Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL

Journal of Thrombosis and Haemostasis

Volumn 5, Issue 6, 2007, Pages 1274-1282

  Kozuma, Y ^a   Kojima, Hiroshi ^a   Yuki, S ^a   Suzuki, H ^b   Nagasawa, T ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b Tokyo Metropolitan Inst Technol   (Japan)

Author keywords

Apoptosis; Bcl xL; Caspase 3; Megakaryocyte; Thrombopoietin

Indexed keywords

CASPASE 3; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BCL XL; PROTEIN KINASE B; THROMBOPOIETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; RNA CLEAVAGE; THROMBOCYTOPOIESIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BASE SEQUENCE; BCL-X PROTEIN; CELL LINE; CELL SURVIVAL; DNA, COMPLEMENTARY; ENZYME ACTIVATION; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; MEGAKARYOCYTES; MICE; MICE, INBRED C57BL; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THROMBOPOIESIS; THROMBOPOIETIN; TRANSFECTION;

EID: 34250183122     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2007.02546.x     Document Type: Article

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