Expression of concern: Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes (Journal of Cell Science (2006) 119 (744-752) DOI: 10.1242/jcs.02784);Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes

Journal of Cell Science

Volumn 119, Issue 4, 2006, Pages 744-752

  Guerriero, Raffaella ^a   Parolini, Isabella ^a   Testa, Ugo ^a   Samoggia, Paola ^a   Petrucci, Eleonora ^a   Sargiacomo, Massimo ^a   Chelucci, Christiana ^a   Gabbianelli, Marco ^a   Peschle, Cesare ^a,b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

MAPK; Megakaryocytopoiesis; mTOR; P13K; Polyploidization; Signal transduction

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CD34 ANTIGEN; CD61 ANTIGEN; CYCLIN D3; DNA; FIBRINOGEN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SHC; RAPAMYCIN; RAS PROTEIN; THROMBOPOIETIN;

ADULT; ARTICLE; CD34 SELECTION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL MATURATION; CELL NUCLEUS; CELL POPULATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DNA CONTENT; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MALE; MAMMAL CELL; MEGAKARYOCYTE; MITOSIS INHIBITION; NORMAL HUMAN; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STEM CELL; WESTERN BLOTTING;

MAMMALIA;

EID: 33645070791     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.237495     Document Type: Erratum

References (47)

1. Alvarez, B., Garrido, E., Garcia-Sanz, J. A. and Carrera, A. C. (2003). Phosphoinositide 3-kinase activation regulates cell division time by coordinated control of cell mass and cell cycle progression rate. J. Biol. Chem. 278, 26466-26473.
2. Bjornsti, M. A. and Houghton, P. J. (2004). The TOR pathway: a target for cancer therapy. Nat. Rev. Cancer 4, 335-348.
3. Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J. et al. (2001). Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat. Cell Biol. 3, 1014-1019.
4. Breslin, E. M., White, P. C., Shore, A. M., Clement, M. and Brennan, P. (2005). LY294002 and rapamycin co-operate to inhibit T-cell proliferation. Br. J. Pharmacol. 144, 791-800.
5. Cramer, E. M., Norol, F., Guichard, J., Breton-Gorius, J., Vainchenker, W., Masse, J. M. and Debili, N. (1997). Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand. Blood 89, 2336-2346.
6. Datta, S. R., Brunet, A. and Greenberg, M. E. (1999). Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927.
7. Decker, T., Hipp, S., Ringshausen, I., Bogner, C., Oelsner, M., Schneller, F. and Peschel, C. (2003). Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin. Blood 101, 278-285.
8. Dolci, S., Pellegrini, M., Di Agostino, S., Geremia, R. and Rossi, P. (2001). Signaling through extracellular signal-regulated kinase is required for spermatogonial proliferative response to stem cell factor. J. Biol. Chem. 276, 40225-40233.
9. Dolzhanskiy, A., Basch, R. S. and Karpatkin, S. (1996). Development of human megakaryocytes: I. Hematopoietic progenitors (CD34+ bone marrow cells) are enriched with megakaryocytes expressing CD4. Blood 87, 1353-1360.
10. Drachman, J. G., Griffin, J. D. and Kaushansky, K. (1995). The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J. Biol. Chem. 270, 4979-4982.
11. Feng, L. X., Ravindranath, N. and Dym, M. (2000). Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia. J. Biol. Chem. 275, 25572-25576.
12. Fichelson, S., Freyssinier, J. M., Picard, F., Fontenay-Roupie, M., Guesnu, M., Cherai, M., Gisselbrecht, S. and Porten, F. (1999). Megakaryocyte growth and development factor-induced proliferation and differentiation are regulated by the mitogen-activated protein kinase pathway in primitive cord blood hematopoietic progenitors. Blood 94, 1601-1613.
13. Fingar, D. C., Salama, S., Tsou, C., Harlow, E. and Blenis, J. (2002). Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16, 1472-1487.
14. Furukawa, Y., Kikuchi, J., Nakamura, M., Iwase, S., Yamada, H. and Matsuda, M. (2000). Lineage-specific regulation of cell cycle control gene expression during haematopoietic cell differentiation. Br. J. Haematol. 110, 663-673.
15. Gao, N., Zhang, Z., Jiang, B. H. and Shi, X. (2003). Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem. Biophys. Res. Commun. 310, 1124-1132.
16. Geddis, A. E., Fox, N. E. and Kaushansky, K. (2001). Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors. J. Biol. Chem. 276, 34473-34479.
17. Guerriero, R., Testa, U., Gabbianelli, M., Mattia, G., Montesoro, E., Macioce, G., Pace, A., Ziegler, B., Hassan, H. J. and Peschle, C. (1995). Unilineage megakaryocytic proliferation and differentiation of purified hematopoietic progenitors in serum-free liquid culture. Blood 86, 3725-3736.
18. Guerriero, R., Mattia, G., Testa, U., Chelucci, C., Macioce, G., Casella, I., Samoggia, P., Peschle, C. and Hassan, H. J. (2001). Stromal cell-derived factor 1alpha increases polyploidization of megakaryocytes generated by human hematopoietic progenitor cells. Blood 97, 2587-2595.
19. Kanaji, T., Russell, S., Cunningham, J., Izuhara, K., Fox, J. E. and Ware, J. (2004). Megakaryocyte proliferation and ploidy regulated by the cytoplasmic tail of glycoprotein Ibalpha. Blood 104, 3161-3168.
20. Kaushansky, K., Broudy, V. C., Lin, N., Jorgensen, M. J., McCarty, J., Fox, N., Zucker-Franklin, D. and Lofton-Day, C. (1995). Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. Proc. Natl. Acad. Sci. USA 92, 3234-3238.
21. Majka, M., Ratajczak, J., Villaire, G., Kubiczek, K., Marquez, L. A., Janowska-Wieczorek, A. and Ratajczak, M. Z. (2002). Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets. Exp. Hematol. 30, 751-760.
22. Martens, A. C., Van Der Engh, G. and Hagenbeek, A. (1981). The fluorescence intensity of propidium iodide bound to DANN depends on the concentration of sodium chloride. Cytometry 2, 24-25.
23. Melemed, A. S., Ryder, J. W. and Vik, T. A. (1997). Activation of the mitogen-activated protein kinase pathway is involved in and sufficient for megakaryocytic differentiation of CMK cells. Blood 90, 3462-3470.
24. Minamiguchi, H., Kimura, T., Urata, Y., Miyazaki, H., Bamba, T., Abe, T. and Sonoda, Y. (2001). Simultaneous signalling through c-mpl, c-kit and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3-K, PKC and MAPK pathways. Br. J. Haematol. 115, 175-185.
25. Miyakawa, Y., Rojnuckarin, P., Habib, T. and Kaushansky, K. (2001). Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes. J. Biol. Chem. 276, 2494-2502.
26. Nagata, Y. and Todokoro, K. (1995). Thrombopoietin induces activation of at least two distinct signaling pathways. FEBS Lett. 337, 497-501.
27. Racke, F. K., Lewandowska, K., Goueli, S. and Goldfarb, A. N. (1997). Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells. J. Biol. Chem. 272, 23366-23370.
28. Rojnuckarin, P., Drachman, J. G. and Kaushansky, K. (1999). Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. Blood 94, 1273-1282.
29. Rojnuckarin, P., Miyakawa, Y., Fox, N. E., Deou, J., Daum, G. and Kaushansky, K. (2001). The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes. J. Biol. Chem. 276, 41014-41022.
30. Rommel, C., Clarke, B. A., Zimmermann, S., Nunez, L., Rossman, R., Reid, K., Moelling, K., Yancopoulos, G. D. and Glass, D. J. (1999). Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 286, 1738-1741.
31. Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D. and Glass, D. J. (2001). Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat. Cell Biol. 3, 1009-1013.
32. Rouyez, M. C., Boucheron, C., Gisselbrecht, S., Dusanter-Fourt, I. and Porteu, F. (1997). Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway. Mol. Cell. Biol. 17, 4991-5000.
33. Roy, L., Coullin, P., Vitrat, N., Hellio, R., Debili, N., Weinstein, J., Bernheim, A. and Vainchenker, W. (2001). Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes. Blood 97, 2238-2247.
34. Sattler, M., Salgia, R., Durstin, M. A., Prasad, K. V. and Griffin, J. D. (1997). Thrombopoietin induces activation of the phosphatidylinositol-3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120. CBL. J. Cell. Phys. 171, 28-33.
35. Sebolt-Leopold, J. S. and Herrera, R. (2004). Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat. Rev. Cancer 4, 937-947.
36. Shao, J., Evers, B. M. and Sheng, H. (2004). Roles of phosphatidylinositol 3′-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation ofintestinal epithelial cells. Cancer Res. 64, 229-235.
37. Songyang, Z., Baltimore, D., Cantley, L. C., Kaplan, D. R. and Franke, T. F. (1997). Interleukin 3-dependent survival by the Akt protein kinase. Proc. Natl. Acad. Sci. USA 94, 11345-11350.
38. Sun, S., Zimmet, J. M., Toselli, P., Thompson, A., Jackson, C. W. and Ravid, K. (2001). Overexpression of cyclin D1 moderately increases ploidy in megakaryocytes. Haematologica 86, 17-23.
39. Tong, W. and Lodish, H. F. (2004). Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J. Exp. Med. 200, 569-580.
40. Wang, Z., Zhang, Y., Kamen, D., Lees, E. and Ravid, K. (1995). Cyclin D3 is essential for megakaryocytopoiesis. Blood 86, 3783-3788.
41. Wendling, F. and Vainchenker, W. (1998). Thrombopoietin and its receptor. Eur. Cytokine Netw. 9, 221-231.
42. Whalen, A. M., Galasinski, S. C., Shapiro, P. S., Nahreini, T. S. and Ahn, N. G. (1997). Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol. Cell. Biol. 17, 1947-1958.
43. Vindelov, L. L., Christensen, I. J. and Nissen, N. I. (1983). A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 3, 323-327.
44. Yamada, M., Komatsu, N., Okada, K., Kato, T., Miyazaki, H. and Miura, Y. (1995). Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line. Biochem. Biophys. Res. Commun. 217, 230-237.
45. Zhang, Y., Wang, Z. and Ravid, K. (1996). The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase. J. Biol. Chem. 271, 4266-4272.
46. Zimmet, J. and Ravid, K. (2000). Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system. Exp. Hematol. 28, 3-16.
47. Zimmet, J. M., Ladd, D., Jackson, C. W., Stenberg, P. E. and Ravid, K. (1997). A role for cyclin D3 in the endomitotic cell cycle. Mol. Cell. Biol. 17, 7248-7259.