu, N.14
  • 62
    • 31044439372 scopus 로고    scopus 로고
    • The molecular mechanisms that control thrombopoiesis
    • Kaushansky K. (2005). The molecular mechanisms that control thrombopoiesis. J. Clin. Invest. 115, 3339-3347.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3339-3347
    • Kaushansky, K.1
  • 63
    • 33646490285 scopus 로고    scopus 로고
    • Lineage-specific hematopoietic growth factors
    • Kaushansky K. (2006). Lineage-specific hematopoietic growth factors. N. Engl. J. Med. 354, 2034-2045.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2034-2045
    • Kaushansky, K.1
  • 64
    • 51849097348 scopus 로고    scopus 로고
    • The role of PTEN signaling perturbations in cancer and in targeted therapy
    • Keniry M. and Parsons R. (2008). The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene 27, 5477-5485.
    • (2008) Oncogene , vol.27 , pp. 5477-5485
    • Keniry, M.1    Parsons, R.2
  • 65
    • 41149109622 scopus 로고    scopus 로고
    • Uncertainty in the niches that maintain haematopoietic stem cells
    • Kiel M.J. and Morrison S.J. (2008). Uncertainty in the niches that maintain haematopoietic stem cells. Nat. Rev. Immunol. 8, 290-301.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 290-301
    • Kiel, M.J.1    Morrison, S.J.2
  • 66
    • 0029900227 scopus 로고    scopus 로고
    • Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3
    • Kobayashi M., Laver J.H., Kato T., Miyazaki H. and Ogawa M. (1996). Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3. Blood 88, 429-436.
    • (1996) Blood , vol.88 , pp. 429-436
    • Kobayashi, M.1    Laver, J.H.2    Kato, T.3    Miyazaki, H.4    Ogawa, M.5
  • 67
    • 62849114529 scopus 로고    scopus 로고
    • Regulation of phosphoinositide 3-kinase expression in health and disease
    • Kok K., Geering B. and Vanhaesebroeck B. (2009). Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem. Sci. 34, 115-127.
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 115-127
    • Kok, K.1    Geering, B.2    Vanhaesebroeck, B.3
  • 68
    • 0030831130 scopus 로고    scopus 로고
    • Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    • Kondo M., Weissman I.L. and Akashi K. (1997). Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661-672.
    • (1997) Cell , vol.91 , pp. 661-672
    • Kondo, M.1    Weissman, I.L.2    Akashi, K.3
  • 69
    • 34250183122 scopus 로고    scopus 로고
    • Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL
    • Kozuma Y., Kojima H., Yuki S., Suzuki H. and Nagasawa T. (2007). Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL. J. Thromb. Haemost. 5, 1274-1282.
    • (2007) J. Thromb. Haemost. , vol.5 , pp. 1274-1282
    • Kozuma, Y.1    Kojima, H.2    Yuki, S.3    Suzuki, H.4    Nagasawa, T.5
  • 70
    • 32044466965 scopus 로고    scopus 로고
    • Involvement of protein kinase Cγ in the negative regulation of Akt activation stimulated by granulocyte colony-stimulating factor
    • Liu H., Qiu Y., Xiao L. and Dong F. (2006). Involvement of protein kinase Cγ in the negative regulation of Akt activation stimulated by granulocyte colony-stimulating factor. J. Immunol. 176, 2407-2413.
    • (2006) J. Immunol. , vol.176 , pp. 2407-2413
    • Liu, H.1    Qiu, Y.2    Xiao, L.3    Dong, F.4
  • 72
    • 50849112769 scopus 로고    scopus 로고
    • Delineating the cellular pathways of hematopoietic lineage commitment
    • Luc S., Buza-Vidas N. and Jacobsen S.E. (2008). Delineating the cellular pathways of hematopoietic lineage commitment. Semin. Immunol. 20, 213-220.
    • (2008) Semin. Immunol. , vol.20 , pp. 213-220
    • Luc, S.1    Buza-Vidas, N.2    Jacobsen, S.E.3
  • 73
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • Ma L., Chen Z., Erdjument-Bromage H., Tempst P. and Pandolfi P.P. (2005). Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121, 179-193.
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 74
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma X.M. and Blenis J. (2009). Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 10, 307-318.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 77
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning B.D. and Cantley L.C. (2007). AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 78
    • 33646379862 scopus 로고    scopus 로고
    • Intranuclear 3'-phosphoinositide metabolism and Akt signaling: New mechanisms for tumorigenesis and protection against apoptosis?
    • Martelli A.M., Faenza I., Billi A.M., Manzoli L., Evangelisti C., Fala F. and Cocco L. (2006). Intranuclear 3′-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis? Cell. Signal. 18, 1101-1107.
    • (2006) Cell. Signal. , vol.18 , pp. 1101-1107
    • Martelli, A.M.1    Faenza, I.2    Billi, A.M.3    Manzoli, L.4    Evangelisti, C.5    Fala, F.6    Cocco, L.7
  • 80
    • 60549096247 scopus 로고    scopus 로고
    • Akt-dependent and -independent mechanisms of mTOR regulation in cancer
    • Memmott R.M. and Dennis P.A. (2009). Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell. Signal. 21, 656-664.
    • (2009) Cell. Signal. , vol.21 , pp. 656-664
    • Memmott, R.M.1    Dennis, P.A.2
  • 81
    • 0035951790 scopus 로고    scopus 로고
    • Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes
    • Miyakawa Y., Rojnuckarin P., Habib T. and Kaushansky K. (2001). Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes. J. Biol. Chem. 276, 2494-2502.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2494-2502
    • Miyakawa, Y.1    Rojnuckarin, P.2    Habib, T.3    Kaushansky, K.4
  • 83
    • 0035230221 scopus 로고    scopus 로고
    • Bipotential B-macrophage progenitors are present in adult bone marrow
    • Montecino-Rodriguez E., Leathers H. and Dorshkind K. (2001). Bipotential B-macrophage progenitors are present in adult bone marrow. Nat. Immunol. 2, 83-88.
    • (2001) Nat. Immunol. , vol.2 , pp. 83-88
    • Montecino-Rodriguez, E.1    Leathers, H.2    Dorshkind, K.3
  • 84
    • 0036754036 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells
    • Myklebust J.H., Blomhoff H.K., Rusten L.S., Stokke T. and Smeland E.B. (2002). Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells. Exp. Hematol. 30, 990-1000.
    • (2002) Exp. Hematol. , vol.30 , pp. 990-1000
    • Myklebust, J.H.1    Blomhoff, H.K.2    Rusten, L.S.3    Stokke, T.4    Smeland, E.B.5
  • 85
    • 40549087266 scopus 로고    scopus 로고
    • PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1)
    • Nakao T., Geddis A.E., Fox N.E. and Kaushansky K. (2008). PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1). Cell Cycle 7, 257-266.
    • (2008) Cell Cycle , vol.7 , pp. 257-266
    • Nakao, T.1    Geddis, A.E.2    Fox, N.E.3    Kaushansky, K.4
  • 87
    • 38349132624 scopus 로고    scopus 로고
    • Deconstructing stem cell self-renewal: Genetic insights into cell-cycle regulation
    • Orford K.W. and Scadden D.T. (2008). Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat. Rev. Genet. 9, 115-128.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 115-128
    • Orford, K.W.1    Scadden, D.T.2
  • 88
    • 39349096526 scopus 로고    scopus 로고
    • Hematopoiesis: An evolving paradigm for stem cell biology
    • Orkin S.H. and Zon L.I. (2008). Hematopoiesis: an evolving paradigm for stem cell biology. Cell 132, 631-644.
    • (2008) Cell , vol.132 , pp. 631-644
    • Orkin, S.H.1    Zon, L.I.2
  • 89
    • 67349241955 scopus 로고    scopus 로고
    • DEPTOR is an mTOR inhibitor frequently opverexpressed in multiple myeloma cells and required for their survival
    • Peterson T.R., Laplante M., Thoreen C.C., Sancak Y., Kang S.A., Kuehl W.M., Gray N.S. and Sabatini D.M. (2009). DEPTOR is an mTOR inhibitor frequently opverexpressed in multiple myeloma cells and required for their survival. Cell 137, 873-886.
    • (2009) Cell , vol.137 , pp. 873-886
    • Peterson, T.R.1    Laplante, M.2    Thoreen, C.C.3    Sancak, Y.4    Kang, S.A.5    Kuehl, W.M.6    Gray, N.S.7    Sabatini, D.M.8
  • 90
    • 47149084029 scopus 로고    scopus 로고
    • Evolving concepts on the microenvironmental niche for hematopoietic stem cells
    • Raaijmakers M.H. and Scadden D.T. (2008). Evolving concepts on the microenvironmental niche for hematopoietic stem cells. Curr. Opin. Hematol. 15, 301-306.
    • (2008) Curr. Opin. Hematol. , vol.15 , pp. 301-306
    • Raaijmakers, M.H.1    Scadden, D.T.2
  • 91
    • 33644769115 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation
    • Raslova H., Baccini V., Loussaief L., Comba B., Larghero J., Debili N. and Vainchenker W. (2006). Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation. Blood 107, 2303-2310.
    • (2006) Blood , vol.107 , pp. 2303-2310
    • Raslova, H.1    Baccini, V.2    Loussaief, L.3    Comba, B.4    Larghero, J.5    Debili, N.6    Vainchenker, W.7
  • 93
    • 35348875375 scopus 로고    scopus 로고
    • Cytokine receptors and hematopoietic differentiation
    • Robb L. (2007). Cytokine receptors and hematopoietic differentiation. Oncogene 26, 6715-6723.
    • (2007) Oncogene , vol.26 , pp. 6715-6723
    • Robb, L.1
  • 94
    • 0035798667 scopus 로고    scopus 로고
    • The roles of phosphatidylinositol 3-kinase and protein kinase C for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes
    • Rojnuckarin P., Miyakawa Y., Fox N.E., Deou J., Daum G. and Kaushansky K. (2001). The roles of phosphatidylinositol 3-kinase and protein kinase C for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes. J. Biol. Chem. 276, 41014-41022.
    • (2001) J. Biol. Chem. , vol.276 , pp. 41014-41022
    • Rojnuckarin, P.1    Miyakawa, Y.2    Fox, N.E.3    Deou, J.4    Daum, G.5    Kaushansky, K.6
  • 96
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov D.D., Guertin D.A., Ali S.M. and Sabatini D.M. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 97
    • 0018102359 scopus 로고
    • The relationship between the spleen colony-forming cell and the haemopoietic stem cell
    • Schofield R. (1978). The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4, 7-25.
    • (1978) Blood Cells , vol.4 , pp. 7-25
    • Schofield, R.1
  • 99
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • Shah O.J., Wang Z. and Hunter T. (2004). Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14, 1650-1656.
    • (2004) Curr. Biol. , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 100
    • 43749115751 scopus 로고    scopus 로고
    • The bone marrow niche: Habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites
    • Shiozawa Y., Havens A.M., Pienta K.J. and Taichman R.S. (2008). The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites. Leukemia 22, 941-950.
    • (2008) Leukemia , vol.22 , pp. 941-950
    • Shiozawa, Y.1    Havens, A.M.2    Pienta, K.J.3    Taichman, R.S.4
  • 101
    • 0002059910 scopus 로고
    • Decline in colony-forming ability of marrow cells subjected to serial transplantation into irradiated mice
    • Siminovitch L., Till J.E. and McCulloch E.A. (1964). Decline in colony-forming ability of marrow cells subjected to serial transplantation into irradiated mice. J. Cell. Physiol. 64, 23-31.
    • (1964) J. Cell. Physiol. , vol.64 , pp. 23-31
    • Siminovitch, L.1    Till, J.E.2    McCulloch, E.A.3
  • 102
    • 0030014681 scopus 로고    scopus 로고
    • The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells
    • Sitnicka E., Lin N., Priestley G.V., Fox N., Broudy V.C., Wolf N.S. and Kaushansky K. (1996). The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 87, 4998-5005.
    • (1996) Blood , vol.87 , pp. 4998-5005
    • Sitnicka, E.1    Lin, N.2    Priestley, G.V.3    Fox, N.4    Broudy, V.C.5    Wolf, N.S.6    Kaushansky, K.7
  • 104
    • 55049091452 scopus 로고    scopus 로고
    • Inhibition of GSK-3, promotes survival and proliferation of megakaryocytic cells through a beta-catenin-independent pathway
    • Soda M., Willert K., Kaushansky K. and Geddis A.E. (2008). Inhibition of GSK-3, promotes survival and proliferation of megakaryocytic cells through a beta-catenin-independent pathway. Cell. Signal. 20, 2317-2323.
    • (2008) Cell. Signal. , vol.20 , pp. 2317-2323
    • Soda, M.1    Willert, K.2    Kaushansky, K.3    Geddis, A.E.4
  • 105
    • 5444222234 scopus 로고    scopus 로고
    • XBP1: A link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
    • Sriburi R., Jackowski S., Mori K. and Brewer J.W. (2004). XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J. Cell Biol. 167, 35-41.
    • (2004) J. Cell Biol. , vol.167 , pp. 35-41
    • Sriburi, R.1    Jackowski, S.2    Mori, K.3    Brewer, J.W.4
  • 106
    • 59649130242 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue deleted on chromosome 10: Extending its PTENtacles
    • Stiles B.L. (2009). Phosphatase and tensin homologue deleted on chromosome 10: extending its PTENtacles. Int. J. Biochem. Cell Biol. 41, 757-761.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 757-761
    • Stiles, B.L.1
  • 107
    • 38049187096 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways
    • Tamburini J., Chapuis N., Bardet V., Park S., Sujobert P., Willems L., Ifrah N., Dreyfus F., Mayeux P., Lacombe C. and Bouscary D. (2008). Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. Blood 111, 379-382.
    • (2008) Blood , vol.111 , pp. 379-382
    • Tamburini, J.1    Chapuis, N.2    Bardet, V.3    Park, S.4    Sujobert, P.5    Willems, L.6    Ifrah, N.7    Dreyfus, F.8    Mayeux, P.9    Lacombe, C.10    Bouscary, D.11
  • 108
    • 0035805516 scopus 로고    scopus 로고
    • Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes. Regulation of cell cycling as a downstream molecule of thrombopoietin signaling
    • Tanaka M., Kirito K., Kashii Y., Uchida M., Watanabe T., Endo H., Endoh T., Sawada K., Ozawa K. and Komatsu N. (2001). Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes. Regulation of cell cycling as a downstream molecule of thrombopoietin signaling. J. Biol. Chem. 276, 15082-15089.
    • (2001) J. Biol. Chem. , vol.276 , pp. 15082-15089
    • Tanaka, M.1    Kirito, K.2    Kashii, Y.3    Uchida, M.4    Watanabe, T.5    Endo, H.6    Endoh, T.7    Sawada, K.8    Ozawa, K.9    Komatsu, N.10
  • 109
    • 34547660196 scopus 로고    scopus 로고
    • FoxO transcription factors and stem cell homeostasis: Insights from the hematopoietic system
    • Tothova Z. and Gilliland D.G. (2007). FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system. Cell Stem Cell 1, 140-152.
    • (2007) Cell Stem Cell , vol.1 , pp. 140-152
    • Tothova, Z.1    Gilliland, D.G.2
  • 111
    • 0034683050 scopus 로고    scopus 로고
    • Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors
    • Uddin S., Kottegoda S., Stigger D., Platanias L.C. and Wickrema A. (2000). Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors. Biochem. Biophys. Res. Commun. 275, 16-19.
    • (2000) Biochem. Biophys. Res. Commun. , vol.275 , pp. 16-19
    • Uddin, S.1    Kottegoda, S.2    Stigger, D.3    Platanias, L.C.4    Wickrema, A.5
  • 112
    • 0035927590 scopus 로고    scopus 로고
    • Leukemic transformation of normal murine erythroid progenitors: V- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis
    • von Lindern M., Deiner E.M., Dolznig H., Parren-Van Amelsvoort M., Hayman M.J., Mullner E.W. and Beug H. (2001). Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis. Oncogene 20, 3651-3664.
    • (2001) Oncogene , vol.20 , pp. 3651-3664
    • Von Lindern, M.1    Deiner, E.M.2    Dolznig, H.3    Parren-Van Amelsvoort, M.4    Hayman, M.J.5    Mullner, E.W.6    Beug, H.7
  • 113
    • 47049127002 scopus 로고    scopus 로고
    • Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
    • Wang L., Harris T.E. and Lawrence J.C. Jr (2008). Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J. Biol. Chem. 283, 15619-15627.
    • (2008) J. Biol. Chem. , vol.283 , pp. 15619-15627
    • Wang, L.1    Harris, T.E.2    Lawrence Jr., J.C.3
  • 114
    • 55749107812 scopus 로고    scopus 로고
    • The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases
    • Weissman I.L. and Shizuru J.A. (2008). The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases. Blood 112, 3543-3553.
    • (2008) Blood , vol.112 , pp. 3543-3553
    • Weissman, I.L.1    Shizuru, J.A.2
  • 117
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • DOI 10.1038/nature04703, PII NATURE04703
    • Yilmaz O.H., Valdez R., Theisen B.K., Guo W., Ferguson D.O., Wu H. and Morrison S.J. (2006). Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482. (Pubitemid 44050144)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3    Guo, W.4    Ferguson, D.O.5    Wu, H.6    Morrison, S.J.7
  • 119
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan T.L. and Cantley L.C. (2008). PI3K pathway alterations in cancer: variations on a theme. Oncogene 27, 5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 121
    • 26844473307 scopus 로고    scopus 로고
    • Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo
    • Zhang J. and Lodish H.F. (2005). Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo. Proc. Natl. Acad. Sci. USA 102, 14605-14610.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 14605-14610
    • Zhang, J.1    Lodish, H.F.2
  • 122
    • 31544481433 scopus 로고    scopus 로고
    • Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway
    • Zhao W., Kitidis C., Fleming M.D., Lodish H.F. and Ghaffari S. (2006). Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway. Blood 107, 907-915.
    • (2006) Blood , vol.107 , pp. 907-915
    • Zhao, W.1    Kitidis, C.2    Fleming, M.D.3    Lodish, H.F.4    Ghaffari, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.