Evolving concepts on the microenvironmental niche for hematopoietic stem cells

Current Opinion in Hematology

Volumn 15, Issue 4, 2008, Pages 301-306

  Raaijmakers, Marc H G P ^a,b   Scadden, David T ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD STEM CELL INSTITUTE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

Hematopoietic stem cell; Leukemia; Microenvironment; Niche; Transplantation

Indexed keywords

CYTARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; IMATINIB; PARATHYROID HORMONE;

BONE MARROW; CELL INTERACTION; CELL STRUCTURE; CLINICAL TRIAL; DROSOPHILA; HEMATOLOGIC DISEASE; HEMATOPOIETIC STEM CELL; HUMAN; LEUKEMIA CELL; MICROENVIRONMENT; MOLECULAR BIOLOGY; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; REVIEW; STEM CELL TRANSPLANTATION; ANIMAL; CELL COMMUNICATION; CYTOLOGY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; PHYSIOLOGY;

ANIMALS; CELL COMMUNICATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS;

EID: 47149084029     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e328303e14c     Document Type: Review

References (34)

1. Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003; 425:841-846.
2. Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003; 425:836-841.
3. Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006; 25:977-988.
4. Arai F, Hirao A, Ohmura M, et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004; 118:149-161.
5. AdamsGB, Chabner KT, Alley IR, et al. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 2006; 439:599-603.
6. Stier S, Ko Y, Forkert R, et al. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med 2005; 201:1781-1791.
7. Adams GB, Scadden DT. The hematopoietic stem cell in its place. Nat Immunol 2006; 7:333-337.
8. Martinez-Agosto JA, Mikkola HK, Hartenstein V, Banerjee U. The hematopoietic stem cell and its niche: a comparative view. Genes Dev 2007; 21: 3044-3060.
9. Kiel MJ, Yilmaz OH, Iwashita T, et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005; 121:1109-1121.
10. Katayama Y, Battista M, Kao WM, et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 2006; 124:407-421.
11. Kollet O, Dar A, Shivtiel S, et al. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med 2006; 12:657-664.
12. XieT, Spradling AC. A niche maintaining germ line stem cells in the Drosophila ovary. Science 2000; 290:328-330.
13. Kiger AA, White-Cooper H, Fuller MT. Somatic support cells restrict germline stem cell self-renewal and promote differentiation. Nature 2000; 407:750-754.
14. Crittenden SL, Bernstein DS, Bachorik JL, et al. A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans. Nature 2002; 417:660-663.
15. Krzemien J, Dubois L, Makki R, et al. Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre. Nature 2007; 446:325-328.
16. Mandal L, Martinez-Agosto JA, Evans CJ, et al. A hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors. Nature 2007; 446:320-324.
17. Sacchetti B, Funari A, Michienzi S, et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 2007; 131:324-336.
18. Jung Y, Wang J, Song J, et al. Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation. Blood 2007; 110:82-90.
19. Yang L, Wang L, Geiger H, et al. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc Natl Acad Sci USA 2007; 104:5091-5096.
20. Oguro H, Iwama A, Morita Y, et al. Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med 2006; 203:2247-2253.
21. Flynn CM, Kaufman DS. Donor cell leukemia: insight into cancer stem cells and the stem cell niche. Blood 2007; 109:2688-2692.
22. Walkley CR, Olsen GH, Dworkin S, et al. A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell 2007; 129:1097-1110.
23. Walkley CR, Shea JM, Sims NA, et al. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 2007; 129:1081-1095.
24. Huntly BJ, Gilliland DG. Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer 2005; 5:311-321.
25. Krause DS, Lazarides K, von Andrian UH, Van Etten RA. Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med 2006; 12:1175-1180.
26. Jin L, Hope KJ, Zhai Q, et al. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 2006; 12:1167-1174.
27. Ishikawa F, Yoshida S, Saito Y, et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol 2007; 25:1315-1321.
28. Castor A, Nilsson L, Astrand-Grundstrom I, et al. Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. Nat Med 2005; 11:630-637.
29. Wang L, O'Leary H, Fortney J, Gibson LF. Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells. Blood 2007; 110:3334-3344.
30. Iwamoto S, Mihara K, Downing JR, et al. Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. J Clin Invest 2007; 117:1049-1057.
31. Williams RT, den BW, Sherr CJ. Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia. Genes Dev 2007; 21:2283-2287.
32. Adams GB, Scadden DT. A niche opportunity for stem cell therapeutics. Gene Ther 2008; 15:96-99.
33. Adams GB, Martin RP, Alley IR, et al. Therapeutic targeting of a stem cell niche. Nat Biotechnol 2007; 25:238-243.
34. Ballen KK, Shpall EJ, Avigan D, et al. Phase I trial of parathyroid hormone to facilitate stem cell mobilization. Biol Blood Marrow Transplant 2007; 13:838-843.