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Journal of Pharmaceutical and Biomedical Analysis

Volumn 40, Issue 5, 2006, Pages 1121-1130

Characterization of the cytochrome P450 enzymes and enzyme kinetic parameters for metabolism of BVT.2938 using different in vitro systems

(3) Baranczewski, Pawel a Edlund, Per Olof a Postlind, Hans a

a Preclinical R and D (Sweden)

Author keywords

CYP2D6 CYP2D2; Dark Agouti rats; Drug metabolism; Enzyme kinetics

Indexed keywords

[1 [3 [2 [(2 ETHOXY 3 PYRIDINYL)OXY]ETHOXY] 2 PYRAZINYL] METHYLPIPERAZINE]; BVT 2938; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2D; CYTOCHROME P450 2D2; CYTOCHROME P450 2D6; DRUG METABOLITE; ENZYME INHIBITOR; QUINIDINE; SEROTONIN 2C RECEPTOR; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME KINETICS; FEMALE; HUMAN; HUMAN CELL; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FEMALE; HUMANS; ISOENZYMES; KINETICS; MALE; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; PIPERAZINES; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 32644472284 PISSN: 07317085 EISSN: None Source Type: Journal
DOI: 10.1016/j.jpba.2005.09.006 Document Type: Article

Times cited : (9)

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