Role of human liver microsomes in in vitro metabolism of drugs-A review

Applied Biochemistry and Biotechnology

Volumn 160, Issue 6, 2010, Pages 1699-1722

  Asha, Sepuri ^a   Vidyavathi, Maravajhala ^a  

^a INSTITUTE OF PHARMACEUTICAL TECHNOLOGY   (India)

Author keywords

Biotransformation; CYP450; Drug; Human liver microsomes; In vitro metabolism study; Metabolism; Metabolites

Indexed keywords

BIOTRANSFORMATION; CYP450; DRUG METABOLISMS; DRUG METABOLITES; EXPERIMENTAL MODELS; HIGH PROBABILITY; HUMAN LIVER MICROSOMES; HUMAN LIVER MODEL; IN-VITRO; IN-VIVO; METABOLIC FATE;

BIOMOLECULES; LIVER; METABOLITES;

METABOLISM;

ADINAZOLAM; ALACHLOR; AMIODARONE; AMITRIPTYLINE; AMPRENAVIR; AZELASTINE; BENZO[A]PYRENE; BUFURALOL; CELECOXIB; CERIVASTATIN; CHLORPROMAZINE; CHLORPYRIFOS; CILNIDIPINE; CITALOPRAM; COLCHICINE; CYCLOPHOSPHAMIDE; DESOGESTREL; DEXFENFLURAMINE; DEXTROMETHORPHAN; DIAZEPAM; DIMPYLATE; DISOPYRAMIDE; DOCETAXEL; DOXORUBICIN; EBASTINE; ENDOSULFAN; ESTRADIOL; ESTRONE; ETOPOSIDE; UNINDEXED DRUG;

CELL LINE; CYTOSOL; DRUG METABOLISM; EXPERIMENTAL MODEL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KINETICS; LIVER CELL; LIVER MICROSOME; LIVER PERFUSION; LIVER SLICE; METHODOLOGY; NONHUMAN; PROBABILITY; REVIEW;

HEPATOCYTES; HUMANS; KINETICS; LIVER; MICROSOMES, LIVER; PERFUSION; PHARMACEUTICAL PREPARATIONS;

EID: 77949280164     PISSN: 02732289     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12010-009-8689-6     Document Type: Review

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