Involvement of human liver cytochrome P4502B6 in the metabolism of propofol

British Journal of Clinical Pharmacology

Volumn 51, Issue 3, 2001, Pages 281-285

  Oda, Yutaka ^a,b   Hamaoka, Naoya ^a,b   Hiroi, Toyoko ^b   Imaoka, Susumu ^b   Hase, Ichiro ^a,b   Tanaka, Kazuo ^a,b   Funae, Yoshihiko ^b   Ishizaki, Takashi ^b,c   Asada, Akira ^a,b  

^a Department of Anaesthesiology and Intensive Care Medicine ^*  (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Cytochrome P4502B6; Liver; Metabolism; Propofol

Indexed keywords

4' HYDROXYMEPHENYTOIN; ALPHA HYDROXYMIDAZOLAM; CYTOCHROME P450 2B6; DIETHYLDITHIOCARBAMIC ACID; MEPHENYTOIN; MIDAZOLAM; MONOCLONAL ANTIBODY; NORMEPHENYTOIN; ORPHENADRINE; PHENACETIN; PROPOFOL; QUINIDINE; SULFAPHENAZOLE; THYMOL; TROLEANDOMYCIN;

ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; LIVER MICROSOME METABOLISM; METABOLIC REGULATION; PRIORITY JOURNAL;

ANALGESICS, OPIOID; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MICROSOMES, LIVER; OXIDATION-REDUCTION; OXIDOREDUCTASES, N-DEMETHYLATING; PROPOFOL;

EID: 0035039705     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2001.00344.x     Document Type: Article

References (27)

1. 14C-propofol
2. Propofol metabolism in man during the anhepatic and reperfusion phases of liver transplantation
3. Direct high-performance liquid chromatography determination of propofol and its metabolite quinol with their glucuronide conjugates and preliminary pharmacokinetics in plasma and urine of man
4. Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol
5. Propofol inhibits enzymatic degradation of alfentanil and sufentanil by isolated liver microsomes in vitro
6. Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers
7. Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study
8. Human cytochrome P450 mono-oxygenase system is suppressed by propofol
9. Effects of propofol on functional activities of hepatic and extrahepatic conjugation enzyme systems
10. Cimetidine: Interaction with oral anticoagulants in man
11. Fentanyl inhibits metabolism of midazolam: Competitive inhibition of CYP3A4 in vitro
12. Improved method for the determination of propofol in blood by high-performance liquid chromatography with fluorescence detection
13. Identifcation of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin
14. Specifcity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2
15. Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin
16. Isolation and characterization of human liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4k-hydroxylation
17. Inhibition of oxidative drug metabolism by orphenadrine: In vitro and in vivo evidence for isozyme-specifc complexation of cytochrome P-450 and inhibition kinetics
18. Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1
19. Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450
20. Identification of human cytochrome P-450 isoforms involved in metabolism of R(+)- and S(-) -gallopamil: Utility of in vitro disappearance rate
21. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
22. Evidence for propofol hydroxylation by cytochrome P4502B11 in canine liver microsomes: Breed and gender differences
23. Hepatic and extrahepatic disposition of propofol in patients undergoing coronary bypass surgery
24. Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4
25. Further characterization of the expression in liver and catalytic activity of CYP2B6
26. Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat
27. Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes