Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3

Blood

Volumn 88, Issue 2, 1996, Pages 429-436

  Kobayashi, Masao ^b   Laver, Joseph H ^b   Kato, Takashi ^b   Miyazaki, Hiroshi ^b   Ogawa, Makio ^a  

^a RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 11; INTERLEUKIN 3; INTERLEUKIN 6; METHYLCELLULOSE; THROMBOPOIETIN;

ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CELL SEPARATION; CELL SUBPOPULATION; COLONY FORMING UNIT; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MEGAKARYOPOIESIS; PRIORITY JOURNAL; STEM CELL; THROMBOCYTE COUNT; THROMBOCYTOPOIESIS;

EID: 0029900227     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.2.429.bloodjournal882429     Document Type: Article

References (42)

1. de Sauvage FJ, Mass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC. Kuang W-J, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and throinhopoiesis by the c-Mpl ligand. Nature 369:533, 1994
2. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM. Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
3. Bartley TD, Bogenberger J, Hunt P, Li Y-S, Lu HS, Martin F, Chang MS, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD. Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu MCT, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
4. Sohma Y, Akahori H, Seki N, Hori T, Ogami K, Kato T, Shimoda Y, Kawamura K, Miyazaki H: Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett 353:57, 1994
5. Kato T, Ogami K, Shimada Y, Iwamatsu A, Sohma Y, Akahori H, Horie K, Kokubo A, Kudo Y, Maeda E, Kobayashi K, Ohashi H, Ozawa T, Inoue H, Kawamura K, Miyazaki H: Purification and characterization of thrombopoietin. J Biochem 118:229, 1995
6. Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 91:11104, 1994
7. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369:568, 1994
8. Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vuinchenker W: c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
9. Zeigler FC, de Sauvage F, Widmer HR, Keller GA, Donahue C, Schreiber RD, Malloy B, Hass B, Eaton D, Matthews W: In vitro megakaryopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 84:4045, 1994
10. Kaushansky K: Thrombopoietin: The primary regulator of platelet production. Blood 86:419, 1995
11. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
12. Souyri M, Vigon I, Penciolelli J-F, Heard J-M, Tambourin P, Wendling F: A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137, 1990
13. Wendung F, Varlet P, Charon M, Tambourin P: A retrovirus complex inducing an acute myeloproliferalive leukemia disorder in mice. Virology 149:242, 1986
14. Wendung F. Penciolelli JF, Charon M, Tambourin P: Factorindependent erythropoietic progenitro cells in leukemia in duced by the myeloproliferative leukemia virus. Blood 73:1161, 1989
15. Methia N, Louache F, Vainchenker W, Wendling F: Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82:1395, 1993
16. Kaushansky K, Broudy VC, Grossmann A, Humes J, Lin N, Ren HP, Bailey MC, Papayannopoulou T, Forstrom JW, Sprugel KH: Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 96:1683, 1995
17. Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M: Recombinant human thrombopoietin (Mp1 ligand) enhances proliferation of erythroid progenitors. Blood 86:2494, 1995
18. Ku H, Yonemura Y, Kaushansky K, Ogawa M: Thrombopoietin, the ligand of the Mpl receptor, synergises with steel factor and other early-acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood (in press)
19. Iscove NN, Guilbert LJ, Weyman C: Complete replacement of serum in primary cultures of erythropoietin-dependent red cell precursors (CFU-E) by albumin, transferrin, iron, unsturated fatty acid, lecithin and cholesterol. Exp Cell Res 126:121, 1980
20. Sonoda Y, Ogawa M: Serum-free culture of human hempoietic progenitors in attenuated cuture media. Am J Hematol 28:227, 1988
21. Leary AG, Ogawa M: Assay for human blast cell colonies, in Freshney RI, Pragnell IB, Freshney MG (eds): Culture of Hematopoietic Cells. New York, NY. Wiley-Liss, 1994, p 55
22. Leary AG, Yang Y-C, Clark SC, Gasson JC, Golde DW, Ogawa M: Recombinant gibbon interleukin-3 supports formation of human multilineage colonies and blast cell colonies in culture: Comparison with recombinant human granulocyte-macrophage colony-stimulationg factor. Blood 70:1343, 1987
23. Katayama N, Shih JP, Nishikawa S, Kina T, Clark SC, Ogawa M: Stage-specific expression of c-kit protein by murine hematopoietic progenitors. Blood 82:2353, 1993
24. Zanjani ED, Kawashima I, Almeida-Porada G, Zeng HQ, Leary AG, Flake AW, Ogawa M: Human/sheep hematopoietic chimerism: a relatively specific and sensitive model for the in vivo assay of human hematopoietic stem cells. Blood 86:487a, 1995 (suppl 1, abstr)
25. Kawashima I, Zanjani ED, Almaida-Porada G, Flake AW, Zeng HQ, Ogawa M: CD34-positive human marrow cells that express low levels of Kit protein are enriched for long-term marrow engrafting cells. Blood (in press)
26. -/CD38 progenitor cells. Blood 77:1218, 1991
27. - progenitor cells in long-term cultures and semisolid assays. Blood 81:2916, 1993
28. + human hematopoietic progenitor cells. J Exp Med 180:1177, 1994
29. lo human marrow cells after in vitro cytokine exposure. Blood 85:1480, 1995
30. high cells. Blood 82:3283, 1993
31. Ikebuchi K, Wong GG, Clark SC, Ihle JN, Hirai Y, Ogawa M: Interleukin-6 enhancement of interleukin-3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci USA 84:9035, 1987
32. Ikebuchi K, Clark SC, Ihle JN, Souza LM, Ogawa M: Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci USA 85:3445, 1988
33. Leary AG, Ikebuchi K, Hirai Y, Wong GG, Yang Y-C, Clark SC, Ogawa M: Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hemopoietic stem cells: Comparison with interleukin-1α. Blood 71:1759, 1988
34. 0 does not require early hemopoietic regulators. Proc Natl Acad Sci USA 86:4535, 1989
35. Musashi M, Yang Y-C, Paul SR, Clark SC, Sudo T, Ogawa M: Direct and synergistic effects of interleukin-11 on murine hemopoiesis in culture. Proc Natl Acad Sci USA 88:1223, 1991
36. Tsuji K, Lyman SD, Sudo T, Clark SC, Ogawa M: Enhancement of murine hemopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11 and other early-acting factors in culture. Blood 79:2855, 1992
37. 0 and enrty into cell cycle of primitive human hematopoietic progenitors. Proc Natl Acad Sci USA 89:4013, 1992
38. Ogawa M: Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844, 1993
39. Zanjani ED, Almeida-Porada G, Flake AW: Retention and multilineage expression of human hematopoietic stem cells in human-sheep chimeras. Stem Cells 13:101, 1995
40. - cells in cord blood and bone maroow. Blood 86:3745, 1995
41. Yonemura Y, Ku H, Hirayama F, Ogawa M: IL-3 or IL-1 abrogates the reconstituting ability of hematopoietic stem cells. Proc Natl Acad Sci USA (in press)
42. Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT: Functional isolation and characterization of human hematopoietic stem cells. Science 267:104, 1995