Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes

Chemical Research in Toxicology

Volumn 11, Issue 6, 1998, Pages 659-665

  Yamazaki, Hiroshi ^a   Shaw, Peter M ^b   Guengerich, F Peter ^c   Shimada, Tsutomu ^a  

^a OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^b INVITROGEN CORPORATION   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DRUG METABOLIZING ENZYME; ESTRADIOL; ESTRONE;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; ESTROGEN METABOLISM; HORMONAL CARCINOGENESIS; HORMONE METABOLISM; HUMAN; HUMAN TISSUE; LIVER MICROSOME; STEROID HYDROXYLATION;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; ESTRADIOL; ESTRONE; HUMANS; HYDROXYLATION; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; STEROID 16-ALPHA-HYDROXYLASE;

EID: 0031830896     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx970217f     Document Type: Article

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