In vitro metabolism of BYZX in human liver microsomes and the structural elucidation of metabolite by liquid chromatography-mass spectrometry method

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 857, Issue 2, 2007, Pages 266-274

  Xia, Zong ling ^a   Ying, Jing yan ^a   Sheng, Rong ^a   Zeng, Su ^a   Hu, Yong zhou ^a   Yao, Tong Wei ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

BYZX; HPLC MS MS; Human liver microsomes (HLM); In vitro metabolism

Indexed keywords

CHOLINESTERASE INHIBITOR; HUMAN LIVER MICROSOMES (HLM); IN VITRO METABOLISM;

BIOLOGICAL ORGANS; CORRELATION METHODS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METABOLITES;

MAMMALS;

2 [4 [(DIETHYLAMINO)METHYL]BENZYLIDENE] 5,6 DIMETHOXY 2,3 DIHYDROINDENONE; CHOLINESTERASE INHIBITOR; CYCLOSPORIN A; KETOCONAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CLEARANCE; DRUG DETERMINATION; DRUG METABOLISM; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL;

BIOLOGICAL ASSAY; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUG STABILITY; ENZYME INHIBITORS; HUMANS; INDENES; INHIBITORY CONCENTRATION 50; KINETICS; MASS SPECTROMETRY; MICROSOMES, LIVER; REPRODUCIBILITY OF RESULTS; SOLUTIONS;

EID: 34548816992     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.07.029     Document Type: Article

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