Metabolism pathway of vinorelbine (Navelbine®) in human: Characterisation of the metabolites by HPLC-MS/MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 47, Issue 1, 2008, Pages 47-58

  de Graeve, J ^a   van Heugen, J C ^a   Zorza, G ^b   Fahy, J ^b   Puozzo, C ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

HPLC MS MS; Human; Metabolites; Vinorelbine

Indexed keywords

4 O DEACETYL VINORELBINE; ACETONITRILE; AMMONIUM ACETATE; CYTOCHROME P450; DRUG METABOLITE; NAVELBINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEACETYLATION; DEALKYLATION; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG FECES LEVEL; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG URINE LEVEL; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROXYLATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MASS SPECTROMETRY; VINBLASTINE;

EID: 41549142711     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.12.006     Document Type: Article

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